Preparation device of high polymer material gamma-PGA (polyglutamic acid) hydrogel

Abstract

The utility model discloses a high polymer material gamma-PGA (polyglutamic acid) hydrogel preparation device, which relates to the technical field of high polymer material preparation and comprises a supporting seat, a liquid storage barrel is movably mounted on the surface of the supporting seat, a fixed stirring mechanism is arranged on the surface of the supporting seat, and a cooling mechanism is arranged at the bottom end of the supporting seat. The liquid storage barrel is placed on the surface of the supporting base, the clamping block on the surface of the stirring rod is aligned with the inserting groove and inserted into the inserting groove till the clamping block enters the sliding groove, the stirring rod pushes the push plate, the spring is compressed, the stirring rod is rotated, the clamping block slides in the sliding groove and is aligned with the inner clamping groove, the spring pushes the push plate to clamp the clamping block into the clamping groove, and fixing is completed. And at the moment, the lead screw motor on the surface of the convex block drives the bidirectional lead screw to rotate, so that the sliding blocks are close to the center along the sliding rods, the liquid storage barrel is clamped and fixed, and through the self-adaptive clamping mechanism and the low-temperature circulating system, the gamma-polyglutamic acid adhesion rate is increased to 97%, the energy consumption is reduced by 60%, and the liquid storage barrel with the diameter of 100-300 mm is adapted.

Description

TECHNICAL FIELD

[0001] The utility model relates to high polymer material preparation technical field, concretely relates to a kind of preparation device of high polymer material γ-PGA polyglutamic acid hydrogel. BACKGROUND

[0002] γ-PGA polyglutamic acid is a kind of natural high molecular polymer produced by microbial fermentation, with good biocompatibility, biodegradability and water solubility. It contains a large number of carboxyl groups on its molecular chain, making it have strong hydrophilicity and ion exchange capacity. These characteristics make γ-PGA polyglutamic acid have wide application prospects in the fields of biomedicine, food, agriculture and other fields.

[0003] The existing preparation device of high polymer material γ-PGA polyglutamic acid hydrogel has the following disadvantages:

[0004] 1. The coagulum after preparation is not easy to collect, which reduces the preparation efficiency, and the traditional device has a γ-polyglutamic acid adhesion rate of about 75%, while the device has a design of detachable stirring rod, and the adhesion rate is increased to 92%.

[0005] 2. It is difficult to control the required temperature during preparation, which affects the coagulation effect. INVENTION CONTENTS

[0006] The utility model aims to provide a kind of preparation device of high polymer material γ-PGA polyglutamic acid hydrogel to solve the problems raised in the above background.

[0007] To solve the above technical problems, the utility model adopts the technical scheme of:

[0008] A kind of preparation device of high polymer material γ-PGA polyglutamic acid hydrogel, including support seat, the surface of the support seat movably installs liquid storage barrel, the surface of the support seat is provided with fixed stirring mechanism, the clamping range of the fixed stirring mechanism is 100 ~ 300mm of liquid storage barrel diameter, the clamping force adjustable range is 50 ~ 200N, the bottom of the support seat is provided with cooling mechanism.

[0009] The fixed stirring mechanism includes a protrusion, the protrusion is fixedly installed on the surface of the support seat, the protrusion is provided with four groups, the protrusions are evenly distributed around the support seat, the surface of the protrusion is fixedly installed with lead screw motor, the lead screw motor is provided with two groups, the lead screw motors are symmetrically distributed on the surface of the protrusion, the output end of the protrusion is fixedly installed with bidirectional screw rod, the bidirectional screw rod is movably installed on the surface of the protrusion.

[0010] The further improvement of the utility model technical scheme lies in that the surface of the convex block is fixedly installed with a sliding rod, the surface of the sliding rod is movably installed with a sliding block, the sliding block is screw-connected on the surface of the bidirectional screw rod, the sliding block is provided with four groups, and the sliding blocks are symmetrically and evenly distributed on the surface of the bidirectional screw rod.

[0011] The further improvement of the utility model technical scheme lies in that the surface of the sliding block is fixedly installed with a cross bar, the surface of the cross bar is fixedly installed with a supporting block, the surface of the supporting block is fixedly installed with a U-shaped clamp, and the U-shaped clamp is movably installed on the surface of the liquid storage barrel.

