Extraction device for hirudin

Abstract

The utility model belongs to the technical field of hirudin extraction, and particularly relates to an extraction device for hirudin, which comprises an extraction box. Living leeches are placed in a filter box, then a top cover is fixed, a driving motor drives an eccentric wheel to rotate, the eccentric wheel extrudes a ball when rotating for the first half circle, the ball drives an L-shaped plate to move rightwards, the L-shaped plate drives a connecting plate to slide on a guide rod and compress a first spring, and the connecting plate drives the filter box to move rightwards. When the eccentric wheel rotates to the rear half circle, extrusion on the ball is gradually released, the first spring is reset, the first spring drives the filter box to move leftwards through the connecting plate, the filter box shakes left and right in a reciprocating mode, then the leeches are stimulated to automatically spit saliva, and then the saliva of the leeches is flushed to the bottom of the extraction box through the filter box by spraying water through a spray head; when hirudin is separated out in water, shaking of the filtering box is achieved, the leeches are stimulated to secrete saliva more actively, and therefore the extraction period is shortened.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of hirudin extraction technology, in particular to an extraction device for hirudin. BACKGROUND

[0002] Natural hirudin is extracted from leeches and their saliva. Natural hirudin is a small molecule protein composed of 65-66 amino acids, with a molecular weight of 7000 daltons. Natural hirudin can irreversibly bind to thrombin, rendering it inactive, making it the most powerful natural thrombin inhibitor ever discovered. In addition, it has a very strong antithrombotic effect and inhibits various experimental thrombosis models. Natural hirudin has preventive and therapeutic effects on various thrombotic diseases such as venous thrombosis, disseminated intravascular coagulation, cerebral coagulation, thrombophlebitis, and coronary artery thrombosis, especially for the treatment of venous thrombosis and diffuse intravascular coagulation. It can also be used to prevent the formation of arterial thrombosis after surgery, prevent re-embolization after thrombolysis or angioplasty, and improve extracorporeal blood circulation and hemodialysis. During surgery, anastomotic vascular embolism often leads to failure, and the use of live leeches to suck blood can effectively dissolve vascular embolism and promote limb survival.

[0003] Chinese patent CN218188020U discloses a repeated extraction device for live hirudin, which includes an extraction box, a heater, a temperature sensor, a temperature display screen, a first slide, a filter screen structure, a second slide, a baffle, a collection mechanism, and a spraying mechanism. The heater is fixedly installed on the inner wall of the extraction box. The temperature sensor is fixedly installed on the inner wall of the extraction box. The temperature display screen is fixedly installed on the outer wall of the extraction box and is electrically connected with the temperature sensor. The first slide is fixedly installed on the inner wall of the extraction box. The filter screen structure includes an outer frame and a filter screen, and the two ends of the filter screen structure are slidably connected with the two first slides. The second slide is installed below the first slide. The baffle is slidably connected with the second slide. The collection mechanism includes a collection box, a first water pump, and a connecting pipeline. The spraying mechanism includes a water tank, a second water pump, and a spray head. The device can guide the secretion of saliva by leeches when the guide liquid is used to guide the secretion of saliva by leeches.

[0004] However, the device still has some problems. During actual use, the screen is fixedly installed and cannot produce shaking or vibration, which limits the stimulation of the leeches. The secretion of saliva by leeches in a static environment is slow, which prolongs the extraction period and reduces the overall production efficiency. Therefore, we propose a hirudin extraction device to solve the above problems. UTILITY MODEL CONTENT

[0005] (I) Technical problems solved

[0006] The utility model provides a kind of extraction device for hirudin, solve the problems presented in the above background art.

