Automatic chromatography filtering device

Abstract

The utility model discloses an automatic chromatography filtering device which comprises a supporting component, a filtering component and a filtering component, wherein the supporting component comprises a chromatography column; the flow equalizing component comprises a first flow equalizing disc, a second flow equalizing disc, hole bodies, hole rings, limiting rings and inner grooves, the first flow equalizing disc and the second flow equalizing disc are located on the upper portion of the inner surface of the chromatographic column, the hole bodies are formed in the first flow equalizing disc and the second flow equalizing disc, the hole rings are connected into the hole bodies in an embedded mode, and the limiting rings are located in the limiting rings. The limiting ring is connected to the top of the hole ring and connected into the inner groove in an embedded mode. The utility model relates to a chromatographic filtration device, and aims to solve the problems that high-purity substance separation is difficult to realize due to the influence of factors such as column design and non-uniform medium distribution in the separation process of some devices in the actual use of the existing chromatographic filtration device, and the improvement of the purification effect is limited due to the insufficient automation degree and precision control.

Description

TECHNICAL FIELD

[0001] The utility model relates to filter technical field, in particular to a kind of automatic chromatography filtration device. BACKGROUND

[0002] Chromatography filtration is a commonly used separation and analysis technique, using the partition coefficient difference between different substances in stationary phase and mobile phase to separate. When sample passes through chromatography column, different components are different in migration speed in column due to different affinity with stationary phase and mobile phase, so as to realize separation.

[0003] When existing chromatography filtration device is actually used, some devices are difficult to realize high-purity material separation in separation process due to the influence of column design and uneven medium distribution, and the lack of automation degree and precision control also limits the improvement of purification effect, so an automatic chromatography filtration device is needed, which significantly improves the purification effect and realizes more accurate material separation. UTILITY MODEL CONTENT

[0004] The utility model aims at providing an automatic chromatography filtration device to solve the problem that existing chromatography filtration device is difficult to realize high-purity material separation in separation process due to the influence of column design and uneven medium distribution, and the lack of automation degree and precision control also limits the improvement of purification effect.

[0005] To solve the above technical problems, the utility model is realized by the following technical schemes:

[0006] The utility model is an automatic chromatography filtration device, comprising:

[0007] Supporting component, the supporting component includes chromatography column;

[0008] Flow equalizing component, the flow equalizing component includes flow equalizing disc one, flow equalizing disc two, hole body, hole ring, limiting ring and inner recess, flow equalizing disc one and flow equalizing disc two are located at the upper portion of the inner surface of chromatography column, the inside of flow equalizing disc one and flow equalizing disc two is provided with hole body, hole ring is inlaidly connected in the inside of hole body, limiting ring is connected at the top of hole ring and inlaidly connected in the inside of inner recess.

[0009] Further, the flow equalizing component further includes stand plate and limiting plate, the stand plate is symmetrically connected at the top of flow equalizing disc one, the limiting plate is connected at the top of stand plate and hangs at the top of chromatography column.

[0010] Further, the fixed component further comprises a fixing ring and a fixing groove, the fixing ring is connected to the bottom of the limiting ring, the top of the inner groove is provided with the fixing groove, and the fixing ring is inserted and connected to the inside of the fixing groove.

[0011] Further, the fixed component further comprises a fixing ring and a fixing groove, the fixing ring is connected to the bottom of the limiting ring, the top of the inner groove is provided with the fixing groove, and the fixing ring is inserted and connected to the inside of the fixing groove.

[0012] Further, the support component further comprises a top cover and a support frame, the top cover is connected to the top of the chromatography column, and the support frame is welded and connected to the bottom of the outer surface of the chromatography column.

[0013] Further, the cleaning component further comprises an inner threaded ring, a threaded rod, a side plate, a rubber block and a handle, the side plate is connected to the lower part of one end of the outer surface of the rotating rod, the inner threaded ring is connected to the outer end of the side plate, the threaded rod is connected to the middle part of the inner threaded ring, the handle is rotationally connected to one end of the threaded rod, and the rubber block is connected to the other end of the outer surface of the threaded rod.

