RO (Reverse Osmosis) membrane equipment for citicoline sodium

By designing an RO membrane device for sodium citicoline, which automatically collects solid sodium citicoline using a fixed ring and a collection mechanism, the problem of large product loss during separation and purification is solved, achieving efficient separation and simplifying RO membrane replacement, thereby improving yield and stability.

CN223747337UActive Publication Date: 2026-01-02ZENJI PHARM (SUZHOU) LTD
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Patent Information

Application Number
CN202423112214.6
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-12-17
Publication Date
2026-01-02
Estimated Expiration
2034-12-17

AI Technical Summary

Technical Problem

In existing technologies, the separation and purification of sodium citicoline results in significant product loss, and the limited lifespan and inconvenient replacement of RO membranes lead to low yields.

Method used

A sodium citicoline RO membrane device was designed, comprising a fixed ring, an RO membrane, and a collection mechanism. The fixed ring is driven to rotate by a servo motor, which causes the RO membrane to separate and the sodium citicoline solid is automatically collected by a cleaning scraper. Combined with a support frame, it provides stable support and simplifies the RO membrane replacement process.

Benefits of technology

It improved the yield of sodium cytidine diphosphate choline, reduced the difficulty of wastewater treatment, improved separation efficiency, and simplified the RO membrane replacement process.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses RO (Reverse Osmosis) membrane equipment of citicoline sodium, which relates to the technical field of citicoline sodium production and comprises a separation tank, the end part of the separation tank is fixedly connected with a mounting disc through a bolt, two fixing rings are arranged in the separation tank, the outer part of each fixing ring is in threaded connection with a threaded connection ring, and the threaded connection ring is in threaded connection with the separation tank. And an RO membrane is arranged in the separation tank, the two ends of the RO membrane are slidably connected with the two fixing rings correspondingly, and a collecting mechanism is arranged in the RO membrane. By arranging the fixing ring, the RO membrane and the collecting mechanism, a water system in the separation and purification stage in the citicoline sodium synthesis process can be treated, so that products discharged along with the water system are intercepted and recycled, the yield of the products is improved, meanwhile, the treatment difficulty of wastewater is also reduced, and the treatment cost is reduced. And the collection mechanism can be effectively utilized to complete automatic collection of citicoline sodium solids, and convenience is also brought to follow-up replacement of RO membranes by workers.
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Description

TECHNICAL FIELD

[0001] The utility model relates to the field of cytidine sodium production technology, and specifically relates to a cytidine sodium RO membrane equipment. BACKGROUND

[0002] Cytidine sodium is a nucleoside derivative, which is a complex organic molecule composed of cytosine, pyrophosphate and choline, and is one of the main components of cell membrane phospholipids. It can promote brain metabolism and improve brain circulation by reducing cerebral vascular resistance and increasing cerebral blood flow. There are two main methods for preparing cytidine sodium bulk drug: one is to use cytidine as the starting material; the other is to use cytidine acid as the starting material. Both methods require separation and purification during the synthesis process.

[0003] In the process of separating and purifying cytidine sodium in the prior art, the material will be lost due to the water solubility of cytidine sodium, which will lead to low yield. Therefore, it is necessary to use RO membrane to improve the separation and purification effect of cytidine sodium. However, the RO membrane has a certain service life and needs to be replaced regularly to ensure that the device can fully intercept and recover the cytidine sodium product. The process of replacing the RO membrane is troublesome. Therefore, we provide a cytidine sodium RO membrane equipment to solve the above problems. UTILITY MODEL CONTENTS

[0004] The utility model aims to provide a cytidine sodium RO membrane equipment to solve the problems in the prior art.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: a cytidine sodium RO membrane equipment, comprising a separation tank, the end of the separation tank is fixedly connected with a mounting disc through bolts, the inside of the separation tank is provided with two fixed rings, the outside of each fixed ring is threadedly connected with a threaded connecting ring, the inside of the separation tank is provided with an RO membrane, the two ends of the RO membrane are respectively connected with two fixed rings in a sliding mode, the inside of the RO membrane is provided with a collecting mechanism, the collecting mechanism comprises a receiving box, the top surface of the receiving box is fixedly connected with a cleaning scraper, and the bottom surface of the receiving box is fixedly connected with a conveying chute.

[0006] Preferably, the inside of the mounting disc is rotatably connected with a rotating rod, and the outer surface of the rotating rod is fixedly connected with two transmission gears. The rotating rod can drive the transmission gears to rotate.

[0007] Preferably, the inner walls of the two fixed rings are fixedly connected with connecting gear rings, and the two transmission gears are respectively engaged with the two connecting gear rings. The transmission gears have the effect of driving the fixed rings to rotate.

