Cell culture bag harvesting device

Abstract

The utility model provides a cell culture bag harvesting device which comprises a supporting table and supporting seats symmetrically arranged on the supporting table, a tray is rotationally connected between the supporting seats through torsional springs, two symmetrically-arranged movable plates are arranged on one side of the tray, movable rods are fixed to the bottoms of the movable plates, through holes corresponding to the movable rods are formed in the supporting table, and the supporting seats are arranged on the supporting table. One end of the movable rod is vertically and slidably arranged in the through hole, and the movable rod is connected with the through hole through a first reset spring; limiting frames are fixedly arranged on the movable plates, limiting discs are movably arranged in the limiting frames, extrusion rollers are fixed between the two limiting discs, rotating gears are coaxially fixed to the sides, away from the extrusion rollers, of the limiting discs, hand-cranking wheels are coaxially fixed to one sides of the rotating gears, and rack plates correspondingly meshed with the rotating gears are fixedly arranged on one sides of the limiting frames. According to the extrusion device for the cell suspension, the labor intensity is greatly reduced, and meanwhile, the extrusion amount of the cell suspension can be quantitatively controlled.

Description

Technical Field

[0001] This utility model belongs to the technical field of cell culture auxiliary tools, and specifically relates to a cell culture bag harvesting device. Background Technology

[0002] When harvesting cells cultured in cell culture bags, technicians need to lift the cell culture bags to create a height difference in the liquid level, and then pour out the cell suspension inside the bags for harvesting. Harvesting a single cell suspension requires holding the cell culture bag in the air for a long time, which increases the labor intensity and causes hand soreness. Moreover, during the harvesting process, cells need to be harvested in accordance with the quantity, and lifting and pouring the cell suspension by hand can easily lead to over-pouring. Utility Model Content

[0003] To address the aforementioned technical problems, this invention provides a cell culture bag harvesting device to solve the problems described in the background section.

[0004] This utility model provides the following technical solution: a cell culture bag harvesting device, including a support platform and support seats symmetrically arranged on the support platform. A tray is rotatably connected between the support seats by a torsion spring. Two symmetrically arranged movable plates are provided on one side of the tray. A movable rod is fixed at the bottom of the movable plate. A through hole corresponding to the movable rod is provided on the support platform. One end of the movable rod is vertically slidably disposed in the through hole. The movable rod is connected to the through hole by a first return spring.

[0005] A limiting frame is fixedly provided on the movable plate, and a limiting plate is movably provided inside the limiting frame. A squeezing roller is fixed between the two limiting plates. A rotating gear is coaxially fixed on the side of the limiting plate away from the squeezing roller. A hand crank is coaxially fixed on one side of the rotating gear. A rack plate is fixed on one side of the limiting frame and meshes with the rotating gear. In the initial state, the side of the tray away from the squeezing roller is tilted downward.

[0006] Compared with the prior art, the beneficial effects of this application are as follows: When using this application, the cell culture bag is placed on a tray, and the culture bag tubing connected to the cell culture bag passes through the bottom of the squeezing roller. When it is necessary to squeeze out the cell suspension in the cell culture bag, the squeezing roller can be squeezed against the culture bag tubing by pressing the movable plate. Then, by rotating the squeezing roller, the squeezing roller rolls on the culture bag tubing under the meshing action of the rotating gear and the rack plate, thereby squeezing out the cell suspension in the cell culture bag. This replaces the traditional method of hanging and pouring out, greatly reducing labor intensity, and at the same time, it can quantitatively control the amount of cell suspension squeezed out.

[0007] Preferably, an elastic corner pad is fixedly provided at the bottom corner of the support platform.

[0008] Preferably, the tray is symmetrically fixed with fixed clamps, the fixed clamps are symmetrically fixed with threaded rods, and the threaded rods are vertically slidably provided with movable clamps.

[0009] Preferably, a rotating ring is threaded onto the threaded rod, and the rotating ring is located below the movable clamping plate.

[0010] Preferably, a pressing rod is provided on one side of the tray, the pressing rod is vertically slidably disposed on the support platform, and the pressing rod is connected to the support platform through a second return spring.

[0011] Preferably, the pressing rod is fixedly provided with a squeezing roller plate and a tray plate, the tray plate being disposed above the tray, and the squeezing roller plate being disposed above the movable plate.

[0012] Preferably, the limiting frame is provided with a limiting groove that allows the limiting disk to move. Attached Figure Description

[0013] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 A perspective view of the cell culture bag harvesting device provided in an embodiment of this utility model;

[0015] Figure 2 A detailed structural diagram of the tray provided in this embodiment of the utility model;

[0016] Figure 3 A detailed structural diagram of the extrusion roller provided in an embodiment of this utility model.

[0017] Explanation of reference numerals in the attached figures:

[0018]

[0019]

[0020] The present invention will be further described below with reference to the accompanying drawings and description. Detailed Implementation

[0021] The embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the embodiments of the present invention, and should not be construed as limiting the present invention.

