Device for preparing platelet-rich plasma with small blood volume

Abstract

The utility model relates to a device for preparing platelet-rich plasma with less blood volume. The device comprises a preparation tube unit, an upper tube cover unit, an isolation unit and a lower tube cover unit, the platelet-rich plasma preparation device has the advantages that by changing the structure of the preparation tube unit, the platelet-rich plasma preparation device can be suitable for treatment of small animals or pets; the volume of blood contained in the preparation tube unit is reduced, so that the centrifugation time is shortened, and the risks of infection and blood coagulation are reduced; besides, after the blood is centrifugally separated, a lower tube cover unit is arranged and is in threaded connection with a preparation tube unit, so that the lower tube cover unit can be rotated to adjust the volume of a fourth cavity of the preparation tube unit, the buffy yellow layer by layer is positioned in a third cavity, and the plasma is completely positioned in a second cavity of the preparation tube unit; therefore, subsequent extraction by medical staff is facilitated.

Description

TECHNICAL FIELD

[0001] The utility model relates to platelet rich plasma preparation technical field especially, a kind of platelet rich plasma preparation device for little blood. BACKGROUND

[0002] Platelet rich plasma (Platelet-rich plasma, for short PRP), is the platelet concentrate obtained after centrifugation of autologous whole blood, PRP contains a large number of growth factors and proteins, can accurately self-position to the injury site, control inflammation, can promote cell and tissue regeneration from different aspects, so as to accelerate the repair of damaged tissue, widely used in clinical, for example, the repair of bone joint, the repair of large area burn skin and medical plastic surgery etc.

[0003] In prior art, the preparation method of PRP is usually secondary centrifugation method, that is, after extracting blood, blood is injected into container by syringe, first, through first centrifugation, red blood cells are separated from platelets and plasma, then platelets and plasma are transferred to new container for second centrifugation, and after second centrifugation, platelet rich plasma PRP at the bottom of new container is extracted by syringe.

[0004] When blood is centrifuged, it is separated into upper plasma part and lower erythrocyte part, and a thin layer of "buffy coat" composed of platelets and lymphocytes is formed between the upper plasma part and the lower erythrocyte part. Lymphocyte system includes non-granular cells and granular cells, and some mononuclear cells contain stem cells. In addition, various growth hormones secreted by platelets can activate stem cells.

[0005] However, the existing preparation equipment has the following defects:

[0006] 1. Because the existing preparation tube needs a large amount of blood, the centrifugation time is too long, and the whole process needs about 30-40 minutes, so the preparation is slow.

[0007] 2. Because the existing preparation tube is designed as a straight cylinder, liquid mixing is easy to occur after centrifugation, the red blood cell removal rate is low, and high concentration of red blood cells is not conducive to tissue repair.

[0008] 3. The existing preparation tube does not consider animal use, and the original blood required by the technology needs to be collected as much as 40ml, which is too large for pet or small animal blood collection, and cannot bear the blood collection amount.

[0009] 4. The PRP enrichment multiple of the existing technology is low (less than 2 times), which has certain influence on treatment effect.

[0010] 5. Existing PRP products cannot differentiate between anemic and leukocyte-rich cells, and cannot be used for different indications.

[0011] Currently, no effective solutions have been proposed for the problems existing in the related technologies, such as the need for large amounts of blood to be collected for the preparation tube, which leads to excessively long centrifugation time; the straight cylindrical design of the preparation tube, which makes it easy for liquids to mix after centrifugation; and the fact that the preparation tube is not suitable for pets or small animals. Utility Model Content

[0012] The purpose of this invention is to address the shortcomings of existing technologies by providing a device for preparing platelet-rich plasma with small blood volumes. This device solves problems such as the need for large blood collection leading to excessively long centrifugation times, the straight cylindrical design of the preparation tube causing easy liquid mixing after centrifugation, and the unsuitability of the preparation tube for pets or small animals.

[0013] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0014] This utility model provides an apparatus for preparing platelet-rich plasma with low blood volume, comprising:

[0015] A preparation tube unit, the preparation tube unit including a first cavity, a second cavity, a third cavity, and a fourth cavity, wherein the first cavity, the second cavity, the third cavity, and the fourth cavity are connected in sequence;

[0016] The upper tube cap unit is disposed at the first end of the preparation tube unit and is detachably connected to the preparation tube unit. It is used to seal the end of the first cavity and to allow the syringe to inject blood into the preparation tube unit and to allow the syringe to draw the prepared platelet-rich plasma from the preparation tube.

