Temperature control device suitable for micro bioreactor

Abstract

The utility model discloses a temperature control device suitable for a micro bioreactor, and relates to the technical field of micro bioreactors, a reactor assembly comprises a tank body, an upper partition plate, a lower partition plate, an inner cylinder body, a through hole, a liquid inlet and a liquid outlet, a stirring assembly is further arranged at the top of the tank body and on the inner side of the inner cylinder body; the stirring assembly comprises a stirring unit and a driving unit; the driving unit is used for providing rotating force for the stirring unit, the rotating stirring unit is used for stirring raw materials in the inner barrel, and the stirring unit is communicated with the space above the upper partition plate and the space below the lower partition plate and used for providing a channel for flowing of a heat exchange medium, so that temperature adjustment of the materials in the middle area of the inner barrel is achieved. By arranging the stirring assembly, materials in the inner barrel can be synchronously heated inside and outside while the materials are stirred, and compared with a traditional outer side heating structure, heating is more uniform, efficiency is higher, and then efficient temperature adjustment is achieved.

Description

TECHNICAL FIELD

[0001] The utility model relates to microorganism reactor technical field, concretely is a kind of temperature control device suitable for microorganism reactor. BACKGROUND

[0002] Microorganism reactor refers to the reaction system that natural existing microorganism or microorganism with special degradation ability is inoculated to liquid phase or solid phase, and it is the equipment for microorganism / mammal cell culture.

[0003] Microorganism reactor needs to be adjusted temperature according to the growth of internal microorganism / mammal cell in its use process, and the temperature control mode of traditional microorganism reactor adopts water jacket mode, that is, the temperature of circulating water in the jacket of microorganism reactor is adjusted to control the temperature of material in tank, this mode can realize the accurate control of tank temperature, but the temperature of material close to tank inner wall rises and falls faster, and the temperature of material close to middle part rises and falls slowly, temperature rises and falls unevenly, and tank temperature cannot be quickly raised, based on this, a temperature control device suitable for microorganism reactor is provided. SUMMARY

[0004] The utility model aims at: in order to solve the problem in the above background, provide a kind of temperature control device suitable for microorganism reactor.

[0005] To achieve the above object, the utility model provides the following technical scheme: a kind of temperature control device suitable for microorganism reactor, the reactor component includes tank body, upper baffle, lower baffle, inner cylinder, through hole, liquid inlet, liquid outlet;

[0006] The upper baffle and the lower baffle are fixed to the upper and lower ends inside the tank body, the inner cylinder is fixed to the middle of the upper baffle and the lower baffle, the through hole is arranged at the edge of the upper surface of the upper baffle and the lower baffle and completely penetrates the bottom of the upper baffle and the lower baffle;

[0007] The liquid inlet and the liquid outlet are fixed to the upper and lower ends outside the tank body and penetrate into the tank body, the port of the liquid inlet is above the upper baffle, and the port of the liquid outlet is below the lower baffle;

[0008] The liquid inlet, the through hole and the liquid outlet form a channel for the flow of heat exchange medium, and the temperature of the material close to the inner wall of the inner cylinder is adjusted.

[0009] The inner side of the inner cylinder and the top of the tank body is also provided with a stirring assembly, and the stirring assembly comprises a stirring unit and a driving unit.

[0010] The driving unit is used to provide rotational power to the stirring unit. The rotating stirring unit is used to stir the raw materials inside the inner cylinder. The stirring unit is connected to the space above the upper partition and the space below the lower partition to provide a channel for the flow of heat exchange medium and realize the temperature regulation of the material in the middle area of ​​the inner cylinder.

[0011] As a further embodiment of this utility model: the stirring unit includes a central heat exchange cylinder, reinforcing ribs, a rotating shaft, and a stirring rod;

[0012] The middle heat exchange cylinder is rotatably connected between the upper partition and the lower partition and passes through the top of the upper partition and the bottom of the lower partition. The rotating shaft is distributed inside the middle heat exchange cylinder and is fixedly connected to the middle heat exchange cylinder through reinforcing ribs. The stirring rod is distributed inside the inner cylinder and is symmetrically fixed outside the middle heat exchange cylinder.

[0013] The rotation of the shaft drives the central heat exchange cylinder and the stirring rod to agitate the materials inside the inner cylinder.

[0014] As a further improvement of this invention: the stirring unit also includes a through-hole;

[0015] The upper and lower ports of the central heat exchange cylinder are open. The through-hole is located on the outer side of the part of the central heat exchange cylinder that protrudes from the top of the upper partition plate. Multiple through-holes are provided along the circumferential direction. The heat exchange medium above the upper partition plate flows through the channel formed by the through-hole and the inner cavity of the central heat exchange cylinder to achieve temperature regulation of the material in the middle of the inner cylinder.

