Liquid chromatogram sample batch filtering device

Abstract

The utility model provides a batch filtering device for liquid chromatogram samples. Comprising a supporting seat, a first mounting plate, a second mounting plate, a third mounting plate, a first adjusting assembly and a second adjusting assembly, wherein the first mounting plate is mounted at the lower part of the supporting seat; the second mounting plate and the third mounting plate are mounted at the upper part of the supporting seat; the first mounting plate is mounted on the supporting seat, the second mounting plate is mounted on the supporting seat, the fourth mounting plate is mounted in the middle of the supporting seat, the fifth mounting plate is mounted on the lower portion of the supporting seat, the sample storage bottles are mounted on the first mounting plate, the injectors are mounted on the second mounting plate, the needle filters are mounted on the fourth mounting plate, and the liquid-phase small bottles are mounted on the fifth mounting plate. The first adjusting assembly and the second adjusting assembly can synchronously drive the plurality of injectors to move, and the plurality of injectors can be operated at the same time for batch extraction and batch filtration of samples at a time, so that the operation is simplified, the workload is greatly simplified, the repeated operation of experimenters is reduced, and the detection efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, specifically to a liquid chromatography sample batch filtration device. Background Technology

[0002] In the field of testing and inspection, high-performance liquid chromatography (HPLC) is frequently used for separation and analysis. Because the column packing material has a small particle size, it is easily clogged by impurities. These impurities can also cause wear on the pump head piston, leading to leakage. Therefore, HPLC samples need to be pre-filtered to remove impurities from the solvent, preventing blockages in the delivery lines or injection valves and thus protecting the instrument.

[0003] Currently, the equipment required for pre-filtration of liquid chromatography samples includes: a syringe, a needle filter (microporous membrane), and a liquid chromatography vial. The filtration method is as follows: first, use a syringe to draw the liquid chromatography sample, then connect and fix the needle filter to the syringe tip, and finally push the syringe plunger so that the liquid chromatography sample in the syringe barrel passes through the needle filter and is collected in the liquid chromatography vial to complete the liquid chromatography sample filtration.

[0004] However, in actual testing and inspection work, there are often scenarios where large quantities of sample solutions to be tested need to be filtered through needle filters. When using the above method, each sample solution can only be filtered manually one by one, and filtering each sample solution separately into a bottle seriously affects the experimental efficiency. At the same time, there are also problems such as high labor costs, cumbersome preparation work, and time and effort consumption. Therefore, there is an urgent need for a new type of liquid chromatography sample batch filtration device to solve the above problems. Utility Model Content

[0005] To address the problems mentioned in the background section, this invention provides a liquid chromatography sample batch filtration device that can filter multiple samples at once, saving time and effort, greatly improving pretreatment efficiency, and reducing waste of time, manpower, and resources.

[0006] This utility model adopts the following technical solution: a liquid chromatography sample batch filtration device, comprising:

[0007] Support base;

[0008] A first mounting plate is detachably and horizontally mounted on the lower part of the support base, and a plurality of sample storage bottles are mounted on the first mounting plate.

[0009] A second mounting plate is horizontally mounted on the upper part of the support base, and a plurality of syringes are mounted on the second mounting plate;

[0010] The third mounting plate is horizontally mounted on the upper part of the support base, located on top of the second mounting plate, and is fixedly connected to the piston handle of the syringe.

[0011] A first adjustment component is used to drive the second mounting plate to move vertically up and down;

[0012] The second adjustment component is used to drive the third mounting plate away from or towards the second mounting plate;

[0013] A fourth mounting plate, which is detachably and horizontally mounted in the middle of the support base, is equipped with a plurality of needle filters;

[0014] A fifth mounting plate is detachably and horizontally mounted on the lower part of the support base, and multiple liquid phase vials are mounted on the fifth mounting plate.

[0015] Furthermore, the support base includes a base and a guide column. The base is a hollow box shape with its top and front surfaces open. At least one guide column is vertically fixed to the top surface of the base. The first adjustment component is installed on the rear side of the top surface of the base.

[0016] Furthermore, multiple sample storage bottle mounting recesses are arrayed on the top surface of the first mounting plate, and a sample storage bottle is placed in each sample storage bottle mounting recess; first sliding grooves are formed on opposite sides inside the base, and first sliding rails matching the first sliding grooves are provided on opposite sides of the first mounting plate.