[0017] An isolation unit is disposed inside the preparation tube unit and connected to the upper tube cover unit, for isolating the second cavity and the third cavity;

[0018] The lower tube cap unit is disposed at the second end of the preparation tube unit and is detachably connected to the preparation tube unit. It is used to seal the end of the fourth cavity and to squeeze the separated plasma upward.

[0019] In some embodiments, the end of the first cavity near the second cavity, the ends of the second cavity and the fourth cavity near each other are all funnel-shaped, and the inner wall of the third cavity is a bottleneck structure.

[0020] In some embodiments, the upper tube cover unit includes:

[0021] An upper tube cover element is arranged on the preparation tube unit and detachably connected with the preparation tube unit, for closing an end of the first cavity and for a syringe to inject blood into the preparation tube unit and for the syringe to extract prepared platelet-rich plasma from the preparation tube unit;

[0022] A first sealing element is arranged on the upper tube cover element, for sealing a hole of the upper tube cover element;

[0023] A fixing element is arranged on the first sealing element, for connecting the first sealing element with the upper tube cover element.

[0024] In some embodiments, the upper tube cover unit comprises:

[0025] A first through hole is arranged on the upper tube cover element, for a syringe to inject blood into the preparation tube unit and for the syringe to extract prepared platelet-rich plasma from the preparation tube unit;

[0026] A second through hole is arranged on the upper tube cover element, for connecting the isolation unit.

[0027] In some embodiments, the isolation unit comprises:

[0028] An isolation element is connected with the upper tube cover unit at a first end, and a second end of the isolation element extends into an interior of the preparation tube unit and isolates the second cavity and the third cavity under the driving of the upper tube cover unit;

[0029] A second sealing element is sleeved on the second end of the isolation element, for sealing an abutting position of the isolation element and the third cavity.

[0030] In some embodiments, the isolation unit further comprises:

[0031] A first sealing groove is formed on the second end of the isolation element, for mounting the second sealing element.

[0032] In some embodiments, the lower tube cover unit comprises:

[0033] A lower tube cover element is arranged on the preparation tube unit and detachably connected with the preparation tube unit, for closing an end of the fourth cavity;

[0034] A third sealing element is arranged on the second end of the preparation tube unit, for sealing.

[0035] In some embodiments, the lower tube cover unit further comprises:

[0036] A second sealing groove is formed at the second end of the preparation tube unit for mounting the third sealing element.

[0037] In some embodiments, further comprising:

[0038] A pushing-up unit is arranged on the lower tube cover unit and rotationally connected with the lower tube cover unit for extruding the separated blood plasma upward.

[0039] In some embodiments, the pushing-up unit comprises:

[0040] A pushing-up element is arranged inside the lower tube cover unit and movably connected with the lower tube cover unit for extruding the separated blood plasma upward.

[0041] A connecting element has a first end connected with the pushing-up element and a second end rotationally connected with the lower tube cover unit and extending to the outside of the lower tube cover unit.

[0042] A rotating element is connected with the second end of the connecting element for driving the connecting element to rotate.

[0043] A limiting element is formed between the pushing-up element and the preparation tube unit for limiting the rotation of the pushing-up element.

[0044] Compared with the prior art, the above technical scheme has the following technical effects:

[0045] The platelet-rich plasma preparation device for small amount of blood can be applied to the treatment of small animals or pets by changing the structure of the preparation tube unit. In addition, after blood centrifugal separation, the lower tube cover unit is arranged and threadedly connected with the preparation tube unit, so that the lower tube cover unit can be rotated to adjust the volume of the fourth cavity of the preparation tube unit, so as to position the blood sedimentation brown yellow layer in the third cavity, and then make the blood plasma completely located in the second cavity of the preparation tube unit, thereby facilitating the extraction of medical staff. BRIEF DESCRIPTION OF DRAWINGS

[0046] Figure 1 is a schematic view of a platelet-rich plasma preparation device according to an embodiment of the present application;

[0047] Figure 2 is a schematic view of a preparation tube unit according to an embodiment of the present application;

[0048] Figure 3 is a schematic view of an upper tube cover unit and an isolation unit according to an embodiment of the present application;

[0049] Figure 4 is a schematic view of a lower tube cover unit according to an embodiment of the present application;

[0050] Figure 5 is a schematic view of an upper pushing unit according to an embodiment of the present application.

