Desktop type penicillin bottle low-temperature filling, plugging and capping all-in-one machine

Abstract

The utility model relates to a desktop type penicillin bottle low-temperature filling, plugging and capping all-in-one machine which comprises an arranging and feeding mechanism, a filling mechanism, a stepping type rail conveying mechanism, a plugging and capping mechanism, a capping dust collection mechanism, a discharging mechanism, a waste discharging box and an equipment case. The equipment case is of a desktop type, and the material arranging and feeding mechanism comprises a product unpacking temporary storage table and a bottle arranging rotating table and is used for adjusting the positions of penicillin bottles and conveying the penicillin bottles to the stepping type rail conveying mechanism. The filling mechanism is used for conducting raw material filling on the penicillin bottles on the stepping type rail conveying mechanism. The plugging and capping mechanism is used for adding rubber plugs and aluminum caps to penicillin bottles; the capping dust collection mechanism is used for capping penicillin bottles and absorbing aluminum scraps generated in the capping process; the discharging mechanism is used for screening and collecting the penicillin bottles with qualified filling, and the waste discharging box is used for collecting the penicillin bottles with unqualified filling.

Description

Technical Field

[0001] This utility model relates to the field of vial filling technology, and in particular to a desktop vial low-temperature filling, capping and corking machine. Background Technology

[0002] Currently, most filling, capping, and coring integrated machines on the market are vertical structures, occupying a large area, and require customized isolators depending on the application scenario. In the production of reagents and other products packaged in vials, to avoid the impact of aluminum shavings from the capping process on the production environment and drug contamination, the filling, coring, and coring processes are performed on separate production lines. This leads to reduced production efficiency and increased space requirements, presenting certain shortcomings. The filling equipment lacks a low-temperature mixing module, failing to meet the need for low-temperature solution storage during the filling process. Furthermore, achieving low-temperature filling within an isolator typically involves adding a low-temperature device outside the isolator, using a sterile material transfer system to transfer the solution to the isolator for filling; however, this material transfer system is a disposable product and expensive. Additionally, in the later stages of low-temperature filling, the solution significantly decreases, making mixing difficult. Existing filling equipment can only meet the filling requirements of one specification, unable to meet the needs of multiple specifications and models. Most filling equipment requires an external air source, where air expands in a cylinder, converting thermal energy into mechanical energy. If used within an isolator, the isolator must have a reserved port for an external air source. If the isolator does not have a pre-drilled opening, drilling is required, which may damage the isolator's pressure protection system, sealing airflow system, etc. Summary of the Invention

[0003] This utility model provides a desktop-type low-temperature filling, capping, and coring machine for vials, comprising a material feeding mechanism, a filling mechanism, a stepping track transmission mechanism, a coring and capping mechanism, a capping and dust extraction mechanism, a feeding mechanism, a waste discharge box, and a machine housing; the machine housing is desktop-type, and the material feeding mechanism, filling mechanism, stepping track transmission mechanism, coring and capping mechanism, capping and dust extraction mechanism, feeding mechanism, and waste discharge box are all located on top of the machine housing;

[0004] The feeding and handling mechanism includes a product unpacking temporary storage table and a bottle rotating table, used to adjust the position of the vials and convey them to the stepping track conveying mechanism; the filling mechanism is used to fill the vials on the stepping track conveying mechanism with raw materials; the stoppering and capping mechanism is used to add rubber stoppers and aluminum caps to the vials; the capping and dust collection mechanism is used to cap the vials and absorb the aluminum shavings generated during the capping process; the unloading mechanism is used to screen and collect qualified filled vials, and the waste discharge box is used to collect unqualified filled vials.

[0005] Furthermore, the stepping track transmission mechanism includes a product conveying and positioning track, a quick-change handling claw, a handling servo module, and an obstacle avoidance electric cylinder module;

[0006] The transport servo module drives the avoidance electric cylinder module to move back and forth in the first direction. The avoidance electric cylinder module is fixedly connected to the quick-change transport claw and drives the quick-change transport claw to move back and forth in the second direction.

[0007] The quick-change transport claw is provided with multiple semi-circular grooves that match the body of the vial. The vial is transported from the material feeding mechanism to the product conveying and positioning track by the quick-change transport claw.

[0008] The first direction is the transmission direction of the vial on the product conveying and positioning track; the second direction is perpendicular to the first direction and parallel to the plane of the product conveying and positioning track.

[0009] Furthermore, the plugging and capping mechanism includes a rubber plug vibratory plate, an aluminum cap vibratory plate, and a rubber plug and aluminum cap transplanting mechanism. The rubber plug vibratory plate is provided with a rubber plug conveying groove and a rubber plug outlet. The aluminum cap vibratory plate is provided with an aluminum cap conveying groove and an aluminum cap outlet. The rubber plug and aluminum cap transplanting mechanism is provided with rubber plug grippers and aluminum cap grippers.

