Collagen particle preparation system

Abstract

The utility model discloses a collagen particle preparation system, and relates to the field of biomedical treatment. The collagen particle preparation system comprises a feeding device, a cutting device and a collecting device, the feeding device communicates with the cutting device through a feeding pipeline, the cutting device comprises a cutting container, a rotary cutting assembly and a driving assembly, the cutting container forms a containing cavity, the rotary cutting assembly is arranged in the containing cavity and comprises a plurality of cutting pieces, and the cutting pieces are arranged in the containing cavity. The driving assembly is used for driving the rotary cutting assembly to rotate so that the cutting piece can cut collagen raw materials, a discharging port is formed in the side wall of the cutting container, a filter screen is arranged at the discharging port, the discharging port is communicated with the collecting device, and the collecting device is used for collecting collagen particles passing through the filter screen. The collagen particles prepared by the collagen particle preparation system have the characteristics of low bulk density, large specific surface area, good liquid absorption capability, high utilization rate and the like.

Description

Technical Field

[0001] This application relates to the biomedical field, and more specifically, to a collagen particle preparation system. Background Technology

[0002] Collagen, the most abundant protein in animals, accounts for approximately 30% of the total protein in the human body. Its triple helix structure endows it with excellent physicochemical and biological properties, including good biocompatibility, low immunogenicity, biodegradability, high cell affinity, promotion of cell growth and proliferation, platelet adsorption for coagulation, and promotion of wound healing. Therefore, collagen is widely used in the biomedical field, and collagen-based medical products come in various forms, including solutions, sponges, powders, gels, and films. Representative medical products include collagen sponges, collagen scaffold materials, and collagen tissue engineering materials. Collagen sponges, with their porous internal structure, offer advantages when used as wound dressings, facilitating the absorption of wound exudate, providing a moist environment for wound healing, and promoting granulation tissue growth and wound healing. Compared to collagen sponges, collagen powder has the structural advantage of a larger specific surface area, making it more convenient for use in sinus tracts and cavity wounds. Currently, the conventional preparation method involves grinding pre-formed collagen sponge products into powder using grinding equipment. However, this method results in high density, reduced specific surface area / utilization rate, crushed and damaged pore structure, decreased liquid absorption capacity, and poor support effect. Utility Model Content

[0003] The purpose of this application is to provide a collagen particle preparation system that can retain more of the porous structure in collagen particles, so that the prepared collagen particles have the characteristics of low density, large specific surface area, good liquid absorption capacity, and high utilization rate.

[0004] The embodiments of this application can be implemented as follows:

[0005] This application provides a collagen particle preparation system, including a feeding device, a cutting device, and a collecting device. The feeding device is connected to the cutting device through a feeding pipeline. The cutting device includes a cutting container, a rotary cutting assembly, and a driving assembly. The cutting container forms a receiving cavity, and the rotary cutting assembly is disposed in the receiving cavity. The rotary cutting assembly includes multiple cutting elements. The driving assembly is used to drive the rotary cutting assembly to rotate so that the cutting elements cut the collagen raw material. A discharge port is formed on the side wall of the cutting container, and a filter screen is provided at the discharge port. The discharge port is connected to the collecting device, which is used to collect the collagen particles that pass through the filter screen.

[0006] In an optional embodiment, the rotary cutting assembly further includes a cutter head, with multiple cutting elements disposed on one side of the cutter head, and the cutter head is connected to the drive assembly for transmission.

[0007] In an optional embodiment, the plurality of cutting elements includes a plurality of first cutting elements and a plurality of second cutting elements. The plurality of first cutting elements are arranged at intervals around the rotation axis of the rotary cutting assembly, and the plurality of second cutting elements are arranged at intervals around the rotation axis of the rotary cutting assembly. The distance between the second cutting elements and the rotation axis is greater than the distance between the first cutting elements and the rotation axis.

[0008] In an alternative implementation, each first cutter is opposite the gap between two adjacent second cutters in the radial direction of the rotary cutting assembly.

[0009] In an optional embodiment, the first cutting element has a serrated cutting edge, and the second cutting element has a straight cutting edge.

[0010] In an optional embodiment, a plurality of fixed blades are provided on the inner wall surface of the cutting container, and at least some of the fixed blades are arranged at intervals around the rotation axis of the rotary cutting assembly.

[0011] In an optional embodiment, a cooling channel is provided between the inner and outer walls of the cutting container. The collagen particle preparation system also includes a cooling device that is connected to the cooling channel and is used to provide circulating coolant to the cooling channel.

[0012] In an optional implementation, the feed line is a curved line or a zigzag line.