[0016] As a further embodiment of this utility model: the interior of the stirring rod has a hollow structure, and the upper and lower ends of the stirring rod have an open structure. The tops of the two stirring rods extend into the interior of the central heat exchange cylinder and are respectively aligned with the two through holes.

[0017] The bottoms of the two stirring rods are connected to the bottom of the inner cavity of the central heat exchange cylinder.

[0018] As a further embodiment of this utility model: the drive unit includes a driven gear, a drive motor, and a driving gear;

[0019] The agitation units are arranged in a ring around the center of the tank. A transmission box is fixed to the top of the tank. Multiple rotating shafts in the multiple agitation units pass through the tank and into the transmission box. The driven gear is fixed to the top of the rotating shaft.

[0020] The drive motor is fixed to the top center of the transmission box. The output end of the drive motor passes through the inside of the transmission box and is fixedly connected to the drive gear. The drive gear is distributed among multiple driven gears and meshes synchronously with multiple driven gears. The drive motor is used to drive multiple rotating shafts to rotate synchronously.

[0021] As a further improvement of this utility model: the top of the tank is provided with multiple upper connection ports, which penetrate the tank body, the upper partition and communicate with the inner cavity of the inner cylinder;

[0022] A discharge port is also provided on one side of the outer wall of the tank. The discharge port passes through the tank body and the inner cylinder and is connected to the inner cavity of the inner cylinder.

[0023] Compared with the prior art, the beneficial effects of this utility model are:

[0024] By setting up a stirring component, the material can be stirred at the same time, and the material inside the inner cylinder can be heated simultaneously from the inside and outside. Compared with the traditional external heating structure, the heating is not only more uniform and faster, but also achieves efficient temperature regulation. Attached Figure Description

[0025] Fig. 1 This is a schematic diagram of the structure of this utility model;

[0026] Fig. 2 This is a cross-sectional view of the structure of this utility model;

[0027] Fig. 3 This is a cross-sectional exploded view of the present invention;

[0028] Fig. 4 This is a cross-sectional view of the central heat exchange cylinder and stirring rod of this utility model.

[0029] In the diagram: 1. Reactor assembly; 101. Tank body; 102. Upper baffle; 103. Lower baffle; 104. Inner cylinder; 105. Through hole; 106. Liquid inlet; 107. Liquid outlet; 108. Transmission box; 109. Upper connection port; 110. Discharge port; 2. Stirring assembly; 201. Central heat exchange cylinder; 202. Reinforcing rib; 203. Rotating shaft; 204. Driven gear; 205. Through hole; 206. Stirring rod; 207. Drive motor; 208. Driving gear. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] Please see Figs. 1-4In this embodiment of the present invention, a temperature control device suitable for a micro bioreactor includes a reactor assembly 1 and a stirring assembly 2. The reactor assembly 1 includes a tank 101, an upper partition 102, a lower partition 103, an inner cylinder 104, a through hole 105, a liquid inlet 106, and a liquid outlet 107.

[0032] The upper partition 102 and the lower partition 103 are respectively fixed to the upper and lower ends inside the tank body 101. The inner cylinder 104 is fixed in the middle between the upper partition 102 and the lower partition 103. The through hole 105 is opened at the upper surface edge of the upper partition 102 and the lower partition 103 and completely penetrates the bottom of the upper partition 102 and the lower partition 103.

[0033] The inlet 106 and outlet 107 are fixed to the upper and lower ends of the outer side of the tank 101 and extend into the inside of the tank 101. The port of the inlet 106 is located above the upper partition 102, and the port of the outlet 107 is located below the lower partition 103.

[0034] The inlet 106, through hole 105, and outlet 107 form a channel for the flow of heat exchange medium, thereby achieving temperature regulation of the material near the inner wall of the inner cylinder 104.

[0035] A stirring assembly 2 is also provided on the top of the tank body 101 and the inner side of the inner cylinder 104. The stirring assembly 2 includes an agitation unit and a drive unit.

[0036] The drive unit is used to provide rotational power to the agitation unit. The rotating agitation unit is used to agitate the raw materials inside the inner cylinder 104. The agitation unit is connected to the space above the upper partition 102 and the space below the lower partition 103 to provide a channel for the flow of heat exchange medium and realize the temperature regulation of the material in the middle area of ​​the inner cylinder 104.