[0017] Furthermore, a first guide through hole and a syringe mounting through hole are provided on the second mounting plate. At least one first guide through hole is provided on the edge of the second mounting plate, and multiple syringe mounting through holes are distributed in an array. A syringe is fitted inside each syringe mounting through hole. A fixing component for fixing a wing plate for fixing a syringe is fixed on the edge of each syringe mounting through hole. The second adjustment component is installed on the rear side of the top surface of the second mounting plate.

[0018] Furthermore, the fixing component includes two locking blocks, which are fixed to the top surface of the second mounting plate. The two locking blocks are arranged opposite to each other on both sides of the syringe mounting through hole. A first locking groove is provided on the side of the locking block facing the syringe mounting through hole. One end of the first locking groove extends into a side adjacent to the first locking groove. That is, one side of the locking block is provided with an opening communicating with the first locking groove, and the openings on the two locking blocks communicating with the first locking groove are in opposite directions.

[0019] Furthermore, a second guide through hole and a strip groove are provided on the third mounting plate. At least one second guide through hole is provided on the edge of the third mounting plate, and multiple strip grooves are provided parallel to each other on the bottom surface of the third mounting plate. The cross-section of the strip groove is convex, and the strip groove extends at least beyond the front surface of the third mounting plate. The piston handle of the syringe is fitted into the strip groove and can slide along the length of the strip groove.

[0020] Furthermore, the strip groove includes a connected sleeve portion and an extension portion, and the width of the sleeve portion is greater than the width of the extension portion. The extension portion extends out of the bottom surface of the third mounting plate. A plurality of second snap-fit ​​grooves are provided on the bottom surface of the sleeve portion. The second snap-fit ​​grooves are used to pre-position the piston handle of the syringe.

[0021] Furthermore, the first adjustment assembly includes a first lead screw and a first handwheel fixed to the top of the first lead screw; a first bearing is installed on the rear side of the top surface of the base, and the bottom end of the first lead screw is fixedly connected to the first bearing, so that the first lead screw can rotate around the first bearing;

[0022] A first threaded sleeve is fixedly provided on the rear side of the top surface of the second mounting plate, and a threaded through hole is provided in the center of the first threaded sleeve. The first lead screw is threadedly connected to the threaded through hole. A passage hole is opened on the rear side of the top surface of the third mounting plate, and the first lead screw passes through the passage hole.

[0023] Furthermore, the second adjustment assembly includes a second lead screw and a second handwheel fixed to the top of the second lead screw; a second bearing is installed on the rear side of the top surface of the second mounting plate, and the bottom end of the second lead screw is fixedly connected to the second bearing, so that the second lead screw can rotate around the second bearing;

[0024] A second threaded sleeve is fixedly provided on the rear side of the top surface of the third mounting plate, and a threaded through hole is provided in the center of the second threaded sleeve. The second lead screw is threadedly connected to the threaded through hole.

[0025] Furthermore, multiple filter mounting recesses are arrayed on the fourth mounting plate, and a filter mounting through hole is formed at the center of the bottom surface of each filter mounting recess. The diameter of the filter mounting recess is larger than the diameter of the filter mounting through hole, and a needle filter is placed in each filter mounting recess. Second sliding grooves are formed on opposite sides inside the base, and second sliding rails matching the second sliding grooves are provided on opposite sides of the fourth mounting plate.

[0026] Furthermore, multiple liquid phase vial mounting recesses are arrayed on the top surface of the fifth mounting plate, with one liquid phase vial placed in each recess; first sliding grooves are formed on opposite sides inside the base, and third sliding rails matching the first sliding grooves are provided on opposite sides of the fifth mounting plate.

[0027] Furthermore, the number of sample storage bottles, syringes, needle filters, and liquid chromatography vials is the same, and their positions correspond one-to-one in the vertical direction.