[0051] The reference signs in the drawings are as follows: 100, preparation tube unit; 110, first cavity; 120, second cavity; 130, third cavity; 140, fourth cavity; 150, second sealing groove;

[0052] 200, upper tube cover unit; 210, upper tube cover element; 211, first through hole; 212, second through hole; 220, first sealing element; 230, fixing element;

[0053] 300, isolation unit; 310, isolation element; 311, first sealing groove; 320, second sealing element;

[0054] 400, lower tube cover unit; 410, lower tube cover element; 420, third sealing element;

[0055] 500, upper pushing unit; 510, upper pushing element; 520, connecting element; 530, rotating element; 540, limiting element. DETAILED DESCRIPTION

[0056] In order to make the purpose, technical scheme and advantages of the present application clearer, the present application is described and explained below in combination with the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and do not limit the present application. Based on the embodiments provided in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the present application.

[0057] It is apparent that the drawings in the following description merely show some examples or embodiments of the present application, and for those skilled in the art, the present application can be applied to other similar situations without creative labor on the basis of these drawings. In addition, it can be understood that although the efforts made in this development process can be complex and lengthy, some design, manufacture or production changes made on the basis of the technical content disclosed in the present application are only routine technical means for those skilled in the art related to the content disclosed in the present application, and should not be understood as insufficient disclosure of the content disclosed in the present application.

[0058] Reference to "an embodiment" in this application means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are they necessarily mutually exclusive of one another. It is explicitly contemplated that embodiments described herein can be combined with other embodiments in a non- conflicting manner.

[0059] Embodiment 1

[0060] As shown in Figure 1 An embodiment of the present application, a platelet-rich plasma preparation device for less blood, comprising preparation tube unit 100, upper tube cover unit 200, isolation unit 300 and lower tube cover unit 400. Wherein, preparation tube unit 100 includes first cavity 110, second cavity 120, third cavity 130, fourth cavity 140, and the first cavity 110, second cavity 120, third cavity 130 and fourth cavity 140 are communicated in turn; The upper tube cover unit 200 is arranged at the first end of the preparation tube unit 100, and is detachably connected with the preparation tube unit 100, which is used for closing the end of the first cavity 110 and supplying the syringe to inject liquid blood into the preparation tube unit 100, and the syringe is used to extract the prepared platelet-rich plasma from the preparation tube; The isolation unit 300 is arranged in the interior of the preparation tube unit 100 and connected with the upper tube cover unit 200, which is used for isolating the second cavity 120 and the third cavity 130; The lower tube cover unit 400 is arranged at the second end of the preparation tube unit 100 and is detachably connected with the preparation tube unit 100, which is used for closing the end of the fourth cavity 140 and extruding the separated plasma upward.

[0061] As shown in Figure 1 And Figure 2 The preparation tube unit 100 is arranged in a substantially cylindrical shape, and the first cavity 110 and the fourth cavity 140 are respectively formed at the first end and the second end of the preparation tube unit 100; It should be noted that the first end and the second end of the preparation tube unit 100 are respectively the two ends in the length direction.

[0062] In some embodiments, the preparation tube unit 100 includes, but is not limited to, a transparent columnar body.

[0063] Specifically, the end of the first cavity 110 close to the second cavity 120, the end of the second cavity 120 close to the fourth cavity 140, and the inner wall of the third cavity 130 are all funnel-shaped structures.

[0064] More specifically, the upper half of the first cavity 110 is a hollow cylindrical structure, and the lower half of the first cavity 110 is a funnel-shaped structure (i.e., the diameter of the first cavity 110 decreases as it gets closer to the second cavity 120); the first three- thirds of the second cavity 120 is a hollow cylindrical structure, and the last third of the second cavity 120 is a funnel-shaped structure (i.e., the diameter of the second cavity 120 decreases as it gets closer to the third cavity 130); the first fifth of the fourth cavity 140 is a funnel-shaped structure (i.e., the diameter of the fourth cavity 140 decreases as it gets closer to the third cavity 130), and the last four- fourths of the fourth cavity 140 is a hollow cylindrical structure.