[0010] Furthermore, the rubber stopper outlet and the aluminum cap outlet are on the same machined part.

[0011] Furthermore, the capping and dust extraction mechanism includes a capping cutter head, a dust extraction device, and a capping and sealing device. The capping and sealing device includes a stainless steel capping cover and a transition joint. The dust extraction device includes a dust extraction device outer cover, a dust extraction device upper cover, a dust extraction fan, and a filter element. The stainless steel capping cover and the transition joint are fixedly connected by threads to form a cavity for accommodating the vial cap portion. The capping cutter head is located inside the cavity. The stainless steel capping cover and the capping cutter head can move up and down synchronously. The transition joint is provided with an interface for connecting to the dust extraction device, thereby connecting the dust extraction device to the cavity.

[0012] Furthermore, the stainless steel capping cover is fixed on the capping lifting shaft. As the capping lifting shaft descends, the stainless steel capping cover and the transition joint wrap around the capping cutter head and move downwards simultaneously, allowing the vial cap to enter the cavity. As the capping lifting shaft rises, the vial cap exits the cavity.

[0013] Furthermore, when the capping cutter is working, the dust collection device is turned on to draw the aluminum shavings generated during capping into the filter element through the pipeline.

[0014] Furthermore, the integrated machine also includes a low-temperature mixing device for the raw liquid, which is used to mix and control the temperature of the raw liquid to be filled.

[0015] The raw material low-temperature mixing equipment includes a cooling plate, an outer frame, and a reciprocating extrusion device. The reciprocating extrusion device includes a roller assembly and a rocking arm. The rocking arm includes a first rocking plate and a second rocking plate arranged opposite each other. The roller assembly includes three rollers arranged at the top, middle, and bottom, and three bearings passing through the three rollers respectively. Gaskets are provided on both sides of the three rollers. The bearings of the upper and lower rollers are fixedly connected to the gaskets at both ends. The bearings of the middle roller pass through the gaskets on both sides and are fixedly connected to the front ends of the first and second rocking plates respectively. The rear ends of the first and second rocking plates are connected to a drive mechanism on the back of the outer frame. The drive mechanism can drive the first and second rocking plates to reciprocate around the axis.

[0016] Furthermore, the raw liquid low-temperature mixing device also includes an extrusion head assembly, which is disposed at the lower part of the cooling plate. The extrusion head assembly includes multiple extrusion heads that can extend and retract relative to the outer surface of the cooling plate.

[0017] Furthermore, the filling mechanism includes a peristaltic pump, upper and lower follower filling heads, and a weighing sensor. The peristaltic pump is connected to a low-temperature mixing device for the concentrate and is used to deliver the concentrate to the upper and lower follower filling heads. The upper and lower follower filling heads are used to fill the concentrate into vials. The weighing sensor is used to weigh the vials before and after filling.

[0018] This utility model has the following technical effects: (1) The equipment chassis is desktop type. The feeding mechanism, filling mechanism, stepping track transmission mechanism, capping and cork mechanism, capping and dust collection mechanism, unloading mechanism and waste discharge box are all set on the top of the equipment chassis, thus forming a compact structure with a small footprint, which is convenient for movement and arrangement; (2) The filling, capping and cork of vials are all completed on a stepping track transmission mechanism, which greatly improves production efficiency; (3) The low temperature mixing module is adopted, which solves the requirement of low temperature when filling raw materials; (4) The rubber stopper claw and aluminum cap claw are designed on a transfer mechanism, which effectively saves cost and space. The rubber stopper and aluminum cap are gripped and inserted into the vial mouth at the same time using a transfer mechanism. It saves space, time and cost to a great extent, improves efficiency, and the design is simple and easy to implement; (5) It adds a capping device with aluminum chip collection function, which does not affect the filling speed. While ensuring efficiency, it also ensures product quality, and the collection design is simple and easy to implement; (6) The quick-change handling claw can be customized with semi-circular grooves of different diameters to realize the filling of different specifications and models of vials. Attached Figure Description

[0019] Figure 1 This is the main view of a desktop low-temperature filling, capping, and coring machine for vials;

[0020] Figure 2This is a top view of a desktop low-temperature filling, capping, and coring machine for vials;

[0021] Figure 3 This is a schematic diagram of the material handling and feeding mechanism;

[0022] Figure 4 This is a schematic diagram of the stepping track transmission mechanism and the filling mechanism;

[0023] Figure 5 This is a top view of a stepping track transmission mechanism;

[0024] Figure 6 The structure of the low-temperature mixing equipment for raw liquid Figure 1 ;

[0025] Figure 7 The structure of the low-temperature mixing equipment for raw liquid Figure 2 ;