[0037] The stirring unit includes a central heat exchange cylinder 201, a reinforcing rib 202, a rotating shaft 203, and a stirring rod 206;

[0038] The middle heat exchange cylinder 201 is rotatably connected between the upper partition 102 and the lower partition 103 and passes through the top of the upper partition 102 and the bottom of the lower partition 103. The rotating shaft 203 is distributed inside the middle heat exchange cylinder 201 and is fixedly connected to the middle heat exchange cylinder 201 through the reinforcing rib 202. The stirring rod 206 is distributed inside the inner cylinder 104 and is symmetrically fixed outside the middle heat exchange cylinder 201.

[0039] The rotation of the rotating shaft 203 drives the central heat exchange cylinder 201 and the stirring rod 206 to rotate, thereby agitating the material inside the inner cylinder 104.

[0040] The agitation unit also includes a through-hole 205;

[0041] The upper and lower ends of the middle heat exchange cylinder 201 are open. The through-hole 205 is opened on the outer side of the part of the middle heat exchange cylinder 201 that protrudes from the top of the upper partition 102. Multiple through-holes 205 are opened along the circumferential direction. The heat exchange medium above the upper partition 102 flows through the channel formed by the through-hole 205 and the inner cavity of the middle heat exchange cylinder 201 to achieve temperature regulation of the material in the middle of the inner cylinder 104.

[0042] The stirring rod 206 has a hollow internal structure, and the upper and lower ends of the stirring rod 206 are open. The tops of the two stirring rods 206 extend into the interior of the central heat exchange cylinder 201 and are respectively aligned with the two through holes 205.

[0043] The bottoms of the two stirring rods 206 are connected to the bottom of the inner cavity of the central heat exchange cylinder 201;

[0044] The drive unit includes a driven gear 204, a drive motor 207, and a driving gear 208;

[0045] Multiple agitation units are arranged in a ring around the center of the tank 101. A transmission box 108 is fixed to the top of the tank 101. Multiple rotating shafts 203 in the multiple agitation units pass through the tank 101 to the inside of the transmission box 108. A driven gear 204 is fixed to the top of the rotating shaft 203.

[0046] The drive motor 207 is fixed to the top center of the transmission box 108. The output end of the drive motor 207 passes through the inside of the transmission box 108 and is fixedly connected to the drive gear 208. The drive gear 208 is distributed among multiple driven gears 204 and meshes synchronously with multiple driven gears 204. The drive motor 207 drives multiple rotating shafts 203 to rotate synchronously.

[0047] In this embodiment, it should be noted that: two sets of inlet 106 and outlet 107 are provided, and the two sets of inlet 106 and outlet 107 are respectively connected to the heating medium conveying pipeline and the cooling medium conveying pipeline. When adjusting the temperature, taking temperature rise as an example, its operating principle is as follows:

[0048] Start the external delivery pump and connect the inlet 106 and outlet 107 to the heating medium delivery pipeline. The external delivery pump delivers the heating medium through the inlet 106 to the inside of the tank 101 and above the upper partition 102. At this time, the heating medium will flow downward through the through hole 105 and through port 205 respectively. The heating medium flowing downward through the through hole 105 is located between the inner cylinder 103 and the tank 101. This part of the heating medium can heat the material close to the inner wall of the inner cylinder 103.

[0049] The heating medium flows downward through the through-hole 205 into the central heat exchange cylinder 201. At the same time, some of the heating medium flows into the interior of the stirring rod 206, thus heating the material near the middle of the inner cylinder 104.

[0050] Afterwards, all the heating medium flows into the space below the lower partition 103 and finally flows out through the outlet 107;

[0051] At the same time, the drive motor 207 runs synchronously. The drive motor 207 drives multiple driven gears 204 to rotate synchronously through the drive gear 208, thereby realizing the rotation of the central heat exchange cylinder 201 and the stirring rod 206. The rotating stirring rod 206 can stir the material inside the inner cylinder 104, making the material heat more evenly.

[0052] By coordinating the above components, the material inside the inner cylinder 104 can be heated synchronously from both inside and outside. Compared with the traditional external heating structure, the heating is not only more uniform but also faster, thereby achieving efficient temperature regulation (it should be noted that the principle of cooling is the same).

[0053] Please refer to this carefully. Figs. 1-4 The top of the tank body 101 is provided with multiple upper connection ports 109, which penetrate the tank body 101, the upper partition 102 and communicate with the inner cavity of the inner cylinder 104.

[0054] A discharge port 110 is also provided on one side of the outer wall of the tank body 101. The discharge port 110 passes through the tank body 101 and the inner cylinder 104 and communicates with the inner cavity of the inner cylinder 104.

[0055] In this embodiment, it should be noted that the upper connection port 109 includes, but is not limited to, interfaces such as a feed port, a temperature sensor detection port, a pressure sensor detection port, and a pneumatic safety port, which are used to realize material conveying, temperature monitoring, pressure monitoring, and pressure control. Finally, the material that has completed the reaction can be discharged through the discharge port 110.