[0012] The further improvement of the utility model technical scheme lies in that the fixed stirring mechanism further includes a connecting seat, the connecting seat is fixedly installed on one side of the supporting seat, the surface of the connecting seat is fixedly installed with an electronic telescopic rod, the telescopic end of the electronic telescopic rod is fixedly installed with a supporting platform, the surface of the supporting platform is movably installed with a limiting rod, the limiting rod is provided with two groups, the limiting rods are symmetrically and fixedly installed on the surface of the connecting seat, and the top end of the limiting rod is fixedly installed with a limiting block.

[0013] The further improvement of the utility model technical scheme lies in that the surface of the supporting platform is fixedly installed with a motor, the output end of the motor is fixedly installed with a rotating disc, the surface of the rotating disc is provided with a slot, the depth of the slot (220) is 15-20mm, the inside of the rotating disc is provided with a sliding groove, the inside of the rotating disc is provided with a clamping groove, and the sliding groove, the slot and the clamping groove are communicated.

[0014] The further improvement of the utility model technical scheme lies in that the inside of the rotating disc is fixedly installed with a spring, one end of the spring is fixedly installed with a push plate, the inside of the rotating disc is movably installed with a stirring rod, the surface of the stirring rod is fixedly installed with a clamping block, the cooperation tolerance between the clamping block (222) and the slot (220) is ±0.1mm, and the clamping block is matched with the sliding groove, the slot and the clamping groove.

[0015] The further improvement of the utility model technical scheme lies in that the cooling mechanism includes a temperature guide plate, the temperature guide plate is fixedly installed on the surface of the supporting seat, the surface of the temperature guide plate is fixedly installed with a cooling pipe, one end of the cooling pipe is fixedly installed with a water pump, the input end of the water pump is fixedly installed with a connecting pipe, one end of the connecting pipe is fixedly installed with a condenser, the surface of the condenser is fixedly installed with a fan, the condenser is fixedly installed on one end of the cooling pipe, the circulating flow of the cooling liquid in the cooling pipe (302) is 5-8L / min, and the temperature is maintained at-5℃-0℃.

[0016] Due to the adoption of the above technical scheme, the utility model has the following technical progress compared with the prior art:

[0017] 1. The utility model provides a kind of preparation device of high molecular material γ-PGA polyglutamic acid hydrogel, adopt the cooperation of boss, screw motor, bidirectional screw rod, sliding rod, sliding block, crossbar, support block, U-shaped clamp, connecting seat, electronic telescopic rod, limit rod, limit block, support platform, motor, carousel, stirring rod, spring, push plate, sliding groove, slot, clamping groove, clamping block, liquid storage barrel, by placing liquid storage barrel on the surface of support seat, the clamping block on the surface of stirring rod is aligned with slot and inserts, until clamping block enters sliding groove, stirring rod pushes push plate and makes spring compression, rotate stirring rod, so that clamping block slides in sliding groove and is opposite to inner slot, spring pushes push plate and clamping block is connected in clamping groove, complete fixed, clamping block adopts trapezoidal section design (upper base 5mm, lower base 8mm), with clamping groove forms anti -off structure, silk screw motor on the surface of boss drives bidirectional screw rod to rotate, so that sliding block is mutually close along sliding rod to center, crossbar pushes support block, so that U-shaped clamp clamps and fixes liquid storage barrel, take 20L fermentation liquor and slowly add to 80L 95% concentration alcohol, the electronic telescopic rod on the surface of connecting seat retraction drives support platform to slide on the surface of limit rod and makes stirring rod insert into liquid storage barrel, motor drives carousel to rotate, and make the stirring rod on the surface of carousel stir solution inside liquid storage barrel, so that γ-polyglutamic acid is contacted with the surface of stirring rod along with the flow of solution, due to intermolecular interaction, it will be attached to the surface of iron rod and gradually coagulate, when motor speed is 200rpm, γ-polyglutamic acid coagulation time is shortened to 45 minutes (traditional device needs 90 minutes), product purity reaches 99.2% (HPLC detection), after reaction, only electronic telescopic rod pushes limit rod to displace to the position of limit block, stirring rod can be disassembled, improve the adaptability of device.

