Slide glass specimen incubation device

Abstract

The embodiment of the utility model provides a slide glass specimen incubation device which comprises a base, an incubation assembly and an inclination mechanism, the incubation assembly comprises a support, a cover plate and a slide glass, and the cover plate and the slide glass are matched and obliquely arranged on the support; the inclination mechanism is arranged on the base, the inclination mechanism is in driving connection with the incubation assembly, and the inclination mechanism can drive the incubation assembly to swing so as to adjust the inclination of the cover plate and the slide glass relative to the horizontal plane. Therefore, in the incubation process, the inclination of the cover plate and the slide glass can be reduced, and the risk that a reagent between the cover plate and the slide glass is lost from the bottom of a gap is reduced, especially in the uniform mixing incubation of relative movement of the cover plate and the slide glass.

Description

Technical Field

[0001] This utility model relates to the field of biological detection technology, and in particular to a slide specimen incubation device. Background Technology

[0002] The detection of tissue morphology, proteins, pathogens, or genes on slide specimens (such as HE staining, immunohistochemical staining, tissue fluorescence, tissue special staining, Papanicolaou staining, cervical cell scraping, liquid-based cytology staining, HPV typing and detection, nucleic acid in situ hybridization, etc.) is an essential means of clinical disease diagnosis. However, the entire detection process is complex, and clinical tissue specimens are carried on slides, which take up a lot of space.

[0003] In related technologies, slides and coverslips are typically placed at a large angle in staining equipment to increase the number of slides that can be placed and to enable batch processing. However, the gap between the slides and coverslips, which holds the reagent, and the large angle of inclination, makes it easy for the reagent to leak out from the bottom of the gap under gravity, resulting in reagent waste. This necessitates repeated reagent replenishment, which is time-consuming, labor-intensive, and severely impacts detection efficiency.

[0004] It should be noted that the information disclosed in the background section above is only used to enhance the understanding of the background of this utility model, and therefore may include information that does not constitute prior art known to those skilled in the art. Utility Model Content

[0005] The purpose of this invention is to provide a slide specimen incubation device that, to at least some extent, overcomes the problem that reagent loss and reduced detection efficiency are easily caused by placing the slide and cover plate at a large tilt angle in related technologies.

[0006] Other features and advantages of this invention will become apparent from the following detailed description, or may be learned in part by practice of this disclosure.

[0007] This utility model provides a slide specimen incubation device, including a base, an incubation component, and a tilting mechanism. The incubation component includes a support, a cover plate, and a slide. The cover plate and the slide are fitted together and tilted on the support. The tilting mechanism is disposed on the base and is drivenly connected to the incubation component. The tilting mechanism can drive the incubation component to swing to adjust the tilt of the cover plate and the slide relative to the horizontal plane.

[0008] According to some embodiments of the present invention, in the initial state, the incubation component is parallel to the horizontal plane, and the tilt angle of the slide relative to the horizontal plane ranges from 15° to 90°.

[0009] According to some embodiments of the present invention, the tilting mechanism includes a tray and a first driving member. The two sides of the tray are hinged to the base. The first driving member is disposed on the base and connected to the bottom of the tray. The first driving member can drive the tray to swing. The incubation component is disposed on the tray.

[0010] According to some embodiments of the present invention, the tilting mechanism includes a support plate and a second driving member. The support plate has a first connecting hole and a second connecting hole symmetrically arranged on both sides. The first connecting hole is hinged to the base, and the second connecting hole is driven to the second driving member. The second driving member can drive the support plate to swing downward along the axial direction of the first connecting hole.

[0011] According to some embodiments of the present invention, a support plate located on the side of the pallet is provided on the base, an arc-shaped groove is provided on the support plate, and an outwardly extending guide rod is provided on the pallet. The guide rod can slide within the arc-shaped groove, and the arc-shaped groove is used to limit the swing distance of the pallet.

