Sample addition support device

Abstract

The utility model provides a sample adding auxiliary device, and relates to the technical field of auxiliary tools, the sample adding auxiliary device comprises a main plate and auxiliary plates, the main plate is provided with hole position grooves which are arranged in an array and are provided with upper and lower openings, the side wall of each hole position groove is provided with a slide way, one auxiliary plate is arranged corresponding to each hole position groove, the auxiliary plates are arranged in the slide ways, and the auxiliary plates are arranged in the slide ways. The auxiliary plate is pushed and pulled to shield or expose the adding hole sites of the hole site grooves, each adding hole site corresponds to one sample hole in the deep hole plate, and the sample holes are used for containing samples. According to the technical scheme, the technical problems that in the prior art, when samples are added to a deep hole plate, wrong hole positions are prone to being added, and cross contamination between the samples is caused are solved.

Description

Technical Field

[0001] This application relates to the field of auxiliary tools technology, and in particular to auxiliary devices for sample addition. Background Technology

[0002] Compared to pipette-based nucleic acid extractors, magnetic rod-type nucleic acid extractors offer advantages such as faster extraction speed and more stable results, leading to their increasing market adoption. However, the following issues arise during instrument use: incorrect well placement when adding samples to deep-well plates and cross-contamination between samples. This cross-contamination is often caused by accidental dripping or tip mis-contamination during sample addition. Summary of the Invention

[0003] This application provides a sample addition auxiliary device to solve the technical problems in the prior art, such as incorrect well placement and cross-contamination between samples, when adding samples to a deep well plate. The preferred technical solutions among the various technical solutions provided in this application and their numerous technical effects are detailed below.

[0004] To achieve the above objectives, this application provides a sample addition auxiliary device, including a main board and a sub-board. The main board has slots with upper and lower openings arranged in an array. A slide is provided on the side wall of each slot. A sub-board is provided for each slot and is disposed in the slide. The sub-board can be pushed or pulled to cover or expose the addition hole of the slot. Each addition hole corresponds to a sample hole on the deep well plate. The sample hole is used to hold a sample.

[0005] Optionally, the motherboard may be marked on its adjacent two sides to indicate the coordinate position of each sample hole.

[0006] Optionally, a groove is provided on the bottom surface of the motherboard, and the motherboard is fastened to the deep hole plate through the groove.

[0007] Optionally, support wood is provided at each of the four corners of the groove, and when the main board is fastened to the deep hole plate, the support wood abuts against the four corners of the deep hole plate.

[0008] Optionally, a handle for assisting in pushing and pulling the sub-plate is provided at one end of the sub-plate.

[0009] Optionally, the handle is plate-shaped and perpendicular to the surface of the sub-plate.

[0010] Optionally, each slot is provided with a baffle in the push-pull direction of the sub-plate, the baffle being used to block the handle.

[0011] Optionally, a sub-plate groove is provided on one side of the baffle, and the handle is located in the sub-plate groove.

[0012] Optionally, the hole slots are arranged adjacent to each other in every two columns or every two rows.

[0013] Optionally, the added holes in every two columns or every two rows of the hole slots are arranged adjacently.

[0014] The technical solution of this application may include the following beneficial effects:

[0015] This application provides a sample addition auxiliary device, comprising a main board and a sub-board. The main board has addition positions corresponding to each sample well, and the sub-board is provided at each addition position to either cover or expose the sample well. This allows for sample addition by opening only the corresponding sub-board to expose the sample well to be added, avoiding incorrect well placement and preventing cross-contamination between samples. Therefore, this sample addition auxiliary device solves the technical problems of incorrect well placement and cross-contamination between samples when adding samples to a deep-well plate in the prior art. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the structure of the auxiliary device for adding samples according to an embodiment of this application;

[0018] Figure 2 This is a schematic diagram of the deep hole plate in the embodiments of this application;

[0019] Figure 3 This is a schematic diagram of the structure of the sample of the embodiment of this application when the auxiliary device is fastened to the deep hole plate;

[0020] Figure 4 This is a schematic diagram of the bottom structure of the auxiliary device for adding samples in the embodiments of this application.