[0026] Figure 8 This is a schematic diagram of the roller running trajectory of the low-temperature mixing equipment for the raw liquid;

[0027] Figure 9 This is a schematic diagram of the extrusion head assembly structure;

[0028] Figure 10 This is a schematic diagram of the mechanism for adding a stopper and a cover;

[0029] Figure 11 This is a schematic diagram of the capping dust collection mechanism;

[0030] Figure 12 This is a schematic diagram of the cap sealing device structure of the cap dust extraction structure;

[0031] Figure 13 This is a schematic diagram of a dust collection device with a cap-type dust collection structure. Figure 1 ;

[0032] Figure 14 This is a schematic diagram of a dust collection device with a cap-type dust collection structure. Figure 2 ;

[0033] Figure 15 This is a schematic diagram of the feeding mechanism;

[0034] Figure 16 This is the operation flowchart of a desktop bottle low-temperature filling, capping, and coring integrated machine. Detailed Implementation

[0035] See Figure 1-2The desktop-type low-temperature filling, capping, and coring machine for vials includes a feeding mechanism 2, a filling mechanism 4, a stepping track transmission mechanism 8, a coring and capping mechanism 5, a capping and dust extraction mechanism 6, a feeding mechanism 9, a waste discharge box 13, and a machine housing 15. The machine housing 15 is desktop-type, and the feeding mechanism 2, filling mechanism 4, stepping track transmission mechanism 8, coring and capping mechanism 5, capping and dust extraction mechanism 6, feeding mechanism 9, and waste discharge box 13 are all located above the machine housing 15.

[0036] See Figure 3 The feeding mechanism 2 includes a product unpacking and storage platform 36 and a bottle-sorting rotating platform 38. In use, the disposable vials are unpacked, and the trays are inverted on the product unpacking and storage platform 36 with the vials facing upwards. After placement, the feeding mode is activated. The rotation of the bottle-sorting rotating platform 38 ensures the vials are evenly distributed on it, and the platform then transports the vials to the stepper track conveyor mechanism 8. The rotation of the bottle-sorting rotating platform 38 is controlled by a speed-regulating motor, a precision reducer, and sensors.

[0037] See Figure 4-5 The stepping track transmission mechanism 8 includes a material feeding inspection station 3, a finished product inspection station 7, a product conveying and positioning track 42, a quick-change handling claw 43, a handling servo module 40, and an obstacle avoidance electric cylinder module 41.

[0038] The quick-change transport claw 43 is provided with multiple semi-circular grooves that match the body of the vial 37; the transport servo module 40 and the avoidance electric cylinder module 41 drive the quick-change transport claw 43 to transport the vial from the material feeding mechanism 2 to the product conveying positioning track 42.

[0039] The direction of the vial's transport on the product conveying and positioning track 42 is the first direction (represented by the X-axis), and the direction perpendicular to the first direction and in the horizontal plane is the second direction (the direction from the product conveying and positioning track 42 to the transport servo module 40 / avoidance electric cylinder module 41, represented by the Y-axis). The transport servo module 40 drives the avoidance electric cylinder module 41 to move back and forth in the first direction. The avoidance electric cylinder module 41 is fixedly connected to the quick-change transport claw 43 and moves back and forth in the second direction. The vial 37 is transported from the material feeding mechanism 2 to the product conveying and positioning track 42 by the quick-change transport claw 43. The specific process is as follows:

[0040] First, the feeding mechanism 2 transports the vials 37 to the semi-circular groove of the quick-change transport claw 43 (the first vial station). The quick-change transport claw 43 moves a distance in the X-axis direction under the drive of the transport servo module 40. Figure 5As shown, the moving distance is a fixed value, which is the distance between two adjacent vials), pushing the vial to the next workstation. Then, the avoidance electric cylinder module 41 drives the quick-change transport claw 43 to move a distance in the Y-axis direction (the moving distance is a fixed value, which is the radius of the vial + 5mm), so that the vial 37 is no longer in the semi-circular groove of the quick-change transport claw 43. Subsequently, the quick-change transport claw 43 moves a distance in the opposite X-axis direction under the drive of the transport servo module 40 ( Figure 5 As shown, the moving distance is a fixed value, which is the distance between two adjacent vials. Finally, the avoidance electric cylinder module 41 drives the quick-change transport claw 43 to move a distance in the opposite direction of the Y-axis (the moving distance is a fixed value, which is the radius of the vial + 5mm). At this time, the new vial enters the semi-circular groove of the quick-change transport claw 43 again, and the transfer of vials is completed by repeating this process.