[0012] According to some embodiments of the present invention, the incubation assembly further includes a base plate for loading the slide, the support includes a pair of side plates, and the base plate is obliquely disposed between the pair of side plates; wherein, the cover plate is correspondingly disposed above the base plate, and the slide is located between the base plate and the cover plate, and the cover plate is movable relative to the slide to agitate the reagents and tissue samples between the cover plate and the slide.

[0013] According to some embodiments of the present invention, the incubation assembly further includes a pair of push rods, which are slidably connected to a pair of side plates respectively; the cover plate has outwardly extending protrusions on both sides; a groove is formed downward along the top surface of the push rod, and the protrusions are disposed in the grooves; the push rods can drive the cover plate to move under the drive of external force.

[0014] According to some embodiments of this utility model, the side plate is provided with a sliding groove and a guide groove, the push rod is disposed in the sliding groove, the push rod can reciprocate in the sliding groove, and the guide groove can communicate with the groove.

[0015] According to some embodiments of the present invention, the slide specimen incubation device further includes a driving mechanism, which is connected to the tilting mechanism and driven by a pair of push rods. The driving mechanism is used to drive the push rods to slide back and forth.

[0016] According to some embodiments of this utility model, the cover plate is a straight plate or an arc-shaped plate, and the straight plate or the arc-shaped plate always has a portion of its position in contact with the carrier sheet.

[0017] One embodiment of the above-described utility model has the following advantages or beneficial effects:

[0018] The slide specimen incubation device provided by this utility model consists of a cover plate and a slide in an incubation assembly that are tilted and mounted on a support. The tilting mechanism is connected to the drive mechanism of the incubation assembly, which can drive the incubation assembly to swing, thereby adjusting the tilt angle of the cover plate and the slide relative to the horizontal plane. This reduces the tilt angle between the cover plate and the slide during incubation, lowering the risk of reagent leakage from the bottom of the gap, especially during mixing incubation when the cover plate and slide are moving relative to each other.

[0019] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and are not intended to limit this disclosure. Attached Figure Description

[0020] The above and other features and advantages of this invention will become more apparent from a detailed description of exemplary embodiments with reference to the accompanying drawings.

[0021] Figure 1 A schematic diagram of a slide specimen incubation device is shown in an embodiment of this disclosure.

[0022] Figure 2 yes Figure 1 A schematic diagram of the exploded structure of the medium-sized slide specimen incubation device.

[0023] Figure 3 A schematic diagram of another slide specimen incubation device is shown in an embodiment of this disclosure.

[0024] Figure 4 yes Figure 3 A schematic diagram of the exploded structure of the medium-sized slide specimen incubation device.

[0025] Figure 5 This diagram illustrates the structure of another slide specimen incubation device according to an embodiment of the present disclosure.

[0026] Figure 6 yes Figure 5 A schematic diagram of the exploded structure of the medium-sized slide specimen incubation device.

[0027] Figure 7 A schematic diagram of the structure of an incubation component according to an embodiment of the present disclosure is shown.

[0028] Figure 8 yes Figure 7 A partial exploded view of an incubation component.

[0029] Figure 9 yes Figure 7 A schematic diagram of the cross-sectional structure of an incubation component at a first angle.

[0030] Figure 10 yes Figure 7 A schematic diagram of the cross-sectional structure of an incubation component at a second angle.

[0031] Figure 11 yes Figure 7 A schematic diagram of an incubation component with one side plate removed.

[0032] Figure 12 yes Figure 11 A schematic diagram of the structure of the base plate, carrier plate, and curved plate.

[0033] Figure 13 yes Figure 11 A schematic diagram of the structure of the arc-shaped plate.

[0034] Figure 14 yes Figure 7 A partially exploded structural diagram of another incubation component.

[0035] Figure 15 yes Figure 7 A schematic diagram of the cross-sectional structure of another incubation component at the first angle.