[0014] Further, the cleaning component further comprises an inner threaded ring, a threaded rod, a side plate, a rubber block and a handle, the side plate is connected to the lower part of one end of the outer surface of the rotating rod, the inner threaded ring is connected to the outer end of the side plate, the threaded rod is connected to the middle part of the inner threaded ring, the handle is rotationally connected to one end of the threaded rod, and the rubber block is connected to the other end of the outer surface of the threaded rod.

[0015] Compared with the prior art, the advantages of the present application are that:

[0016] The present application has the advantages that: the chromatography column is provided with the flow equalizing disc I and the flow equalizing disc II, and the holes are arranged in the flow equalizing disc I and the flow equalizing disc II, so that the liquid is evenly distributed when flowing through the flow equalizing disc I and the flow equalizing disc II, the liquid is divided into a plurality of small flow streams, the fluid is more evenly distributed when entering the subsequent area of the column body, the uniform distribution of the fluid in the chromatography column is ensured, the phenomenon of channeling or too fast local flow rate is avoided, the sample and the separation medium are fully contacted, the purification effect is significantly improved, and more accurate material separation is realized.

[0017] Based on the above beneficial effects, the rotating rod, the scraper and the sleeve ring are arranged in the chromatography column, some liquid is attached to the inner wall of the chromatography column after being evenly distributed by the flow equalizing disc I and the flow equalizing disc II, the rotating rod is rotated through the operation of the motor, and the scraper is scraped off the liquid attached to the inner wall of the chromatography column in a rotating manner, so that the liquid can be better transmitted. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical scheme of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiment description, obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.

[0019] Figure 1 It is a whole schematic view of the chromatography column of the present application.

[0020] Figure 2 It is an internal schematic view of the chromatography column of the present application.

[0021] Figure 3 It is a schematic view of the flow equalizing disc one and the flow equalizing disc two of the present application.

[0022] Figure 4 It is a bottom schematic view of the flow equalizing disc one and the flow equalizing disc two of the present application.

[0023] Figure 5 It is a schematic view of the scraper of the present application.

[0024] In the drawings, the component list represented by each number is as follows:

[0025] 100, chromatography column; 101, top cover; 102, support frame;

[0026] 200, flow equalizing disc one; 201, flow equalizing disc two; 202, hole body; 203, hole ring; 204, limiting ring; 205, vertical plate; 206, limiting plate; 207, inner groove;

[0027] 300, clamping block; 301, fixing ring; 302, bottom block; 303, clamping groove; 304, fixing groove; 305, inner groove;

[0028] 400, rotating rod; 401, scraper; 402, sleeve ring; 403, horizontal plate; 404, inner thread ring; 405, threaded rod; 406, side plate; 407, rubber block; 408, handle. DETAILED DESCRIPTION

[0029] In order to make the above-mentioned purpose, features and advantages of the present application more apparent and easy to understand, the following will make a detailed description of the specific embodiments of the present application in combination with the drawings.

[0030] In the following description, many specific details are set forth in order to provide a thorough understanding of the present application, but the present application can also be implemented in other ways different from those described herein, and those skilled in the art can make similar generalizations without departing from the connotation of the present application, therefore, the present application is not limited by the specific embodiments disclosed below.

[0031] In order to make the purpose, technical scheme and advantages of the utility model more clear, the embodiments of the utility model will be described in further detail below with reference to the drawings.

[0032] Please refer to Figure 1-4 The embodiment is an automatic chromatography filtration device, which comprises:

[0033] The support component comprises a chromatography column 100;

[0034] The flow uniformizing component comprises a flow uniformizing disc one 200, a flow uniformizing disc two 201, a hole body 202, a hole ring 203, a limiting ring 204 and an inner groove 207, the flow uniformizing disc one 200 and the flow uniformizing disc two 201 are located at the upper part of the inner surface of the chromatography column 100, the hole body 202 is formed in the inner part of the flow uniformizing disc one 200 and the flow uniformizing disc two 201, the hole ring 203 is inlaidly connected in the inner part of the hole body 202, and the limiting ring 204 is connected at the top of the hole ring 203 and inlaidly connected in the inner part of the inner groove 207;

[0035] When the liquid flows through the flow uniformizing disc one 200 and the flow uniformizing disc two 201, the liquid is divided into multiple small flow streams due to the uniform distribution of the hole body 202, so that the fluid is more uniformly distributed when entering the subsequent area of the column body, the uniform distribution of the fluid in the chromatography column 100 is ensured, the phenomenon of channeling or too fast local flow rate is avoided, the full contact of the sample and the separation medium is ensured, the purification effect is significantly improved, and more accurate material separation is realized.

