Novel immunoaffinity preparation leaching mechanism

Abstract

A novel immunoaffinity preparation leaching mechanism comprises a mounting frame and two lifting driving machines arranged on the left side and the right side of one side of the mounting frame, a first horizontal plate and a second horizontal plate which are arranged side by side in the left-right direction are in transmission connection through the two lifting driving machines, and a pressing assembly and an air blowing assembly are arranged on the left side and the right side of the first horizontal plate; a spraying assembly, a blowing spraying assembly and an elution assembly are sequentially arranged on the second horizontal plate from left to right, liquid adding can be normally carried out when cap removing work is carried out, in other words, when the cap removing work is carried out, liquid adding work of spraying and elution can be synchronously carried out, the immunoaffinity preparation efficiency is guaranteed, and meanwhile, in the immunoaffinity preparation work, liquid adding work of spraying and elution can be synchronously carried out; the sequential treatment of the immunoaffinity columns can be carried out only by controlling the lifting of the two horizontal plates, the control difficulty is reduced, and the smooth proceeding of immunoaffinity preparation work can be ensured and the setting difficulty is reduced only by adjusting the distance between the two horizontal plates.

Description

TECHNICAL FIELD

[0001] The utility model relates to material analysis device technical field, concretely is a kind of novel immunoaffinity preparation elution mechanism. BACKGROUND

[0002] Elution mechanism is the core component of immunoaffinity preparation, and its structural design is related to the quality and preparation efficiency of immunoaffinity preparation. The application number for 202420046004.2 application file applied by the applicant before discloses an integrated immunoaffinity preparation elution device. The integrated compression head, air blowing head, flushing head, air blowing flushing head and elution head are used to sequentially process the immunoaffinity column, and then the immunoaffinity preparation work is completed, which significantly improves the preparation quality and preparation efficiency. However, it is found that there are still some limitations in the use process.

[0003] The above-mentioned integrated immunoaffinity preparation elution device is used to coordinate the sequence of compression, air blowing, flushing, air blowing flushing and elution. The compression head and the air blowing head are integrated on one horizontal plate, and are driven to lift by a set of elevators. The flushing head and the air blowing flushing head are integrated on the second horizontal plate, and are driven to lift by the second set of elevators. Finally, the elution head is separately installed on the third horizontal plate, and is driven to lift by the third set of elevators. This way of coordinating work through three horizontal plates is relatively complex in control process, which leads to complicated system program setting. On the other hand, since it needs to sequentially process multiple rows of immunoaffinity columns, the spacing between the compression head, air blowing head, flushing head, air blowing flushing head and elution head must meet a fixed condition. The setting of three horizontal plates greatly increases the spacing adjustment difficulty between the compression head, air blowing head, flushing head, air blowing flushing head and elution head, and even causes position deviation after long-term use, which affects the immunoaffinity preparation work. TECHNICAL SOLUTION

[0004] To solve the technical problems in the above background art, the utility model provides a novel immunoaffinity preparation elution mechanism.

[0005] The utility model technical scheme is as follows:

[0006] The utility model provides a new type of immunoaffinity preparation elution mechanism, including mounting bracket and its one side's lifting drive, and the horizontal setting lifting plate is connected with through the lifting drive transmission, as the core technical concept of the utility model, the lifting drive is equipped with two groups left and right, the lifting plate includes first horizontal plate and second horizontal plate who sets up side by side left and right and respectively with two groups lifting drive transmission connection, wherein the first horizontal plate is equipped with pressure assembly and blowing assembly left and right, the second horizontal plate is equipped with from left to right in proper order and is washed out subassembly, blowing and washing subassembly and elution subassembly, this kind of pressure assembly and blowing assembly integration on the first horizontal plate, washing subassembly, blowing and washing subassembly and elution subassembly integration on the second horizontal plate, on the one hand make the cap work can normally carry out when adding liquid, if is the pressure assembly, blowing assembly, washing subassembly, blowing and washing subassembly and elution subassembly all integration on a horizontal plate, washing subassembly and elution subassembly all will be in the completely sealed state when the cap, liquid adding can cause to flow out, cannot reach the elution effect, and the setting of two horizontal plates makes the cap work when, the liquid adding work of elution elution can be synchronized, guarantees the immunoaffinity preparation efficiency, simultaneously, in the immunoaffinity preparation work, the order processing of immunoaffinity column only needs to pass through the lifting of two horizontal plates and can carry out, reduces the control difficulty, and only needs to adjust the interval of two horizontal plates, can guarantee the smooth progress of immunoaffinity preparation work, reduces the setting difficulty.

