Liquid chromatographic column box device with switching valve

Abstract

The utility model discloses a liquid chromatographic column box device with a switching valve, which comprises a box body, the box body is provided with the switching valve, the switching valve comprises a flat plate, the flat plate is provided with a positioning block and a sliding block, and the sliding blocks on a plurality of groups of switching valves are connected to form a synchronous switching valve group. The linkage type flow path switching device is simple and compact in structure, the switching function is easy to implement, linkage type synchronous flow path switching is achieved in real time by connecting the sliding blocks through the connecting rods when different analysis methods are used, a chromatographic column does not need to be frequently replaced, and dead volume cannot be increased.

Description

TECHNICAL FIELD

[0001] The utility model relates to liquid chromatographic analysis technical field, concretely relates to a liquid chromatographic column box device with switch valve. BACKGROUND

[0002] Liquid chromatograph is a kind of instrument that is used to separate and analyze mixture by the difference of distribution ratio of mixture in liquid-solid or two immiscible liquids.The system is composed of several parts such as liquid reservoir, pump, sample injector, chromatographic column, detector and recorder.The mobile phase in liquid reservoir is pumped into the system by high-pressure pump, sample solution enters the mobile phase through sample injector, and is carried into chromatographic column (stationary phase) by mobile phase, and is separated into single component by repeated adsorption-desorption distribution process when moving relatively in two phases, and then flows out from column, and when passing through detector, sample concentration is converted into electric signal and transmitted to recorder.

[0003] The common liquid chromatograph can only use one chromatographic column when analyzing and identifying, and needs to replace chromatographic column after disassembling when using different analysis methods, and frequent replacement of chromatographic column makes the whole experiment process tedious and lengthy, and there is leakage caused by joint not being tightened when reinstalling chromatographic column each time, so that dead volume (volume in flow path from sample injection point / needle of automatic sample injector to chromatographic column and to detector / flow cell) becomes larger, so that sample diffusion space is very large, chromatographic peak is more likely to be broadened, peak shape is poor, peak height is reduced, signal-to-noise ratio (S / N) is reduced and sensitivity is affected. UTILITY MODEL CONTENT

[0004] The utility model discloses a liquid chromatographic column box device with switch valve.

[0005] The utility model discloses a liquid chromatographic column box device with switch valve.

[0006] The box body is provided with switch valve, and the switch valve includes flat plate, positioning block and sliding block are arranged on the flat plate, and the sliding blocks on multiple groups of switch valves are connected to form synchronous switch valve group.

[0007] As further description of the above technical scheme, the flat plate is provided with first flow-through hole, and the first flow-through hole is symmetrically provided with multiple groups.

[0008] As further description of the above technical scheme, the flat plate is communicated with chromatographic column through the first flow-through hole.

[0009] As further description of the above technical scheme, the flat plate is symmetrically fixed with positioning block, and the sliding block is installed between the positioning blocks.

[0010] As a further description of the above technical solution, the positioning block is provided with a magnetic block close to one side of the sliding block, and metal sheets are symmetrically arranged on the end faces of the two sides of the sliding block.

[0011] As a further description of the above technical solution, the sliding block is detachably connected with the flat plate through fixing bolts, and the fixing bolts are symmetrically arranged in multiple groups.

[0012] As a further description of the above technical solution, a second flow-through hole is formed in the middle of the sliding block, and the second flow-through hole is aligned with the first flow-through hole when the sliding block and the positioning block are attached.

[0013] As a further description of the above technical solution, the sliding block is in communication with a flow phase storage tank or a detector through the second flow-through hole.

[0014] As a further description of the above technical solution, a connecting hole is formed in the side of the sliding block, and the connecting hole is symmetrically arranged in multiple groups.

[0015] As a further description of the above technical solution, a connecting rod is arranged through the connecting hole of the sliding block, and multiple groups of the sliding blocks are connected through the connecting rod to form a synchronous switching valve group.