[0041] The quick-change transport claw 43 is a custom-made mold. Custom-made quick-change transport claws 43, containing semi-circular grooves of different diameters, are designed to accommodate vials of varying diameters. The quick-change transport claw 43 allows for easy disassembly. It connects to the avoidance cylinder module 41 via four mounting screws 431. During installation, the working position is determined by locating pins. Disassembly is completed simply by loosening and tightening the four mounting screws 431, requiring no further adjustments, making it convenient and efficient. By replacing the quick-change transport claw 43 and adjusting the filling program, this equipment can meet the filling needs of multiple vials of various sizes and models, achieving multi-functionality, saving costs, and improving equipment utilization.

[0042] Three inlet inspection stations use sensors to detect the presence of bottles and transmit signals to the PLC control system. The system then determines whether to fill the vials according to the control system's instructions. Unfilled vials or vials with a filling accuracy greater than ±5% subsequently enter waste disposal box 13. The entire filling process is automated, simple, and efficient. Seven finished product inspection stations check whether the height of the filled and capped vials meets the required standards.

[0043] The filling mechanism 4 can be used to fill liquid or powder materials. When filling powder materials, the filling mechanism 4 includes an upper and lower follower filling head 39 and a weighing sensor. During filling, the upper and lower follower filling head 39 adds the powder material into the vial. The weighing sensor is used to weigh the vial before and after filling, and the system records the weight. Vials with a filling accuracy greater than ±5% are subsequently sent to the waste discharge box 13.

[0044] When filling liquid materials, the filling mechanism 4 also includes a peristaltic pump 10. During filling, the rotation speed of the peristaltic pump 10 is controlled according to the set filling volume, and the pump is started to operate. The upper and lower follow-up filling heads 39 add the concentrate to the vials. A weighing sensor is used to weigh the vials before and after filling, and the system records the weight. Vials with a filling accuracy greater than ±5% are subsequently sent to the waste discharge box 13. In this invention, a low-temperature mixing device 1 is used to mix the concentrate at low temperature before supplying it to the peristaltic pump 10.

[0045] See Figure 6-9 The raw liquid low-temperature mixing device 1 includes a roller assembly 21, a rocking arm 75, a cooling plate 104, an outer frame 105, a temperature detection device (not shown), and an extrusion head assembly 108.

[0046] The cooling plate 104 is located within the outer frame 105. The surface temperature of the cooling plate 104 can be set between 2-8℃, with an accuracy controllable within ±2℃, depending on actual needs. The cooling plate 104 employs a conventional cooling method. (See [link to relevant documentation]). Figure 7 A refrigeration pipe 112 is embedded in the refrigeration plate 104 and is connected to the compressor 113. A heat insulation frame 111 is also arranged between the refrigeration plate 104 and the outer frame 105 to block heat transfer between the refrigeration plate 104 and the outer frame 105.

[0047] The outer frame 105 has vertically extending strip grooves at both ends, through which the rocker arm 75 passes. The rocker arm 75 includes a first rocker plate 751 and a second rocker plate 752 arranged opposite each other. The roller assembly 21 includes three rollers 211 arranged at the top, middle, and bottom, and three bearings 22 passing through each roller. Washers 23 are provided on both sides of the three rollers. The bearings of the upper and lower rollers are fixedly connected at both ends to the washers 23. The bearings of the middle roller pass through the washers 23 on both sides and are fixedly connected to the front ends of the first rocker plate 751 and the second rocker plate 752. One end of the bearing passing through the middle roller passes through the washer 23 and the threaded hole 753 at the front end of the first rocker plate 751, and the other end passes through the washer 23 and the threaded hole 753 at the front end of the second rocker plate 752, and is fixed with screws.

[0048] The rear ends of the first rocking plate 751 and the second rocking plate 752 are connected to the drive mechanism on the back of the outer frame 105. The drive mechanism can drive the first rocking plate 751 and the second rocking plate 752 to reciprocate around the axis 754, thereby squeezing the liquid in the storage bag 101.

[0049] During the mixing process of the cell preparation, the three rollers 211 significantly increase the contact area with the liquid storage bag 101. When the liquid volume in the storage bag is large, the liquid can be fully squeezed to achieve the purpose of mixing. As the liquid in the storage bag decreases, the servo motor controls the axis 754 of the rocker arm 75 to move away from the cooling plate 104, and then the roller assembly 21 moves closer to the cooling plate 104, repeating the reciprocating swing trajectory to complete the mixing of different volumes.

[0050] The extrusion head assembly 108 is disposed at the lower part of the cooling plate 104. The extrusion head assembly 108 includes a plurality of extrusion heads 181, which can extend and retract relative to the outer surface of the cooling plate 104. The heads of the extrusion heads are made of silicone material, which will not damage the liquid storage bag.

[0051] The liquid outlet pipe 107 is located below the liquid storage bag 101 and is connected to the peristaltic pump 10, which solves the problem of air bubbles entering the pipeline during the mixing and filling process.