[0007] A new type of immunoaffinity preparation elution mechanism as described above, the pressure assembly, blowing assembly, washing subassembly, blowing and washing subassembly and elution subassembly all include a fixed plate, the fixed plate is located on the upper side of the horizontal plate, and the lower side is provided with a fixed head penetrating through the horizontal plate.

[0008] On the basis of the above structure, the middle part of the blowing assembly, washing subassembly fixed head is vertically provided with a blowing hole and a washing hole, and the blowing work of the immunoaffinity column can be completed through the blowing hole, and the washing work of the immunoaffinity column can be completed through the washing hole; the middle part of the blowing and washing subassembly fixed head is vertically provided with a blowing hole and a washing hole, and the blowing and washing work of the immunoaffinity column can be completed through the blowing hole and the washing hole; the middle part of the elution subassembly fixed head is vertically provided with a blowing hole and an elution hole, and the blowing and elution work of the immunoaffinity column can be completed through the blowing hole and the elution hole.

[0009] As a preferred embodiment, in order to facilitate the connection of the gas supply device with the blowing hole, and the connection of the water supply device with the washing hole, while ensuring the spacing between the washing hole and the blowing hole, prevent interference from occurring, the upper side of the blowing and washing subassembly fixed plate is provided with a first boss, and the different sides of the first boss are provided with a first connection hole and a second connection hole respectively communicating with the blowing hole and the washing hole.

[0010] As further preferred, in order to facilitate the connection of the air supply device with the air blowing hole and the connection of the liquid supply device with the elution hole, prevent the connection from interference while ensuring the spacing between the air blowing hole and the elution hole, the upper side of the elution assembly fixing plate is provided with a second boss, different sides of the second boss are provided with a third connecting hole and a fourth connecting hole which respectively communicate with the air blowing hole and the elution hole.

[0011] More preferably, in order to ensure the connection strength and sealing property of the first boss and the second boss with the fixing plate, the first boss and the second boss are integrally formed with the fixing plate.

[0012] The new type of immunization affinity preparation rinsing mechanism as described above, in order to ensure the compression effect of the compression assembly, ensure the sealing property of the immunization affinity column during the air blowing work, and further ensure the effectiveness of the air blowing work, the lower end of the fixing head of the compression assembly, the air blowing assembly, the air blowing and rinsing assembly and the elution assembly is provided with a rubber plug.

[0013] The beneficial effects of the present application are as follows: the present application is a new type of immunization affinity preparation rinsing mechanism, the compression assembly and the air blowing assembly are integrated on the first horizontal plate, the rinsing assembly, the air blowing and rinsing assembly and the elution assembly are integrated on the second horizontal plate, the liquid adding work of rinsing and elution can be performed synchronously during the cap removal work, the immunization affinity preparation efficiency is ensured, and in the immunization affinity preparation work, the sequential processing of the immunization affinity column can be performed only by controlling the lifting of the two horizontal plates, the control difficulty is reduced, and the immunization affinity preparation work can be ensured to be smoothly performed only by adjusting the spacing of the two horizontal plates, and the setting difficulty is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0014] The scheme and advantages of the present application will become clear to those skilled in the art by reading the detailed description of the preferred embodiments below. The drawings are only for the purpose of illustrating the preferred embodiments and are not considered to be a limitation of the present application.

[0015] In the drawings:

[0016] Figure 1 The structure schematic view of the rinsing mechanism in the embodiment is shown in the figure;

[0017] Figure 2 The structure schematic view of the compression assembly in the embodiment is shown in the figure;

[0018] Figure 3 The structure schematic view of the air blowing assembly in the embodiment is shown in the figure;

[0019] Figure 4 The structure schematic view of the rinsing assembly in the embodiment is shown in the figure;

[0020] Figure 5Structure diagram of the air blowing and rinsing assembly in the embodiment;

[0021] Figure 6 Structure diagram of the elution assembly in the embodiment;

[0022] The components represented by the reference numerals in the drawings are:

[0023] 1, mounting frame; 2, lifting drive; 3, lifting plate; 31, first horizontal plate; 32, second horizontal plate; 4, pressing assembly; 41, first fixed plate; 42, first fixed head; 43, rubber plug; 5, air blowing assembly; 51, second fixed plate; 52, second fixed head; 53, first air blowing hole; 6, rinsing assembly; 61, third fixed plate; 62, third fixed head; 63, first rinsing hole; 7, air blowing and rinsing assembly; 71, fourth fixed plate; 72, fourth fixed head; 73, second air blowing hole; 74, second rinsing hole; 75, first boss; 8, elution assembly; 81, fifth fixed plate; 82, fifth fixed head; 83, third air blowing hole; 84, elution hole; 85, second boss; 86, elution needle; 87, pressing plate. DETAILED DESCRIPTION

[0024] Exemplary embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings.