[0021] In the diagram: 1. Main board; 2. Sub-board; 3. Hole slot; 4. Baffle plate; 5. Slide rail; 6. Add hole; 7. Handle; 8. Sub-board slot; 9. Horizontal marking; 10. Vertical marking; 11. Support wood; 12. Deep hole plate; 13. Sample hole. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions of this application will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other implementation methods obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0023] It should be noted that when a component is referred to as "fixed to" or "set on" another component, it can be directly on the other component or may have an intervening component present. When a component is referred to as "connected to" another component, it can be directly connected to the other component or may have an intervening component present.

[0024] like Figures 1 to 3 As shown, this application provides a sample addition auxiliary device, including: a main board 1 and a sub-board 2. The main board 1 has hole slots 3 with upper and lower openings arranged in an array. Each hole slot 3 has a slide rail 5 on its side wall. A sub-board 2 is provided for each hole slot 3. The sub-board 2 is disposed in the slide rail 5. The addition hole position 6 of the hole slot 3 can be covered or exposed by pushing or pulling the sub-board 2. Each addition hole position 6 corresponds to a sample hole 13 on the deep hole plate 12. The sample hole 13 is used to hold a sample.

[0025] Specifically, the device is equipped with a main board 1 and a sub-board 2. The main board 1 is equipped with an addition hole position 6 corresponding to each sample well 13, and the sub-board 2 is set in the hole position slot 3 at the addition hole position 6 to cover or expose the sample well 13. In this way, only the corresponding sub-board 2 can be opened to expose the sample well 13 that needs to be added according to actual needs, thus avoiding the occurrence of adding the wrong well position and cross-contamination of samples.

[0026] As an optional implementation, the adjacent two sides of the motherboard 1 are respectively marked to indicate the coordinate position of each sample hole 13.

[0027] Specifically, such as Figure 1 As shown, the horizontal side of the motherboard 1 is provided with a horizontal mark 9 to indicate the horizontal coordinate of each column of through slots, and the vertical side is provided with a vertical mark 10 to indicate the vertical coordinate of the hole position on each column of through slots. Thus, the coordinate position of each sample hole 13 can be shown. The horizontal mark 9 and the vertical mark 10 can be, but are not limited to, in the form of numbers or letters.

[0028] As an optional implementation, a groove is provided on the bottom surface of the motherboard 1, and the motherboard 1 is fastened to the deep hole plate 12 through the groove.

[0029] Specifically, such as Figure 4As shown, by setting a groove on the bottom surface of the motherboard 1, the motherboard 1 is fastened to the deep hole plate 12 through the groove, thereby increasing the stability between the motherboard 1 and the deep hole plate 12.

[0030] As an optional implementation, support wood 11 is provided at each of the four corners of the groove. When the main board 1 is fastened to the deep hole plate 12, the support wood 11 abuts against the four corners of the deep hole plate 12.

[0031] Specifically, such as Figure 4 As shown, the support wood 11 is located at the four corners of the groove below the motherboard 1, which is used to support the motherboard 1 and prevent the bottom surface of the motherboard 1 from directly contacting the deep hole plate 12 below the motherboard 1 when they are fastened together.

[0032] As an optional implementation, a handle 7 for assisting in pushing and pulling the sub-plate is provided at one end of the sub-plate 2 to facilitate pulling the sub-plate 2.

[0033] As an optional implementation, the handle 7 is plate-shaped and perpendicular to the surface of the sub-plate 2.

[0034] As an optional implementation, each hole slot 3 is provided with a baffle 4 in the push-pull direction of the sub-plate 2, and the baffle 4 is used to block the handle. When the handle 7 is blocked by the baffle 4, the added hole 6 is blocked. As an optional implementation, a sub-plate slot 8 is provided on one side of the baffle 4, and the handle 7 is located in the sub-plate slot 8.

[0035] Specifically, each sample hole 13 corresponds to a sub-plate 8. Each hole slot 3 is provided with a sub-plate slot 8 on one side of the baffle plate 4. The handle 7 of the sub-plate 2 can move in the sub-plate through slot 8 to provide space for the sub-plate 2 when it is pulled open.

[0036] As an optional implementation, the hole slots 3 are arranged adjacent to each other in every two columns or rows. The sub-plate slots 8 are respectively arranged on the opposite side of the two columns of hole slots 3.

