Multifunctional tissue sample storage box

Abstract

The utility model discloses a multifunctional tissue sample preservation box which comprises a box body, the box body is provided with a box cover, the interior of the box body is a hollow area, the hollow area is divided into a cell cold storage area, a cut sample cold storage area and an organ-like cold storage area, the cell cold storage area is provided with a cell cold storage frame, and the cut sample cold storage area is provided with an organ-like cold storage frame. The cell cold storage frame is provided with an insertion plate for placing a cold storage tube, the cut sample cold storage area is provided with a cut sample cold storage frame, the cut sample cold storage frame is provided with a slide bearing structure for placing a slide, the organ-like cold storage area is provided with a cold storage box, the cold storage box is hollow, and the slide bearing structure is provided with a slide bearing structure for placing a slide. And a cold storage cover for opening or closing the cold storage box is arranged on the cold storage box. The multifunctional tissue sample storage box has the function of supporting cold storage of various types of tissue samples and is good in using effect.

Description

TECHNICAL FIELD

[0001] The utility model relates to tissue sample storage box especially relates to a multifunctional tissue sample storage box. BACKGROUND

[0002] In the actual research process of the biomedical research field, the research of the same project often needs to involve two kinds of samples of 3D organoids and 2D cells at the same time, so the situation of needing to store 3D organoids and 2D cells of the same sample source together often occurs. However, although they are derived from the same sample, there are significant differences in storage conditions. These differences involve temperature, humidity, protective agent composition and other key factors, and different storage conditions are crucial for maintaining the activity, integrity of the sample and the reliability of subsequent research.

[0003] At present, the existing sample storage method has many inconveniences and risks in the face of the situation of needing to store 3D organoids and 2D cells at the same time. For example, if a single storage container or method is used, it is difficult to meet the different cryopreservation conditions of the two, which may lead to poor storage effect of one or both samples, thereby affecting the accuracy and repeatability of subsequent experiments. In addition, in the actual operation process, due to the lack of appropriate classification storage design, it is easy to cause sample mixing and misplacement, which not only brings great trouble to the research work, but also wastes a lot of time and resources, and seriously reduces the efficiency of research and development.

[0004] Therefore, there is an urgent need for a multifunctional tissue sample storage box that can take into account the cryopreservation conditions of different biological samples to achieve the centralized and orderly storage of various biological samples in the same project, avoiding the risk of sample mixing and misplacement, thereby significantly improving the efficiency of research and development. UTILITY MODEL CONTENT

[0005] In view of the above deficiencies in the field of tissue sample storage at present, the utility model provides a multifunctional tissue sample storage box, which has a plurality of independent cold storage areas to meet the cold storage requirements of different types of tissue samples.

[0006] To achieve the above purpose, the embodiments of the utility model adopt the following technical solutions:

[0007] The utility model provides a multifunctional tissue sample preservation box, including box body, the box body has box cover, its characterized in be that the inside of box body is hollow area, the hollow area is divided into cell cold storage area, cut sample cold storage area and organoid cold storage area, cell cold storage area is provided with cell cold storage frame, is equipped with the plugboard for placing the cold storage tube on cell cold storage frame, cut sample cold storage area is provided with cut sample cold storage frame, is equipped with the slide bearing structure for placing the slide on cut sample cold storage frame, organoid cold storage area is provided with cold storage box, the hollow setting of cold storage box, is equipped with the cold storage cover that opens or closes cold storage box.

[0008] Adopt above-mentioned technical scheme, the inside of box body sets up the cell cold storage area, cut sample cold storage area and organoid cold storage area independently, after sampling, different types of tissue sample can be cold in different areas, so can effectively avoid the mutual interference of different types of tissue sample cold storage environment.

[0009] According to one aspect of the utility model, the cell cold storage frame includes a bottom plate and a plurality of vertical partitions fixed on the bottom plate, the plugboard is disposed between adjacent partitions, and the plugboard is provided with a plurality of plug holes.