[0013] In an optional embodiment, the collection device includes a discharge pipe, a suction assembly, and at least one collection container. One end of the discharge pipe is connected to the discharge port of the cutting container. The suction assembly is connected to the discharge pipe to create a negative pressure in the discharge pipe. The collection container is connected to the discharge pipe between the discharge port and the suction assembly.

[0014] In an optional embodiment, the suction assembly includes a dust collection box and an exhaust fan. The dust collection box has an air inlet and an exhaust outlet. The air inlet is connected to the discharge pipe, and the exhaust outlet is connected to the exhaust fan. A dust collection bag is installed inside the dust collection box to filter the airflow passing through the dust collection box.

[0015] The beneficial effects of the collagen particle preparation system provided in this application include:

[0016] The collagen particle preparation system provided in this application includes a feeding device, a cutting device, and a collecting device. The feeding device is connected to the cutting device via a feeding pipeline. The cutting device includes a cutting container, a rotary cutting assembly, and a driving assembly. The cutting container forms a receiving cavity, and the rotary cutting assembly is disposed within the receiving cavity. The rotary cutting assembly includes multiple cutting elements. The driving assembly drives the rotary cutting assembly to rotate so that the cutting elements cut the collagen raw material. A discharge port is formed on the side wall of the cutting container, and a filter screen is provided at the discharge port. The discharge port is connected to the collecting device, which is used to collect the collagen particles that have passed through the filter screen. The collagen particle preparation system of this application achieves the cutting and crushing of collagen raw materials through the rotation of the rotary cutting assembly, thereby obtaining collagen particles. Compared with the formation of collagen powder by grinding, the collagen particle preparation system of this application can preserve as much of the porous structure of the raw material (such as collagen sponge) as possible in the final collagen particles, giving them characteristics such as low bulk density, large specific surface area, good liquid absorption capacity, and high utilization rate. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of a collagen particle preparation system in one embodiment of this application;

[0019] Figure 2 This is a schematic diagram of the internal structure of the cutting device in one embodiment of this application.

[0020] Icons: 100-Feeding device; 110-Feeding pipeline; 111-First pipeline; 112-Second pipeline; 200-Cutting device; 210-Cylinder body; 211-Fixed blade; 212-Cooling channel; 213-Discharge port; 214-Filter screen; 220-Cover body; 230-Rotary cutting assembly; 231-Cutter disc; 232-First cutting piece; 233-Second cutting piece; 240-Drive assembly; 300-Collection device; 310-Discharge pipeline; 320-First collection container; 330-Second collection container; 340-Suction assembly; 341-Exhaust fan; 342-Dust collection box; 343-Dust collection bag; 400-Cooling device; 410-Water inlet pipeline; 420-Water outlet pipeline; 500-Support platform. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0022] Therefore, the following detailed description of the embodiments of this application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments of the application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0023] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0024] In the description of this application, it should be noted that if terms such as "upper," "lower," "inner," or "outer" are used to indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the utility model product is usually placed in during use, they are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0025] Furthermore, the terms "first" and "second" are used only to distinguish descriptions and should not be interpreted as indicating or implying relative importance.

[0026] It should be noted that, where there is no conflict, the features in the embodiments of this application can be combined with each other.

[0027] As described in the background section, related technologies use grinding and compaction to process collagen raw materials (such as collagen sponges) into collagen powder. However, this method severely damages the original porous structure of the raw material. Even if the specific surface area is increased, the surface utilization rate is reduced, the powder has a high bulk density, reduced liquid absorption capacity, and poor support effect.

[0028] Therefore, this application provides a collagen particle preparation system that uses a cutting device to cut raw materials into particles, preserving the porous structure of the raw materials as much as possible, so that the final product has low density, large specific surface area, good liquid absorption capacity, and high utilization rate.