[0028] Beneficial Effects: The liquid chromatography sample batch filtration device in this patent can position multiple sample bottles and syringes, and drive the syringes vertically downward through a first adjusting component to insert into the sample bottles. A second adjusting component then drives the syringe piston handle upward to extract liquid chromatography samples in batches. After batch extraction, multiple syringe filters are positioned with liquid chromatography vials, and the first adjusting component drives the syringes vertically downward so that each syringe is connected to a syringe filter. The second adjusting component then drives the syringe piston handle downward to filter the extracted liquid chromatography samples and collect them into the liquid chromatography vials.

[0029] When performing filtration using a batch filtration device for liquid chromatography, multiple syringes can be operated simultaneously for batch sample extraction and filtration, simplifying the operation, greatly reducing workload, minimizing repetitive operations by laboratory personnel, and improving detection efficiency. At the same time, it allows for the orderly placement of sample vials and liquid chromatography vials, making experimental operations more standardized and reasonable, and realizing integrated operation of batch membrane filtration and placement of sample vials and liquid chromatography vials. Attached Figure Description

[0030] Appendix Figure 1 This is a three-dimensional structural diagram of the sample batch extraction state of the liquid chromatography sample batch filtration device in this utility model.

[0031] Appendix Figure 2 This is a three-dimensional structural diagram of the batch filtration state of the liquid chromatography sample batch filtration device in this utility model.

[0032] Appendix Figure 3 This is a schematic diagram of the structure of the support base 1 and the first adjustment component 7 in this utility model.

[0033] Appendix Figure 4 This is a schematic diagram of the structure of the first mounting plate 2 in this utility model.

[0034] Appendix Figure 5 This is a schematic diagram of the structure of the second mounting plate 4 and the second adjustment component 8 in this utility model.

[0035] Appendix Figure 6 This is a schematic diagram of the structure of the third mounting plate 6 in this utility model.

[0036] Appendix Figure 7 This is a schematic diagram of the structure of the fourth mounting plate 9 in this utility model.

[0037] Appendix Figure 8This is a schematic diagram of the structure of the fifth mounting plate 11 in this utility model.

[0038] The reference numerals in the attached drawings are explained as follows: Support 1, Base 101, First Slide Groove 102, Second Slide Groove 103, Guide Post 104, First Bearing 105, First Mounting Plate 2, Sample Bottle Mounting Recess 201, First Slide Rail 202, Sample Bottle 3, Second Mounting Plate 4, First Guide Through Hole 401, Syringe Mounting Through Hole 402, Locking Block 403, First Locking Groove 4031, Syringe 5, Third Mounting Plate 6, Second Guide Through Hole 601, Strip Groove 60 2. Second snap-fit ​​groove 603, second threaded sleeve 604, passage hole 605, first adjusting component 7, first lead screw 701, first handwheel 702, second adjusting component 8, second lead screw 801, second handwheel 802, fourth mounting plate 9, filter mounting recess 901, filter mounting through hole 902, second slide rail 903, needle filter 10, fifth mounting plate 11, liquid phase vial mounting recess 1101, third slide rail 1102, liquid phase vial 12. Detailed Implementation

[0039] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. The content of the utility model will be further explained below in conjunction with the drawings:

[0040] Example 1

[0041] Refer to the instruction manual appendix Figure 1 , 2 A batch filtration device for liquid chromatography samples includes a support base 1, a first mounting plate 2, a sample storage bottle 3, a second mounting plate 4, a syringe 5, a third mounting plate 6, a first adjustment component 7, a second adjustment component 8, a fourth mounting plate 9, a needle filter 10, a fifth mounting plate 11, and a liquid chromatography vial 12.

[0042] Refer to the instruction manual appendix Figure 3 The support base 1 includes a base 101, guide columns 104, and a first bearing 105. The base 101 is a hollow box shape with its top and front surfaces open. Four guide columns 104 are vertically fixed at the four corners of the top surface of the base 101. The first bearing 105 is fixedly installed on the rear side of the top surface of the base 101 via its outer ring. The support base 1 serves as a support component for a batch filtration device for liquid chromatography samples.

[0043] Refer to the instruction manual appendix Figure 4Nine sample bottle mounting recesses 201 are arranged in a matrix on the top surface of the first mounting plate 2. Each sample bottle 3, containing a liquid chromatography sample, is placed in each recess 201. Horizontally arranged first grooves 102 are formed on opposite left and right sides of the lower inner side of the base 101. First slide rails 202, matching the first grooves 102, are provided on opposite left and right sides of the first mounting plate 2. The first mounting plate 2 is detachably and horizontally mounted on the base 101 by interlocking with the first slide rails 202 and the first grooves 102.