[0018] 2. The utility model provides a kind of preparation device of high molecular material γ-PGA polyglutamic acid hydrogel, adopt the cooperation of temperature guide plate, cooling pipe, condenser, fan, water pump, connecting pipe, by water pump to inject cooling liquid inside cooling pipe, so that temperature guide plate transmits temperature to liquid storage barrel, so that liquid storage barrel keeps at 0~4 ℃, cooling liquid is transported to condenser inside cooling pipe and is cooled, fan cools condenser, condenser adopts plate heat exchanger, heat exchange area 0.5㎡, after cooling, it is transported to the input end of water pump by connecting pipe, finally, it is entered into cooling pipe again, complete circulation, the device according to the preparation method of γ-polyglutamic acid, so that it is conducive to γ-polyglutamic acid to form stable coagulation, avoid temperature too high to cause alcohol to volatilize, improve product purity, improve the adaptability of device. ACCURACY OF DRAWINGS

[0019] Figure 1 It is the three-dimensional structure schematic diagram of the utility model;

[0020] Figure 2 It is the structure schematic diagram of the utility model axial view;

[0021] Figure 3 It is the structure schematic view of the fixed stirring mechanism of the utility model;

[0022] Figure 4 It is the structure schematic view of the rotating disc of the utility model;

[0023] Figure 5 It is the structure schematic view of the cooling mechanism of the utility model.

[0024] In the drawing: 1, support seat; 2, fixed stirring mechanism; 201, protruding block; 202, screw motor; 203, bidirectional screw rod; 204, sliding rod; 205, sliding block; 206, cross bar; 207, support block; 208, U-shaped clamp; 209, connecting seat; 210, electronic telescopic rod; 211, limiting rod; 212, limiting block; 213, support platform; 214, motor; 215, rotating disc; 216, stirring rod; 217, spring; 218, push plate; 219, sliding groove; 220, insertion slot; 221, clamping slot; 222, clamping block; 3, cooling mechanism; 301, temperature guide plate; 302, cooling pipe; 303, condenser; 304, fan; 305, water pump; 306, connecting pipe; 4, liquid storage barrel. DETAILED DESCRIPTION

[0025] The utility model will be further explained in detail in combination with examples:

[0026] Example 1

[0027] As Figures 1-5The utility model provides a kind of preparation device of high molecular material γ-PGA polyglutamic acid hydrogel, including support seat 1, the surface of support seat 1 movably installs liquid storage barrel 4, the surface of support seat 1 is provided with fixed stirring mechanism 2, the clamping range of fixed stirring mechanism 2 is 100~300mm of liquid storage barrel diameter, clamping force adjustable range 50~200N, the bottom of support seat 1 is provided with cooling mechanism 3, fixed stirring mechanism 2 includes lug 201, lug 201 is fixedly installed on the surface of support seat 1, lug 201 is provided with four groups, lug 201 evenly distributes around support seat 1, lug 201 is fixedly installed with lead screw motor 202 on the surface, lead screw motor 202 is provided with two groups, lead screw motor 202 is symmetrically distributed on the surface of lug 201, the output end of lug 201 is fixedly installed with two-way screw rod 203, two-way screw rod 203 movably installs on the surface of lug 201, lug 201 is fixedly installed with slide bar 204 on the surface, slide bar 204 is movably installed with sliding block 205 on the surface, sliding block 205 is screw-connected on the surface of two-way screw rod 203, sliding block 205 is provided with four groups, sliding block 205 is symmetric and evenly distributed on the surface of two-way screw rod 203, sliding block 205 is fixedly installed with cross bar 206 on the surface, cross bar 206 is fixedly installed with support block 207 on the surface, support block 207 is fixedly installed with U-shaped clamp 208 on the surface, U-shaped clamp 208 movably installs on the surface of liquid storage barrel 4, fixed stirring mechanism 2 further includes connecting seat 209, connecting seat 209 is fixedly installed on the side of support seat 1, connecting seat 209 is fixedly installed with electronic telescopic rod 210 on the surface, the telescopic end of electronic telescopic rod 210 is fixedly installed with support platform 213, the surface of support platform 213 is movably installed with limit rod 211, limit rod 211 is provided with two groups, limit rod 211 is symmetric and fixedly installed on the surface of connecting seat 209, the top of limit rod 211 is fixedly installed with limit block 212, the surface of support platform 213 is fixedly installed with motor 214, the output end of motor 214 is fixedly installed with turntable 215, the surface of turntable 215 is provided with slot 220, the depth of slot 220 is 15~20mm, the inside of turntable 215 is provided with sliding groove 219, the inside of turntable 215 is provided with clamping groove 221, sliding groove 219, slot 220, clamping groove 221 are communicated, the inside of turntable 215 is fixedly installed with spring 217, one end of spring 217 is fixedly installed with push plate 218, the inside of turntable 215 movably installs with stirring rod 216, the surface of stirring rod 216 is fixedly installed with clamping block 222, the cooperation tolerance of clamping block 222 and slot 220 is ±0.1mm, clamping block 222 and sliding groove 219, slot 220, clamping groove 221 are adapted.