[0065] It should be noted that the large diameter structure of the first cavity 110 can facilitate medical staff to insert a syringe into the preparation tube unit 100, and as the diameter of the second cavity 120 decreases, the amount of blood contained in the preparation tube unit 100 can be reduced, thereby reducing the centrifugation time and reducing the risk of infection and coagulation; in addition, the second cavity 120, the third cavity 130 and the fourth cavity 140 can ensure that the separated blood can smoothly pass through the passage of the third cavity 130 (i.e., the blood separated along the inclined surface of the inlet of the third cavity 130 can be smoothly pushed upward by the lower tube cover unit 400).

[0066] More specifically, the third cavity 130 is formed between the second cavity 120 and the fourth cavity 140; it should be noted that the volume of the third cavity 130 is smaller than the volume of the second cavity 120 and the third cavity 130, so that the upper and lower thickness of the buffy coat, which is the boundary layer of red blood cells and plasma after centrifugation, becomes larger, and the boundary is clearly visible.

[0067] Further, the preparation tube unit 100 further comprises a first scale mark and a second scale mark. The first scale mark is provided on the outer side wall of the second cavity 120 for medical staff to observe; the second scale mark is provided on the outer side wall of the fourth cavity 140 for medical staff to observe.

[0068] Specifically, the first scale mark is integrally formed on the outer side wall of the preparation tube unit 100, and the first scale mark can be used by medical staff to visually observe the liquid level information in the second cavity 120.

[0069] In some embodiments, the first scale mark comprises, but is not limited to, milliliter scale.

[0070] Specifically, the second scale mark is integrally formed on the outer sidewall of the preparation tube unit 100, and the second scale mark can be visually observed by medical staff to obtain the liquid level information in the fourth cavity 140.

[0071] In some embodiments, the second scale mark comprises, but is not limited to, milliliter scale.

[0072] As shown in Figure 3 The upper tube cover unit 200 comprises an upper tube cover element 210, a first sealing element 220, and a fixing element 230. The upper tube cover element 210 is arranged on the preparation tube unit 100 and detachably connected with the preparation tube unit 100, for closing the end of the first cavity 110 and allowing the syringe to inject blood into the preparation tube unit 100 and extract the prepared platelet-rich plasma from the preparation tube unit 100; the first sealing element 220 is arranged on the upper tube cover element 210, for sealing the hole of the upper tube cover element 210; and the fixing element 230 is arranged on the first sealing element 220, for connecting the first sealing element 220 with the upper tube cover element 210.

[0073] Specifically, the upper tube cover element 210 is arranged in a bottle cap structure, and the upper tube cover element 210 is threadedly connected with the first end of the preparation tube unit 100, so that the upper tube cover element 210 is advanced and retreated at the first end of the preparation tube unit 100 by rotating the upper tube cover element 210.

[0074] In some embodiments, the upper tube cover element 210 comprises, but is not limited to, a cap.

[0075] It should be noted that the size structure of the upper tube cover element 210 can be adapted to the size structure of the preparation tube unit 100; it should be understood that the inner diameter of the upper tube cover element 210 is the same as the outer diameter of the first end of the preparation tube unit 100.

[0076] Further, the upper tube cover unit 200 further comprises a first through hole 211 and a second through hole 212. The first through hole 211 is arranged on the upper tube cover element 210, for allowing the syringe to inject blood into the preparation tube unit 100 and extract the prepared platelet-rich plasma from the preparation tube unit 100; and the second through hole 212 is arranged on the upper tube cover element 210, for communicating with the isolation unit 300.

[0077] Specifically, the first through hole 211 is arranged at the edge of the upper tube cover element 210, so that the syringe can pass through the first through hole 211 and extend into the interior of the preparation tube unit 100.

[0078] It should be noted that the shape and size of the first through hole 211 are matched with the standardized end of the syringe.

[0079] Specifically, the second through hole 212 is provided at the center of the upper tube cover element 210 and communicates with the isolation unit 300.

[0080] It should be noted that the size of the second through hole 212 is matched with the size of the isolation element 310 in the isolation unit 300.

[0081] Further, the upper tube cover element 210 further comprises anti-skid lines. The anti-skid lines are integrally formed at the outer arc side wall of the upper tube cover element 210 and are arranged circumferentially around the upper tube cover element 210.

[0082] It should be noted that the anti-skid lines can assist the medical staff in the operation of the platelet-rich plasma preparation device and can reduce the phenomenon of slipping of the upper tube cover element 210 during rotation.