[0025] Embodiment

[0026] The present embodiment provides a new type of immunoaffinity preparation elution mechanism, referring to Figure 1 , comprising a mounting frame 1 and a lifting drive 2 on one side thereof, and a horizontally arranged lifting plate 3 connected by the lifting drive 2, wherein the lifting plate 3 is provided with a rinsing system, and the rinsing system can complete the rinsing treatment of the immunoaffinity column, thereby completing the immunoaffinity preparation work. The structure of the rinsing mechanism (a new type of immunoaffinity preparation rinsing mechanism described above) will be described in detail below with reference to the drawings.

[0027] In this embodiment, as the core technical concept of the utility model, two groups of lifting driving machines 2 are arranged on the left and right, the lifting plate 3 comprises a first horizontal plate 31 and a second horizontal plate 32 which are arranged side by side and are respectively in transmission connection with the two groups of lifting driving machines 2, the rinsing mechanism comprises a pressing assembly 4 and a blowing assembly 5 which are arranged on the first horizontal plate 31, and a flushing assembly 6, a blowing flushing assembly 7 and an elution assembly 8 which are sequentially arranged on the second horizontal plate 32 from left to right, the pressing assembly 4 can press the immunoaffinity column to assist in the uncapping work of the immunoaffinity column, the blowing assembly 5 can blow out the waste liquid in the immunoaffinity column in advance, the flushing assembly 6 can slowly flush the immunoaffinity column once, the blowing flushing assembly 7 can quickly flush the immunoaffinity column twice, and the elution assembly 8 can complete the elution work of the sample in the immunoaffinity column.

[0028] On the basis of the above structure, in this way that the pressing assembly 4 and the blowing assembly 5 are integrated on the first horizontal plate 31, and the flushing assembly 6, the blowing flushing assembly 7 and the elution assembly 8 are integrated on the second horizontal plate 32, on the one hand, the liquid adding can be normally carried out during the uncapping work, if the pressing assembly 4, the blowing assembly 5, the flushing assembly 6, the blowing flushing assembly 7 and the elution assembly 8 are all integrated on a horizontal plate, the flushing assembly 6 and the elution assembly 8 will be in a completely sealed state during uncapping, at this time, the liquid adding will cause the liquid to flow out while adding, and the rinsing effect cannot be achieved, and the arrangement of the two horizontal plates makes the liquid adding work of rinsing and elution be able to be carried out synchronously during the uncapping work, ensures the immunoaffinity preparation efficiency, and at the same time, in the immunoaffinity preparation work, the sequential processing of the immunoaffinity column only needs to be carried out by controlling the lifting of the two horizontal plates, the control difficulty is reduced, and only the interval of the two horizontal plates needs to be adjusted, the smooth progress of the immunoaffinity preparation work is ensured, and the setting difficulty is reduced.

[0029] In this embodiment, the pressing assembly 4, the blowing assembly 5, the flushing assembly 6, the blowing flushing assembly 7 and the elution assembly 8 all comprise a fixed plate, the fixed plate is located on the upper side of the horizontal plate, and the lower side is provided with a fixed head penetrating through the horizontal plate, on the basis of the above structure, the middle part of the fixed head of the blowing assembly 5 and the flushing assembly 6 is vertically provided with a blowing hole and a flushing hole respectively, and the blowing work of the immunoaffinity column can be completed through the blowing hole, and the rinsing work of the immunoaffinity column can be completed through the flushing hole; the middle part of the fixed head of the blowing flushing assembly 7 is vertically provided with a blowing hole and a flushing hole, and the blowing and rinsing work of the immunoaffinity column can be completed through the blowing hole and the flushing hole; the middle part of the fixed head of the elution assembly 8 is vertically provided with a blowing hole and an elution hole 84, and the blowing and elution work of the immunoaffinity column can be completed through the blowing hole and the elution hole 84.

[0030] In combinationFigure 2 In particular to the structure of the pressing assembly 4, the fixing plate and the fixing head are respectively the first fixing plate 41 and the first fixing head 42. The first fixing plate 41 is horizontally arranged on the upper side of the first horizontal plate 31. The first horizontal plate 31 is provided with a first through hole corresponding to the position of the first fixing head 42. The lower end of the first fixing head 42 passes through the first through hole.