[0044] Refer to the instruction manual appendix Figure 5 The second mounting plate 4 is provided with four first guide through holes 401, nine syringe mounting through holes 402, eighteen locking blocks 403, a first threaded sleeve 404 and a second bearing 405.

[0045] Four first guide holes 401 are provided at the four corners of the edge of the second mounting plate 4. Four guide pillars 104 pass through the four first guide holes 401 respectively, restricting the second mounting plate 4 to only move up and down along the guide pillars 104. Nine syringe mounting holes 402 are opened in a matrix on the top surface of the second mounting plate 4. The distance between two adjacent syringe mounting holes 402 is equal to the distance between two adjacent sample storage bottle mounting recesses 201. A syringe 5 is vertically fitted in each syringe mounting hole 402.

[0046] Two locking blocks 403 form a group, and the two locking blocks 403 in each group are fixed to the top surface of the second mounting plate 4, opposite to the syringe mounting through hole 402. A first locking groove 4031 is provided on the side of the locking block 403 facing the syringe mounting through hole 402. One end of the first locking groove 4031 extends to a side adjacent to the side (the side of the locking block 403 facing the syringe mounting through hole 402). That is, one side of the locking block 403 has an opening that communicates with the first locking groove 4031, and the openings on the two locking blocks 403 that communicate with the first locking groove 4031 are in opposite directions.

[0047] The two locking blocks 403 in each group are used to fix the syringe 5 which is sleeved in the syringe mounting through hole 402. The specific fixing method is as follows: first, insert the syringe 5 syringe into the syringe mounting through hole 402 and make the wing plate of the syringe 5 contact the top surface of the second mounting plate 4. At this time, the wing plate of the syringe 5 is between the two locking blocks 403. Rotate the syringe 5 syringe so that the two ends of the wing plate of the syringe 5 enter the first locking groove 4031 of the two locking blocks 403 from the opening, thus completing the fixing of the syringe 5 and restricting the vertical movement of the syringe 5.

[0048] The first threaded sleeve 404 and the second bearing 405 are respectively fixed to the rear side of the top surface of the second mounting plate 4. The second bearing 405 is fixed to the rear side of the top surface of the second mounting plate 4 through its outer ring. A threaded through hole is provided in the center of the first threaded sleeve 404.

[0049] Refer to the instruction manual appendix Figure 6 The third mounting plate 6 is provided with four second guide through holes 601, three strip grooves 602, a second threaded sleeve 604 and a passage hole 605.

[0050] Four second guide holes 601 are provided at the four corners of the edge of the third mounting plate 6. Four guide posts 104 pass through the four second guide holes 601 respectively, restricting the third mounting plate 6 to only move up and down along the guide posts 104. Three strip grooves 602 are equally spaced and parallel to each other on the bottom surface of the third mounting plate 6, and the strip grooves 602 extend out of the front surface of the third mounting plate 6. The cross-section of the strip groove 602 is convex, which includes a connected sleeve portion and an extension portion. The width of the sleeve portion is greater than the width of the extension portion, and the extension portion extends out of the bottom surface of the third mounting plate 6.

[0051] The main function of the strip groove 602 is to fix the piston handle of the syringe 5. The outer diameter of the piston handle is smaller than the width of the sleeve and larger than the width of the extension. The outer diameter of the piston rod connected to the piston handle of the syringe 5 is smaller than the width of the extension. After the piston handle of the syringe 5 is sleeved into the sleeve, the piston rod of the syringe 5 extends out from the extension, and the piston handle of the syringe 5 can slide along the length direction of the sleeve.

[0052] When installing syringe 5, the piston handle of syringe 5 must be inserted into the slot 602 before the syringe barrel of syringe 5 can be inserted into the syringe mounting through hole 402. Therefore, the piston handle of syringe 5 needs to be pre-positioned so that the syringe 5 inserted into the slot 602 corresponds vertically to the syringe mounting through hole 402 at the corresponding position, thereby improving work efficiency.