[0083] Specifically, the first sealing element 220 comprises a connecting band, a first sealing plug and a second sealing plug. The connecting band is connected with the upper tube cover element 210, and the two ends of the connecting band are respectively connected with the first sealing plug and the second sealing plug; the first sealing plug is buckled on the first through hole 211 for sealing the first through hole 211; and the second sealing plug is buckled on the second through hole 212 for sealing the second through hole 212.

[0084] More specifically, the first end and the second end of the connecting band are respectively connected with the first sealing plug and the second sealing plug, and a hollow circular hole is formed in the middle of the connecting band, which can pass through the fixing element 230.

[0085] It should be noted that the first end and the second end of the connecting band are respectively the two ends in the length direction thereof.

[0086] More specifically, the first sealing plug is integrally formed with the first end of the connecting band, and the first sealing plug is buckled on the first through hole 211, so that the airtightness of the preparation tube unit 100 can be realized without injection or extraction.

[0087] In some embodiments, the first sealing plug comprises but is not limited to a rubber plug.

[0088] More specifically, the second sealing plug is integrally formed with the second end of the connecting band, and the second sealing plug is buckled on the second through hole 212, so that the airtightness of the preparation tube unit 100 can be realized without injection or extraction.

[0089] In some embodiments, the second sealing plug comprises but is not limited to a rubber plug.

[0090] Specifically, the fixing element 230 passes through the hollow circular hole on the first sealing element 220 and is riveted to the upper tube cover element 210, thereby fixing the first sealing element 220 to the upper tube cover element 210.

[0091] In some of these embodiments, the fixing element 230 includes, but is not limited to, rivets.

[0092] like Figure 3 As shown, the isolation unit 300 includes an isolation element 310 and a second sealing element 320. The first end of the isolation element 310 is connected to the upper tube cap unit 200, and the second end of the isolation element 310 extends into the interior of the preparation tube unit 100, isolating the second cavity 120 and the third cavity 130 under the action of the upper tube cap unit 200. The second sealing element 320 is sleeved on the second end of the isolation element 310 to seal the contact point between the isolation element 310 and the third cavity 130.

[0093] Specifically, the first end of the isolation element 310 is integrally formed with the upper tube cover element 210, and the isolation element 310 has a hollow cavity that communicates with the second through hole 212 of the upper tube cover element 210. The second end of the isolation element 310 extends into the interior of the preparation tube unit 100.

[0094] It should be noted that the first end and the second end of the isolation element 310 are the two ends of its length direction, respectively.

[0095] In some of these embodiments, the isolation element 310 includes, but is not limited to, a hollow tube.

[0096] In addition, medical staff can rotate the upper tube cap element 210, which can drive the isolation element 310 to move back and forth vertically inside the preparation tube unit 100. When the upper tube cap element 210 is tightened, the second end of the isolation element 310 can abut against the connection between the second cavity 120 and the third cavity 130, thereby achieving isolation between the second cavity 120 and the third cavity 130.

[0097] In some of these embodiments, the second sealing element 320 includes, but is not limited to, a sealing ring.

[0098] Furthermore, the isolation unit 300 also includes a first sealing groove 311. The first sealing groove 311 is formed at the second end of the isolation element 310 for mounting the second sealing element 320.

[0099] It should be noted that the first sealing groove 311 is formed around the second end of the isolation element 310, and the first sealing groove 311 can be embedded in the second sealing element 320.

[0100] like Figure 4As shown, the lower tube cover unit 400 comprises a lower tube cover element 410 and a third sealing element 420. Among them, the lower tube cover element 410 is arranged on the preparation tube unit 100 and detachably connected with the preparation tube unit 100, used for closing the end of the fourth cavity 140; the third sealing element 420 is arranged at the second end of the preparation tube unit 100, used for sealing.

[0101] Specifically, the lower tube cover element 410 is arranged in a bottle cap structure, and the lower tube cover element 410 is threadedly connected with the second end of the preparation tube unit 100, so that by rotating the lower tube cover element 410, the lower tube cover element 410 is advanced and retreated at the second end of the preparation tube unit 100.

[0102] In some embodiments, the lower tube cover element 410 includes but is not limited to a cover body.

[0103] It should be noted that the size structure of the lower tube cover element 410 can be adapted to the size structure of the preparation tube unit 100; it should be understood that the inner diameter of the lower tube cover element 410 is the same as the outer diameter of the second end of the preparation tube unit 100.

[0104] In some embodiments, the third sealing element 420 includes but is not limited to a sealing ring.

