Efficient positive pressure type solid-phase extraction device

Abstract

The utility model relates to an efficient positive pressure type solid-phase extraction device, which belongs to the field of chemical analysis, and comprises an extraction plate, a collection plate and a positive pressure plate, a plurality of accommodating holes for placing extraction columns are arranged on the extraction plate in an array manner, the extraction plate is placed on the collection plate, and the positive pressure plate is arranged on the collection plate. A plurality of containing holes are formed in the collecting plate, a plurality of collecting grooves corresponding to the containing holes are formed in the collecting plate in an array mode, a pressing plate used for pressing a plurality of extraction columns in an abutting mode is placed on the extraction plate, a plurality of receding holes opposite to pipe openings of the extraction columns are formed in the pressing plate in an array mode, and fixing assemblies fixed to each other are arranged between the extraction plate and the pressing plate. A plurality of piston rods are arranged on the positive pressure plate in an array manner and can be synchronously inserted into the plurality of extraction columns. The method has the advantage of improving the extraction efficiency.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of chemical analysis, in particular to a high-efficiency positive pressure type solid phase extraction device. BACKGROUND

[0002] Solid phase extraction (SPE) is an extraction technique based on liquid-solid separation. It selectively adsorbs the measured components in the solution through a porous solid phase adsorbent with small particles, and then elutes and desorbs or thermally desorbs with another solvent, so as to achieve the purpose of separation and enrichment. Compared with traditional liquid-liquid extraction, this technology has many advantages, such as less use of organic solvents, reduced environmental pollution, no phase separation operation, easy collection and separation of components, and high recovery rate and enrichment factor.

[0003] Solid phase extraction has a wide range of applications, including sample pretreatment in the fields of environment, food, medicine, etc. For example, in environmental monitoring, solid phase extraction can be used to extract and enrich organic pollutants in water samples; in the field of food safety, it can be used to detect harmful substances such as pesticide residues and additives in food; in the medical field, solid phase extraction is often used for analysis of drug metabolites and processing of biological samples.

[0004] The basic operation steps of solid phase extraction include preparation of solid phase extraction column, sample pretreatment, sample loading, elution, recovery and analysis and detection. However, in the existing manual extraction process, the sample liquid is usually added to the solid phase extraction column manually, and then the extraction is performed by pressing the piston rod, so the solid phase extraction efficiency is low. CONTENT OF THE INVENTION

[0005] In order to improve the solid phase extraction efficiency, the present application provides a high-efficiency positive pressure type solid phase extraction device.

[0006] The high-efficiency positive pressure type solid phase extraction device provided by the present application adopts the following technical scheme: a high-efficiency positive pressure type solid phase extraction device, comprising an extraction plate, a collection plate and a positive pressure plate, a plurality of accommodation holes for placing extraction columns are arranged in an array on the extraction plate, the extraction plate is placed on the collection plate, a plurality of collection grooves corresponding to the accommodation holes are arranged in an array on the collection plate, a pressing plate for pressing a plurality of extraction columns is placed on the extraction plate, a plurality of displacement holes opposite to the pipe openings of the extraction columns are arranged in an array on the pressing plate, a fixing assembly that is fixed to each other is arranged between the extraction plate and the pressing plate, a plurality of piston rods are arranged in an array on the positive pressure plate, and a plurality of the piston rods can be inserted into a plurality of the extraction columns synchronously.

[0007] By adopting the technical scheme, the extraction columns are placed in the accommodation holes on the extraction plate, then the extraction plate with the extraction columns is placed on the collection plate, so that the lower ends of the extraction columns correspond to the collection grooves on the collection plate, then the sample is added into the extraction columns through the pipette, then the pressing plate is placed on the extraction plate, the pressing plate is fixed on the extraction plate through the fixing assembly, so that the extraction columns are stably fixed on the extraction plate, then the piston rods on the positive pressure plate are synchronously inserted into the extraction columns, different extractions are carried out by pressing, and the extraction efficiency is improved.

[0008] Preferably, the fixing assembly comprises a plurality of fixing rods and a locking nut, the fixing rods are vertically fixed on the upper surface of the extraction plate, the pressing plate is provided with through holes through the fixing rods, and the locking nut is threadedly connected to the fixing rods to lock the pressing plate on the extraction plate.

[0009] By adopting the technical scheme, the through holes on the pressing plate are placed on the upper surface of the extraction plate through the fixing rods, so that the accommodation holes correspond to the pipe mouths of the extraction columns, then the pressing plate is fixed on the extraction plate through the locking nut, and the extraction columns are stably fixed in the accommodation holes, so that the consistency of the downward pressing of the piston rods on the positive pressure plate and the convenience of the upward removal of the piston rods are improved.