[0053] Therefore, three second snap-fit ​​grooves 603 are provided at equal intervals on the bottom surface of the sleeve portion of each strip groove 602. The distance between two adjacent second snap-fit ​​grooves 603 is equal to the distance between two adjacent syringe mounting through holes 402. When the piston handle of the syringe 5 slides along the sleeve portion of the strip groove 602 into the second snap-fit ​​groove 603, the syringe 5 corresponds to the syringe mounting through hole 402 directly below it.

[0054] The second threaded sleeve 604 and the passage hole 605 are respectively fixed to the rear side of the top surface of the third mounting plate 6. A threaded through hole is provided in the center of the second threaded sleeve 604; the first adjusting component 7 passes through the passage hole 605.

[0055] Refer to the instruction manual appendix Figure 3The first adjustment component 7 includes a first lead screw 701 and a first handwheel 702 fixed to the top of the first lead screw 701; the bottom end of the first lead screw 701 is fixedly connected to the inner ring of the first bearing 105, so that the first lead screw 701 can rotate around the first bearing 105.

[0056] The first lead screw 701 is threadedly connected to the threaded through hole of the first threaded sleeve 404; the first lead screw 701 passes through the passage hole 605. When the first handwheel 702 is rotated, the first lead screw 701 rotates synchronously, and the first lead screw 701 drives the first threaded sleeve 404 to move the second mounting plate 4 vertically up and down, thereby making the syringe 5 vertically up and down.

[0057] Refer to the instruction manual appendix Figure 5 The second adjustment assembly 8 includes a second lead screw 801 and a second handwheel 802 fixed to the top of the second lead screw 801; the bottom end of the second lead screw 801 is fixedly connected to the inner ring of the second bearing 405, so that the second lead screw 801 can rotate around the second bearing 405.

[0058] The second lead screw 801 is threadedly connected to the threaded through hole of the second threaded sleeve 604; when the second handwheel 802 is rotated, the second lead screw 801 rotates synchronously, and the second lead screw 801 drives the second threaded sleeve 604 to drive the third mounting plate 6 to move vertically up and down, so that the third mounting plate 6 moves closer to or away from the second mounting plate 4, thereby realizing the push and pull of the piston handle of the syringe 5.

[0059] At the same time, when the second handwheel 802 is not rotated and only the first handwheel 702 is rotated, the second mounting plate 4 and the third mounting plate 6 rise and fall vertically in sync.

[0060] Refer to the instruction manual appendix Figure 7 Nine filter mounting recesses 901 are arranged in a matrix on the fourth mounting plate 9. The distance between two adjacent filter mounting recesses 901 is equal to the distance between two adjacent syringe mounting through holes 402. A filter mounting through hole 902 is provided at the center of the bottom surface of each filter mounting recess 901. The diameter of the filter mounting recess 901 is larger than the diameter of the filter mounting through hole 902. A needle filter 10 is placed in each filter mounting recess 901. The drain tube of the needle filter 10 passes through the filter mounting through hole 902.

[0061] A second slide groove 103 is provided on the upper inner side of the base 101 on the left and right sides respectively, and a second slide rail 903 matching the second slide groove 103 is provided on the upper inner side of the fourth mounting plate 9 on the left and right sides respectively. The fourth mounting plate 9 is detachably and horizontally mounted on the base 101 by matching and inserting the second slide rail 903 into the second slide groove 103.

[0062] Refer to the instruction manual appendix Figure 8Nine liquid phase vial mounting recesses 1101 are provided in a matrix on the top surface of the fifth mounting plate 11. The distance between two adjacent liquid phase vial mounting recesses 1101 is equal to the distance between two adjacent syringe mounting through holes 402. One liquid phase vial 12 is placed in each liquid phase vial mounting recess 1101.

[0063] A first slide groove 102 is provided on the upper inner side of the base 101 on the left and right sides respectively. A third slide rail 1102 matching the first slide groove 102 is provided on the upper inner side of the fifth mounting plate 11 on the left and right sides respectively. The fifth mounting plate 11 is detachably and horizontally mounted on the base 101 by matching and inserting with the first slide groove 102 through the third slide rail 1102.