[0008] Preferably, the outer part of the mounting disc is fixedly provided with a servo motor, and the end of the rotating rod is fixedly connected with the output rotating shaft of the servo motor, and the servo motor provides power for the rotation of the fixed ring.

[0009] Preferably, the inner wall of the separation tank is fixedly connected with a support frame, the two fixed rings are rotationally connected with the mounting disc and the support frame respectively, and the support frame provides support and limiting effect for the rotation of the fixed ring.

[0010] Preferably, the inner wall of the separation tank is fixedly connected with a support frame, the two fixed rings are rotationally connected with the mounting disc and the support frame respectively, and the support frame provides support and limiting effect for the rotation of the fixed ring.

[0011] Preferably, the inner wall of the separation tank is fixedly connected with a support frame, the two fixed rings are rotationally connected with the mounting disc and the support frame respectively, and the support frame provides support and limiting effect for the rotation of the fixed ring.

[0012] Preferably, the inner wall of the separation tank is fixedly connected with a support frame, the two fixed rings are rotationally connected with the mounting disc and the support frame respectively, and the support frame provides support and limiting effect for the rotation of the fixed ring.

[0013] Compared with the prior art, the application has the following beneficial effects:

[0014] 1、Through the arrangement of the fixed ring, the RO membrane and the collecting mechanism, the water system in the separation and purification stage in the synthesis process of sodium choline alfoscerate can be treated, so that the product discharged with the water system is intercepted and recovered, the yield of the product is improved, the treatment difficulty of the wastewater is reduced, the automatic collection of the sodium choline alfoscerate solid can be completed by the collecting mechanism, and the subsequent staff is facilitated to replace the RO membrane.

[0015] 2、Through the arrangement of the rotating rod, the transmission gear and the connecting gear ring, the rotating rod can drive the two fixed rings to rotate when rotating, so that the RO membrane can separate the aqueous solution of sodium choline alfoscerate, and the sodium choline alfoscerate solid separated by the RO membrane can be automatically collected by the cleaning scraper, the difficulty of collecting the sodium choline alfoscerate solid is reduced, and the efficiency of separating the sodium choline alfoscerate is improved.

[0016] 3、Through the arrangement of the mounting disc and the support frame, stable support and limiting for the rotation of the fixed ring can be provided, so that the fixed ring can drive the RO membrane to separate and purify the sodium choline alfoscerate, position deviation of the fixed ring in the rotating process is avoided, and the use stability of the device is improved. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is a whole structure schematic view of the application.

[0018] Figure 2It is partial sectional view of the separation tank of the utility model;

[0019] Figure 3 It is internal structure sectional view of the fixed ring of the utility model;

[0020] Figure 4 It is partial structure explosion drawing of the utility model;

[0021] Figure 5 It is structure schematic view of the fixed ring of the utility model.

[0022] Marked number in the drawing: 1, separation tank; 2, mounting disc; 3, fixed ring; 4, threaded connecting ring; 5, RO membrane;

[0023] 6, collection mechanism; 601, receiving box; 602, cleaning scraper; 603, conveying slide; 604, rotating rod; 605, transmission gear; 606, connecting gear ring; 607, servo motor;

[0024] 7, support frame; 8, liquid inlet pipe; 9, blow-off pipe; 10, sealing disc; 11, collection box. DETAILED DESCRIPTION

[0025] The technical scheme in the embodiments of the utility model will be described clearly and completely below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the utility model.

[0026] The utility model provides a kind of technical scheme of the RO membrane equipment of cytidine sodium,

[0027] As Figure 1 And Figure 2 Shown, including separation tank 1, the inside of separation tank 1 is slidably connected with liquid inlet pipe 8, the inner wall of separation tank 1 is fixedly connected with blow-off pipe 9, liquid inlet pipe 8 is convenient to be transported into separation tank 1 with cytidine sodium original solution and is separated and purified, blow-off pipe 9 can be separated after sewage is discharged into sewage recovery device, separation tank 1 inner wall specific position place has certain recess, it is convenient for the sewage after separation can be discharged from blow-off pipe 9 under the action of gravity.

[0028] As Figure 1 、 Figure 2 、 Figure 3 And Figure 4As shown, the end of the separation tank 1 is fixedly connected with the mounting disc 2 by bolts, the outside of the mounting disc 2 is fixedly installed with a servo motor 607, the servo motor 607 is a prior art, and excessive description will not be given herein. The mounting disc 2 provides support for the operation of the servo motor 607. A sliding groove adapted to the fixed ring 3 is formed in the inner wall of the mounting disc 2, which can provide support and stability for the rotation of the fixed ring 3, thereby improving the use stability of the device.