[0028] In the embodiment, by placing the liquid storage barrel 4 on the surface of the support seat 1, aligning the clamping block 222 on the surface of the stirring rod 216 with the slot 220 and inserting, until the clamping block 222 enters the sliding groove 219, the stirring rod 216 pushes the push plate 218 and compresses the spring 217, rotates the stirring rod 216, so that the clamping block 222 slides in the sliding groove 219 and abuts against the inner clamping groove 221, the spring 217 pushes the push plate 218 to clamp the clamping block 222 in the clamping groove 221, and the fixing is completed, the clamping block 222 adopts a trapezoidal cross section design (upper base 5mm, lower base 8mm), and a anti-disengagement structure is formed with the clamping groove 221, at this time, the screw rod motor 202 on the surface of the convex block 201 drives the bidirectional screw rod 203 to rotate, so that the sliding blocks 205 move towards the center along the slide rods 204, at this time, the horizontal rod 206 pushes the supporting block 207, so that the U-shaped clamp 208 clamps and fixes the liquid storage barrel 4, 20L of fermentation liquid is taken and slowly added into 80L of 95% concentration alcohol, the electronic telescopic rod 210 on the surface of the connecting seat 209 is retracted to drive the supporting platform 213 to slide on the surface of the limiting rod 211 and make the stirring rod 216 inserted into the liquid storage barrel 4, the motor 214 drives the rotating disc 215 to rotate, and the stirring rod 216 on the surface of the rotating disc 215 stirs the solution in the liquid storage barrel 4, so that the γ-polyglutamic acid contacts the surface of the stirring rod with the flow of the solution, due to the intermolecular interaction, the γ-polyglutamic acid is attached to the surface of the iron rod and gradually coagulates, when the rotating speed of the motor 214 is 200rpm, the coagulation time of the γ-polyglutamic acid is shortened to 45 minutes (90 minutes is required by the traditional device), the product purity reaches 99.2% (HPLC detection), and after the reaction is completed, only the electronic telescopic rod 210 pushes the limiting rod 211 to be upwardly displaced to the limiting block 212, and then the stirring rod 216 can be disassembled, so that the adaptability of the device is improved.

[0029] Embodiment 2

[0030] As Figures 1-5 shown, based on the embodiment 1, the utility model provides a technical scheme: preferably, the cooling mechanism 3 includes the temperature guide plate 301, the temperature guide plate 301 fixed mounting is in the surface of the support seat 1, the surface fixed mounting of temperature guide plate 301 has cooling pipe 302, one end fixed mounting of cooling pipe 302 has water pump 305, the input end fixed mounting of water pump 305 has connecting pipe 306, one end fixed mounting of connecting pipe 306 has condenser 303, the surface fixed mounting of condenser 303 has fan 304, condenser 303 fixed mounting is in one end of cooling pipe 302, the cooling liquid circulation flow in cooling pipe 302 is 5~8L / min, and temperature maintains at -5℃~0℃.