[0036] The flow uniformizing component further comprises a vertical plate 205 and a limiting plate 206, the vertical plate 205 is symmetrically connected at the top of the flow uniformizing disc one 200, and the limiting plate 206 is connected at the top of the vertical plate 205 and hung at the top of the chromatography column 100;

[0037] The vertical plate 205 is used for supporting the flow uniformizing disc one 200 and the flow uniformizing disc two 201.

[0038] The fixing component comprises a clamping block 300, a bottom block 302, a clamping groove 303 and an inner groove 305, the inner groove 305 is inlaidly connected at the outer surface of the vertical plate 205, the bottom block 302 is connected at both ends of the outer surface of the vertical plate 205, the clamping block 300 is connected at the top of the bottom block 302, the bottom of the flow uniformizing disc two 201 is provided with the clamping groove 303, and the clamping block 300 is insertedly connected in the inner part of the clamping groove 303;

[0039] The clamping block 300 is inserted in the inner part of the clamping groove 303, so that the flow uniformizing disc two 201 is fixedly installed at the upper part of the flow uniformizing disc one 200.

[0040] The fixing part further comprises a fixing ring 301 connected at the bottom of the limiting ring 204 and a fixing groove 304 opened at the top of the inner groove 207, and the fixing ring 301 is inserted and connected inside the fixing groove 304.

[0041] The hole ring 203 is fixedly installed inside the hole body 202 by fixing the fixing ring 301 inside the fixing groove 304.

[0042] The supporting part further comprises a top cover 101 connected at the top of the chromatography column 100 and a supporting frame 102 welded and connected at the bottom of the outer surface of the chromatography column 100.

[0043] The chromatography column 100 is supported by the supporting frame 102 to improve the stability during operation of the chromatography column 100.

[0044] The working principle is that first, the spacing of the hole body 202 is adjusted according to the required uniform flow effect of the chromatography column 100, the fixing ring 301 is inserted inside the fixing groove 304, so that the hole ring 203 is fixedly installed inside the hole body 202, then the clamping block 300 is inserted inside the clamping groove 303, so that the uniform flow disc two 201 is installed on the upper part of the uniform flow disc one 200, when the liquid flows through the uniform flow disc one 200 and the uniform flow disc two 201, due to the uniform distribution of the hole body 202, the liquid is divided into multiple small flow streams, so that the fluid is more evenly distributed when entering the subsequent area of the column body, ensuring that the fluid is evenly distributed in the chromatography column 100, avoiding the phenomenon of channeling or local flow rate being too fast, ensuring that the sample and the separation medium are in full contact, significantly improving the purification effect, and realizing more accurate material separation.

[0045] Please refer to Figure 1 、 Figure 2 、 Figure 5 The embodiment further comprises a cleaning part, the cleaning part comprises a rotating rod 400, a scraper 401, a sleeve ring 402 and a cross plate 403, the rotating rod 400 is connected at the lower part of the inner surface of the chromatography column 100, the sleeve ring 402 is sleeved and connected at the outer surface of the rotating rod 400, the cross plate 403 is connected at both sides of the outer surface of the sleeve ring 402, and the scraper 401 is connected at one side of the outer surface of the cross plate 403 and is connected in close contact with the inner wall of the chromatography column 100.

[0046] The rotating rod 400 rotates by the operation of the motor, and the scraper 401 scrapes off the liquid attached to the inner wall of the chromatography column 100 in a rotating manner, so that the liquid can be better transmitted.

[0047] The cleaning component further comprises an inner threaded ring 404, a threaded rod 405, a side plate 406, rubber blocks 407 and a handle 408, the side plate 406 is connected to the lower part of one end of the outer surface of the rotating rod 400, the inner threaded ring 404 is connected to the outer end of the side plate 406, the threaded rod 405 is connected to the middle part of the inner threaded ring 404, the handle 408 is rotatably connected to one end of the threaded rod 405, and the rubber blocks 407 are connected to the other end of the outer surface of the threaded rod 405;

[0048] The threaded rod 405 is rotated, so that the rubber blocks 407 are clamped at the outer end of the sleeve ring 402, and the installed sleeve ring 402 is fixed.