[0037] As an optional implementation, the adding hole positions 6 of each two columns or two rows of the hole slots 3 are arranged adjacently, thus ensuring that the operating directions of the handles in the two columns or two rows of hole slots 3 are exactly opposite when pushed or pulled, avoiding mutual conflict. The adding hole positions 6 are set according to the sample adding positions of the corresponding sample holes 13, and the sub-plate slots 8 are set on the opposite sides of the adding hole positions 6 in the two adjacent columns or two rows, so that the adding hole position 6 of any of the hole slots 3 can be covered or exposed by pushing or pulling the sub-plate 2 on one side.

[0038] The following is an implementation example of the above technical solution:

[0039] This experimental case study demonstrates a cross-contamination test during the development of the extraction instrument. The reagents used were pre-packaged reagents from Xi'an Tianlong. The horizontal markings on the main board use numbers 1-12 to indicate the horizontal coordinates of the sample wells, while the vertical markings use uppercase letters AH to indicate the vertical coordinates of the sample wells. The process includes the following steps:

[0040] (1) Pull open the sub-plates A5, C5, E5, G5, A6, C6, E6, G6, and sub-plates B11, D11, F11, H11, B11, D11, F11, H11, and use a pipette to add the negative sample into the corresponding well of the deep well plate in sequence.

[0041] (2) Push the above-mentioned auxiliary plate forward, and the negative sample addition is complete.

[0042] (3) Pull open the sub-plates B5, D5, F5, H5, B6, D6, F6, H6, and sub-plates A11, C11, E11, G11, A12, C12, E12, G12, and use a pipette to add the positive samples into the corresponding wells of the deep well plate in sequence.

[0043] (4) Proceed to the main sub-plate above, and the positive samples have been added.

[0044] (5) Remove the device and transfer the deep well plate to the nucleic acid extractor for nucleic acid extraction.

[0045] This technical solution has the following beneficial effects:

[0046] 1. This utility model has a simple structure, is easy to use, has low cost, and is widely applicable.

[0047] 2. This invention can effectively reduce errors by laboratory personnel during the sample addition process, avoid adding samples to the wrong wells, and prevent cross-contamination between samples caused by dripping.

[0048] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0049] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0050] The above are merely specific embodiments of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A sample addition aid, characterized in that The utility model relates to a deep well plate, which comprises: a main plate and a sub plate, wherein the main plate is provided with a plurality of upper and lower opening hole position grooves arranged in an array, each of the hole position grooves is provided with a slide on the side wall, and each of the hole position grooves is provided with the sub plate, the sub plate is arranged in the slide, and the sub plate is pushed and pulled to cover or expose the additional hole position of the hole position groove, each of the additional hole positions corresponds to a sample hole on the deep well plate, and the sample hole is used for containing a sample.

2. The sample addition auxiliary device according to claim 1, characterized by, Two adjacent side edges of the main plate are provided with marks, respectively, to show the coordinate position of each sample hole.

3. The sample addition auxiliary device according to claim 1, characterized by, The main plate is provided with a groove at the bottom surface, and the main plate is buckled with the deep well plate through the groove.

4. The sample addition auxiliary device according to claim 3, characterized in that, The four corners of the groove are provided with support woods, and the support woods are abutted on the four corners of the deep well plate when the main plate is buckled on the deep well plate.

5. The sample addition aid of claim 1, wherein, One end of the sub plate is provided with a handle for assisting in pushing and pulling the sub plate.

6. The sample addition auxiliary device according to claim 5, characterized in that The handle is plate-shaped and perpendicular to the surface of the sub plate.

7. The sample addition auxiliary device according to claim 6, characterized in that Each of the hole position grooves is provided with a blocking plate in the pushing and pulling direction of the sub plate, and the blocking plate is used for blocking the handle.

8. The sample addition auxiliary device according to claim 7, characterized in that One side of the blocking plate is provided with a sub plate groove, and the handle is located in the sub plate groove.

9. The sample addition assistance device according to any one of claims 1 to 8, characterized in that, Each two columns or each two rows of the hole position grooves are arranged adjacently.

10. The sample addition aid of claim 9, wherein, Each two columns or each two rows of the additional hole positions of the hole position grooves are arranged adjacently.

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