[0010] According to one aspect of the utility model, the partitions are equally spaced, the plug holes are evenly distributed on the plugboard, and the plugboard is in a horizontal state.

[0011] According to one aspect of the utility model, the open end of the cold storage tube is provided with an end cap.

[0012] According to one aspect of the utility model, the cut sample cold storage frame includes a bottom plate, the slide bearing structure includes side plates disposed on opposite sides of the bottom plate, the inner side of each side plate in the vertical direction is provided with a blocking strip, the space between adjacent blocking strips forms a slot, and the slide is inserted into the slot.

[0013] According to one aspect of the utility model, the top of the cold storage box is a magnetic plate, the magnetic plate is provided with an opening, the lower side of the cold storage cover is fixedly provided with an upper magnetic block, the shape of the magnetic block is the same as that of the opening, and the position and size of the magnetic block are adapted to the position and size of the opening.

[0014] According to one aspect of the utility model, the opening is located at the middle position of the magnetic plate and is square, and the magnetic block is located at the middle position of the lower side of the cold storage cover and is square.

[0015] According to one aspect of the utility model, the inside of the magnetic plate and the magnetic block is filled with magnetic fluid, the magnetic fluid has greater magnetic force in the cold storage environment, so that the cold storage cover seals the cold storage box.

[0016] According to one aspect of the utility model, the upper side of cold storage cover is provided with handle, the handle is the recess that is inwards inclinedly arranged along the upper surface of cold storage cover.

[0017] According to one aspect of the utility model, the box body is provided with a lock catch, the lock catch is a press type lock catch, the press type lock catch includes a lock hook arranged on the lower side of the box cover and a lock seat arranged on the upper side of the front side plate of the box body, the positions of the lock hook and the lock seat correspond, and the box body can be locked by pressing the lock hook after the box cover is closed.

[0018] The utility model has the beneficial effects that: first, by setting the cell cold storage area, the sample cutting cold storage area and the organoid cold storage area which are independent of each other in the box body, the cold storage requirements of different types of tissue samples can be met.Secondly, by the setting of the cold storage box, the cold storage area is further divided into a dry environment area and a liquid environment area, wherein the dry environment area can meet the cold storage requirements of cell samples and tissue section samples, and the liquid environment area can meet the cold storage requirements of organoid samples.Thirdly, the cold storage box is sealed by using the characteristics of magnetic fluid material, and the sealing effect is better in the cold storage environment.At the same time, the hidden handle on the cold storage box is not only beautiful but also does not occupy the internal space of the box body.Finally, the box body is provided with a lock catch which is hidden when locked, and the surface of the box body is clean and beautiful, and the use effect is good. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical scheme in the embodiment of the utility model, the drawings needed to be used in the embodiment will be briefly introduced below, and obviously, the drawings in the following description are only some embodiments of the utility model, and other drawings can be obtained according to these drawings without creative labor for those skilled in the art.

[0020] Figure 1 It is a whole structure schematic view of the multifunctional tissue sample preservation box.

[0021] Figure 2 It is a cell cold storage frame structure schematic view.

[0022] Figure 3 It is a sample cutting cold storage frame structure schematic view.

[0023] Figure 4 It is a cold storage box structure schematic view.

[0024] Figure 5 It is a press type lock catch lock hook structure schematic view.

[0025] Figure 6The structure diagram of the press type lock catch lock seat is described in the utility model.

[0026] Figure 7 The effect diagram of the magnetic fluid condensation in air is described in the utility model. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all the other embodiments obtained by the ordinary skilled in the art without creative labor fall within the protection scope of the utility model.

[0028] Figure 1 The utility model discloses a multifunctional tissue sample storage box, which comprises a box body 100, the box body 100 is provided with a box cover 101, the box body 100 is internally provided with mutually independent cell cold storage area 102, sample cutting cold storage area 103 and organoid cold storage area 104, the cell cold storage area 102 is provided with cell cold storage rack 200 and cold storage tube 204 placed thereon, the sample cutting cold storage area 103 is provided with sample cutting cold storage rack 300 and glass slide 304 placed thereon, and the organoid cold storage area is provided with cold storage box 400.