[0016] The beneficial effects of the present application are as follows:

[0017] The present application has the advantages of simple and compact structure, easy switching function, linkage type synchronous switching flow path realized by connecting the sliding blocks through connecting rods in real time when different analysis methods are used, no need for frequent replacement of chromatographic columns and no increase in dead volume.

[0018] To more clearly illustrate the structural features and effects of the present application, the present application will be described in detail below in combination with the drawings and specific embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 is a structure schematic of a liquid chromatographic column box device provided with a switching valve of the present application Figure One ;

[0020] Figure 2 is a structure schematic of a liquid chromatographic column box device provided with a switching valve of the present application Figure Two .

[0021] REFERENCE SIGNS:

[0022] 1, box; 2, switching valve; 21, flat plate; 211, first flow-through hole; 22, positioning block; 221, magnetic block; 23, sliding block; 231, metal sheet; 232, second flow-through hole; 233, connecting hole; 24, fixing bolt; 25, connecting rod; 3, chromatographic column. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical scheme and advantages of the utility model embodiment clearer, the technical scheme in the utility model embodiment will be clearly and completely described below in combination with the drawings in the utility model embodiment.

[0024] As shown in the drawings, Figures 1-2 In one embodiment, a liquid chromatography column box device provided with a switching valve comprises: a box body 1, and the box body 1 is provided with a switching valve 2 capable of switching flow paths.

[0025] The switching valve 2 comprises a flat plate 21, and the flat plate 21 is correspondingly provided with a positioning block 22 and a sliding block 23, the positioning block 22 is used for limiting the sliding stroke of the sliding block 23 and further switching the corresponding flow path, and the sliding block 23 can be accurately positioned when switching the flow path; and the sliding blocks 23 on the multiple groups of switching valves 2 can be connected by connecting rods 25 to form a synchronous switching valve 2 group, so that when different analysis methods are used, the sliding blocks 23 can be connected by the connecting rods 25 to realize linkage type synchronous switching of the flow path, which not only can avoid frequent replacement of the chromatography column 3, but also can effectively reduce the generation of dead volume, thereby improving the separation efficiency and analysis accuracy.

[0026] Further, the flat plate 21 is provided with a first flow-through hole 211, and the first flow-through hole 211 is symmetrically provided with multiple groups, and the flat plate 21 is in communication with the chromatography column 3 through the first flow-through hole 211.

[0027] Specifically, the material of the flat plate 21 is polytetrafluoroethylene (PTFE), which has good corrosion resistance, chemical stability and high mechanical strength, and is suitable for use in a liquid chromatography system.

[0028] Exemplarily, the length of the flat plate 21 is 4 cm, and the first flow-through holes 211 are symmetrically arranged at a distance of 1.5 cm from both ends, and the arrangement mode and the number of the first flow-through holes 211 can be adjusted according to actual requirements to realize the switching function of multiple flow paths.

[0029] It should be noted that the positioning blocks 22 are symmetrically fixed on the flat plate 21, and the sliding blocks 23 are installed between the positioning blocks 22. The side of the positioning block 22 close to the sliding block 23 is provided with a magnetic block 221 (such as a ferrite magnet), and the metal sheets 231 (such as iron sheets) are symmetrically arranged on the two side surfaces of the sliding block 23, which not only can realize accurate positioning between the sliding block 23 and the positioning block 22, but also can enhance the stability of the sliding block 23 through the action of magnetic force, so as to ensure that the sliding block 23 moves to the corresponding position along the preset sliding path during the switching process.

[0030] Further, the slider 23 is detachably connected with the flat plate 21 through the fixing bolts 24, the fixing bolts 24 are symmetrically provided with multiple groups, so that the slider 23 is easy to operate and firmly connected during installation and disassembly, and the slider 23 can be moved to switch the flow path by loosening the fixing bolts 24, and then the fixing bolts 24 are tightened to prevent liquid leakage.