[0007] (II) Technical solutions

[0008] The utility model discloses a kind of extraction device for hirudin, to achieve the following technical solutions specifically to the above purpose:

[0009] A kind of extraction device for hirudin, including extraction box, recess is set on the inside wall of the two sides of the extraction box, guide rod is welded between the inside wall of the two sides of the recess, the same connecting plate is slidably connected on the two guide rods, first spring is welded between the side of the connecting plate and the inside wall of the side of recess, the right side of the extraction box is equipped with L-shaped plate, the side of the L-shaped plate extends to the extraction box and is fixedly connected with the right side of connecting plate, ball is embedded on the right side inner wall of the L-shaped plate, support block is welded on the right side of the extraction box, driving motor is fixedly connected on the bottom of the support block, the output shaft of the driving motor extends to the upper of support block and is fixedly connected with eccentric wheel, the eccentric wheel is in rolling contact with ball, the top of the connecting plate is fixedly connected with filter box, the top of the extraction box is rotatably connected with top cover, rectangular tube is fixedly connected on the top inner wall of the top cover, a plurality of spray heads are communicated and fixed on the bottom of the rectangular tube, soft tube is communicated and fixed on the end of the rectangular tube, the end of the soft tube extends to the outside of top cover.

[0010] Further, the first spring movably sheaths on the corresponding guide rod, the left side of the extraction box is fixedly connected with output pump, the input pipe of the output pump extends to the extraction box.

[0011] Further, U-shaped plate is welded on the right side of the extraction box, positioning rod is welded between the inside wall of the two sides of the U-shaped plate.

[0012] Further, two sliding blocks are slidably connected on the positioning rod, second spring is welded between the side of the sliding block and the inside wall of the side of U-shaped plate, the second spring movably sheaths on the positioning rod.

[0013] Further, pin is welded on the other side of the sliding block, fixed block is fixedly connected on the right side of the top cover, clamping groove is formed on the two sides of the fixed block, the clamping groove is clamped with the corresponding pin.

[0014] Further, square hole is formed on the right side inner wall of the extraction box, the extraction box is slidably connected with L-shaped plate through square hole.

[0015] (III) Beneficial effects

[0016] Compared with prior art, the utility model provides a kind of extraction device for hirudin, with the following beneficial effects:

[0017] The utility model discloses a filter box is placed to the living body leech, then the top cover is fixed, and the eccentric wheel is rotated to drive motor, and the eccentric wheel is extruded to the ball when rotating the first half of the circle, and the ball drives L-shaped plate to move right, and L-shaped plate drives the connecting plate to slide on the guide rod and is compressed to the first spring, and the connecting plate drives filter box to move right, when the eccentric wheel rotates to the second half of the circle, gradually relaxes extrusion to the ball, and the first spring resets under the compression state, and the first spring drives filter box to move left through the connecting plate, makes filter box reciprocating swing, and then stimulates leech to spit automatically, and the spittle of leech is washed to the bottom of the extraction tank through the filter box through the water jet, and waits for the hirudin to separate out in water, thereby realize the swing of filter box, and stimulate leech to secrete saliva more actively, thereby shorten the extraction period. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is the three-dimensional structure schematic diagram of the utility model;

[0019] Figure 2 It is another side three-dimensional structure schematic diagram of the utility model;

[0020] Figure 3 It is the three-dimensional structure schematic diagram of the utility model top cover after opening;

[0021] Figure 4 It is the three-dimensional structure schematic diagram of the utility model extraction tank after cutting partly;

[0022] Figure 5 It is the three-dimensional structure schematic diagram of the utility model L-shaped plate, ball, eccentric wheel and drive motor connection;

[0023] Figure 6 It is the three-dimensional structure schematic diagram of the utility model Figure 1 It is the three-dimensional structure schematic diagram of the utility model A area amplification structure.

[0024] In the drawing: 1, extraction tank;2, recess;3, guide rod;4, connecting plate;5, first spring;6, L-shaped plate;7, ball;8, support block;9, drive motor;10, eccentric wheel;11, filter box;12, top cover;13, rectangular tube;14, water jet;15, hose;16, output pump;17, U-shaped plate;18, positioning rod;19, sliding block;20, second spring;21, snap pin;22, fixed block;23, clamping groove. DETAILED DESCRIPTION

