Stirrer for preparing PLGA (poly (lactic-co-glycolic acid)) nanoparticles coated with florfenicol medicine

Abstract

The utility model relates to the technical field of pharmaceutical equipment, in particular to a preparation stirrer for PLGA (poly (lactic-co-glycolic acid)) nano-particles containing florfenicol medicine, which comprises a stirring barrel, a mounting rack is arranged on the stirring barrel, connecting rotating rods are arranged at the tops of two sides of the mounting rack, one end of each connecting rotating rod is fixedly connected with the outer wall of the stirring barrel, and the other end of each connecting rotating rod is fixedly connected with the stirring barrel. A driving motor is provided with an encoder and a controller, the encoder provides an accurate rotating speed feedback signal to help the controller to adjust the speed of the driving motor in real time, and under the transmission that a driving gear drives a driven gear, two groups of screw rods synchronously rotate, so that the mixing uniformity in the stirring barrel can be improved, and the stirring efficiency is improved while stirring. And through cooperation of the double-shaft motor, the rotating rod, the rotating disc and the movable rod, the barrel body can be shaken, the effect of providing power for shaking of the barrel body is achieved, so that raw materials are shaken, the up-and-down fluidity of the raw materials in the stirring barrel is accelerated, the mixing effect and efficiency are improved, and the practicability is higher.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, specifically to a stirrer for preparing PLGA nanoparticles containing florfenicol. Background Technology

[0002] In the pharmaceutical industry, nanoparticles, as a novel drug delivery system, have attracted widespread attention due to their potential to improve drug bioavailability, targeting, and stability. This is particularly true for antibiotics such as florfenicol, where nanotechnology can enhance their pharmacokinetic properties. However, traditional stirring equipment suffers from inaccurate speed control and uneven mixing during nanoparticle preparation, leading to uneven nanoparticle size distribution and impacting drug efficacy and safety. Therefore, developing an efficient and stable stirring device is crucial for the research and production of nanomedicine formulations. Utility Model Content

[0003] (a) Technical problems to be solved

[0004] To address the shortcomings of existing technologies, this invention provides a stirrer for preparing PLGA nanoparticles containing florfenicol.

[0005] (II) Technical Solution

[0006] To achieve the above objectives, this utility model provides the following technical solution: a stirrer for preparing PLGA nanoparticles containing florfenicol, comprising a stirring tank, a mounting frame on the stirring tank, connecting rods on the top of both sides of the mounting frame, one end of each connecting rod being fixedly connected to the outer wall of the stirring tank, the connecting rods being rotatably connected to the mounting frame, a controller on the side of the mounting frame, a tank lid on the top of the stirring tank, a feed inlet on one side of the top of the tank lid, a fixing frame on the top of the tank lid, a drive motor on the top of the fixing frame, and an encoder at the output end of the drive motor. A transmission rod is located at the center of the bottom of the bucket lid. The top of the transmission rod is connected to a drive motor. A drive gear is mounted on the transmission rod and is located inside the fixed frame. Spiral rods are located on both sides of the bottom of the bucket lid. Driven gears are mounted at the top of the spiral rods and are located on both sides inside the fixed frame. The driven gears are meshed with the drive gears. A discharge pipe is located at the bottom of the mixing bucket. A dual-shaft motor is located at the bottom of the side of the mounting frame. A rotating rod is located at the output end of the dual-shaft motor. A turntable is mounted on the rotating rod. A movable rod is mounted on the turntable. One end of the movable rod is rotatably connected to the mixing bucket.

[0007] Furthermore, the present invention is improved by providing a scraper on the transmission rod, wherein three sets of scrapers are provided and evenly arranged at the bottom of the transmission rod.

[0008] Furthermore, the present invention is improved by providing a stirring rod at the bottom end of the transmission rod, and multiple stirring rods are provided.

[0009] Furthermore, the present invention is improved in that the spiral rod and the driven gear are provided in two sets and are symmetrically arranged on the bucket lid.

[0010] Furthermore, an improvement of this utility model is that the drive motor, encoder, and dual-axis motor are all electrically connected to the controller.

[0011] Furthermore, an improvement of this utility model is that a valve is provided on the discharge pipe.