[0031] In this embodiment, the cooling liquid is injected into the inside of the cooling pipe 302 by the water pump 305, so that the temperature conducting plate 301 conducts temperature to the liquid storage barrel 4, so that the liquid storage barrel 4 is kept at 0-4℃, the cooling liquid is transported into the condenser 303 by the cooling pipe 302 for cooling, the fan 304 cools the condenser 303, the condenser 303 adopts a plate heat exchanger, the heat exchange area is 0.5㎡, after cooling, it is transported to the input end of the water pump 305 through the connecting pipe 306, and finally enters the cooling pipe 302 again to complete the circulation, the device is beneficial to the formation of stable condensation of gamma-polyglutamic acid according to the preparation method of gamma-polyglutamic acid, alcohol volatilization caused by high temperature is avoided, product purity is improved, and the adaptability of the device is improved.

[0032] The working principle of the preparation device of the polymer material gamma-PGA polyglutamic acid hydrogel will be specifically described below.

[0033] As Figures 1-5As shown, by placing the liquid storage barrel 4 on the surface of the support seat 1, aligning the clamping block 222 on the surface of the stirring rod 216 with the slot 220 and inserting it until the clamping block 222 enters the sliding groove 219, the stirring rod 216 pushes the push plate 218 and compresses the spring 217, rotates the stirring rod 216 so that the clamping block 222 slides in the sliding groove 219 and abuts against the inner clamping slot 221, the spring 217 pushes the push plate 218 to clamp the clamping block 222 in the clamping slot 221, and the fixing is completed. The clamping block 222 adopts a trapezoidal cross-section design (upper base 5mm, lower base 8mm), and forms an anti-disengagement structure with the clamping slot 221. At this time, the screw rod motor 202 on the surface of the protrusion 201 drives the bidirectional screw rod 203 to rotate, so that the sliding blocks 205 move towards the center along the sliding rods 204. At this time, the horizontal rod 206 pushes the support block 207, so that the U-shaped clamp 208 clamps and fixes the liquid storage barrel 4. Take 20L of fermentation liquid and slowly add it to 80L of 95% concentration alcohol. The electronic telescopic rod 210 on the surface of the connecting seat 209 retracts to drive the support platform 213 to slide on the surface of the limiting rod 211 and make the stirring rod 216 inserted into the liquid storage barrel 4. The motor 214 drives the turntable 215 to rotate, and the stirring rod 216 on the surface of the turntable 215 stirs the solution inside the liquid storage barrel 4, so that the γ-polyglutamic acid contacts the surface of the stirring rod with the flow of the solution. Due to the intermolecular interaction, it will adhere to the surface of the iron rod and gradually condense. When the motor 214 rotates at 200rpm, the γ-polyglutamic acid condensation time is shortened to 45 minutes (traditional device needs 90 minutes), and the product purity reaches 99.2% (HPLC detection). After the reaction is completed, only the electronic telescopic rod 210 pushes the limiting rod 211 to displace upward to the limiting block 212, and the stirring rod 216 can be removed. The water pump 305 injects cooling liquid into the cooling pipe 302, so that the temperature conducting plate 301 conducts the temperature to the liquid storage barrel 4, so that the liquid storage barrel 4 is kept at 0-4℃. The cooling liquid is transported to the condenser 303 through the cooling pipe 302 for cooling. The condenser 303 adopts a plate heat exchanger with a heat exchange area of 0.5㎡. The fan 304 cools the condenser 303. After cooling, it is transported to the input end of the water pump 305 through the connecting pipe 306, and finally enters the cooling pipe 302 again to complete the circulation. According to the preparation method of γ-polyglutamic acid, the device is beneficial to the formation of stable condensation of γ-polyglutamic acid, avoids alcohol volatilization caused by high temperature, improves product purity, and improves the adaptability of the device.

[0034] The above is a detailed description of the general utility model, but some modifications or improvements can be made on the basis of the utility model, which is obvious to those skilled in the art. Therefore, without departing from the spirit of the utility model, the modifications or improvements are within the protection scope of the utility model.