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Example

[0027] like Figures 1-6 As shown, an embodiment of this utility model discloses a hirudin extraction device, including an extraction box 1. Grooves 2 are formed on both inner walls of the extraction box 1. Guide rods 3 are welded between the inner walls of the two sides of the grooves 2. A common connecting plate 4 is slidably connected to the two guide rods 3. A first spring 5 is welded between one side of the connecting plate 4 and one side of the inner wall of the groove 2. An L-shaped plate 6 is provided on the right side of the extraction box 1. One side of the L-shaped plate 6 extends into the extraction box 1 and is fixedly connected to the right side of the connecting plate 4. The right side of the L-shaped plate 6... Ball bearings 7 are embedded in the wall. A support block 8 is welded to the right side of the extraction box 1. A drive motor 9 is fixedly connected to the bottom of the support block 8. The output shaft of the drive motor 9 extends to the top of the support block 8 and is fixedly connected to an eccentric wheel 10. The eccentric wheel 10 rolls in contact with the ball bearings 7. A filter box 11 with an open top is fixedly connected to the top of the connecting plate 4. A top cover 12 is rotatably connected to the top of the extraction box 1. A rectangular tube 13 is fixedly connected to the inner wall of the top of the top of the top cover 12. The bottom of the rectangular tube 13 is connected to and fixed with multiple spray nozzles. The head 14, the end of the rectangular tube 13 is connected to and fixed with a flexible hose 15, the end of the flexible hose 15 extends to the outside of the top cover 12, the live leech is placed in the filter box 11, and then the top cover 12 is fixed. The drive motor 9 is started to drive the eccentric wheel 10 to rotate. When the eccentric wheel 10 rotates the first half turn, it squeezes the ball 7. The ball 7 drives the L-shaped plate 6 to move to the right. The L-shaped plate 6 drives the connecting plate 4 to slide on the guide rod 3 and compress the first spring 5. The connecting plate 4 drives the filter box 11 to move to the right. When the eccentric wheel 10 rotates the first half turn, the eccentric wheel 10 rotates the second half turn. When the filter box 11 rotates to the second half of its rotation, the pressure on the ball bearing 7 is gradually released. At this time, the first spring 5, which was under compression, returns to its original position. The first spring 5 drives the filter box 11 to move to the left through the connecting plate 4, causing the filter box 11 to sway back and forth. This stimulates the leeches to automatically spit out saliva. Water is then sprayed through the nozzle 14 to flush the leech saliva through the filter box 11 to the bottom of the extraction box 1, where the hirudin is precipitated in the water. This causes the filter box 11 to sway, stimulating the leeches to secrete saliva more actively, thereby shortening the extraction cycle.

[0028] In some embodiments, the first spring 5 is movably sleeved on the corresponding guide rod 3, and the left side of the extraction box 1 is fixedly connected to the output pump 16, with the input pipe of the output pump 16 extending into the extraction box 1.

[0029] In some embodiments, the right side of the extraction box 1 is welded with a U-shaped plate 17, and a positioning rod 18 is welded between the inner walls of the two sides of the U-shaped plate 17. The positioning rod 18 serves the role of positioning.

[0030] In some embodiments, two sliding blocks 19 are slidingly connected to the positioning rod 18, a second spring 20 is welded between one side of the sliding block 19 and the inner wall of one side of the U-shaped plate 17, the second spring 20 is movably sleeved on the positioning rod 18, and the second spring 20 serves the role of resetting.

[0031] In some embodiments, the other side of the sliding block 19 is welded with a pin 21, the right side of the top cover 12 is fixedly connected with a fixed block 22, and the two sides of the fixed block 22 are both provided with a clamping groove 23 which is clamped with the corresponding pin 21.

[0032] In some embodiments, a square hole is formed in the right inner wall of the extraction box 1, and the extraction box 1 is slidingly connected with the L-shaped plate 6 through the square hole. The L-shaped plate 6 serves the role of connection.