[0010] Preferably, the fixing rods are upwardly extended, the positive pressure plate is provided with guide holes, and the guide holes pass through the fixing rods.

[0011] By adopting the technical scheme, the positive pressure plate is inserted into the fixing rods through the guide holes, and the piston rods on the positive pressure plate are synchronously pressed downward through the guide effect of the fixing rods, so that the consistency of the extraction process of the extraction columns is improved.

[0012] Preferably, the accommodation holes accommodate the column bodies of the extraction columns, and the bottom of the extraction plate is provided with small holes corresponding to the positions of the accommodation holes, so that the joints of the extraction columns extend out of the outside.

[0013] By adopting the technical scheme, the column bodies of the extraction columns are placed in the accommodation holes, and the joints at the lower ends of the extraction columns extend to the collection grooves through the small holes, so that the extraction columns are stably fixed in the extraction plate, and the stability of the extraction columns in the downward pressing process of the positive pressure plate is improved.

[0014] Preferably, the upper surface of the extraction plate is provided with an embedding groove at the edge of the accommodation hole, and the embedding groove is used for embedding the ear plate at the upper end of the extraction column, so that the upper end of the extraction column is flush with the surface of the extraction plate.

[0015] By adopting the technical scheme, the extraction column is placed in the accommodation hole, and the ear plate at the upper end of the extraction column is embedded in the embedding groove, so that the upper end of the extraction column is flush with the upper surface of the extraction plate, and the stability of the pressing of the pressing plate on the upper surface of the extraction plate is improved.

[0016] Preferably, the hole of the giving-hole on the upper surface of the pressing plate is outwardly open.

[0017] By using the above technical solution, the open giving-hole plays a guiding role on the piston rod, facilitating the insertion of the piston rod into the extraction column.

[0018] Preferably, vertical positioning columns are arranged at each corner of the upper surface of the collecting plate, and the bottom of the extraction plate is provided with positioning holes corresponding to the positioning columns and being inserted into each other.

[0019] By using the above technical solution, during the placement of the extraction plate on the collecting plate, the positioning columns are inserted into the positioning holes at the bottom of the extraction plate, thereby improving the stability of the placement of the extraction plate on the collecting plate and making the extraction columns on the extraction plate accurately correspond to the collection grooves on the collecting plate.

[0020] Preferably, the extraction plate and the collecting plate are both made of transparent acrylic plate.

[0021] By using the above technical solution, the transparent acrylic plate can facilitate the observation of the extraction process of the extraction column.

[0022] In summary, the present application has at least one of the following beneficial technical effects:

[0023] The extraction columns are placed in the containing holes on the extraction plate, and then the extraction plate with the extraction columns is placed on the collecting plate, so that the lower ends of the extraction columns correspond to the collection grooves on the collecting plate, and then the sample is added into the extraction columns through the pipette, and then the pressing plate is placed on the extraction plate, and the pressing plate is fixed on the extraction plate through the fixing assembly, so that the extraction columns are stably fixed on the extraction plate, and then the piston rod on the pressing plate is inserted into the extraction column simultaneously, different extraction under pressure is carried out, thereby improving the extraction efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 is a sectional view of the solid-phase extraction device in the embodiment of the present application.

[0025] Figure 2 is an exploded structural schematic view of the pressing plate and the extraction plate in the embodiment of the present application.

[0026] Figure 3 is an exploded structural schematic view of the extraction plate and the collecting plate in the embodiment of the present application.

[0027] Figure 4 is a whole structural schematic view of the solid-phase extraction device in the embodiment of the present application.

[0028] Explanation of reference numerals in the attached drawings: 1. Extraction plate; 11. Accommodation hole; 12. Small hole; 13. Groove; 2. Collection plate; 21. Collection groove; 22. Positioning column; 3. Positive pressure plate; 31. Piston rod; 32. Guide hole; 4. Pressure plate; 41. Displacement hole; 42. Through hole; 5. Fixing rod; 6. Locking nut; 7. Extraction column. Detailed Implementation

[0029] The following is in conjunction with the appendix Figures 1-4 This application will be described in further detail.