[0029] As shown in Figure 2 , Figure 3 , Figure 4 and Figure 5 , the inside of the separation tank 1 is provided with two fixed rings 3, and the outside of each fixed ring 3 is threadedly connected with a threaded connecting ring 4. When installing the RO membrane 5, the staff first adheres the end of the RO membrane 5 to the fixed ring 3 by adhesive, and then threadedly installs the threaded connecting ring 4 into the fixed ring 3. The threaded connecting ring 4 will extrude the end of the RO membrane 5 during installation, so that the fixed ring 3 and the threaded connecting ring 4 can fully fix the end of the RO membrane 5, and the rotation of the fixed ring 3 can stably drive the RO membrane 5 to rotate, thereby facilitating the RO membrane 5 to separate and purify the citicoline sodium.

[0030] As shown in Figure 2 , Figure 3 and Figure 4 , the inside of the separation tank 1 is provided with an RO membrane 5, and the two ends of the RO membrane 5 are respectively slidably connected with the two fixed rings 3. The RO (Reverse-Osmosis) membrane technology is an existing advanced water treatment technology. It can effectively remove dissolved solids, organic matter, bacteria, viruses and other impurities in water through the selective permeation of the semi-permeable membrane, and is mainly applied in many fields such as drinking water desalination, seawater treatment, industrial high-purity water preparation, industrial wastewater treatment, etc. When the citicoline sodium solution enters the RO membrane 5, the citicoline sodium will be blocked inside the RO membrane 5, and the sewage will penetrate the RO membrane 5 and flow out from the sewage pipe 9, thereby completing the separation of the citicoline sodium.

[0031] As shown in Figure 3 and Figure 4 , the inside of the RO membrane 5 is provided with a collecting mechanism 6, which includes a receiving box 601, and the top surface of the receiving box 601 is fixedly connected with a cleaning scraper 602. The distance between the top end of the cleaning scraper 602 and the inner wall of the RO membrane 5 is small. When the RO membrane 5 rotates, the cleaning scraper 602 can clean the citicoline sodium dissolved solids remaining on the inner wall of the RO membrane 5 into the receiving box 601. The inner wall of the receiving box 601 is an angled surface, which can collect the falling citicoline sodium dissolved solids and make them slide into the conveying slide 603.

[0032] The bottom surface of the receiving box 601 is fixedly connected with a conveying chute 603, the outside of the separation tank 1 is provided with a collection box 11, the conveying chute 603 is fixedly connected with the collection box 11 through a hose, the conveying chute 603 penetrates through the mounting disc 2 and is fixedly connected with the mounting disc 2, through the setting of the conveying chute 603, stable support can be provided for the receiving box 601 and the cleaning scraper 602, the conveying chute 603 has a certain angle of inclination, and the inner wall thereof is smooth, so that the fallen sodium choline solubles can slide into the collection box 11 under the action of gravity, the collection box 11 can collect the sodium choline solubles, facilitating subsequent processing and use of the sodium choline solubles, and the surface of the conveying chute 603 is also provided with a baffle, which can limit the fixed ring 3 to a certain extent, preventing the fixed ring 3 from being separated from the mounting disc 2.

[0033] The inside of the mounting disc 2 is rotatably connected with a rotating rod 604, the end of the rotating rod 604 is fixedly connected with the output rotating shaft of the servo motor 607, the outer surface of the rotating rod 604 is fixedly connected with two transmission gears 605, the servo motor 607 can drive the rotating rod 604 to rotate, the rotating rod 604 can drive the two transmission gears 605 on the surface to rotate synchronously, so that the transmission gear 605 can drive the two fixed rings 3 to rotate synchronously through the connecting gear ring 606, thereby providing power for the separation of the sodium choline solubles.

[0034] The inner walls of the two fixed rings 3 are fixedly connected with the connecting gear ring 606, the two transmission gears 605 are respectively engaged with the two connecting gear rings 606, the transmission gear 605 can drive the connecting gear ring 606 to rotate, so that the two fixed rings 3 drive the RO membrane 5 to rotate at the same rotating direction and speed, the RO membrane 5 is usually made of high molecular materials, such as polyamide composite membrane, which has certain toughness and strength and can remain stable in high pressure and chemical environment, when the two fixed rings 3 drive the RO membrane 5 to rotate, the sodium choline solubles will be adhered to the inner wall of the RO membrane 5 to a certain extent due to the certain humidity after separation.