[0052] The operation of the low-temperature mixing equipment 1 for the stock solution is divided into four stages:

[0053] (1) Set the temperature and install the liquid storage bag 101. Set the temperature value (e.g., 4℃) through the operation panel. The compressor 113 starts running, and the temperature detection device feeds back the temperature information of the cooling plate 104 to the control system in real time. After the temperature reaches the set value, initialize the mixing device on the operation panel. The roller assembly 21 and the rocker arm 75 move away from the cooling plate 104, with a distance of approximately 80-100mm. Install the liquid storage bag 101 onto the cooling plate 104 (e.g., by using a hook to hang it on the cooling plate). After installation, set the corresponding parameters (e.g., swing start position, swing speed, retraction distance, etc.) according to the initial volume of the liquid storage bag 101. By controlling the distance between the axis 754 of the rocker arm 75 and the cooling plate 104, adjust the distance between the roller assembly 21 and the cooling plate 104 so that the roller assembly 21 just contacts the lower end of the liquid storage bag 101.

[0054] (2) Initial mixing. Before filling, the servo motor drives the rocker arm 75, causing the roller assembly 21 to oscillate back and forth relative to the axis 754 of the rocker arm 75, gradually approaching the cooling plate 104 and squeezing the liquid in the storage bag 101. After the roller assembly 21 reaches the highest point of the movement trajectory, it quickly returns to the lower end of the storage bag 101. The above reciprocating oscillation is repeated. After mixing for 5-10 minutes, filling is started.

[0055] (3) In the early stage of filling the original solution, the same as the initial mixing mode, the servo motor drives the rocker arm 75, so that the roller assembly 21 swings back and forth relative to the axis 754 of the rocker arm 75, mainly relying on the roller 211 to squeeze the liquid storage bag 101. As the liquid in the liquid storage bag decreases, the servo motor controls the axis 754 of the rocker arm 75 to move away from the cooling plate 104, and then the roller 211 moves closer to the cooling plate 104, repeating the reciprocating swing trajectory to complete the mixing of different volumes.

[0056] By using the rolling of the drive roller 211 to squeeze and mix the liquid upwards, the problem of uneven cell density due to sedimentation over time during the filling of bulk cell preparations is solved. Moreover, compared with mixing methods such as stirring, the shear force is smaller, resulting in less damage to the cells.

[0057] (4) In the later stage of filling the original liquid, when the distance between the roller 211 and the cooling plate 104 is about 10-20mm, the extrusion head assembly 108 extrudes the liquid storage bag 101. The control system stops the movement of the roller 211 and the rocker arm 75. The roller 211 stops at the lower end of the liquid storage bag 101, about 10-20mm away from the cooling plate 104, and is in close contact with the liquid storage bag 101. During the mixing process in the later stage of filling, it plays the role of fixing the liquid storage bag 101.

[0058] The control system activates the extrusion head assembly 108, driving multiple extrusion heads 181 to alternately extend and retract, thereby squeezing the liquid storage bag 101, similar to massaging, to mix the liquid inside the bag. This solves the problem of difficulty in mixing the liquid in the later stages of filling in other low-temperature mixing equipment currently on the market. The extrusion head 181 is mushroom-shaped. The head of the extrusion head is made of silicone material, which will not damage the liquid storage bag.

[0059] See Figure 10 The stopper and capping mechanism 5 includes a rubber stopper vibratory feeder 11, an aluminum cap vibratory feeder 12, and a rubber stopper / aluminum cap transfer mechanism 70. The rubber stopper and aluminum cap are placed in the rubber stopper vibratory feeder 11 and the aluminum cap vibratory feeder 12, respectively. A motor provides power, converting it into rotational vibrational force. The vibratory feeder continuously changes the direction and amplitude of the vibrational force, converting the input mechanical kinetic energy into the kinetic energy of the rubber stopper and aluminum cap. When the vibratory feeder is vibrating, the rubber stopper and aluminum cap are subjected to the vibrational force, causing them to move up and down, left and right, or in a circular direction, conveying them to the rubber stopper conveying groove 66 and the aluminum cap conveying groove 67, respectively, for later use.

[0060] Unlike current market designs where stopper and capping modules are separate processes, this equipment combines them. Firstly, the stopper outlet 44 and aluminum cap outlet 65 are integrated into a single processing component, effectively saving space and cost. Secondly, the stopper gripper 45 and aluminum cap gripper 68 are integrated into a single transfer mechanism, eliminating the need for a separate transfer mechanism and further saving cost and space. A single transfer mechanism simultaneously handles the gripping and insertion of both the stopper and aluminum cap into the vial neck. This significantly saves space, time, and cost, improves efficiency, and the design is simple and easy to implement.