[0030] This application discloses a high-efficiency positive pressure solid-phase extraction device. (Refer to...) Figure 1 and Figure 2 The solid-phase extraction apparatus includes an extraction plate 1, a collection plate 2, and a positive pressure plate 3. The extraction plate 1 has an array of receiving holes 11 for accommodating extraction columns 7. The receiving holes 11 accommodate the column bodies of the extraction columns 7. The bottom of the extraction plate 1 has small holes 12 corresponding to the receiving holes 11, allowing the connectors of the extraction columns 7 to extend to the outside. The bottom of the extraction plate 1 rests on the upper surface of the collection plate 2. The collection plate 2 has an array of collection grooves 21 corresponding to the receiving holes 11. The connector at the lower end of the extraction column 7 is located at the opening of the collection groove 21. In this embodiment, both the extraction plate 1 and the collection plate 2 are made of transparent acrylic sheets, and the receiving holes 11 and collection grooves 21 are injection molded. A pressure plate 4 is placed on the extraction plate 1 to press against the upper ends of the extraction columns 7. The pressure plate 4 has an array of clearance holes 41 corresponding to the openings of the extraction columns 7. The pressure plate 4 is detachably fixed to the extraction plate 1 by a fixing assembly. A plurality of piston rods 31 are arrayed on the positive pressure plate 3, and the piston rods 31 can be simultaneously inserted into a plurality of extraction columns 7. The extraction columns 7 are placed in the receiving holes 11 on the extraction plate 1, and then the extraction plate 1 with the extraction columns 7 is placed on the collection plate 2, so that the lower ends of the extraction columns 7 correspond to the collection grooves 21 on the collection plate 2. The sample is then added to the extraction columns 7 using a pipette. A pressure plate 4 is then placed on the extraction plate 1 and fixed to the extraction plate 1 using a fixing assembly, thus stably fixing the extraction columns 7 on the extraction plate 1. Finally, the piston rods 31 on the positive pressure plate 3 are simultaneously inserted into the extraction columns 7 to perform extraction at different pressures, thereby improving the extraction efficiency.

[0031] Reference Figure 2 and Figure 3The fixing assembly includes multiple fixing rods 5 and locking nuts 6. The fixing rods 5 are vertically fixed to the upper surface of the extraction plate 1. The pressure plate 4 has through holes 42 for the fixing rods 5. The locking nuts 6 are threaded onto the fixing rods 5 to press and lock the pressure plate 4 onto the extraction plate 1. In this embodiment, four fixing rods 5 and four locking nuts 6 are provided, and the four fixing rods 5 are fixed at each corner of the upper surface of the extraction plate 1. The locking nuts 6 in this embodiment are wing nuts. The through holes 42 on the pressure plate 4 pass through the fixing rods 5 and are placed on the upper surface of the extraction plate 1, so that the clearance hole 41 corresponds to the opening of the extraction column 7. Then, the pressure plate 4 is fixed to the extraction plate 1 by the locking nuts 6, thereby making the extraction column 7 stably fixed in the receiving hole 11, thus improving the consistency of the downward pressing of the piston rod 31 on the positive pressure plate 3 and the convenience of moving the piston rod 31 upward.

[0032] Furthermore, the fixing rod 5 extends upward, and the diameter of the upper side of the fixing rod 5 is smaller than the diameter of the lower side. A guide hole 32 is provided on the positive pressure plate 3, and the guide hole 32 passes through the fixing rod 5. The positive pressure plate 3 is inserted into the fixing rod 5 through the guide hole 32. Through the guiding action of the fixing rod 5, the piston rod 31 on the positive pressure plate 3 is pressed down synchronously, thereby improving the consistency of the extraction process of the extraction column 7.

[0033] A groove 13 is provided on the upper surface of the extraction plate 1 at the edge of the receiving hole 11. The groove 13 is for the upper end ear plate of the extraction column 7 to be inserted, so that the upper end of the extraction column 7 is flush with the surface of the extraction plate 1. The extraction column 7 is placed in the receiving hole 11, and the ear plate at the upper end of the extraction column 7 is inserted into the groove 13, so that the upper end of the extraction column 7 is flush with the upper surface of the extraction plate 1, thereby improving the stability of the pressure plate 4 pressing against the upper surface of the extraction plate 1. The opening of the relief hole 41 on the upper surface of the pressure plate 4 is open outward. The open relief hole 41 serves to guide the piston rod 31, making it easier for the piston rod 31 to be inserted into the extraction column 7.