[0029] As shown in the drawings, Figure 2 The cell cold storage rack 200 comprises a bottom plate 201, a partition plate 202 and an insertion plate 203. The partition plate 202 is vertically fixed on the bottom plate 201 at uniform intervals, and the insertion plate 203 is horizontally arranged between adjacent partition plates 202. The insertion plate 203 is uniformly provided with insertion holes, and the size of the insertion holes is adapted to the size of the cold storage tube 203. The cold storage tube 204 is usually made of glass and is provided with an end cover 205 at the opening end.

[0030] In the embodiment, the cold storage tube 204 can be used to store cell tissue samples, and a dry cold storage environment is required. After sampling, the tissue sample is placed in the cold storage tube 204, and then the end cover 205 is covered. Finally, the cold storage tube 204 is inserted into the insertion hole of the insertion plate 203, and the bottom thereof abuts against the bottom plate 201, so that the placement is relatively stable.

[0031] As shown in the drawings, Figure 3 The sample cutting cold storage rack 300 comprises a bottom plate 301, and in the embodiment, the bottom plate 301 is square. The opposite sides of the bottom plate 301 are provided with side plates 302, and the inner sides of the side plates 302 in the vertical direction are uniformly provided with blocking strips 303. The space between adjacent blocking strips forms an insertion slot, and the size of the insertion slot is adapted to the size of the glass slide 304. In this way, the side plates 302 and the blocking strips 303 constitute the glass slide bearing structure of the sample cutting cold storage rack 300.

[0032] In this embodiment, the slide 304 can be used to save the tissue section, and a dry cold storage environment is required, and after the sampling is completed, the slide 304 is inserted into the slot of the section cold storage rack 300.

[0033] The organoid generally refers to a 3D organoid, and the cold storage environment requirement of the organoid is generally different from the cold storage environment requirement of the 2D sample such as the cell tissue sample and the tissue section, and the 2D sample generally requires a dry cold storage environment, and the 3D organoid can require a liquid environment. Therefore, the multifunctional tissue sample storage box provides an organoid cold storage area 104, and a cold storage box 400 provided in the organoid cold storage area 104 can store a liquid to meet the cold storage requirement of the organoid sample.

[0034] Combining Figure 4 As shown in the figure, the cold storage box 400 has a cold storage cover 401, and the top of the cold storage box 400 is a magnetic plate 402, the magnetic plate 402 is provided with an opening 404, the opening 404 is the opening of the cold storage box 400, and the lower side of the cold storage cover 401 is fixed with a magnetic block 403, the shape of the magnetic block 403 is the same as that of the magnetic plate opening 404, and at the same time, the position and size of the magnetic block 403 are adapted to the position and size of the magnetic plate opening 404. In this way, when the cold storage cover 401 is closed, the magnetic block 403 is just embedded in the opening of the magnetic plate 402, and due to the magnetic force, the cold storage box 400 is sealed to avoid the mutual influence of different cold storage environments. In this embodiment, the opening 404 is located at the middle position of the magnetic plate 402 and is square, and correspondingly, the magnetic block 403 is also located at the middle position of the lower side of the cold storage cover 401 and is square.

[0035] The magnetic plate 402 and the magnetic block 403 of the utility model are filled with magnetic fluid inside, the magnetic fluid is a new type of functional material, which has the liquidity of liquid and the magnetism of solid magnetic material, and the utility model seals the cold storage box 400 by using the magnetic force of the magnetic fluid, and the magnetic fluid will be simply introduced below.