[0049] The working principle is that after the liquid is uniformly distributed through the flow-distributing disc 1 and the flow-distributing disc 2, some liquid will adhere to the inner wall of the chromatographic column 100, the rotating rod 400 is rotated through the operation of the motor, and the scraper 401 scrapes the liquid adhered to the inner wall of the chromatographic column 100 in a rotating manner, so that the liquid can be better transmitted.

[0050] In the description of the present application, it should be further pointed out that, unless otherwise explicitly specified and limited, the terms "arrangement", "installation", "connection", "connection" should be broadly understood, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the communication between two elements. For ordinary skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0051] Finally, it should be pointed out that: the above-mentioned only for the preferred embodiments of the present application, and does not limit the present application, although the present application has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for some technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. An automated chromatofiltration device, characterized in that, Include: Supporting components, the supporting components include chromatography column (100); The uniform flow component includes uniform flow disc one (200), uniform flow disc two (201), hole body (202), hole ring (203), limiting ring (204) and inner groove (207), the uniform flow disc one (200) and the uniform flow disc two (201) are located in the upper portion of the inner surface of chromatography column (100), the inside of the uniform flow disc one (200) and the uniform flow disc two (201) is provided with hole body (202), hole ring (203) is inlaidly connected in the inside of hole body (202), limiting ring (204) is connected at the top of hole ring (203) and inlaidly connected in the inside of inner groove (207).

2. An automated chromatofiltration device according to claim 1, wherein, The uniform flow component further includes vertical plate (205) and limiting plate (206), the vertical plate (205) is symmetrically connected at the top of uniform flow disc one (200), the limiting plate (206) is connected at the top of vertical plate (205) and hangs at the top of chromatography column (100).

3. An automated chromatofiltration device according to claim 1, wherein, It also includes a fixing component, the fixing component includes clamping block (300), bottom block (302), clamping groove (303) and inner groove (305), the inner groove (305) is inlaidly connected to the outer surface of vertical plate (205), the bottom block (302) is connected at both ends of the outer surface of vertical plate (205), the clamping block (300) is connected at the top of bottom block (302), the bottom of uniform flow disc two (201) is provided with clamping groove (303), and the clamping block (300) is insertedly connected in the inside of clamping groove (303).

4. The automated chromatofiltration device of claim 1, wherein, The fixing component further includes fixing ring (301) and fixing groove (304), the fixing ring (301) is connected at the bottom of limiting ring (204), the top of inner groove (207) is provided with fixing groove (304), and the fixing ring (301) is insertedly connected in the inside of fixing groove (304).

5. The automated chromatofiltration device of claim 1, wherein, The supporting component further includes top cover (101) and support frame (102), the top cover (101) is connected at the top of chromatography column (100), and the support frame (102) is weldedly connected at the bottom of the outer surface of chromatography column (100).

6. An automated chromatofiltration device according to claim 1, wherein, It also includes a cleaning component, the cleaning component includes rotating rod (400), scraper (401), sleeve ring (402) and horizontal plate (403), the rotating rod (400) is connected at the lower portion of the inner surface of chromatography column (100), the sleeve ring (402) is sleevedly connected to the outer surface of rotating rod (400), the horizontal plate (403) is connected at both sides of the outer surface of sleeve ring (402), and the scraper (401) is connected at one side of the outer surface of horizontal plate (403) and abuttingly connected to the inner wall of chromatography column (100).

7. An automated chromatofiltration device according to claim 6, wherein, The cleaning component further comprises an inner threaded ring (404), a threaded rod (405), a side plate (406), a rubber block (407) and a handle (408), the side plate (406) is connected to the lower part of one end of the outer surface of the rotating rod (400), the inner threaded ring (404) is connected to the outer end of the side plate (406), the threaded rod (405) is connected to the middle part of the inner threaded ring (404), the handle (408) is rotatably connected to one end of the threaded rod (405), and the rubber block (407) is connected to the other end of the outer surface of the threaded rod (405).

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