[0034] Reference Figure 3 and Figure 4 Positioning posts 22 are vertically arranged at each corner of the upper surface of the collecting plate 2, and positioning holes corresponding to the positioning posts 22 are provided on the bottom of the extraction plate 1. During the process of placing the extraction plate 1 on the collecting plate 2, the positioning posts 22 are inserted into the positioning holes at the bottom of the extraction plate 1, thereby improving the stability of the extraction plate 1 on the collecting plate 2, and at the same time ensuring that the extraction posts 7 on the extraction plate 1 are precisely aligned with the collection grooves 21 on the collecting plate 2.

[0035] The implementation principle of the high-efficiency positive pressure solid phase extraction device in this application embodiment is as follows: Several extraction columns 7 are placed in the receiving holes 11 on the extraction plate 1, and then the extraction plate 1 with the extraction columns 7 is placed on the collection plate 2, so that the lower ends of the extraction columns 7 correspond to the collection grooves 21 on the collection plate 2. Then, the sample is added into the extraction column 7 by a pipette. Then, the pressure plate 4 is placed on the extraction plate 1 and fixed on the extraction plate 1 by a fixing component, so that the extraction column 7 is stably fixed on the extraction plate 1. Then, the piston rod 31 on the positive pressure plate 3 is simultaneously inserted into the extraction column 7 to perform extraction under different pressures, thereby improving the extraction efficiency.

[0036] Unless otherwise defined, the technical or scientific terms used in this application shall have the ordinary meaning understood by one of ordinary skill in the art to which this application pertains. The terms "first," "second," "third," and similar terms used in this application specification and claims do not indicate any order, quantity, or importance, but are merely used to distinguish different components. The terms "an" or "a" and similar terms do not indicate a quantity limitation, but rather indicate the presence of at least one. The terms "comprising" or "including" and similar terms mean that the elements or objects preceding "comprising" or "including" encompass the elements or objects listed following "comprising" or "including" and their equivalents, and do not exclude other elements or objects. "Above," "below," "left," "right," etc., are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0037] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A high-efficiency positive pressure solid-phase extraction device, characterized in that: The assembly includes an extraction plate (1), a collection plate (2), and a positive pressure plate (3). The extraction plate (1) is provided with an array of several receiving holes (11) for placing extraction columns (7). The extraction plate (1) is placed on the collection plate (2). The collection plate (2) is provided with an array of several collection grooves (21) corresponding to the receiving holes (11). The extraction plate (1) is provided with a pressure plate (4) for pressing against several extraction columns (7). The pressure plate (4) is provided with an array of several clearance holes (41) opposite to the openings of the extraction columns (7). The extraction plate (1) and the pressure plate (4) are provided with a fixing component that fixes each other. The positive pressure plate (3) is provided with an array of several piston rods (31). Several piston rods (31) can be inserted into several extraction columns (7) simultaneously.

2. The high-efficiency positive pressure solid-phase extraction device according to claim 1, characterized in that: The fixing assembly includes multiple fixing rods (5) and locking nuts (6). The multiple fixing rods (5) are vertically fixed on the upper surface of the extraction plate. The pressure plate (4) has through holes (42) through the fixing rods (5). The locking nuts (6) are threaded onto the fixing rods (5) to press and lock the pressure plate (4) onto the extraction plate (1).

3. The high-efficiency positive pressure solid-phase extraction device according to claim 2, characterized in that: The fixing rod (5) extends upward, and the positive pressure plate (3) has a guide hole (32) that passes through the fixing rod (5).

4. The high-efficiency positive pressure solid-phase extraction device according to claim 1, characterized in that: The receiving hole (11) is for housing the column of the extraction column (7), and the bottom of the extraction plate (1) has a small hole (12) at the position corresponding to the receiving hole (11) for the connector of the extraction column (7) to extend to the outside.

5. The high-efficiency positive pressure solid-phase extraction device according to claim 1, characterized in that: The upper surface of the extraction plate (1) is provided with a groove (13) at the edge of the receiving hole (11). The groove (13) is for the upper end ear plate of the extraction column (7) to be inserted so that the upper end of the extraction column (7) is flush with the surface of the extraction plate (1).

6. The high-efficiency positive pressure solid-phase extraction device according to claim 1, characterized in that: The opening of the relief hole (41) on the upper surface of the pressure plate (4) is set to face outward.

7. The high-efficiency positive pressure solid-phase extraction device according to claim 1, characterized in that: The collecting plate (2) has vertically arranged positioning posts (22) at each corner of its upper surface, and the bottom of the extraction plate (1) has positioning holes that are interlocked with each other, corresponding to the positioning posts (22).

8. The high-efficiency positive pressure solid-phase extraction device according to claim 1, characterized in that: Both the extraction plate (1) and the collection plate (2) are made of transparent acrylic sheets.

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