[0105] Further, the lower tube cover element 410 further comprises an anti-skid pattern. Among them, the anti-skid pattern is integrally formed at the circular arc outer side wall of the lower tube cover element 410, and the anti-skid pattern is arranged around the circumference of the lower tube cover element 410.

[0106] It should be noted that the anti-skid pattern plays a certain auxiliary role in the process of operating the platelet-rich plasma preparation device by medical staff, which can reduce the phenomenon of slipping of the medical staff in rotating the lower tube cover element 410.

[0107] Further, the lower tube cover unit 400 further comprises a second sealing groove 150. Among them, the second sealing groove 150 is formed at the second end of the preparation tube unit 100, used for installing the third sealing element 420.

[0108] It should be noted that the second sealing groove 150 is opened around the second end of the preparation tube unit 100, and the third sealing element 420 can be embedded in the second sealing groove 150.

[0109] It should be noted that when the lower cap element 410 is engaged with the second end of the preparation tube unit 100, a sealed fourth cavity 140 is formed. When the lower cap element 410 rotates, it moves closer to the first end of the preparation tube unit 100, thereby reducing the space within the fourth cavity 140. Conversely, when the lower cap element 410 rotates in the opposite direction, it moves further away from the first end of the preparation tube unit 100, thereby increasing the space within the fourth cavity 140. In other words, the volume of the fourth cavity 140 of the preparation tube unit 100 can be adjusted using the lower cap element 410.

[0110] The usage method of this embodiment is as follows:

[0111] First, an anticoagulant is drawn into a syringe before blood is drawn. The amount of anticoagulant is approximately 10% of the blood volume to be collected. Then, blood is drawn from the patient using the syringe with the anticoagulant drawn into it. After blood collection, the syringe needle is removed, and the syringe discharge port is brought into close contact with the first through-hole 211 formed on the upper tube cap element 210 of the platelet-rich plasma preparation device, injecting the blood into the preparation tube unit 100. It should be noted that the tight contact between the syringe discharge port and the first through-hole 211 is to prevent blood ejected from the syringe from mistakenly leaking out of the preparation tube unit 100.

[0112] Furthermore, when the second end of the isolation element 310 is in close contact with the inner wall of the third cavity 130 of the preparation tube unit 100, the blood injected into the preparation tube unit 100 cannot flow to the fourth cavity 140 because the third cavity 130 is blocked by the second end of the isolation element 310. Therefore, during blood injection, the upper tube cap element 210 is rotated in the opposite direction by a certain amount to ensure that there is a certain gap between the isolation element 310 and the upper end of the third cavity 130, and that the connection between the upper tube cap element 210 and the first end of the preparation tube unit 100 is not loosened. Then, the blood injection proceeds smoothly, and the injected blood can flow downward through the third cavity 130 into the interior of the fourth cavity 140.

[0113] Further, after the blood is injected into the preparation tube unit 100, the first through hole 211 of the upper tube cover element 210 is sealed by the first sealing element 220, and then centrifugal separation is performed. At this time, since the third cavity 130 is not sealed, when the blood is centrifuged, the red blood cells drop to the fourth cavity 140 of the preparation tube unit 100, the plasma is located in the second cavity 120 of the preparation tube unit 100, and a thin buffy coat layer is located between the plasma and the red blood cells. The reason why the plasma is collected in the second cavity 120 of the preparation tube unit 100 in the centrifugal separation state is that it is injected by adjusting the lower tube cover element 410 before centrifugal separation. The fourth cavity 140 is set in consideration of the proportion of the plasma in the blood. Here, in order to separate more accurately, centrifugation can be repeated a predetermined number of times.

[0114] Subsequently, the volume of the fourth cavity 140 of the preparation tube unit 100 is adjusted by rotating the lower tube cover element 410 to position the buffy coat layer in the third cavity 130. Therefore, the thin buffy coat layer is gathered in the third cavity 130, and the volume thereof is relatively small, so that the top and bottom thicknesses are increased, and the upper and lower layers of the red blood cells can be distinguished from the plasma.

[0115] Subsequently, the upper tube cover element 210 is rotated so that the upper tube cover element 210 moves the isolation element 310, so that the second end of the isolation element 310 drops and tightly abuts the inner wall of the third cavity 130, so that the plasma and the buffy coat layer are separated; then, the first sealing element 220 on the first through hole 211 is removed, and a syringe is inserted into the inside of the preparation tube unit 100 through the first through hole 211 to extract the plasma.