Claims

1. An apparatus for preparing γ-PGA polyglutamic acid hydrogel, comprising a support (1), characterized in that: A liquid storage tank (4) is movably mounted on the surface of the support base (1). A fixed stirring mechanism (2) is provided on the surface of the support base (1). The clamping range of the fixed stirring mechanism (2) is 100-300mm in diameter of the liquid storage tank, and the clamping force is adjustable from 50 to 200N. A cooling mechanism (3) is provided at the bottom of the support base (1). The fixed stirring mechanism (2) includes a protrusion (201), which is fixedly installed on the surface of the support base (1). There are four sets of protrusions (201), which are evenly distributed around the support base (1). A lead screw motor (202) is fixedly installed on the surface of the protrusion (201). There are two sets of lead screw motors (202), which are symmetrically distributed on the surface of the protrusion (201). A bidirectional lead screw (203) is fixedly installed at the output end of the protrusion (201), and the bidirectional lead screw (203) is movably installed on the surface of the protrusion (201).

2. The apparatus for preparing γ-PGA polyglutamic acid hydrogel according to claim 1, characterized in that: A slide rod (204) is fixedly installed on the surface of the protrusion (201), and a slider (205) is movably installed on the surface of the slide rod (204). The slider (205) is threadedly connected to the surface of the bidirectional lead screw (203). There are four sets of sliders (205), and the sliders (205) are symmetrically and evenly distributed on the surface of the bidirectional lead screw (203).

3. The apparatus for preparing γ-PGA polyglutamic acid hydrogel according to claim 2, characterized in that: A crossbar (206) is fixedly installed on the surface of the slider (205), a support block (207) is fixedly installed on the surface of the crossbar (206), a U-shaped clamp (208) is fixedly installed on the surface of the support block (207), and the U-shaped clamp (208) is movably installed on the surface of the liquid storage tank (4).

4. The apparatus for preparing γ-PGA polyglutamic acid hydrogel according to claim 1, characterized in that: The fixed stirring mechanism (2) further includes a connecting seat (209), which is fixedly installed on one side of the support seat (1). An electronic telescopic rod (210) is fixedly installed on the surface of the connecting seat (209). A support platform (213) is fixedly installed at the telescopic end of the electronic telescopic rod (210). A limit rod (211) is movably installed on the surface of the support platform (213). Two sets of limit rods (211) are provided. The limit rods (211) are symmetrical and fixedly installed on the surface of the connecting seat (209). A limit block (212) is fixedly installed at the top of the limit rod (211).

5. The apparatus for preparing γ-PGA polyglutamic acid hydrogel according to claim 4, characterized in that: A motor (214) is fixedly installed on the surface of the support platform (213). A turntable (215) is fixedly installed at the output end of the motor (214). A slot (220) is provided on the surface of the turntable (215). The depth of the slot (220) is 15-20mm. A sliding groove (219) is provided inside the turntable (215). A card slot (221) is provided inside the turntable (215). The sliding groove (219), the slot (220), and the card slot (221) are connected.

6. The apparatus for preparing γ-PGA polyglutamic acid hydrogel according to claim 5, characterized in that: A spring (217) is fixedly installed inside the turntable (215). A push plate (218) is fixedly installed at one end of the spring (217). A stirring rod (216) is movably installed inside the turntable (215). A locking block (222) is fixedly installed on the surface of the stirring rod (216). The fit tolerance between the locking block (222) and the slot (220) is ±0.1mm. The locking block (222) is compatible with the slide (219), the slot (220), and the slot (221).

7. The apparatus for preparing γ-PGA polyglutamic acid hydrogel according to claim 1, characterized in that: The cooling mechanism (3) includes a temperature guide plate (301), which is fixedly installed on the surface of the support base (1). A cooling pipe (302) is fixedly installed on the surface of the temperature guide plate (301). A water pump (305) is fixedly installed at one end of the cooling pipe (302). A connecting pipe (306) is fixedly installed at the input end of the water pump (305). A condenser (303) is fixedly installed at one end of the connecting pipe (306). A fan (304) is fixedly installed on the surface of the condenser (303). The condenser (303) is fixedly installed at one end of the cooling pipe (302). The coolant circulation flow rate in the cooling pipe (302) is 5-8 L / min, and the temperature is maintained at -5℃ to 0℃.

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