[0031] Specifically, the middle part of the slider 23 is provided with a second flow-through hole 232, when the slider 23 is attached to the positioning block 22, the second flow-through hole 232 is aligned with the first flow-through hole 211, so that the flow path is communicated. At this time, the slider 23 is communicated with the flow phase storage tank or detector through the second flow-through hole 232, so that the flow phase can flow smoothly; and the side part of the slider 23 is provided with a connecting hole 233, the connecting hole 233 is symmetrically provided with multiple groups, and the connecting hole 233 of the slider 23 is provided with a connecting rod 25, so that multiple groups of sliders 23 can be connected with each other through the connecting rod 25 to form a synchronous switching valve 2 group.

[0032] Working principle: one switching valve 2 is connected with each of the two chromatographic columns 3 through a pipeline, and the sliders 23 of the two switching valves 2 are connected through the connecting rod 25, so that synchronous switching can be realized, the flow path error is effectively prevented, and the liquid can flow along the predetermined path between the two chromatographic columns 3; then the fixing bolts 24 are slightly loosened, the slider 23 is moved, and then the chromatographic columns 3 corresponding to different flow paths can be quickly switched, the fixing bolts 24 are tightened again after switching to prevent liquid leakage, and the system is balanced for a period of time to remove air before analysis is continued.

[0033] Through the above technical scheme, the present application has the characteristics of simple and compact structure, easy operation and high efficiency switching, linkage synchronous switching flow path is realized by connecting the sliders 23 through the connecting rod 25 when different analysis methods are used, the accuracy and reliability of the flow path switching process are ensured, the occurrence of flow path error is effectively prevented, the dead volume is not increased, the efficient separation performance and stable running state are ensured, and the analysis efficiency and the accuracy of experimental results are further improved.

[0034] The above description of the disclosed embodiments enables a person skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A liquid chromatography column cartridge device provided with a switching valve, characterized in that, Include: Box (1), the box (1) is provided with switch valve (2), the switch valve (2) includes flat plate (21), the flat plate (21) is provided with positioning block (22) and slider (23), multiple sets of sliders (23) on switch valve (2) are connected to constitute synchronous switch valve (2) group.

2. The liquid chromatography column box apparatus provided with a switching valve according to claim 1, characterized by The flat plate (21) is provided with a plurality of groups of first flow holes (211) symmetrically.

3. The liquid chromatography column box apparatus provided with a switching valve according to claim 2, characterized in that, The flat plate (21) is communicated with the chromatographic column (3) through the first flow hole (211).

4. The liquid chromatography column box apparatus with a switching valve according to claim 2, characterized in that, The flat plate (21) is symmetrically fixed with positioning block (22), the slider (23) is installed between the positioning block (22).

5. The liquid chromatography column box apparatus provided with a switching valve according to claim 4, characterized in that, The side of the positioning block (22) close to the slider (23) is provided with a magnetic block (221), and the both sides of the slider (23) are provided with metal sheets (231) symmetrically.

6. The liquid chromatography column box apparatus provided with a switching valve according to claim 5, characterized in that, The slider (23) is detachably connected with the flat plate (21) through the fixing bolt (24), and the fixing bolt (24) is provided with a plurality of groups of symmetrically.

7. The liquid chromatography column box apparatus provided with a switching valve according to claim 5, characterized by The middle part of the slider (23) is provided with a second flow hole (232), and the second flow hole (232) is aligned with the first flow hole (211) when the slider (23) and the positioning block (22) are attached.

8. The liquid chromatography column box apparatus provided with a switching valve according to claim 5, characterized by The slider (23) is communicated with the mobile phase storage tank or detector through the second flow hole (232).

9. The liquid chromatography column box apparatus provided with a switching valve according to claim 5, characterized by, The side of the slider (23) is provided with a plurality of groups of connecting holes (233) symmetrically.

10. The liquid chromatography column box apparatus provided with a switching valve according to claim 5, characterized by The connecting hole (233) of the slider (23) is provided with a connecting rod (25), and a plurality of groups of sliders (23) are connected to constitute a synchronous switch valve (2) group through the connecting rod (25).

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