[0033] When in use, the hose 15 is connected with an external water supply device, the sliding block 19 is moved, the sliding block 19 slides on the positioning rod 18 and compresses the second spring 20, the sliding block 19 drives the corresponding pin 21 to separate from the clamping groove 23, then the top cover 12 is rotated to open it, the living leeches are placed in the filter box 11, the top cover 12 is fixed, the driving motor 9 is started, the driving motor 9 drives the eccentric wheel 10 to rotate, the eccentric wheel 10 extrudes the ball 7 when rotating for half a circle, under the action of the extrusion force, the ball 7 drives the L-shaped plate 6 to move rightwards, the L-shaped plate 6 drives the connecting plate 4 to slide on the guide rod 3 and compresses the first spring 5, the connecting plate 4 drives the filter box 11 to move rightwards, when the eccentric wheel 10 rotates to the second half of the circle, the extrusion on the ball 7 is gradually released, at this time, the first spring 5 in the compressed state is reset, the first spring 5 drives the filter box 11 to move leftwards through the connecting plate 4, so that the filter box 11 reciprocates left and right, thereby stimulating the leeches to automatically spit saliva, and then the saliva of the leeches is washed to the bottom of the extraction box 1 through the filter box 11 by the water sprayed through the spray head 14, and the hirudin is precipitated in the water, so as to realize the shaking of the filter box 11 to stimulate the leeches to more actively secrete saliva, thereby shortening the extraction period.

[0034] Finally, it should be noted that: the above only for the preferred embodiments of the present application, and is not intended to limit the present application, although the foregoing embodiments of the present application have been described in detail, for the skilled in the art, it still can be modified, or for the equivalent replacement of part of the technical features of the technical solutions recorded in the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application, shall be included within the scope of the present application.

Claims

1. An apparatus for extracting hirudin comprising an extraction tank (1) characterised in that: The both sides of the extraction box (1) are provided with grooves (2), the both sides of the grooves (2) are welded with guide rods (3), the same connecting plate (4) is slidably connected on the two guide rods (3), the one side of the connecting plate (4) is welded with the first spring (5) between the one side of the groove (2), the right side of the extraction box (1) is provided with the L-shaped plate (6), the one side of the L-shaped plate (6) extends into the extraction box (1) and is fixedly connected with the right side of the connecting plate (4), the right side inner wall of the L-shaped plate (6) is embedded with the ball (7), the right side of the extraction box (1) is welded with the supporting block (8), the bottom of the supporting block (8) is fixedly connected with the driving motor (9), the output shaft of the driving motor (9) extends above the supporting block (8) and is fixedly connected with the eccentric wheel (10), the eccentric wheel (10) is in rolling contact with the ball (7), the top of the connecting plate (4) is fixedly connected with the filter box (11) with an open top, the top of the extraction box (1) is rotatably connected with the top cover (12), the top inner wall of the top cover (12) is fixedly connected with the rectangular tube (13), the bottom of the rectangular tube (13) is communicated and fixedly connected with a plurality of spray heads (14), the end of the rectangular tube (13) is communicated and fixedly connected with the hose (15), and the end of the hose (15) extends out of the top cover (12).

2. The apparatus for extracting hirudin according to claim 1, wherein: The first spring (5) is movably sleeved on the corresponding guide rod (3), and the left side of the extraction box (1) is fixedly connected with the output pump (16).

3. The apparatus for extracting hirudin according to claim 1, wherein: The right side of the extraction box (1) is welded with the U-shaped plate (17), and the both sides of the U-shaped plate (17) are welded with the positioning rods (18).

4. The apparatus for extracting hirudin according to claim 3, wherein: The two sliding blocks (19) are slidably connected on the positioning rods (18), the one side of the sliding block (19) is welded with the second spring (20) between the one side of the U-shaped plate (17), and the second spring (20) is movably sleeved on the positioning rod (18).

5. The apparatus for extracting hirudin according to claim 4, wherein: The other side of the sliding block (19) is welded with the pin (21), the right side of the top cover (12) is fixedly connected with the fixed block (22), the both sides of the fixed block (22) are provided with the clamping grooves (23), and the clamping grooves (23) are clamped with the corresponding pins (21).

6. The apparatus for extracting hirudin according to claim 1, wherein: The right side inner wall of the extraction box (1) is provided with a square hole, and the extraction box (1) is slidably connected with the L-shaped plate (6) through the square hole.

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