Pressurizing auxiliary device of solid-phase extraction column

Abstract

The utility model relates to the technical field of laboratory auxiliary equipment, in particular to a pressurization auxiliary device of a solid-phase extraction column. The pressurization auxiliary device of the solid-phase extraction column is used for auxiliary pressurization of the solid-phase extraction column and comprises an injector and a connector connected between the injector and a solid-phase extraction device, the connector comprises a base plate, a rubber sealing piece and a pressing and pressing piece. A sliding hole is formed in the base plate, and the compression pressure supply piece is arranged in the sliding hole; the rubber sealing piece is fixed to the lower side of the base plate. A sealing face is arranged on the outer side of the rubber sealing piece. A pressing hole is formed in the rubber sealing part, and the pressing part can slide into the pressing hole. The pressing hole is provided with a circular-truncated-cone-shaped inclined face, and the included angle between the circular-truncated-cone-shaped inclined face and the lower end face of the rubber sealing piece is alpha. And the upper end of the pressing part is provided with an insertion hole for insertion of a nipple of an injector. The connector of the device and the solid-phase extraction column are good in sealing performance, gas can be pushed into the solid-phase extraction column through the pushing injector, and the solid-liquid separation process of extraction of the solid-phase extraction column is facilitated.

Description

Technical Field

[0001] This utility model relates to the field of laboratory auxiliary equipment technology, specifically to a pressurization auxiliary device for solid phase extraction columns. Background Technology

[0002] Solid phase extraction (SPE) columns (or solid phase extraction cartridges) are sample pretreatment devices developed from chromatography columns for extraction, separation, and concentration. Packing materials or sieves are often placed in SPE columns to achieve extraction, separation, and purification.

[0003] Currently, solid-phase extraction (SPE) columns often encounter difficulties in extraction due to clogging of the packing material or sieve plates by substances such as oils or proteins. This necessitates pressurizing the sample to accelerate solid-liquid separation during the extraction process, thus requiring pressurization auxiliary devices. However, current pressurization auxiliary devices still present the following problems: 1. Various specifications of SPE columns exist in laboratories, each requiring a separate pressurization auxiliary device; 2. Sealing the pressurization auxiliary device with the SPE column is difficult, leading to leaks and affecting the pressurization effect; 3. Different samples contain different volatile substances, which can easily enter the pressurization auxiliary device during depressurization, posing a risk of cross-contamination when other samples are subjected to pressurized extraction.

[0004] Therefore, there is a need to provide a new pressurization auxiliary device for solid phase extraction columns to address the above-mentioned shortcomings. Utility Model Content

[0005] To solve the above-mentioned technical problems, this utility model provides a pressurization auxiliary device for a solid phase extraction column. The connector of the device has good sealing performance with the solid phase extraction column, and the gas can be pushed into the solid phase extraction column through the pusher, which is beneficial to the solid-liquid separation process of solid phase extraction column extraction.

[0006] The technical solution of this utility model to solve the above-mentioned technical problems is as follows:

[0007] A pressurization auxiliary device for a solid phase extraction column, used for auxiliary pressurization of the solid phase extraction column, includes a pusher and a connector connected between the pusher and the solid phase extractor.

[0008] The connector includes a base plate, a rubber seal, and a pressure supply component;

[0009] The substrate is provided with a sliding hole, the sliding hole has a sliding wall, the pressing and supplying member is disposed in the sliding hole, and its outer side wall surface is slidably connected to the sliding wall.

[0010] The rubber seal is fixed to the lower side of the substrate, and a sealing surface is provided on the outer side of the rubber seal. The diameter of the sealing surface is the same as the inner diameter of the solid phase extraction column.

[0011] The rubber seal is provided with a pressing hole, which is coaxially arranged with the sliding hole. The pressing supply can slide into the pressing hole. The pressing hole has a frustum-shaped inclined surface. The upper end of the frustum-shaped inclined surface is the same as the inner diameter of the sliding hole. The angle between the frustum-shaped inclined surface and the lower end face of the rubber seal is α, where α > 90°.