[0035] As shown in Figure 2 The inner wall of the separation tank 1 is fixedly connected with a support frame 7, the two fixed rings 3 are rotatably connected with the mounting disc 2 and the support frame 7 respectively, the support frame 7 provides stable support for the rotation of the fixed ring 3 and limits the fixed ring 3, avoiding position deviation of the fixed ring 3 during rotation and ensuring normal operation of the fixed ring 3.

[0036] The inner part of the fixed ring 3 is fixedly connected with a sealing disc 10, the liquid inlet pipe 8 penetrates through the sealing disc 10 and is in sliding connection with the sealing disc 10, the sealing disc 10 has good sealing property with the fixed ring 3 and the mounting disc 2 and the fixed ring 3, so that the raw material solution in the RO membrane 5 through the liquid inlet pipe 8 can be prevented from flowing out from the connected gap, and the waste of the sodium choline alfoscerate product is reduced.

[0037] Working principle: when the staff wants to separate the sodium choline alfoscerate raw material solution, first, the raw material is transported into the RO membrane 5 through the liquid inlet pipe 8, then the servo motor 607 is started, the servo motor 607 can drive the two fixed rings 3 to rotate through the rotating rod 604 and the transmission gear 605, so as to drive the RO membrane 5 to separate the solution, block the sodium choline alfoscerate solid on the inner wall of the RO membrane 5, and collect the sodium choline alfoscerate solid on the inner wall into the receiving box 601 through the cleaning scraper 602 in the rotating process of the RO membrane 5, when the RO membrane 5 needs to be replaced, the staff removes the mounting disc 2 by rotating the bolt, then removes the fixed ring 3 and the RO membrane 5 from the separation tank 1, and removes the threaded connection ring 4 from the fixed ring 3, so that the RO membrane 5 can be disassembled, and the above steps are reversed to install the RO membrane 5.

[0038] It is apparent for those skilled in the art that the present application is not limited to the details of the above exemplary embodiments, but can be implemented in other concrete forms without departing from the spirit or essential characteristics of the present application. Therefore, the embodiments should be considered in all aspects as exemplary and not restrictive, and the scope of the present application is defined by the appended claims rather than the above description, and all changes falling within the meaning and range of equivalent elements of the claims are intended to be embraced in the present application. Any reference signs in the claims should not be considered as limiting the claims involved.

Claims

1. An RO membrane device for sodium citicoline, comprising a separation tank (1), characterized in that: The end of the separation tank (1) is fixedly connected to the mounting plate (2) by bolts. The separation tank (1) is provided with two fixing rings (3). Each fixing ring (3) is threadedly connected to a threaded connecting ring (4). The separation tank (1) is provided with an RO membrane (5). The two ends of the RO membrane (5) are slidably connected to the two fixing rings (3) respectively. The RO membrane (5) is provided with a collection mechanism (6) inside. The collection mechanism (6) includes a receiving box (601), a cleaning scraper (602) is fixedly connected to the top surface of the receiving box (601), and a conveying slide (603) is fixedly connected to the bottom surface of the receiving box (601).

2. The RO membrane device for sodium citicoline according to claim 1, characterized in that: The mounting plate (2) is rotatably connected to a rotating rod (604), and two transmission gears (605) are fixedly connected to the outer surface of the rotating rod (604).

3. The RO membrane device for sodium citicoline according to claim 2, characterized in that: The inner walls of the two fixed rings (3) are fixedly connected with connecting toothed rings (606), and the two transmission gears (605) mesh with the two connecting toothed rings (606) respectively.

4. The RO membrane device for sodium citicoline according to claim 2, characterized in that: A servo motor (607) is fixedly mounted on the outside of the mounting plate (2), and the end of the rotating rod (604) is fixedly connected to the output shaft of the servo motor (607).

5. The RO membrane device for sodium citicoline according to claim 1, characterized in that: The inner wall of the separation tank (1) is fixedly connected to a support frame (7), and the two fixing rings (3) are rotatably connected to the mounting plate (2) and the support frame (7) respectively.

6. The RO membrane device for sodium citicoline according to claim 1, characterized in that: The separator (1) is slidably connected to an inlet pipe (8), and the inner wall of the separator (1) is fixedly connected to a drain pipe (9).

7. The RO membrane device for sodium citicoline according to claim 6, characterized in that: The sealing disc (10) is fixedly connected inside the fixing ring (3), and the liquid inlet pipe (8) passes through the sealing disc (10) and is slidably connected to the sealing disc (10).

8. The RO membrane device for sodium citicoline according to claim 1, characterized in that: The separation tank (1) is provided with a collection box (11) on the outside, and the conveying chute (603) is fixedly connected to the collection box (11) through a hose.