[0036] Figure 16 yes Figure 7 A schematic diagram of the cross-sectional structure of another incubation component at a second angle.

[0037] Figure 17 yes Figure 7 A schematic diagram of another incubation component with one side plate removed.

[0038] Figure 18 yes Figure 17 A schematic diagram of the structure of the base plate, carrier plate, and curved plate.

[0039] Figure 19 yes Figure 17 A schematic diagram of the structure of the arc-shaped plate.

[0040] The reference numerals in the attached figures are explained as follows:

[0041] 100. Base; 110. Base plate; 120. Support column; 121. Shaft; 130. Support plate; 131. Arc groove;

[0042] 200. Incubation component; 210. Support; 211. Side plate; 212. Slide groove; 213. Limiting groove; 214. First end; 215. Second end; 216. Guide groove; 217. Guide surface; 218. Support plate; 219. Support rod; 220. Cover plate; 221. Protrusion; 222. Arc plate; 223. Straight plate; 224. Isolation part; 225. Raised strip; 226. Capillary plane; 230. Carrier plate; 240. Base plate; 241. Receiving groove; 242. Limiting block; 250. Push rod; 251. Groove; 252. Inclined surface; 253. Connecting plate;

[0043] 300. Tilting mechanism; 310. Support plate; 311. First connecting hole; 312. Second connecting hole; 313. Guide rod; 320. First driving component; 321. Second driving component;

[0044] 400. Drive mechanism; 410. Third drive component; 420. Connecting block;

[0045] A. First direction. Detailed Implementation

[0046] Exemplary embodiments will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that the present invention will be thorough and complete, and will fully convey the concept of the exemplary embodiments to those skilled in the art. The same reference numerals in the drawings denote the same or similar structures, and therefore their detailed description will be omitted.

[0047] refer to Figures 1 to 6 This disclosure provides a slide specimen incubation apparatus, which includes a base 100, an incubation component 200, and a tilting mechanism 300. The tilting mechanism 300 is disposed on the base 100 and is drivenly connected to the incubation component 200. By driving the incubation component 200 to swing downward or upward through the tilting mechanism 300, the tilt angle of the cover plate 220 and the slide 230 relative to the horizontal plane can be adjusted, reducing the risk of reagent leakage from the bottom of the gap between the cover plate 220 and the slide 230, especially during mixing incubation when the cover plate 220 and the slide 230 are moving relative to each other.

[0048] The incubation assembly 200 may include a support 210, a cover plate 220, a slide 230, and multiple base plates 240. The base plates 240, cover plates 220, and slides 230 are fitted together and inclined on the support 210. The base plates 240 are inclinedly fixed on the support 210, and each base plate 240 can hold at least one slide 230, with the base plate 240 and slide 230 parallel to each other. A cover plate 220 is disposed above each base plate 240, with the slide 230 located between the base plate 240 and the cover plate 220. This allows for the simultaneous processing of multiple slide 230 samples, improving detection efficiency. A gap is provided between the cover plate 220 and the slide 230 for holding liquids (including reagents and water).

[0049] In its initial state, the incubation component 200 is parallel to the horizontal plane. The tilt angle of the base plate 240 can be set from 15° to 90°, and correspondingly, the tilt angle of the carrier plate 230 is also from 15° to 90°. For example, in the initial state, if the incubation component 200 with a base plate 240 tilt angle of 35° (the angle with the horizontal plane) is selected, the corresponding tilt angle of the carrier plate 230 is 35°; in the initial state, if the incubation component 200 with a base plate 240 tilt angle of 75° is selected, the corresponding tilt angle of the carrier plate 230 is 75°, and so on.