[0012] The upper end of the pressure supply component has an insertion hole for inserting the nipple of the injector, and the lower side of the pressure supply component is provided with an exhaust port. The inside of the pressure supply component is provided with an air supply channel connecting the insertion hole and the exhaust port.

[0013] The beneficial effects of the above technical solution are: the pressure supply component can slide into the pressure hole, so that the pressure hole generates an outward elastic force. This elastic force extends to the sealing surface, strengthens the contact between the sealing surface and the inner wall of the solid phase extraction column, and improves the sealing performance between the connector and the solid phase extraction column.

[0014] Furthermore, the sealing surface is provided in multiple ways, and the diameter of the multiple sealing surfaces decreases sequentially from top to bottom.

[0015] The beneficial effect of adopting the aforementioned further technical solution is that multiple sealing surfaces can be used for solid phase extraction columns with different inner diameters.

[0016] Furthermore, the included angle α is 91–93°.

[0017] The beneficial effect of adopting the aforementioned further technical solution is that the pressing supply component can be easily slid into the pressing hole and make close contact with the frustum-shaped inclined surface.

[0018] Furthermore, one end of the pressure supply component is connected to a pull wire, and the other end of the pull wire is connected to a pull ring.

[0019] The beneficial effects of adopting the aforementioned further technical solution are: the pull ring pulls the pull wire, which can easily pull the pressure supply component from the pressure hole to the sliding hole. After the solid phase extraction column is pressurized and extracted, the connector can be easily separated from the solid phase extraction column.

[0020] Furthermore, the gas supply channel is filled with activated carbon filter particles.

[0021] The beneficial effects of adopting the aforementioned further technical solution are: activated carbon filter particles can filter the gas passing through the gas supply channel and remove organic matter in the gas to a certain extent, preventing organic matter from entering the solid phase extraction tube and reducing the risk of cross-contamination.

[0022] Furthermore, a limiting protrusion is provided on the lower surface of the frustum-shaped inclined surface.

[0023] The beneficial effect of adopting the aforementioned further technical solution is that the limiting protrusion can prevent the lower end of the pressing hole of the pressing supply component from slipping.

[0024] Furthermore, multiple limiting protrusions are provided, and the multiple limiting protrusions are circumferentially spaced at the lower end of the frustum-shaped inclined surface.

[0025] The beneficial effect of adopting the aforementioned further technical solution is that the setting of multiple limiting protrusions provides a better anti-detachment effect.

[0026] Furthermore, a sealing ring is provided on the inner wall of the insertion hole.

[0027] The beneficial effect of adopting the aforementioned further technical solution is that the sealing ring can improve the sealing between the insertion hole and the nipple of the injector, reducing air leakage. Attached Figure Description

[0028] Figure 1 This is a schematic diagram of the pressurization auxiliary device for the solid-phase extraction column of this utility model;

[0029] Figure 2 This is a cross-sectional view of the rubber seal structure of this utility model;

[0030] Figure 3 This is a cross-sectional view of the pressing and supplying component of this utility model.

[0031] The attached diagram lists the components represented by each number as follows:

[0032] 1. Solid phase extraction column; 2. Pusher; 3. Connector; 31. Substrate; 311. Sliding wall; 32. Rubber seal; 321. Sealing surface; 322. Frustum-shaped inclined surface; 323. Limiting protrusion; 33. Pressing and supplying component; 331. Insertion hole; 332. Exhaust port; 333. Activated carbon filter particles; 334. Pull cord; 335. Pull ring. Detailed Implementation

[0033] The principles and features of this utility model are described below with reference to the accompanying drawings. The examples given are only for explaining this utility model and are not intended to limit the scope of this utility model.

[0034] A pressurization auxiliary device for a solid phase extraction column, used for auxiliary pressurization of a solid phase extraction column 1, includes a pusher 2 and a connector 3 connected between the pusher 2 and the solid phase extractor.

[0035] The connector 3 includes a base plate 31, a rubber seal 32, and a pressure supply component 33;

[0036] A sliding hole is provided on the substrate 31. The sliding hole has a sliding wall 311. The pressing and supplying member 33 is disposed in the sliding hole, and its outer wall surface is slidably connected to the sliding wall 311.