[0029] Figure 1This is a schematic diagram of a collagen particle preparation system in one embodiment of this application; Figure 2 This is a schematic diagram of the internal structure of the cutting device 200 in one embodiment of this application. Figure 1 and Figure 2 As shown, the collagen particle preparation system provided in this application embodiment includes a feeding device 100, a cutting device 200, and a collecting device 300. The feeding device 100 is connected to the cutting device 200 through a feeding pipeline 110. The cutting device 200 includes a cutting container, a rotary cutting assembly 230, and a driving assembly 240. The cutting container forms a receiving cavity, and the rotary cutting assembly 230 is disposed within the receiving cavity. The rotary cutting assembly 230 includes multiple cutting elements. The driving assembly 240 is used to drive the rotary cutting assembly 230 to rotate so that the cutting elements cut the collagen raw material, thereby breaking the collagen raw material (such as collagen sponge) into particles. An outlet 213 is formed on the side wall of the cutting container, and a filter screen 214 is provided at the outlet 213. The outlet 213 is connected to the collecting device 300, which is used to collect the collagen particles that pass through the filter screen 214. The cutting component has a cutting edge for cutting the raw material. The collagen particle preparation system of this application can cut and break down collagen raw materials into particles by rotating the cutting component 230. When the particle size of the collagen particles is smaller than the pore size of the filter screen 214, it can pass through the filter screen 214 and be collected by the collection device 300; while particles with a particle size larger than the pore size of the filter screen 214 will remain in the cutting container for further crushing. Compared with the method of forming collagen powder by crushing and grinding, the collagen particles prepared by the system of this application can retain more of the porous structure of the raw material, thereby ensuring that the obtained collagen particles have a larger specific surface area, lower density, better liquid absorption capacity, and higher utilization rate.

[0030] Optionally, the drive assembly 240 is disposed outside the cutting container and is connected to the rotary cutting assembly 230 via an output shaft passing through the side wall of the cutting container. The drive assembly 240 includes a motor, and the output shaft is connected to the cutting container via bearings, ensuring both sealing and smooth rotation.

[0031] Optionally, the cutting container includes a cylinder 210 and a cover 220, the cover 220 being used to close the opening of the cylinder 210. The cylinder 210 and the cover 220 are detachably connected, or the cylinder 210 and the cover 220 are hinged so that the cover 220 can be flipped open or closed to open the opening of the cylinder 210. It should be noted that when the cover 220 closes the opening of the cylinder 210, a seal should be maintained between the cover 220 and the cylinder 210, for example, by adding a sealing ring or other sealing element to ensure sealing performance. The drive assembly 240 may be located on the outer bottom of the cylinder 210.

[0032] Optionally, the rotary cutting assembly 230 also includes a cutter head 231 for supporting and fixing the various cutting components. Figure 2 As shown, in this embodiment, the cutter head 231 is a circular plate and is disposed at the bottom of the receiving cavity of the cutting container. Multiple cutting elements are disposed on one side of the cutter head 231, specifically on the side of the cutter head 231 facing the opening of the receiving cavity. The cutter head 231 is connected to the drive assembly 240. The drive assembly 240 can drive the cutter head 231 to rotate, and the cutter head 231, in turn, drives the multiple cutting elements to rotate.

[0033] Optionally, each cutting element has at least two cutting edges, with the two cutting edges facing opposite directions, so that at least one cutting edge on the cutting element can cut and crush the raw material when the cutter head 231 rotates in both the forward and reverse directions. Optionally, each cutting element may have two, four, or six cutting edges.

[0034] like Figure 2 As shown, the plurality of cutting elements includes a plurality of first cutting elements 232 and a plurality of second cutting elements 233. The plurality of first cutting elements 232 are arranged at intervals around the rotation axis of the rotary cutting assembly 230, and the plurality of second cutting elements 233 are arranged at intervals around the rotation axis of the rotary cutting assembly 230. The distance between the second cutting elements 233 and the rotation axis is greater than the distance between the first cutting elements 232 and the rotation axis. By providing two rings of cutting elements on the cutter head 231, the crushing efficiency of the raw materials can be improved. In other embodiments, more rings of cutting elements can be provided.

[0035] Optionally, in the radial direction of the rotary cutting assembly 230, each first cutting element 232 is opposite to the gap between two adjacent second cutting elements 233. This arrangement makes the distribution of cutting elements more uniform, allowing the raw material in the cutting container to be cut and crushed more fully and evenly.

[0036] Optionally, the first cutting element 232 has a serrated cutting edge, and the second cutting element 233 has a straight cutting edge. By using two different cutting edge shapes, the raw materials can be crushed more thoroughly.

[0037] Optionally, a plurality of fixed blades 211 are provided on the inner wall surface of the cutting container, with at least some of the fixed blades 211 arranged at intervals around the rotation axis of the rotary cutting assembly 230. Specifically, the fixed blades 211 are disposed on the inner wall surface of the cylinder 210. It can be understood that when the rotary cutting assembly 230 rotates, the raw material will impact the side wall of the cylinder 210 under the action of centrifugal force, and the fixed blades 211 can cut and crush the raw material impacting the inner wall of the cylinder 210, thereby improving the crushing efficiency of the raw material. The fixed blades 211 of the cutting device 200 can extend along the depth direction of the cylinder 210, and the cutting edge can be tilted in the opposite direction to the rotation direction of the rotary cutting assembly 230, thereby improving the cutting effect.