[0012] Furthermore, the present invention is improved in that the mixing tank, the tank cover, the transmission rod and the screw rod are all made of corrosion-resistant materials.

[0013] (III) Beneficial Effects

[0014] Compared with the prior art, this utility model provides a stirrer for preparing PLGA nanoparticles coated with florfenicol, which has the following beneficial effects:

[0015] This stirrer for preparing PLGA nanoparticles of florfenicol uses an encoder and controller to drive the motor. The encoder provides precise speed feedback signals, helping the controller adjust the motor speed in real time. Furthermore, the drive gear, coupled with the driven gear, causes the two sets of screws to rotate synchronously, improving the mixing uniformity within the mixing tank. Simultaneously, the dual-shaft motor, rotating rod, turntable, and movable rod work together to shake the tank, providing power for the shaking and thus agitating the raw materials. This accelerates the flow of materials within the mixing tank, enhancing mixing efficiency and practicality. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of this utility model;

[0017] Figure 2 This utility model Figure 1 A structural diagram of the middle barrel lid;

[0018] Figure 3 This utility model Figure 1 A schematic diagram of the structure viewed from below;

[0019] Figure 4 This utility model Figure 3 A schematic diagram of the side view structure;

[0020] In the diagram: 1. Mixing tank; 2. Mounting frame; 3. Controller; 4. Connecting rotating rod; 5. Tank lid; 6. Feed inlet; 7. Fixing frame; 8. Drive motor; 9. Encoder; 10. Transmission rod; 11. Scraper; 12. Mixing rod; 13. Spiral rod; 14. Drive gear; 15. Driven gear; 16. Discharge pipe; 17. Dual-shaft motor; 18. Rotating rod; 19. Turntable; 20. Movable rod. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Please see Figure 1-4 A stirrer for preparing PLGA nanoparticles containing florfenicol includes a stirring tank 1, a mounting frame 2 on the stirring tank 1, connecting rotating rods 4 on both sides of the top of the mounting frame 2, one end of the connecting rotating rod 4 being fixedly connected to the outer wall of the stirring tank 1, and the connecting rotating rods being rotatably connected to the mounting frame 2, a controller 3 on the side of the mounting frame 2, a tank cover 5 at the top of the stirring tank 1, a feed inlet 6 on one side of the top of the tank cover 5, a fixing frame 7 at the top of the tank cover 5, a drive motor 8 at the top of the fixing frame 7, an encoder 9 at the output end of the drive motor 8, a transmission rod 10 at the middle of the bottom end of the tank cover 5, the top of the transmission rod 10 being connected to the drive motor 8, and a drive gear 14 on the transmission rod 10. The driving gear 14 is located inside the fixed frame 7. The bottom of the bucket cover 5 is provided with two spiral rods 13. The top of the spiral rod 13 is provided with a driven gear 15. The driven gear 15 is located on both sides inside the fixed frame 7. The driven gear 15 is meshed with the driving gear 14. The bottom of the mixing bucket 1 is provided with a discharge pipe 16. The bottom of the side of the mounting frame 2 is provided with a dual-shaft motor 17. The output end of the dual-shaft motor 17 is provided with a rotating rod 18. The rotating rod 18 is provided with a turntable 19. The turntable 19 is provided with a movable rod 20. One end of the movable rod 20 is rotatably connected to the mixing bucket 1. There are two sets of spiral rods 13 and driven gears 15, which are symmetrically arranged on the bucket cover 5. The drive motor 8, encoder 9, and dual-shaft motor 17 are all electrically connected to the controller 3.

[0023] In actual use, the above structure first introduces the raw materials into the mixing tank 1 through the feed inlet 6. Then, the drive motor 8 is turned on, which drives the transmission rod 10 to rotate. The transmission rod 10 drives the driven gear 15 to rotate through the drive gear 14. The driven gear 15 then drives the spiral rod 13 to rotate inside the mixing tank 1, thereby achieving the mixing of the raw materials. At the same time, the drive motor 8 is equipped with an encoder 9, which provides a precise speed feedback signal to help the controller 3 adjust the speed of the drive motor 8 in real time. While mixing, the dual-axis motor 17 is turned on, which drives the rotating rod 18 to rotate. The rotating rod 18 drives the turntable 19, which in turn drives the movable rod 20. Therefore, the movable rod 20 can drive the mixing tank 1 to move back and forth, realizing the shaking of the mixing tank 1 and accelerating the flow of the raw materials up and down in the mixing tank 1, improving the mixing effect and efficiency. After mixing is completed, the raw materials are discharged through the discharge pipe 16.