[0037] The rubber seal 32 is fixed to the lower side of the substrate 31. A sealing surface 321 is provided on the outer side of the rubber seal 32. The diameter of the sealing surface 321 is the same as the inner diameter of the solid phase extraction column 1.

[0038] The rubber seal 32 is provided with a pressing hole, which is coaxially arranged with the sliding hole. The pressing supply 33 can slide into the pressing hole. The pressing hole has a frustum-shaped inclined surface 322. The upper end of the frustum-shaped inclined surface 322 is the same as the inner diameter of the sliding hole. The angle between the frustum-shaped inclined surface 322 and the lower end face of the rubber seal 32 is α, where α > 90°.

[0039] The upper end of the pressure supply component 33 has an insertion hole 331 for inserting the nipple of the injector 2, and the lower side of the pressure supply component 33 is provided with an exhaust port 332. The inside of the pressure supply component 33 is provided with an air supply channel that connects the insertion hole 331 and the exhaust port 332.

[0040] Preferably, multiple sealing surfaces 321 are provided, and the diameters of the multiple sealing surfaces 321 decrease sequentially from top to bottom.

[0041] Preferably, the included angle α is 91 to 93°; this included angle cannot be greater than 93°, otherwise the force of the inward contraction of the pressing hole will act on the pressing supply component 33, and the upward component force will be greater, causing the pressing supply component 33 to move upward, which is not conducive to sealing; while the included angle is less than 91°, the effect of the expansion deformation of the pressing hole is small, which is not conducive to the contact surface between the pressing cover 321 and the solid phase extraction column 1, and it is easy to leak air.

[0042] Preferably, one end of the pressure supply component 33 is connected to the pull wire 334, and the other end of the pull wire 334 is connected to a pull ring 335.

[0043] Preferably, the gas supply channel is filled with activated carbon filter particles.

[0044] Preferably, a limiting protrusion 323 is provided on the lower surface of the frustum-shaped inclined surface 322.

[0045] Preferably, multiple limiting protrusions 323 are provided, and the multiple limiting protrusions 323 are circumferentially spaced at the lower end of the frustum-shaped inclined surface 322; one end of the limiting protrusion 323 is integrated with the rubber seal 32, and the other end extends toward the center line of the pressing hole.

[0046] Preferably, a sealing ring is provided on the inner wall of the insertion hole 331, and the sealing ring is in transitional fit with the nipple of the injector 2.

[0047] It should be noted that the pressure supply component 33 consists of a cylinder, a bottom plate, and a top plate. The circumferential edge of the top plate is integrally connected to the upper end of the cylinder or connected by a threaded seal. The circumferential edge of the bottom plate is spaced apart from the lower end of the cylinder. An exhaust port 332 is provided between the bottom plate and the lower end of the cylinder, and a connecting strip is provided in the exhaust port 332 to fix the bottom plate and the lower end of the cylinder. An upwardly extending boss is provided on the top plate, and an insertion hole 331 is provided on the boss so that the nipple of the injector 2 can be inserted through the insertion hole 331. After entering the cylinder, a sufficient gap is maintained between the lower end of the nipple and the bottom plate, so that the gas pushed out by the pusher 2 is discharged from the lower end of the nipple, filtered by the activated carbon particles 333 above the exhaust port 332, and then discharged from the exhaust port 332, finally entering the solid phase extraction column 1 to assist the sample in the solid phase extraction column 1 to be extracted and separated into solid and liquid. Of course, the liquid extracted and separated into solid and liquid by the solid phase extraction column 1 is discharged from the lower end of the solid phase extraction column 1, while the solid separated into solid and liquid is retained above its packing or sieve plate.