[0038] Optionally, the collagen particle preparation system provided in this application embodiment further includes a cooling device 400. A cooling channel 212 is provided between the inner and outer walls of the cutting container, and the cooling device 400 is connected to the cooling channel 212, providing circulating coolant to the cooling channel 212. It should be understood that during the cutting and crushing process of the cutting device 200, a large amount of heat is generated, causing the collagen temperature to rise. Excessively high temperatures may cause collagen denaturation, resulting in the loss of its original medical value. Therefore, circulating coolant is used to cool the cutting container, remove heat in time, and prevent collagen denaturation at high temperatures. Specifically, a cooling channel 212 is provided between the inner and outer walls of the cylinder 210, and the cooling device 400 is connected to the cooling channel 212 through an inlet pipe 410 and an outlet pipe 420, thereby forming a cooling circuit. After the cooling device 400 cools the coolant (such as water), it is pumped into the cooling channel 212 through the inlet pipe 410. After absorbing heat, the coolant returns to the cooling device 400 through the outlet pipe 420 and is cooled down again, completing one cycle.

[0039] Optionally, a cooling channel 212 may also be provided inside the cover 220 to cool the cover 220. The cooling channel 212 in the cover 220 may also form a coolant circulation loop with the cooling device 400 through the water inlet pipe 410 and the water outlet pipe 420.

[0040] In this embodiment, the feeding device 100 may include a barrel and a cap. The barrel is used to contain collagen raw materials, and the cap is used to close the opening of the barrel. The cap is detachably connected to the opening of the barrel, or rotatably connected to the edge of the opening of the barrel via a hinge.

[0041] Optionally, the feeding pipe 110 is a curved or zigzag-shaped pipe to prevent raw material from splashing back into the feeding device 100 during the operation of the cutting device 200. Optionally, the feeding pipe 110 includes a first pipe 111 and a second pipe 112 connected in sequence. The first pipe 111 is connected to the feeding device 100, and the second pipe 112 is connected to the receiving cavity of the cutting container. The first pipe 111 and the second pipe 112 are arranged at an angle. For example, the first pipe 111 forms a 45° angle with the horizontal plane, and the second pipe 112 forms a 60° angle with the horizontal plane, allowing the raw material to pass through the feeding pipe 110 under its own gravity.

[0042] In this embodiment, the collecting device 300 includes a discharge pipe 310, a suction assembly 340, and at least one collecting container. One end of the discharge pipe 310 is connected to the discharge port 213 of the cutting container. The suction assembly 340 is connected to the discharge pipe 310 and is used to create a negative pressure in the discharge pipe 310. The collecting container is connected to the discharge pipe 310 between the discharge port 213 and the suction assembly 340. Figure 1 As shown, optionally, the collection device 300 includes a first collection container 320 and a second collection container 330. Along the airflow conveying path, the first collection container 320 is located upstream of the second collection container 330, while the suction component 340 is located at the downstream end. By setting the suction component 340, airflow can be generated by negative pressure to guide the movement of collagen particles, allowing them to enter the collection container from the outlet 213. It can be understood that the smaller the particles, the stronger their ability to move with the airflow. Therefore, the particle size of the collagen particles collected by the first collection container 320 is generally larger than that of the collagen particles collected by the second collection container. By distributing multiple collection containers along the upstream to downstream direction, the collagen particles can be classified by particle size.

[0043] Optionally, the suction assembly 340 includes a dust collection box 342 and an induced draft fan 341. The dust collection box 342 has an air inlet and an exhaust outlet. The air inlet is connected to the discharge pipe 310, and the exhaust outlet is connected to the induced draft fan 341. A dust collection bag 343 is installed inside the dust collection box 342 to filter the airflow passing through it. Since excessive dust may adversely affect the reliability of the induced draft fan 341, the dust collection box 342 and dust collection bag 343 are provided to intercept collagen dust within the dust collection bag 343, thereby preventing dust from entering the induced draft fan 341 and causing adverse effects. Furthermore, the dust collection box 342 also prevents dust from entering the environment and causing environmental pollution. Specifically, the opening of the dust bag 343 can be placed over the air inlet of the dust collection box 342 to ensure that all dust can enter the dust bag 343.

[0044] Optionally, the collagen particle preparation system further includes a support platform 500 for supporting at least one of the feeding device 100, the cutting device 200, the collecting device 300, and the cooling device 400.