[0022] In the description of the embodiments of this utility model, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing the embodiments of this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0023] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of embodiments of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0024] In this embodiment of the invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this embodiment of the invention according to the specific circumstances.

[0025] In one embodiment of this utility model, such as Figure 1 As shown, a cell culture bag harvesting device includes a support platform 1 and support seats 4 symmetrically arranged on the support platform 1. A tray 3 is rotatably connected between the support seats 4 via a torsion spring 9. Two symmetrically arranged movable plates 6 are provided on one side of the tray 3. A movable rod 21 is fixed at the bottom of the movable plate 6. A through hole 16 corresponding to the movable rod 21 is provided on the support platform 1. One end of the movable rod 21 is vertically slidably disposed in the through hole 16. The movable rod 21 is connected to the through hole 16 via a first return spring 22.

[0026] like Figure 2As shown, specifically, the support platform 1 is a square platform-shaped structure. Two opposing support seats 4 are symmetrically arranged on the support platform 1. A tray 3 is rotatably arranged between the two support seats 4. The tray 3 is rotatably connected to the support seats 4 via a movable shaft, and a torsion spring 9 is provided on the movable shaft. Under the elastic force of the torsion spring 9, the side of the tray 3 away from the squeezing roller 8 is tilted downward. That is, in the initial state, the side of the tray 3 away from the squeezing roller 8 is tilted downward. The tray 3 itself is a concave plate-shaped structure to place the cell culture bag. Before collecting the cell suspension, the cell culture bag needs to be placed in the tray 3, and a culture bag hose is led out from the side of the cell culture bag near the squeezing roller 8. The culture bag hose is used to output the cell suspension in the cell culture bag, and the culture bag hose passes under the squeezing roller 8. There is a notch on one side of the tray 3 for the culture bag hose to lead out.

[0027] like Figure 3 As shown, a limiting frame 7 is fixedly provided on the movable plate 6, a limiting disk 19 is movably provided in the limiting frame 7, a squeezing roller 8 is fixed between the two limiting disks 19, a rotating gear 17 is coaxially fixed on the side of the limiting disk 19 away from the squeezing roller 8, a hand crank 18 is coaxially fixed on the side of the rotating gear 17, and a rack plate 24 is fixed on the side of the limiting frame 7 that meshes with the rotating gear 17. In the initial state, the side of the tray 3 away from the squeezing roller 8 is tilted downwards.

[0028] Specifically, during the actual harvesting of cell suspension, the movable plate 6 is lifted by the elastic force of the first reset spring 22. At this time, the squeezing roller 8 is not in contact with the culture bag tubing. Then, by pressing the movable plate 6, the squeezing roller 8 is brought into contact with the culture bag tubing and squeezed. The squeezing roller 8 can then be rotated by turning the handwheel 18. Since the handwheel 18 is coaxially fixed with a rotating gear 17, and a rack plate 24 meshes with it below the rotating gear 17, the squeezing roller 8 can be moved laterally by the meshing of the rotating gear 17 and the rack plate 24. Therefore, the movement of the squeezing roller 8 is rolling. Thus, the cell suspension in the culture bag tubing is squeezed out by the rolling and squeezing of the squeezing roller 8, thereby achieving quantitative collection of cell suspension and greatly reducing labor intensity. After the cell suspension is squeezed, the squeezing roller 8 can be moved upward by the elastic force of the first reset spring 22 to disengage it from the culture bag tubing. Then, the handwheel 18 is turned to reset the squeezing roller 8 for the next squeezing process of cell suspension.

[0029] It should be noted that, in the initial state, the side of the tray 3 furthest from the extrusion roller 8 is tilted downwards. Therefore, in the initial state, the cell culture bag on the tray 3 is in a left-low-right-high position, and the culture bag tubing is located on the right side of the cell culture bag. Thus, in the initial state, the cell suspension in the cell culture bag will not be output through the culture bag tubing. However, when it is necessary to output the cell suspension, the side of the tray 3 closest to the extrusion roller 8 can be pressed to make the cell culture bag in a left-high-right-low position, at which time the cell suspension in the cell culture bag can be output. Therefore, by controlling the tilt direction of the tray 3, the extrusion process of the cell suspension can be freely controlled, and the output amount of the cell suspension can be quantitatively controlled.

[0030] In this embodiment, an elastic corner pad 2 is fixedly provided at the bottom corner of the support platform 1;

[0031] Specifically, the stability of the support platform 1 can be improved by setting up elastic corner pads 2.

[0032] In this embodiment, a fixed clamping plate 10 is symmetrically fixed on the tray 3, a threaded rod 12 is symmetrically fixed on the fixed clamping plate 10, and a movable clamping plate 11 is vertically slidably provided on the threaded rod 12.

[0033] In this embodiment, a rotating ring 13 is threadedly connected to the threaded rod 12, and the rotating ring 13 is located below the movable clamping plate 11;

[0034] Specifically, in actual operation, the two sides of the cell culture bag can be placed between the movable clamp 11 and the fixed clamp 10. Then, by twisting the rotating ring 13, the movable clamp 11 is moved closer to the fixed clamp 10, thereby fixing the cell culture bag through the fixed clamp 10 and the movable clamp 11, preventing the cell culture bag from moving during the extrusion of the cell suspension, and ensuring the stability of the cell culture bag.