[0048] The method of using the pressurization auxiliary device of the solid-phase extraction column 1 of this utility model is as follows: First, the sample to be extracted and separated into solid and liquid is loaded into the solid-phase extraction column 1; when pressurization is required, the lower end of the rubber seal 32 is inserted into the inner side of the upper end of the solid-phase extraction column 1, and a suitable sealing surface 321 is selected to match the inner diameter of the solid-phase extraction column 1; the pressure supply component 33 is first placed into the sliding hole of the substrate 31, and the piston in the injector 2 is moved to the upper side to draw in air; the outer side of the empty cylinder of the injector 2 is held by hand, and its nipple is inserted into the insertion hole 331, and the pressure supply component 33 is pushed down to the position that matches the sealing surface 321; the piston is pushed down by the push handle of the injector 2, so that the pressure supply component 33 is pushed down by the push handle of the injector 2 to draw in air. Air enters the solid-phase extraction column 1 and enters the pressurization aid. After the pressurization aid is completed, there is pressurized air in the solid-phase extraction column 1. Release the push handle of the injector 2. Under the action of the pressurized air, the piston moves to a position that is in equilibrium with atmospheric pressure. At this time, the injector 2 is removed. After the injector 2 is removed, the pressure supply component 33 is pulled upward by the pull ring 335 through the pull rope, so that the pressure supply component 33 moves upward. When the pressure hole naturally recovers its deformation, the pressing effect between the sealing surface 321 and the contact surface of the solid-phase extraction column 1 is also released. Finally, the rubber seal 32 is separated from the solid-phase extraction column 1. The connector 3 and the injector 2 of this utility model can be recycled for use in the pressurization aid of the next solid-phase extraction column 1.

Claims

1. A booster auxiliary device of a solid phase extraction column (1) for auxiliary boosting of the solid phase extraction column (1), comprising a pusher (2) and a connector (3) connected between the pusher (2) and the solid phase extractor; characterized in that, the connector (3) comprises a base plate (31), a rubber seal (32) and a compression pressure supplier (33); the base plate (31) is provided with a sliding hole having a sliding wall (311), and the compression pressure supplier (33) is arranged in the sliding hole and connected with the sliding wall (311) through the outer side wall surface; the rubber seal (32) is fixed to the lower side of the base plate (31), and the rubber seal (32) is provided with a sealing surface (321) on the outer side, and the diameter of the sealing surface (321) is the same as the inner diameter of the solid phase extraction column (1); the rubber seal (32) is provided with a compression hole coaxially arranged with the sliding hole, and the compression pressure supplier (33) can slide into the compression hole; the compression hole has a circular truncated cone inclined surface (322), the upper end of the circular truncated cone inclined surface (322) is the same as the inner diameter of the sliding hole, and the included angle between the circular truncated cone inclined surface (322) and the lower end surface of the rubber seal (32) is α, and α>90°; the upper end of the compression pressure supplier (33) has a nipple insertion hole (331) for the nipple of the pusher (2), the lower side of the compression pressure supplier (33) is provided with an exhaust port (332), and the inside of the compression pressure supplier (33) is provided with a gas supply channel communicating with the nipple insertion hole (331) and the exhaust port (332).

2. The pressurization aid for solid phase extraction columns according to claim 1, characterized in that: The sealing surface (321) is provided with a plurality of sealing surfaces (321), and the diameters of the plurality of sealing surfaces (321) decrease from top to bottom.

3. The pressurization aid for solid phase extraction columns of claim 1, wherein: The included angle α is 91-93°.

4. The pressurization aid for solid phase extraction columns of claim 1, wherein: One end of the compression pressure supplier (33) is connected with a pull wire (334), and the other end of the pull wire (334) is connected with a pull ring (335).

5. The pressurization aid for solid phase extraction columns of claim 1, wherein: The gas supply channel is filled with activated carbon filter particles (333).

6. The pressurization aid for solid phase extraction columns of claim 1, wherein: The lower side surface of the circular truncated cone inclined surface (322) is provided with a limiting convex (323).

7. A pressurization aid for a solid phase extraction column according to claim 6, characterized in that: The limiting convex (323) is provided with a plurality of limiting convexes (323) circumferentially arranged at the lower end of the circular truncated cone inclined surface (322).

8. The pressurization aid for solid phase extraction columns of claim 1, wherein: The inner side wall of the nipple insertion hole (331) is provided with a sealing ring.

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