[0061] First, the motor controls the rubber stopper and aluminum cap transfer mechanism 70 to move directly above the rubber stopper outlet 44 and the aluminum cap outlet 65. Then, the motor controls the rubber stopper and aluminum cap transfer mechanism 70 to move vertically downwards. The rubber stopper gripper 45 and the aluminum cap gripper 68 open and close electrically to grip one rubber stopper and one aluminum cap respectively. After gripping, the motor controls the rubber stopper and aluminum cap transfer mechanism 70 to move and transfer it above the stepping track conveyor mechanism 8. The rubber stopper gripper 45 is aligned directly above the vial that has been filled but not yet capped, and the aluminum cap gripper 68 is aligned directly above the vial that has been capped. (When capping the first vial, the control system is set to only operate the rubber stopper gripper 45, and not the aluminum cap gripper 68. From the second vial onwards, the rubber stopper gripper 45 and the aluminum cap gripper 68 operate simultaneously. When capping the last vial, the control system is set to not operate the rubber stopper gripper 45, and only the aluminum cap gripper 68 operates.)

[0062] The motor-controlled rubber stopper and aluminum cap transfer mechanism 70 moves vertically downwards. After the rubber stopper contacts the vial neck and the aluminum cap contacts the rubber stopper, the motor-controlled grippers open. Corresponding springs in the rubber stopper gripper 45 and aluminum cap gripper 68 control the pressure applied to the rubber stopper and aluminum cap. The motor-controlled rubber stopper and aluminum cap transfer mechanism 70 then presses the rubber stopper and aluminum cap downwards. After completing the action, the motor-controlled rubber stopper and aluminum cap transfer mechanism 70 moves back to its initial position.

[0063] See Figure 11-14 The capping and dust extraction mechanism 6 includes a servo lifting module 46, a guide fixing structure 50, a capping cutter head 57, a dust extraction device 17, and a capping sealing device. The capping sealing device includes a stainless steel capping cover 63 and a transition joint 64. The dust extraction device 17 includes a pipe 53, a dust extraction device outer cover 60, a dust extraction device upper cover 62, a dust extraction fan 61, and a filter element 55.

[0064] The stainless steel capping cover 63 and the transition joint 64 are fixedly connected by threads to form a cavity for accommodating the cap portion of the vial. The capping cutter head 57 is located inside the cavity. The stainless steel capping cover 63 and the capping cutter head 57 can move up and down synchronously. The transition joint 64 is provided with an interface for connecting to the dust collection device 17, thereby connecting the dust collection device 17 to the cavity.

[0065] In use, after the vials 37 have been capped and corked, they undergo the filling, corking, and capping process via a stepping conveyor mechanism 8 and are then pushed to the capping station. The control system initiates the capping program. The stainless steel capping cover 63 and transition joint 64 enclose the capping cutter head 57 and move downwards simultaneously. The vial 37 passes through the lower circular hole of the stainless steel capping cover 63, and the vial cap enters the capping sealing device. The capping cutter head 57 performs the capping, and the aluminum shavings generated during the process are collected by the dust extraction fan 61 along the pipe 53 into the filter element 55. After capping is completed, the stainless steel capping cover 63 and transition joint 64 enclose the capping cutter head 57 and move upwards simultaneously, and the vial cap exits the capping sealing device. The vial 37 is then pushed to the next station via the stepping conveyor mechanism 8. The vials complete the capping process sequentially via the stepping track conveyor mechanism 8. Because the capping process incorporates aluminum shavings collection, it solves the problem of aluminum shavings polluting the product and the environment. Therefore, vials 37 are conveyed on a stepping track conveyor mechanism 8, allowing the filling, capping, and corking processes to be completed sequentially. This achieves the goal of completing the operation on the same production line, saving space and time. Furthermore, the control system adjusts the descent height of the capping cutter head 57 according to the different heights of the vials, enabling the capping process for vials of different sizes.

[0066] Currently available capping equipment lacks aluminum shavings collection capabilities, leading to product and environmental pollution during the capping process. This equipment incorporates aluminum shavings collection. First, during capping, a sealed environment is created between the vial cap and body using a stainless steel capping cover 63 and transition joint 64. Aluminum shavings generated during capping are collected into the filter element 55 by a dust extraction fan 61. The raising and lowering of the stainless steel capping cover 63 and transition joint 64 are synchronized with the raising and lowering of the capping cutter head 57. Second, to prevent backflow of particles, the pipeline 53 is curved. Third, the filter element 55 is a consumable product, offering convenient replacement and disassembly. This capping equipment with aluminum shavings collection does not affect filling speed, ensuring both efficiency and product quality, and its collection design is simple and easy to implement.