[0031] As a preferred embodiment, in order to ensure the pressing effect of the pressing assembly 4 and prevent damage to the immunoaffinity column during pressing, the lower end of the first fixing head 42 of the pressing assembly 4 is further provided with a rubber plug 43.

[0032] In combination Figure 3 In particular to the structure of the blowing assembly 5, the fixing plate and the fixing head are respectively the second fixing plate 51 and the second fixing head 52. The second fixing plate 51 is horizontally arranged on the upper side of the first horizontal plate 31. The first horizontal plate 31 is provided with a second through hole corresponding to the position of the second fixing head 52. The lower end of the second fixing head 52 passes through the second through hole.

[0033] As a preferred embodiment, a first blowing hole 53 is vertically arranged in the middle of the second fixing head 52. In order to facilitate the connection of the air supply device and the first blowing hole 53, the upper end of the first blowing hole 53 is provided with an air supply interface. In order to ensure the sealing of the immunoaffinity column during blowing and further ensure the effectiveness of blowing, the lower end of the second fixing head 52 of the blowing assembly 5 is also provided with a rubber plug 43, which is sleeved with the outer circle of the second fixing head 52 to prevent the setting from affecting the blowing work.

[0034] In combination Figure 4 In particular to the structure of the flushing assembly 6, the fixing plate and the fixing head are respectively the third fixing plate 61 and the third fixing head 62. The third fixing plate 61 is horizontally arranged on the upper side of the second horizontal plate 32. The second horizontal plate 32 is provided with a third through hole corresponding to the position of the third fixing head 62. The lower end of the third fixing head 62 passes through the third through hole.

[0035] As a preferred embodiment, a first flushing hole 63 is vertically arranged in the middle of the third fixing head 62. In order to facilitate the connection of the water supply device and the first flushing hole 63, the upper end of the first flushing hole 63 is provided with a water supply interface.

[0036] In combination Figure 5 In particular to the structure of the blowing and flushing assembly 7, the fixing plate and the fixing head are respectively the fourth fixing plate 71 and the fourth fixing head 72. The fourth fixing plate 71 is horizontally arranged on the upper side of the second horizontal plate 32. The second horizontal plate 32 is provided with a fourth through hole corresponding to the position of the fourth fixing head 72. The lower end of the fourth fixing head 72 passes through the fourth through hole.

[0037] As a preferred embodiment, the fourth fixed head 72 is vertically provided with a second blowing hole 73 and a second flushing hole 74 in the middle. In order to facilitate the connection of the gas supply device with the second blowing hole 73 and the connection of the water supply device with the second flushing hole 74, while ensuring the spacing between the second flushing hole 74 and the second blowing hole 73 and preventing interference in the connection, the upper side of the fourth fixed plate 71 of the blowing and flushing assembly 7 is provided with a first boss 75 corresponding to the position of the fourth fixed head 72. Different sides of the first boss 75 are provided with a first connecting hole and a second connecting hole respectively communicating with the second blowing hole 73 and the second flushing hole 74. Meanwhile, the outer ends of the first connecting hole and the second connecting hole are respectively provided with a gas interface and a water interface.

[0038] As a further preferred, in order to ensure the sealing of the interior of the immunoaffinity column during the blowing work, and further ensure the effectiveness of the blowing work, the lower end of the fourth fixed head 72 of the blowing and flushing assembly 7 is also provided with a rubber plug 43, and the rubber plug 43 is sleeved on the outer circle of the fourth fixed head 72, so as to prevent the setting from affecting the blowing work.

[0039] As a further preferred, in order to ensure the connection strength and sealing property of the first boss 75 and the fourth fixed plate 71, the first boss 75 and the fourth fixed plate 71 are integrally formed.

[0040] In combination Figure 6 As to the structure of the elution assembly 8, the fixed plate and the fixed head are respectively a fifth fixed plate 81 and a fifth fixed head 82. The fifth fixed plate 81 is horizontally provided on the upper side of the second horizontal plate 32. The second horizontal plate 32 is provided with a fifth through hole corresponding to the position of the fifth fixed head 82. The lower end of the fifth fixed head 82 is arranged through the fifth through hole.