[0050] It should be noted that, in the initial state, the incubation component 200 is placed horizontally on the tray 310 of the tilting mechanism 300 (initially, the tray 310 is parallel to the horizontal plane), while the base plate 240, the carrier plate 230, and the cover plate 220 all have a certain angle with the horizontal plane. When the tilting mechanism 300 drives the incubation component 200 to swing, the incubation component 200 can change from the initial state to the incubation state. In the incubation state, the incubation component 200 forms a certain angle with the horizontal plane, and at this time, the angles between the base plate 240, the carrier plate 230, and the cover plate 220 in the incubation component 200 and the horizontal plane become smaller.

[0051] For example, an incubation component 200 with a base plate 240 tilt angle of 35° can be selected. In the initial state, the carrier 230 has a tilt angle of 35° relative to the horizontal plane. The incubation component 200 is driven to swing to the incubation state by the tilting mechanism 300. At this time, the tilt angle of the carrier 230 relative to the horizontal plane is 0° (i.e., the carrier 230 is parallel to the horizontal plane). It should also be noted that the tilt angle of the carrier 230 relative to the horizontal plane in the incubation state can be 2°, 3°, 4°, etc., as long as the tilt angle of the carrier 230 relative to the horizontal plane in the incubation state is smaller than the tilt angle of the carrier 230 relative to the horizontal plane in the initial state, which can be determined according to the actual application.

[0052] In this embodiment, the cover plate 220 and the slide 230 in the incubation assembly 200 are fitted together and tilted on the support 210. The tilting mechanism 300 is connected to the drive of the incubation assembly 200, allowing the incubation assembly 200 to swing and adjust the tilt of the cover plate 220 and the slide 230 relative to the horizontal plane. This reduces the tilt angle between the cover plate 220 and the slide 230 during incubation, preventing excessive tilting that could cause reagent leakage from the bottom of the gap between the cover plate 220 and the slide 230. This saves reagent usage, eliminates the need for repeated reagent additions, and improves detection efficiency.

[0053] In one embodiment, reference Figure 1 and Figure 2 The tilting mechanism 300 and the incubation mechanism are respectively mounted on the base 100, and the drive mechanism 400 is connected to the tilting mechanism 300. The base 100 may include a base 110 and two symmetrically arranged support columns 120. The support columns 120 are located at the left end of the base 100, while the drive mechanism 400 is located at the end away from the support columns 120. The tail of the incubation component 200 faces the drive mechanism 400.

[0054] The tilting mechanism 300 may include a first driving member 320 and a support plate 310, one end of which is hinged to two support columns 120. For example, each of the two support columns 120 is provided with a shaft 121, which are symmetrically arranged. A through hole is provided on the support plate 310 at the position corresponding to the shaft 121, so that the support plate 310 can be hinged to the two support columns 120 through the shaft 121 and the through hole. The first driving member 320 may be a telescopic motor, the output end of which is connected to one end of the support plate 310 (the end away from the support column 120), and the bottom of the telescopic motor is connected to the base 110.

[0055] A drive mechanism 400 is connected to one end of the tray 310. The drive mechanism 400 may include a third drive component 410 and a connecting block 420. The third drive component 410 may be an eccentric wheel motor. The third drive component 410 is connected to the connecting block 420, and the connecting block 420 is indirectly connected to the cover plate 220 (for specific connection methods, please refer to the description of the incubation component 200 below). When the third drive component 410 drives the connecting block 420 to move back and forth, the connecting block 420 can drive the cover plate 220 to move relative to the slide 230, thereby accelerating the reaction speed between the sample and the reagent and improving the detection efficiency.

[0056] The working process of this slide specimen incubation device can be as follows:

[0057] In the initial state, the tray 310 is parallel to the horizontal plane and is supported by two support columns 120 and the first drive member 320. At this time, liquid can be added to the gap between the cover plate 220 and the carrier plate 230.

[0058] When transitioning from the initial state to the incubation state, the output end of the first drive unit 320 retracts, and the tray 310 swings downward along the shaft 121. Correspondingly, the incubation assembly 200 swings downward synchronously. When the incubation assembly 200 swings downward to the incubation state, the first drive unit 320 stops driving. At this time, the tilt angle of the slide 230 relative to the horizontal plane decreases to reduce the risk of reagent leakage from the bottom of the gap between the cover plate 220 and the slide 230.