[0056] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A temperature control device suitable for micro-bioreactors, comprising a reactor assembly (1) and a stirring assembly (2), characterized in that, The reactor assembly (1) includes a tank (101), an upper baffle (102), a lower baffle (103), an inner cylinder (104), a through hole (105), an inlet (106), and an outlet (107). The upper partition (102) and lower partition (103) are respectively fixed to the upper and lower ends inside the tank (101), the inner cylinder (104) is fixed in the middle between the upper partition (102) and the lower partition (103), and the through hole (105) is opened at the upper surface edge of the upper partition (102) and the lower partition (103) and completely penetrates the bottom of the upper partition (102) and the lower partition (103); The inlet (106) and outlet (107) are respectively fixed to the upper and lower ends of the outer side of the tank (101) and penetrate into the inside of the tank (101). The port of the inlet (106) is located above the upper partition (102), and the port of the outlet (107) is located below the lower partition (103). The inlet (106), through hole (105), and outlet (107) form a channel for the flow of heat exchange medium, thereby achieving temperature regulation of the material near the inner wall of the inner cylinder (104). The top of the tank (101) and the inner side of the inner cylinder (104) are also provided with a stirring assembly (2), which includes a stirring unit and a driving unit. The driving unit is used to provide rotational power to the stirring unit. The rotating stirring unit is used to stir the raw materials inside the inner cylinder (104). The stirring unit is connected to the space above the upper partition (102) and the space below the lower partition (103) to provide a channel for the flow of heat exchange medium and realize the temperature regulation of the material in the middle area of ​​the inner cylinder (104).

2. The temperature control device for micro-bioreactors according to claim 1, characterized in that, The stirring unit includes a central heat exchange cylinder (201), reinforcing ribs (202), a rotating shaft (203), and a stirring rod (206). The middle heat exchange cylinder (201) is rotatably connected to the middle of the upper partition (102) and the lower partition (103) and passes through the top of the upper partition (102) and the bottom of the lower partition (103). The rotating shaft (203) is distributed inside the middle heat exchange cylinder (201) and is fixedly connected to the middle heat exchange cylinder (201) through the reinforcing rib (202). The stirring rod (206) is distributed inside the inner cylinder (104) and is symmetrically fixed outside the middle heat exchange cylinder (201). The rotating shaft (203) drives the central heat exchange cylinder (201) and the stirring rod (206) to rotate, thereby agitating the material inside the inner cylinder (104).

3. The temperature control device for micro-bioreactors according to claim 2, characterized in that, The stirring unit also includes a through-hole (205); The upper and lower ports of the middle heat exchange cylinder (201) are open. The through port (205) is opened on the outside of the part of the middle heat exchange cylinder (201) that protrudes from the top of the upper partition (102). Multiple through ports (205) are opened in the circumferential direction. The heat exchange medium above the upper partition (102) flows through the channel formed by the through port (205) and the inner cavity of the middle heat exchange cylinder (201) to achieve temperature regulation of the material in the middle of the inner cylinder (104).

4. A temperature control device for microbioreactors according to claim 3, characterized in that, The stirring rod (206) has a hollow structure inside, and the upper and lower ends of the stirring rod (206) have an open structure. The tops of the two stirring rods (206) extend into the interior of the central heat exchange cylinder (201) and are respectively aligned with the two through holes (205). The bottoms of the two stirring rods (206) are connected to the bottom of the inner cavity of the central heat exchange cylinder (201).

5. A temperature control device for microbioreactors according to claim 2, characterized in that, The drive unit includes a driven gear (204), a drive motor (207), and a driving gear (208). The stirring units are arranged in a ring around the center of the tank (101). A transmission box (108) is fixed on the top of the tank (101). Multiple rotating shafts (203) in the multiple stirring units pass through the tank (101) to the inside of the transmission box (108). The driven gear (204) is fixed on the top of the rotating shaft (203). The drive motor (207) is fixed at the top center of the transmission box (108). The output end of the drive motor (207) extends into the transmission box (108) and is fixedly connected to the drive gear (208). The drive gear (208) is distributed among multiple driven gears (204) and meshes synchronously with multiple driven gears (204). The drive motor (207) drives multiple rotating shafts (203) to rotate synchronously.

6. A temperature control device for microbioreactors according to claim 1, characterized in that, The top of the tank (101) is provided with multiple upper connection ports (109), which are connected to the inner cavity of the inner cylinder (104) through the tank (101) and the upper partition (102); A discharge port (110) is also provided on one side of the outer wall of the tank (101). The discharge port (110) penetrates the tank (101) and the inner cylinder (104) and communicates with the inner cavity of the inner cylinder (104).

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