[0116] The advantage of the embodiment is that, by changing the structure of the preparation tube unit, the platelet-rich plasma preparation device can be applied to the treatment of small animals or pets; by reducing the amount of blood contained in the preparation tube unit, the centrifugal time is further reduced, and the risk of infection and blood clotting is reduced; in addition, after centrifugal separation of the blood, the lower tube cover unit is provided and is threadedly connected with the preparation tube unit, so that the lower tube cover unit can be rotated to adjust the volume of the fourth cavity of the preparation tube unit to position the buffy coat layer in the third cavity, so that the plasma is completely located in the second cavity of the preparation tube unit, thereby facilitating the extraction of medical staff; further, the isolation unit is connected with the upper tube cover unit, and the upper tube cover unit is threadedly connected with the preparation tube unit, so that the upper tube cover unit can be rotated to enable the isolation unit to close the upper end of the second cavity, so that only the plasma located in the second cavity is extracted during the extraction of medical staff, thereby improving the operation convenience.

[0117] Embodiment 2

[0118] The embodiment is a variant of embodiment 1.

[0119] As Figure 1 and Figure 5 shown, the platelet-rich plasma preparation device further comprises an upward pushing unit 500. Wherein, the upward pushing unit 500 is arranged in the lower tube cover unit 400 and is rotationally connected with the lower tube cover unit 400, for extruding the separated plasma upward.

[0120] As Figure 5 shown, the upward pushing unit 500 comprises an upward pushing element 510, a connecting element 520, a rotating element 530 and a limiting element 540. Wherein, the upward pushing element 510 is arranged in the interior of the lower tube cover unit 400 and is movably connected with the lower tube cover unit 400, for extruding the separated plasma upward; the first end of the connecting element 520 is connected with the upward pushing element 510, the second end of the connecting element 520 is rotationally connected with the lower tube cover unit 400 and extends to the exterior of the lower tube cover unit 400; the rotating element 530 is connected with the second end of the connecting element 520, for driving the connecting element 520 to rotate; the limiting element 540 is formed between the upward pushing element 510 and the preparation tube unit 100, for limiting the rotation of the upward pushing element 510.

[0121] Specifically, the upward pushing element 510 is movably arranged in the interior of the lower tube cover element 410, and the upward pushing element 510 locally extends into the interior of the preparation tube unit 100 under the condition that the lower tube cover element 410 is screwed with the second end of the preparation tube unit 100.

[0122] In some embodiments, the upward pushing element 510 comprises but is not limited to a rubber plug.

[0123] Specifically, the first end of the connecting element 520 is rotationally connected with the center of the lower tube cover element 410 and extends to the exterior of the lower tube cover element 410, and the second end of the connecting element 520 extends to the interior of the preparation tube element, the center of the connecting element 520 passes through the upward pushing element 510 and is threadedly connected with the upward pushing element 510, for reciprocating along the length direction of the preparation tube unit 100 under the rotation of the connecting element 520.

[0124] In some embodiments, the connecting element 520 comprises but is not limited to a threaded rod.

[0125] Specifically, the center of the rotating element 530 is connected with the first end of the connecting element 520 by welding, riveting or bolt fixing, etc., for being rotated by medical staff to drive the connecting element 520 to rotate.

[0126] In some embodiments, the rotating element 530 comprises but is not limited to a disc.

[0127] Specifically, the limiting element 540 comprises a limiting block and a limiting groove. The limiting block is formed on the side of the pushing element 510 and is arranged along the length direction of the pushing element 510; the limiting groove is opened on the inner wall of the second end of the preparation tube unit 100 and is connected with the limiting block, thereby limiting the pushing element 510.

[0128] It should be noted that the number of limiting blocks is 2, and the two limiting blocks are symmetrically arranged on the pushing element 510; the number of limiting grooves is 2, and the two limiting grooves are symmetrically arranged on the preparation tube unit 100.

[0129] The use method of the embodiment is as follows:

[0130] When the medical staff needs to further compress the volume of the fourth cavity 140, the medical staff can rotate the rotating element 530, so that the rotating element 530 drives the connecting element 520 to rotate, and then the pushing element 510 is close to the first end of the preparation tube unit 100, so that the space in the fourth cavity 140 of the preparation tube unit 100 is further reduced, and then the blood sedimentation buffy coat is positioned in the third cavity 130, which is convenient for the medical staff to extract later.