[0067] See Figure 15 The feeding mechanism 9 includes a waste discharge cylinder 58, a finished product detection sensor 59, a waste discharge box 13, and a receiving tray 71.

[0068] During operation, the capped vials are transferred to the finished product inspection station 7. The finished product inspection sensor 59 detects the height of the vials and transmits the result to the control system. If the vial height is outside the system's set range, the system will identify it as a defective product, which will then enter the waste discharge box 13. Qualified vials are sent to the discharge track and enter the receiving tray 71. The system's counting function determines whether the receiving tray 71 is full. If it is full, the system will stop and alarm to notify personnel to remove the tray and replace it with a new one. This equipment removes products with unqualified filling volume, capping, or coring defects before discharging, saving the cost and time of subsequent manual removal.

[0069] See Figure 16 This is a flowchart of the operation of the desktop-type low-temperature filling, capping, and coring machine for vials. The rotating bottle unloader 38 delivers vials 37 to the feeding inspection station 3. First, the feeding inspection station 3 checks whether the vials 37 are correctly placed in the designated position. The signal is transmitted to the PLC control system, and the transport servo module 40 and the avoidance electric cylinder module 41 work together to transfer the vials 37 to the next station. When the vials 37 are transferred to the filling station, based on the inspection result from the feeding inspection station 3, the control system issues commands to the upper and lower follow-up filling heads 39 and the peristaltic pump 10 to determine whether to fill. During filling, according to the set filling volume, the control system automatically switches to the corresponding speed of the peristaltic pump 10 and starts operation. The upper and lower follow-up filling heads 39 complete the filling. The weighing sensor records the weight of the vials before and after filling. If the weight exceeds the set accuracy, the system will determine it as a defective product, and the vial will ultimately enter the waste box 13. The vial 37 is transferred to the next station by the coordinated action of the handling servo module 40 and the avoidance electric cylinder module 41, where it undergoes multiple processes including stoppering, capping, and crimping. Finally, it is inspected at the finished product inspection station 7. Qualified products are discharged, while unqualified products are sent to the waste box 13.

[0070] This utility model relates to a desktop low-temperature filling, capping, and coring machine for vials. The overall equipment is compact, requires minimal space, and is easy to transport and adjust. Different sizes and models of vials can be filled by changing relevant mold components. Operation is simple, achieving multi-functionality and greatly improving equipment utilization.

[0071] The equipment is equipped with a low-temperature mixing module to meet the needs of reagents requiring low-temperature filling. While maintaining a low temperature, it can thoroughly mix cell preparations, while minimizing shear force and preventing cell damage. The filling module, through the replacement of quick-change transport claws and adjustment of the filling program, can meet the filling needs of various sizes and models of vials. The filling process is automated, simple, and efficient. The stoppering and capping module combines the rubber stopper outlet and aluminum cap outlet on a single processing unit, using a single transfer mechanism to complete the gripping and insertion of rubber stoppers and aluminum caps (via vial necks). This saves space, time, and cost, and improves efficiency. The capping module is designed with an aluminum shavings collection function, effectively collecting aluminum shavings during the process and avoiding product and environmental contamination.

[0072] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A desktop type low-temperature filling, capping and sealing all-in-one machine for a penicillin bottle, comprising a material sorting and feeding mechanism (2), a filling mechanism (4), a step-by-step track transmission mechanism (8), a capping and sealing mechanism (5), a sealing and dust collection mechanism (6), a discharging mechanism (9), a waste box (13), and a device cabinet (15); characterized in that, The device cabinet (15) is desktop type, the material arranging and feeding mechanism (2), the filling mechanism (4), the step-by-step track transmission mechanism (8), the stoppering and capping mechanism (5), the cover rolling and dust collecting mechanism (6), the discharging mechanism (9) and the waste box (13) are all arranged above the device cabinet (15). The material arranging and feeding mechanism (2) comprises a product unpacking and temporary storage table (36) and a bottle arranging rotary table (38), which are used for adjusting the position of the vials (37) and conveying the vials (37) to the step-by-step track transmission mechanism (8); the filling mechanism (4) is used for filling raw materials into the vials (37) on the step-by-step track transmission mechanism (8); the stoppering and capping mechanism (5) is used for stoppering and capping the vials; the cover rolling and dust collecting mechanism (6) is used for rolling the covers of the vials (37) and absorbing the aluminum scraps generated in the rolling process; the discharging mechanism (9) is used for screening and collecting the qualified vials (37), and the waste box (13) is used for collecting the unqualified vials (37).