[0036] The magnetic fluid is a kind of uniform and stable colloidal solution formed by uniformly dispersing nano-sized magnetic particles wrapped with a layer of long-chain surfactant in base fluid, and the ingredient content is 5% of magnetic solid, 10% of surfactant and 85% of carrier (water and oil). The magnetic fluid is poured out in a container, Fe, Ni and Co are commonly used as magnetic particles, and after the magnetic fluid is exposed to air, due to the action of magnetic field, it will quickly coagulate into Figure 7The magnetic fluid is shown as a sharp half-liquid in the figure, and has the characteristic of reducing magnetic force when heated. By properly reducing the density of the magnetic particles in the magnetic fluid, the size of the magnetic force can be adjusted. When it is heated in a 37℃ water bath, the magnetic force is weakened, at which time the cold storage cover 401 of the cold storage box 400 can be easily opened, while the magnetic fluid maintains sufficient magnetic force in the cold storage or freezing state, so that the cold storage cover 401 can be well sealed to the cold storage box 400.

[0037] It can be understood that a handle is arranged at a proper position on the upper side of the cold storage cover 401 for the convenience of opening the cold storage box 400. In the embodiment, the upper surface of the cold storage cover 401 has an inwardly inclined groove 405, so that when the cold storage box 400 needs to be opened, the edge of the groove 405 is buckled inwardly by a finger to be lifted upward to open the cold storage cover 401. At the same time, it can be known from the structure that the handle formed by the groove 405 is hidden, and the surface of the cold storage box 400 is neat and beautiful after the cold storage cover 401 is closed, and does not occupy the internal space of the box body 100.

[0038] The above is the first embodiment of the utility model, in order to better use effect, the second embodiment of the utility model provides a kind of tissue sample preservation box with locking structure based on the first embodiment, specific scheme is as follows:

[0039] The box body 100 is provided with a lock catch. There are various types of conventional lock catches, such as press type, rotary type, pull rod type, quick release type, threaded type, magnetic type, buckle type, password lock type and sliding type, etc. The structure, use scene, installation method and use effect of different types of lock catches are not the same. The press type lock catch is used in the embodiment, and the press type locking includes a lock hook 501 and a lock seat 502. The lock hook 501 is arranged on the lower side of the box cover 101, and the lock seat 502 is arranged on the upper side of the front side plate 105 of the box body. The positions of the lock hook 501 and the lock seat 502 correspond to each other, so that the lock catch is in a hidden state after locking, and the surface of the box body 100 is neat and beautiful.

[0040] The lock hook 501 is a part used to connect or fix two objects in the lock catch, which is usually made of metal or plastic and has certain bending elasticity and strength. When the lock catch is pressed, the lock hook 501 will protrude and hook another object, thereby realizing the connection or fixation. Figure 5 The structure of the lock hook is shown, which includes a base plate 5013 and a lock tongue 5011. The base plate 5013 is symmetrically provided with screw holes 5014 at both ends, and the lock hook 501 can be fixed to the lower side of the box cover 101 through the screw holes 4014. The lock tongue 5011 is symmetrically provided with protrusions 5012 on both sides, and the protrusions 5012 are clamped in the lock seat 502 when locked.

[0041] The lock seat 502 is a corresponding part of the lock hook 501, which is usually made of plastic or metal and has a certain bending space and structure for accommodating the lock hook 501. Figure 6The structure of the lock seat 502 is shown, including the buckle 5021, the pull rod 5022 and the spring 5023, and the lock seat 502 has a shell to prevent the internal mechanism from being interfered and damaged by the outside.

[0042] The structure and working mode of the press-type lock buckle are common knowledge of those skilled in the art, and will not be described in detail here.

[0043] According to the technical scheme of the utility model, firstly, the box body is internally provided with mutually independent cell cold storage area, sample cutting cold storage area and organoid cold storage area, which can meet the cold storage requirements of different types of samples. Secondly, by the setting of the cold storage box, the cold storage area is further divided into dry environment area and liquid environment area, wherein the dry environment area can meet the cold storage requirements of cell samples and tissue section samples, and the liquid environment area can meet the cold storage requirements of organoid samples. Thirdly, the cold storage box is sealed by utilizing the characteristics of the magnetic fluid material, and the sealing effect is better in the cold storage environment. At the same time, the hidden handle on the cold storage box is not only beautiful but also does not occupy the internal space of the box body. Finally, the box body is provided with a lock buckle, and the lock buckle is hidden when locked, so that the surface of the box body is neat and beautiful, and the use effect is good.