[0041] As a preferred embodiment, the fifth fixed head 82 is vertically provided with a third blowing hole 83 and an elution hole 84 in the middle. In order to facilitate the connection of the gas supply device with the third blowing hole 83 and the connection of the liquid supply device with the elution hole 84, while ensuring the spacing between the third blowing hole 83 and the elution hole 84 and preventing interference in the connection, the upper side of the fifth fixed plate 81 of the elution assembly 8 is further provided with a second boss 85 corresponding to the position of the fifth fixed head 82. Different sides of the second boss 85 are provided with a third connecting hole and a fourth connecting hole respectively communicating with the third blowing hole 83 and the elution hole 84. The outer end of the third connecting hole is provided with a gas interface.

[0042] Further, the elution assembly 8 further comprises an elution needle 86 which passes through the fourth connecting hole and is inserted into the elution hole 84, and the part of the elution needle 86 in the fourth connecting hole is provided with a liquid supply connector which can be connected with a liquid supply device. In order to ensure the firmness of the connection between the liquid supply connector and the liquid supply device, the side of the fourth connecting hole where the second boss 85 is arranged is further provided with a pressing plate 87 which can press and fix the position of the liquid supply connector and the liquid supply device.

[0043] As a further preferred, in order to ensure the sealing of the interior of the immunoaffinity column during the blowing work, and further ensure the effectiveness of the blowing work, the lower end of the fifth fixing head 82 of the elution assembly 8 is also provided with a rubber plug 43 which is sleeved on the outer circle of the fifth fixing head 82, so as to prevent the arrangement of the rubber plug 43 from affecting the blowing work.

[0044] As a further preferred, in order to ensure the connection strength and sealing property of the second boss 85 and the fifth fixing plate 81, the second boss 85 and the fifth fixing plate 81 are integrally formed.

[0045] In the embodiment, in order to ensure the efficiency of the immunoaffinity preparation, the first fixing head 42, the second fixing head 52, the third fixing head 62, the fourth fixing head 72 and the fifth fixing head 82 are linearly arrayed in multiple, and the first fixing head 42, the second fixing head 52, the third fixing head 62, the fourth fixing head 72 and the fifth fixing head 82 are arranged in a rectangular array.

Claims

1. A novel immunoaffinity preparative elution mechanism, characterized in that, The utility model provides a kind of installation rack (1) and its one side's lifting drive (2), and driving connection is provided with the lifting plate (3) of horizontal arrangement by the lifting drive (2), it is characterized by: The lifting drive (2) is provided with two groups left and right, and the lifting plate (3) includes first horizontal plate (31) and second horizontal plate (32) and is respectively drivingly connected with two groups of lifting drive (2) and is arranged side by side left and right; The first horizontal plate (31) is provided with pressing assembly (4) and air blowing assembly (5) left and right; The second horizontal plate (32) is sequentially provided with showering assembly (6), air blowing showering assembly (7) and washing assembly (8) from left to right.

2. A novel immunoaffinity preparation elution mechanism as claimed in claim 1, wherein, The pressing assembly (4), air blowing assembly (5), showering assembly (6), air blowing showering assembly (7) and washing assembly (8) all include fixed plate, the fixed plate is located the upside of horizontal plate, and the downside is provided with fixed head passing through horizontal plate.

3. A novel immunoaffinity preparation elution mechanism as claimed in claim 2, wherein, The middle part of the fixed head of air blowing assembly (5) and showering assembly (6) is respectively vertically provided with air blowing hole and showering hole; The middle part of the fixed head of air blowing showering assembly (7) is vertically provided with air blowing hole and showering hole; The middle part of the fixed head of washing assembly (8) is vertically provided with air blowing hole and washing hole (84).

4. A novel immunoaffinity preparation elution mechanism as claimed in claim 3, wherein, The upside of the fixed plate of air blowing showering assembly (7) is provided with first boss (75), and the different sides of the first boss (75) are provided with first connecting hole and second connecting hole respectively communicated with air blowing hole and showering hole.

5. A novel immunoaffinity preparation elution mechanism as claimed in claim 4, wherein, The upside of the fixed plate of washing assembly (8) is provided with second boss (85), and the different sides of the second boss (85) are provided with third connecting hole and fourth connecting hole respectively communicated with air blowing hole and washing hole (84).

6. A novel immunoaffinity preparative elution mechanism as claimed in claim 5, wherein, The first boss (75) and second boss (85) are integrally formed with the fixed plate.

7. A novel immunoaffinity preparative elution mechanism as claimed in claim 3, wherein, The lower end of the fixed head of pressing assembly (4), air blowing assembly (5), air blowing showering assembly (7) and washing assembly (8) is all provided with rubber plug (43).

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