[0064] During batch sample aspiration for liquid chromatography, each syringe 5 corresponds to a sample storage bottle 3 in the vertical direction. During batch sample filtration for liquid chromatography, each syringe 5 corresponds to a needle filter 10 and a liquid chromatography vial 12 in the vertical direction.

[0065] In the actual liquid chromatography sample filtration process, in order to rinse the filter membrane of the needle filter 10, ensure the concentration and uniformity of the analyte, and effectively remove impurities and contaminants on the filter membrane to ensure that the samples filtered later are purer, the initial filtrate (the sample filtered at the beginning) is usually collected into the waste liquid collection tray and discarded, and the subsequent filtrate (the sample filtered later) is collected into the liquid chromatography vial 12.

[0066] Therefore, the liquid chromatography sample batch filtration device also includes a waste liquid collection tray, which is a stainless steel or plastic tray with an open top surface. It can be placed inside the base 101, directly below the fourth mounting plate 9, or a fourth slide rail that matches the first slide groove 102 is provided on opposite sides of the tray. The waste liquid collection tray is inserted into the first slide groove 102 via the fourth slide rail and is detachably and horizontally installed inside the base 101.

[0067] The initial filtrate filtered by the needle filter 10 is collected by gravity dripping into the waste liquid collection tray.

[0068] The method of using the liquid chromatography sample batch filtration device in this patent is as follows:

[0069] When performing batch sample aspiration for liquid chromatography: First, rotate the second handwheel 802 to move the third mounting plate 6 away from the second mounting plate 4, ensuring that the distance between the third mounting plate 6 and the second mounting plate 4 is sufficient to vertically accommodate the syringe 5. Insert the piston handle of the syringe 5 into the sleeve of the strip groove 602, and slide the piston handle along the sleeve into the second locking groove 603. Install all syringes 5 in place as described above, ensuring each syringe is vertical. Rotate the second handwheel 802, causing the second lead screw 801 to rotate synchronously. The second lead screw 801 drives the second threaded sleeve 604, bringing the third mounting plate 6 closer to the second mounting plate 4. At this point, the syringe barrel of the syringe 5 enters the syringe mounting through hole 402 on the second mounting plate 4. Continue rotating the second handwheel 802 until the wing plate of the syringe 5 contacts the top surface of the second mounting plate 4. Rotate the syringe barrel of the syringe 5 so that both ends of the wing plate of the syringe 5 enter the first locking groove 4031 of the two locking blocks 403, thus completing the fixation of the syringe 5.

[0070] A sample bottle 3 containing a liquid chromatography sample is placed in the mounting recess 201 of each sample bottle. The first mounting plate 2 is then inserted into the first slide groove 102 via the first slide rail 202 and horizontally mounted on the base 101. Rotating the first handwheel 702 causes the first lead screw 701 to rotate synchronously. The first lead screw 701 drives the first threaded sleeve 404 to cause the second mounting plate 4 and the third mounting plate 6 to descend vertically until the nipple at the bottom of the syringe 5 enters the liquid chromatography sample.

[0071] Rotating the second handwheel 802 causes the second lead screw 801 to rotate synchronously. The second lead screw 801 drives the second threaded sleeve 604 to move the third mounting plate 6 away from the second mounting plate 4. At this time, the third mounting plate 6 pulls the piston handle of the syringe 5. The piston handle drives the piston rod and piston of the syringe 5 to move upward in sequence, thereby realizing the batch aspiration of the liquid chromatography sample until the syringe 5 has aspirated the target volume of liquid chromatography sample.

[0072] Rotate the first handwheel 702, and the first lead screw 701 will rotate synchronously. The first lead screw 701 drives the first threaded sleeve 404 to drive the second mounting plate 4 and the third mounting plate 6 to rise vertically until the bottom of the syringe 5 is separated from the sample bottle 3. Finally, the first mounting plate 2 of the sample bottle 3 containing the liquid chromatography sample is pulled out.

[0073] This completes the batch aspiration of liquid chromatography samples into syringe 5.

[0074] When performing batch filtration of liquid chromatography samples:

[0075] A needle filter 10 is placed in each filter mounting recess 901, and the fourth mounting plate 9 is inserted into the second slide groove 103 via the second slide rail 903 and horizontally mounted on the base 101. A waste liquid collection tray is installed inside the base 101, directly below the fourth mounting plate 9.