[0044] The above is only a specific embodiment of the utility model, but the protection scope of the utility model is not limited to this, any skilled person in the art can easily think of changes or replacements within the technical range disclosed by the utility model, which should be covered in the protection scope of the utility model. Therefore, the protection scope of the utility model should be subject to the protection scope of the claims.

Claims

1. A multifunctional tissue sample preservation box comprising a box body (100) having a box cover (101), characterized in that, The box body (100) is internally hollow, and the hollow region is divided into a cell cold storage area (102), a sample cold storage area (103), and an organoid cold storage area (104); The cell cold storage area (102) is provided with a cell cold storage rack (200), and the cell cold storage rack (200) is provided with an insertion board (203) for placing a cold storage tube (204); The sample cold storage area (103) is provided with a sample cold storage rack (300), and the sample cold storage rack (300) is provided with a slide bearing structure for placing a slide (304); The organoid cold storage area (104) is provided with a cold storage box (400), and the cold storage box (400) is hollow, and is provided with a cold storage cover (401) for opening or closing the cold storage box (400).

2. The multi-functional tissue sample storage cassette of claim 1, wherein, The cell cold storage rack (200) comprises a bottom plate (201) and a partition plate (202), the partition plate (202) is vertically fixed on the bottom plate (201), the insertion board (203) is arranged between adjacent partition plates (202), and the insertion board (203) is provided with insertion holes, and the cold storage tube (204) is inserted into the insertion holes and the bottom of the cold storage tube (204) abuts against the bottom plate (201).

3. The multi-functional tissue sample storage cassette of claim 2, wherein, The interval between adjacent partition plates (202) is the same, the insertion holes are uniformly distributed on the insertion board (203), and the insertion board (203) is in a horizontal state.

4. The multi-functional tissue sample storage cassette of claim 2, wherein, The opening end of the cold storage tube (204) is provided with an end cover (205).

5. The multi-functional tissue sample storage cassette of claim 1, wherein, The sample cold storage rack (300) comprises a bottom part (301), the slide bearing structure comprises side plates (302) arranged on opposite sides of the bottom part, the inner side of the side plates in the vertical direction is provided with a blocking strip (303), the space between adjacent blocking strips (303) forms an insertion slot, and the slide (304) is inserted into the insertion slot.

6. The multi-functional tissue sample storage cassette of claim 1, wherein, The top of the cold storage box (400) is a magnetic plate (402), the magnetic plate (402) is provided with an opening (404), the lower side of the cold storage cover (401) is fixedly provided with an upper magnetic block (403), the shape of the magnetic block (403) is the same as that of the opening (404), and the position and size of the magnetic block (403) are adapted to the position and size of the opening (404).

7. The multi-functional tissue sample storage cassette of claim 6, wherein, The opening (404) is located at the middle position of the magnetic plate (402) and is square, and the magnetic block (403) is located at the middle position of the lower side of the cold storage cover (401) and is square.

8. The multi-functional tissue sample storage cassette of claim 6, wherein, The interiors of the magnetic plate (402) and the magnetic block (403) are filled with magnetic fluid, the magnetic fluid has greater magnetic force in a cold storage environment, so that the cold storage cover (401) seals the cold storage box (400).

9. The multi-functional tissue sample storage cassette of claim 6, wherein, The upper side of the cold storage cover (401) is provided with a handle (405), and the handle (405) is a groove inclined inward along the upper surface of the cold storage cover (401).

10. The multi-functional tissue sample storage cassette according to any one of claims 1 to 9, wherein, The box body (100) is provided with a lock catch, which is a press-type lock catch, comprising a lock hook (501) arranged on the lower side of the box cover (101) and a lock seat (502) arranged on the upper side of the front side plate (105) of the box body, the positions of the lock hook (501) and the lock seat (502) correspond, and the box body (100) can be locked by pressing the lock hook (501) after the box cover (101) is closed.

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