[0024] In this embodiment, the transmission rod 10 is provided with scrapers 11. There are three sets of scrapers 11, which are evenly arranged at the bottom of the transmission rod 10. By setting the scrapers 11, the raw materials remaining on the inner wall of the mixing tank 1 can be scraped off to avoid residue.

[0025] In this embodiment, a stirring rod 12 is provided at the bottom end of the transmission rod 10. Multiple stirring rods 12 are provided. The stirring rods 12 can stir the raw materials located at the bottom of the mixing tank 1, thereby further improving the stirring efficiency.

[0026] In this embodiment, a valve is provided on the discharge pipe 16, which improves the efficiency of the discharge pipe 16.

[0027] In this embodiment, the mixing tank 1, the tank cover 5, the transmission rod 10, and the screw rod 13 are all made of corrosion-resistant materials, which improves the durability of the device itself.

[0028] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A stirrer for preparing PLGA nanoparticles coated with florfenicol, characterized in that: The system includes a mixing tank (1), a mounting frame (2) on the mixing tank (1), connecting rotating rods (4) on the top of both sides of the mounting frame (2), one end of the connecting rotating rods (4) being fixedly connected to the outer wall of the mixing tank (1), and the connecting rotating rods (4) being rotatably connected to the mounting frame (2). A controller (3) is provided on the side of the mounting frame (2). A tank cover (5) is provided at the top of the mixing tank (1), a feed inlet (6) is provided on one side of the top of the tank cover (5), a fixing frame (7) is provided at the top of the tank cover (5), a drive motor (8) is provided at the top of the fixing frame (7), an encoder (9) is provided at the output end of the drive motor (8), and a transmission rod (10) is provided at the middle of the bottom end of the tank cover (5). The top of the transmission rod (10) is connected to the drive motor (8). A drive gear (14) is provided on the transmission rod (10). The drive gear (14) is located inside the fixed frame (7). A spiral rod (13) is provided on both sides of the bottom end of the bucket cover (5). A driven gear (15) is provided at the top of the spiral rod (13). The driven gear (15) is located on both sides inside the fixed frame (7). The driven gear (15) is meshed with the drive gear (14). A discharge pipe (16) is provided at the bottom end of the mixing tank (1). A dual-shaft motor (17) is provided at the bottom side of the mounting frame (2). A rotating rod (18) is provided at the output end of the dual-shaft motor (17). A turntable (19) is provided on the rotating rod (18). A movable rod (20) is provided on the turntable (19). One end of the movable rod (20) is rotatably connected to the mixing tank (1).

2. The stirrer for preparing PLGA nanoparticles containing florfenicol according to claim 1, characterized in that: The transmission rod (10) is provided with scrapers (11), and there are three sets of scrapers (11) which are evenly arranged at the bottom of the transmission rod (10).

3. The stirrer for preparing PLGA nanoparticles containing florfenicol according to claim 2, characterized in that: The bottom end of the transmission rod (10) is provided with a stirring rod (12), and there are multiple stirring rods (12).

4. The stirrer for preparing PLGA nanoparticles containing florfenicol according to claim 3, characterized in that: The screw rod (13) and driven gear (15) are provided in two sets and are symmetrically arranged on the barrel cover (5).

5. The stirrer for preparing PLGA nanoparticles containing florfenicol according to claim 4, characterized in that: The drive motor (8), encoder (9), and dual-axis motor (17) are all electrically connected to the controller (3).

6. The stirrer for preparing PLGA nanoparticles containing florfenicol according to claim 5, characterized in that: A valve is installed on the discharge pipe (16).

7. The stirrer for preparing PLGA nanoparticles containing florfenicol according to claim 6, characterized in that: The mixing tank (1), the lid (5), the transmission rod (10), and the screw rod (13) are all made of corrosion-resistant materials.

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