[0131] The advantages of the embodiment are the same as those of the embodiment 1, and will not be described here.

[0132] The technical features of the above-described embodiments can be combined arbitrarily. In order to make the description simple, all possible combinations of the technical features in the above-described embodiments are not described, but as long as the combinations of the technical features do not exist contradictory, they should be considered as the scope of the present application.

[0133] The above-described embodiments only express several implementation manners of the present application, and the description is more specific and detailed, but it should not be understood as the limitation of the scope of the utility model patent. It should be noted that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which are all within the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A device for preparing a platelet-rich plasma with low blood volume, characterized by, The application relates to a preparation tube unit, which comprises a first cavity, a second cavity, a third cavity and a fourth cavity, and the first cavity, the second cavity, the third cavity and the fourth cavity are sequentially communicated; an upper tube cover unit is arranged at the first end of the preparation tube unit and detachably connected with the preparation tube unit, and is used for closing the end of the first cavity and injecting blood into the preparation tube unit by using a syringe and extracting prepared platelet-rich plasma from the preparation tube unit by using a syringe; an isolation unit is arranged in the interior of the preparation tube unit and connected with the upper tube cover unit, and is used for isolating the second cavity and the third cavity; and a lower tube cover unit is arranged at the second end of the preparation tube unit and detachably connected with the preparation tube unit, and is used for closing the end of the fourth cavity and extruding the separated plasma upwards. The end of the first cavity close to the second cavity, the end of the second cavity close to the fourth cavity and the inner wall of the third cavity are all funnel-shaped. The upper tube cover unit comprises an upper tube cover element arranged in the preparation tube unit and detachably connected with the preparation tube unit, which is used for closing the end of the first cavity and injecting blood into the preparation tube unit by using a syringe and extracting prepared platelet-rich plasma from the preparation tube unit by using a syringe; a first sealing element arranged in the upper tube cover element and used for sealing the hole of the upper tube cover element; and a fixing element arranged in the first sealing element and used for connecting the first sealing element with the upper tube cover element. The upper tube cover unit further comprises a first through hole formed in the upper tube cover element and used for injecting blood into the preparation tube unit by using a syringe and extracting prepared platelet-rich plasma from the preparation tube unit by using a syringe; and a second through hole formed in the upper tube cover element and used for connecting the isolation unit. The isolation unit comprises an isolation element, a first end of which is connected with the upper tube cover unit, a second end of which extends into the interior of the preparation tube unit and isolates the second cavity and the third cavity under the driving of the upper tube cover unit; and a second sealing element sleeved on the second end of the isolation element and used for sealing the abutting position of the isolation element and the third cavity.

2. The platelet rich plasma preparation device according to claim 1, wherein The lower tube cover unit comprises a lower tube cover element arranged in the preparation tube unit and detachably connected with the preparation tube unit, which is used for closing the end of the fourth cavity; and a third sealing element arranged at the second end of the preparation tube unit and used for sealing.

3. The platelet rich plasma preparation device of claim 1, wherein, The lower tube cover unit further comprises ​ ​ ​ 4. The platelet rich plasma preparation device according to claim 3, wherein ​ ​ ​ 5. The platelet rich plasma preparation device of claim 1, wherein, ​ ​ ​ 6. The platelet rich plasma preparation device of claim 5, wherein, ​ ​ 7. The platelet rich plasma preparation device of claim 1, wherein, ​ ​ ​ 8. The platelet rich plasma preparation device according to claim 7, wherein ​ A second sealing groove is formed at the second end of the preparation tube unit for mounting the third sealing element.

9. The platelet rich plasma preparation device of claim 1, wherein, Further comprising: A pushing-up unit is arranged on the lower tube cover unit and is rotatably connected with the lower tube cover unit, for pressing the separated blood plasma upward.

10. The platelet rich plasma preparation device of claim 9, wherein, The pushing-up unit comprises: A pushing-up element is arranged inside the lower tube cover unit and is movably connected with the lower tube cover unit, for pressing the separated blood plasma upward; A connecting element has a first end connected with the pushing-up element and a second end rotatably connected with the lower tube cover unit and extending to outside of the lower tube cover unit; A rotating element is connected with the second end of the connecting element, for driving the connecting element to rotate; A limiting element is formed between the pushing-up element and the preparation tube unit, for limiting rotation of the pushing-up element.

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