[0076] Rotate the first handwheel 702, and the first lead screw 701 will rotate synchronously. The first lead screw 701 drives the first threaded sleeve 404 to drive the second mounting plate 4 and the third mounting plate 6 to descend vertically until the connecting tube of the syringe 5 and the needle filter 10 are in place.

[0077] Rotate the second handwheel 802, and the second lead screw 801 rotates synchronously. The second lead screw 801 drives the second threaded sleeve 604 to move the third mounting plate 6 closer to the second mounting plate 4. At this time, the third mounting plate 6 pushes the piston handle of the syringe 5. The piston handle drives the piston rod and piston of the syringe 5 to move down in sequence, discharging part of the liquid chromatography sample (initial filtrate) in the syringe of the syringe 5 and dropping it into the waste liquid collection tray. Remove the waste liquid collection tray, place a liquid chromatography vial 12 in each liquid chromatography vial mounting recess 1101, and insert the fifth mounting plate 11 into the first slide groove 102 through the third slide rail 1102. Horizontally install it on the base 101. Continue to rotate the second handwheel 802 so that all the remaining liquid chromatography sample in the syringe of the syringe 5 is filtered through the needle filter 10 and falls into the liquid chromatography vial 12 directly below the needle filter 10.

[0078] This completed the batch filtration of liquid chromatography samples.

[0079] Obviously, modifications and / or additions can be made to the above-mentioned liquid chromatography sample batch filtration device and corresponding method without departing from the field and scope of this utility model.

[0080] It is equally clear that, although this invention has described the liquid chromatography sample batch filtration device in detail, those skilled in the art will certainly be able to obtain many other equivalent forms of liquid chromatography sample batch filtration devices and corresponding methods, which have the features described in the claims and are therefore within the scope of protection defined herein.

Claims

1. A batch filtration device for liquid chromatography samples, characterized in that: include: Support base (1); A first mounting plate (2) is detachably and horizontally mounted on the lower part of the support base (1), and a plurality of sample storage bottles (3) are mounted on the first mounting plate (2); A second mounting plate (4) is horizontally mounted on the upper part of the support base (1), and a plurality of syringes (5) are mounted on the second mounting plate (4); The third mounting plate (6) is horizontally mounted on the upper part of the support base (1) and is located on top of the second mounting plate (4). The third mounting plate (6) is fixedly connected to the piston handle of the syringe (5). The first adjustment component (7) is used to drive the second mounting plate (4) to move vertically up and down; The second adjustment component (8) is used to drive the third mounting plate (6) away from or towards the second mounting plate (4); A fourth mounting plate (9) is detachably and horizontally mounted in the middle of the support base (1), and a plurality of needle filters (10) are mounted on the fourth mounting plate (9); A fifth mounting plate (11) is detachably and horizontally mounted on the lower part of the support base (1), and a plurality of liquid phase vials (12) are mounted on the fifth mounting plate (11); The number of sample storage bottles (3), syringes (5), needle filters (10) and liquid chromatography vials (12) are the same, and their positions correspond one-to-one.

2. The liquid chromatography sample batch filtration device according to claim 1, characterized in that: The support base (1) includes a base (101) and a guide column (104). The base (101) is a hollow box with its top and front surfaces open. At least one guide column (104) is vertically fixed to the top surface of the base (101). The first adjustment component (7) is installed on the rear side of the top surface of the base (101).

3. The liquid chromatography sample batch filtration device according to claim 2, characterized in that: Multiple sample storage bottle mounting recesses (201) are arrayed on the top surface of the first mounting plate (2), and a sample storage bottle (3) is placed in each sample storage bottle mounting recess (201); a first sliding groove (102) is provided on opposite sides inside the base (101), and a first sliding rail (202) matching the first sliding groove (102) is provided on opposite sides of the first mounting plate (2).