[0035] In this embodiment, a pressing rod 5 is provided on one side of the tray 3. The pressing rod 5 is vertically slidably disposed on the support platform 1. The pressing rod 5 is connected to the support platform 1 through a second return spring 23.

[0036] In this embodiment, the pressing rod 5 is fixedly provided with a squeezing roller plate 14 and a tray plate 15. The tray plate 15 is correspondingly arranged above the tray 3, and the squeezing roller plate 14 is correspondingly arranged above the movable plate 6.

[0037] Specifically, a movable hole is provided on the support platform 1. One end of the pressing rod 5 extends into the movable hole, and the end of the pressing rod 5 extending into the movable hole is connected to the bottom of the movable hole through the second return spring 23. The squeezing roller plate 14 is set above the movable plate 6, and the tray plate 15 is set above the tray 3. The tray plate 15 is set above the tray 3 on the side closer to the squeezing roller 3. When the pressing rod 5 is pressed, the squeezing roller plate 14 can drive the movable plate 6 to move towards the upper surface of the support platform 1 until it touches the culture bag tube. The tray plate 15 can be used to drive the side of the tray 3 close to the squeezing roller 8 to tilt downwards, ensuring that the cell suspension in the cell culture bag can be output through the culture bag tube. The initial distance between the tray plate 15 and the tray 3, the shape and size of the tray plate 15, the initial distance between the squeezing roller plate 14 and the movable plate 6, and the shape and size of the squeezing roller plate 14 can be set according to the actual situation. At the same time, the actual shape of the pressing rod 5 can also be set according to the actual situation. For example, to avoid the pressing rod 5 from rotating, the pressing rod 5 can be set as a columnar structure.

[0038] In this embodiment, the limiting frame 7 is provided with a limiting groove 20 that allows the limiting disk 19 to move;

[0039] Specifically, by setting the limiting groove 20, the limiting disk 19 can be prevented from lateral displacement when the rotating gear 17 rotates, thus ensuring that the extrusion roller 8 can roll in the preset direction without deviation.

[0040] In summary, the cell culture bag harvesting device in the above embodiments of this utility model, when used in this application, places the cell culture bag on the tray 3 and passes the culture bag tubing connected to the cell culture bag through the bottom of the squeeze roller 8. When it is necessary to squeeze out the cell suspension in the cell culture bag, the squeeze roller 8 can be squeezed against the culture bag tubing by pressing the movable plate 6. Then, by rotating the squeeze roller 8, under the meshing action of the rotating gear 17 and the rack plate 24, the squeeze roller 8 rolls on the culture bag tubing, thereby squeezing out the cell suspension in the cell culture bag, replacing the traditional method of hanging and pouring out, greatly reducing labor intensity, and at the same time, it can quantitatively control the amount of cell suspension squeezed out.

[0041] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A cell culture bag harvesting device, characterized in that, It includes a support platform and support seats symmetrically arranged on the support platform. The support seats are rotatably connected to a tray by a torsion spring. Two symmetrically arranged movable plates are provided on one side of the tray. Movable rods are fixed at the bottom of the movable plates. The support platform is provided with through holes corresponding to the movable rods. One end of the movable rod is vertically slidably disposed in the through hole. The movable rod is connected to the through hole by a first return spring. A limiting frame is fixedly provided on the movable plate, and a limiting plate is movably provided inside the limiting frame. A squeezing roller is fixed between the two limiting plates. A rotating gear is coaxially fixed on the side of the limiting plate away from the squeezing roller. A hand crank is coaxially fixed on one side of the rotating gear. A rack plate is fixed on one side of the limiting frame and meshes with the rotating gear. In the initial state, the side of the tray away from the squeezing roller is tilted downward.

2. The cell culture bag harvesting device according to claim 1, characterized in that, An elastic corner pad is fixed at the bottom corner of the support platform.

3. The cell culture bag harvesting device according to claim 1, characterized in that, The tray is symmetrically fixed with fixed clamps, and the fixed clamps are symmetrically fixed with threaded rods. The threaded rods are vertically slidably equipped with movable clamps.

4. The cell culture bag harvesting device according to claim 3, characterized in that, A rotating ring is threaded onto the threaded rod, and the rotating ring is located below the movable clamping plate.

5. The cell culture bag harvesting device according to claim 1, characterized in that, A pressing rod is provided on one side of the tray. The pressing rod is vertically slidably mounted on the support platform. The pressing rod is connected to the support platform through a second return spring.

6. The cell culture bag harvesting device according to claim 5, characterized in that, The pressing rod is fixedly equipped with an extrusion roller plate and a tray plate. The tray plate is positioned above the tray, and the extrusion roller plate is positioned above the movable plate.

7. The cell culture bag harvesting device according to claim 1, characterized in that, The limiting frame is provided with a limiting groove that allows the limiting plate to move.

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