[0045] A specific method of using the collagen particle preparation system provided in this application embodiment is as follows:

[0046] After the collagen sponge sheet to be cut is loaded into the feeding device 100, it enters the cutting container of the cutting device 200 through the two-stage feeding pipeline 110. The rotary cutting component 230 rotates under the drive component 240, and the raw material is turned into smaller and smaller particles by the airflow generated by the rotation of the cutter disc 231 and the repeated impact and cutting action of the cutting piece and the fixed blade 211 in the receiving cavity. When the cut collagen reaches a certain fineness, the collagen particles smaller than the pore size of the filter screen 214 pass through the filter screen 214 and enter the discharge pipeline 310 under the action of centrifugal force and the negative pressure generated by the blower 341. The first collection container 320 and the second collection container 330 connected to the discharge pipeline 310 can collect most of the collagen particles, while the dust collection box 342 and the dust collection bag 343 collect collagen powder with extremely small particle size.

[0047] It is important to note that, considering collagen is a bioactive protein, the processing temperature should not be too high, otherwise it may cause protein denaturation and loss of the material's viability. Since the equipment generates heat during high-speed rotating cutting, a cooling device 400 is required to circulate coolant (e.g., coolant at 4–20°C) into the cooling channel 212 to ensure that the material temperature does not become too high.

[0048] The collagen particle preparation system provided in this application embodiment processes collagen sponges into collagen particles through cutting, preserving as much of the porous structure of the collagen sponge as possible. This results in particles with low density, large specific surface area, good liquid absorption capacity, and high utilization rate. Furthermore, the inclusion of a cooling device 400 ensures operation at a lower temperature, maintaining the bioactivity of the collagen and preventing protein denaturation. The preparation system of this application embodiment is simple to operate, has high processing efficiency, and can be applied to large-scale production.

[0049] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application.

Claims

1. A collagen particle preparation system, characterized in that, The device includes a feeding device, a cutting device, and a collecting device. The feeding device is connected to the cutting device via a feeding pipeline. The cutting device includes a cutting container, a rotary cutting assembly, and a driving assembly. The cutting container forms a receiving cavity, and the rotary cutting assembly is disposed within the receiving cavity. The rotary cutting assembly includes multiple cutting elements. The driving assembly drives the rotary cutting assembly to rotate so that the cutting elements cut the collagen raw material. A discharge port is formed on the side wall of the cutting container, and a filter screen is provided at the discharge port. The discharge port is connected to the collecting device, which collects the collagen particles that pass through the filter screen.

2. The collagen particle preparation system according to claim 1, characterized in that, The rotary cutting assembly also includes a cutter head, and a plurality of the cutting elements are disposed on one side of the cutter head. The cutter head is connected to the drive assembly for transmission.

3. The collagen particle preparation system according to claim 1, characterized in that, The plurality of cutting elements includes a plurality of first cutting elements and a plurality of second cutting elements. The plurality of first cutting elements are arranged at intervals around the rotation axis of the rotary cutting assembly, and the plurality of second cutting elements are arranged at intervals around the rotation axis of the rotary cutting assembly. The distance between the second cutting elements and the rotation axis is greater than the distance between the first cutting elements and the rotation axis.

4. The collagen particle preparation system according to claim 3, characterized in that, In the radial direction of the rotary cutting assembly, each of the first cutting elements is opposite the gap between two adjacent second cutting elements.

5. The collagen particle preparation system according to claim 3, characterized in that, The first cutting element has a serrated cutting edge, and the second cutting element has a straight cutting edge.

6. The collagen particle preparation system according to claim 1, characterized in that, The inner wall of the cutting container is provided with a plurality of fixed blades, at least some of which are arranged at intervals around the rotation axis of the rotary cutting assembly.

7. The collagen particle preparation system according to any one of claims 1-6, characterized in that, A cooling channel is provided between the inner and outer walls of the cutting container. The collagen particle preparation system also includes a cooling device, which is connected to the cooling channel and is used to provide circulating coolant to the cooling channel.

8. The collagen particle preparation system according to any one of claims 1-6, characterized in that, The feeding pipeline is a curved pipeline or a zigzag pipeline.

9. The collagen particle preparation system according to any one of claims 1-6, characterized in that, The collecting device includes a discharge pipe, a suction assembly, and at least one collecting container. One end of the discharge pipe is connected to the discharge port of the cutting container. The suction assembly is connected to the discharge pipe and is used to create a negative pressure in the discharge pipe. The collecting container is connected to the discharge pipe between the discharge port and the suction assembly.

10. The collagen particle preparation system according to claim 9, characterized in that, The suction assembly includes a dust collection box and an exhaust fan. The dust collection box has an air inlet and an exhaust outlet. The air inlet is connected to the discharge pipe, and the exhaust outlet is connected to the exhaust fan. A dust collection bag is installed inside the dust collection box to filter the airflow passing through the dust collection box.

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