2. The all-in-one machine of claim 1, wherein, The step-by-step track transmission mechanism (8) comprises a product conveying and positioning track (42), a quick-change carrying paw (43) and a carrying servo module (40). The carrying servo module (40) drives the quick-change carrying paw (43) to move back and forth in a second direction, and the quick-change carrying paw (43) is fixedly connected with the carrying servo module (40). The quick-change carrying paw (43) is provided with a plurality of semicircular grooves matched with the vial bodies, and the vials (37) are carried from the material arranging and feeding mechanism to the product conveying and positioning track (42) through the quick-change carrying paw (43). The first direction is the conveying direction of the vials (37) on the product conveying and positioning track (42), and the second direction is perpendicular to the first direction and parallel to the plane of the product conveying and positioning track (42).

3. The all-in-one machine of claim 2, wherein, The stoppering and capping mechanism (5) comprises a rubber plug vibrating disc (11), an aluminum cover vibrating disc (12) and a rubber plug and aluminum cover transplanting mechanism (70), the rubber plug vibrating disc (11) is provided with a rubber plug conveying groove (66) and a rubber plug discharge port (44), the aluminum cover vibrating disc (12) is provided with an aluminum cover conveying groove (67) and an aluminum cover discharge port (65), and the rubber plug and aluminum cover transplanting mechanism (70) is provided with a rubber plug clamping jaw (45) and an aluminum cover clamping jaw (68).

4. The all-in-one machine of claim 3, wherein, The rubber plug discharge port (44) and the aluminum cover discharge port (65) are on one processing piece.

5. The all-in-one machine of claim 1, wherein, The rolling cover dust collection mechanism (6) comprises a rolling cover cutter head (57), a dust collection device (17), a rolling cover sealing device, the rolling cover sealing device comprises a stainless steel rolling cover cover (63) and a transition joint (64), the dust collection device (17) comprises a dust collection device cover (60), a dust collection device upper cover (62), a dust collection fan (61) and a filter element (55), the stainless steel rolling cover cover (63) and the transition joint (64) are fixedly connected through threads to form a cavity for accommodating the part of the penicillin bottle cap, the rolling cover cutter head (57) is located inside the cavity, the stainless steel rolling cover cover (63) and the rolling cover cutter head (57) can move up and down synchronously, and the transition joint (64) is provided with an interface connected with the dust collection device (17), so that the dust collection device (17) is communicated with the cavity.

6. The all-in-one machine of claim 5, wherein, The stainless steel rolling cover cover (63) is fixed on a rolling cover lifting shaft, and the stainless steel rolling cover cover (63) and the transition joint (64) wrap the rolling cover cutter head (57) and move downward simultaneously through the descending of the rolling cover lifting shaft, and the part of the penicillin bottle cap enters the cavity, and the part of the penicillin bottle cap exits the cavity through the ascending of the rolling cover lifting shaft.

7. The all-in-one machine of claim 6, wherein, When the rolling cover cutter head (57) works, the dust collection device (17) is opened, and the aluminum scraps generated in the rolling cover are sucked into the filter element (55) through a pipeline (53).

8. The unit of any of claims 1-7, wherein, The all-in-one machine also comprises a raw liquid low-temperature mixing device (1) for mixing and temperature control of the raw liquid to be filled; The raw liquid low-temperature mixing device (1) comprises a refrigeration plate (104), an outer frame (105) and a reciprocating extrusion device, the reciprocating extrusion device comprises a roller assembly (21) and a rocking arm (75), the rocking arm (75) comprises oppositely arranged first and second rocking plates (751) and (752), the roller assembly (21) comprises three rollers (211) arranged in an upper-middle-lower mode and three bearings (22) penetrating the three rollers respectively, and the two sides of the three rollers are provided with gaskets (23), the bearings at the two ends of the upper and lower rollers are fixedly connected with the gaskets (23), and the two ends of the bearings of the middle roller penetrate the gaskets (23) on the two sides and are fixedly connected with the front end portions of the first and second rocking plates (751) and (752) respectively; the rear end portions of the first and second rocking plates (751) and (752) are connected with a driving mechanism on the back of the outer frame (105), and the driving mechanism can drive the first and second rocking plates (751) and (752) to reciprocally swing around the shaft center (754).

9. The all-in-one machine of claim 8, wherein, The raw liquid low-temperature mixing device (1) further comprises an extrusion head assembly (108) arranged at the lower portion of the refrigeration plate (104), and the extrusion head assembly (108) comprises a plurality of extrusion heads (181) capable of extending and retracting relative to the outer surface of the refrigeration plate (104).

10. The all-in-one machine of claim 8, wherein, The filling mechanism (4) comprises a peristaltic pump (10), an up-and-down servo filling head (39) and a weighing sensor, the peristaltic pump (10) is connected with the raw liquid low-temperature mixing device (1) and is used for conveying the raw liquid to the up-and-down servo filling head (39), the up-and-down servo filling head (39) is used for filling the raw liquid into a vial (37), and the weighing sensor is used for weighing the vial before and after filling.

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