4. The liquid chromatography sample batch filtration device according to claim 1, characterized in that: A first guide through hole (401) and a syringe mounting through hole (402) are provided on the second mounting plate (4). At least one first guide through hole (401) is provided on the edge of the second mounting plate (4). A plurality of syringe mounting through holes (402) are arranged in an array. A syringe (5) is fitted inside each syringe mounting through hole (402). A fixing assembly for fixing the wing plate for fixing the syringe (5) is fixed on the edge of each syringe mounting through hole (402). The second adjustment assembly (8) is installed on the rear side of the top surface of the second mounting plate (4). The fixing component includes two locking blocks (403), which are fixed to the top surface of the second mounting plate (4). The two locking blocks (403) are arranged opposite to each other on both sides of the syringe mounting through hole (402). A first locking groove (4031) is provided on the side of the locking block (403) facing the syringe mounting through hole (402). One end of the first locking groove (4031) extends to a side adjacent to the side, that is, one side of the locking block (403) is provided with an opening communicating with the first locking groove (4031), and the openings on the two locking blocks (403) communicating with the first locking groove (4031) are in opposite directions.

5. The liquid chromatography sample batch filtration device according to claim 1, characterized in that: A second guide through hole (601) and a strip groove (602) are provided on the third mounting plate (6). At least one second guide through hole (601) is provided on the edge of the third mounting plate (6). A plurality of strip grooves (602) are provided parallel to each other on the bottom surface of the third mounting plate (6). The cross section of the strip groove (602) is convex, and the strip groove (602) extends at least beyond the front surface of the third mounting plate (6). The piston handle of the syringe (5) is fitted into the strip groove (602) and can slide along the length direction of the strip groove (602).

6. The liquid chromatography sample batch filtration device according to claim 5, characterized in that: The strip groove (602) includes a connected sleeve and an extension, and the width of the sleeve is greater than the width of the extension. The extension extends out of the bottom surface of the third mounting plate (6). A plurality of second snap-fit ​​grooves (603) are provided on the bottom surface of the sleeve. The second snap-fit ​​grooves (603) are used to pre-position the piston handle of the syringe (5).

7. The liquid chromatography sample batch filtration device according to claim 2, characterized in that: The first adjustment assembly (7) includes a first lead screw (701) and a first handwheel (702) fixed to the top of the first lead screw (701); a first bearing (105) is installed on the rear side of the top surface of the base (101), and the bottom end of the first lead screw (701) is fixedly connected to the first bearing (105) so that the first lead screw (701) can rotate around the first bearing (105); A first threaded sleeve (404) is fixed on the rear side of the top surface of the second mounting plate (4), and a threaded through hole is provided in the center of the first threaded sleeve (404). The first lead screw (701) is threadedly connected to the threaded through hole. A passage hole (605) is opened on the rear side of the top surface of the third mounting plate (6), and the first lead screw (701) passes through the passage hole (605).

8. The liquid chromatography sample batch filtration device according to claim 1, characterized in that: The second adjustment assembly (8) includes a second lead screw (801) and a second handwheel (802) fixed to the top of the second lead screw (801); a second bearing (405) is installed on the rear side of the top surface of the second mounting plate (4), and the bottom end of the second lead screw (801) is fixedly connected to the second bearing (405) so that the second lead screw (801) can rotate around the second bearing (405); A second threaded sleeve (604) is fixedly provided on the rear side of the top surface of the third mounting plate (6). A threaded through hole is provided in the center of the second threaded sleeve (604), and the second lead screw (801) is threadedly connected to the threaded through hole.

9. The liquid chromatography sample batch filtration device according to claim 2, characterized in that: Multiple filter mounting recesses (901) are arranged in an array on the fourth mounting plate (9). A filter mounting through hole (902) is provided at the center of the bottom surface of each filter mounting recess (901). The diameter of the filter mounting recess (901) is larger than the diameter of the filter mounting through hole (902). A needle filter (10) is placed in each filter mounting recess (901). A second sliding groove (103) is provided on opposite sides inside the base (101). A second sliding rail (903) matching the second sliding groove (103) is provided on opposite sides of the fourth mounting plate (9).

10. The liquid chromatography sample batch filtration device according to claim 2, characterized in that: Multiple liquid phase vial mounting recesses (1101) are arrayed on the top surface of the fifth mounting plate (11), and a liquid phase vial (12) is placed in each liquid phase vial mounting recess (1101); a first sliding groove (102) is provided on opposite sides inside the base (101), and a third sliding rail (1102) matching the first sliding groove (102) is provided on opposite sides of the fifth mounting plate (11).

Images