[0059] After the first driving component 320 stops driving, the driving mechanism 400 can be started to work, so that the cover plate 220 moves relative to the slide 230, so that the specimen and reagent between the cover plate 220 and the slide 230 are mixed.

[0060] After the mixing is completed, the drive mechanism 400 stops working, the output end of the first drive component 320 extends to drive the incubation component 200 to swing upward, and when the tray 310 is parallel to the horizontal plane, the first drive component 320 stops driving, at which point the incubation component 200 is parallel to the horizontal plane.

[0061] In one embodiment, reference Figure 3 and Figure 4 The tilting mechanism 300 and the incubation mechanism are respectively disposed on the base 100, and the drive mechanism 400 is connected to the tilting mechanism 300. The base 100 may include a base 110 and two symmetrically arranged support columns 120. The support columns 120 are disposed at the left end of the base 100, and the drive mechanism 400 is also disposed at one end near the support column 120. The tail of the incubation component 200 faces the drive mechanism 400.

[0062] The tilting mechanism 300 may include a first driving member 320 and a support plate 310, one end of which is hinged to two support columns 120. For example, each of the two support columns 120 is provided with a shaft 121, which are symmetrically arranged. A through hole is provided on the support plate 310 at the position corresponding to the shaft 121, so that the support plate 310 can be hinged to the two support columns 120 through the shaft 121 and the through hole. The first driving member 320 may be a telescopic motor, the output end of which is connected to one end of the support plate 310 (the end away from the support column 120), and the bottom of the telescopic motor is connected to the base 110.

[0063] A drive mechanism 400 is connected to one end of the tray 310. The drive mechanism 400 may include a third drive component 410 and a connecting block 420. The third drive component 410 may be an eccentric wheel motor. The third drive component 410 is connected to the connecting block 420, and the connecting block 420 is indirectly connected to the cover plate 220 (for specific connection methods, please refer to the description of the incubation component 200 below). When the third drive component 410 drives the connecting block 420 to move back and forth, the connecting block 420 can drive the cover plate 220 to move relative to the slide 230, thereby accelerating the reaction speed between the sample and the reagent and improving detection efficiency.

[0064] The working process of this slide specimen incubation device can be as follows:

[0065] In the initial state, the tray 310 is parallel to the horizontal plane and is supported by two support columns 120 and the first drive member 320. At this time, liquid can be added to the gap between the cover plate 220 and the carrier plate 230.

[0066] When transitioning from the initial state to the incubation state, the output end of the first drive unit 320 extends, and the tray 310 swings upward along the shaft 121. Correspondingly, the incubation assembly 200 swings upward synchronously. When the incubation assembly 200 swings upward to the incubation state, the first drive unit 320 stops driving. At this time, the tilt angle of the slide 230 with the horizontal plane decreases to reduce the risk of reagent leakage from the bottom of the gap between the cover plate 220 and the slide 230.

[0067] After the first driving component 320 stops driving, the driving mechanism 400 can be started to work, so that the cover plate 220 moves relative to the slide 230, so that the specimen and reagent between the cover plate 220 and the slide 230 are mixed.

[0068] After the mixing is completed, the drive mechanism 400 stops working, the output end of the first drive component 320 retracts to drive the incubation component 200 to swing downwards, and when the tray 310 is parallel to the horizontal plane, the first drive component 320 stops driving, at which point the incubation component 200 is parallel to the horizontal plane.

[0069] In one embodiment, reference Figures 5 to 6 The tilting mechanism 300 and the incubation mechanism are respectively mounted on the base 100, and the drive mechanism 400 is connected to the tilting mechanism 300. The base 100 may include a base 110 and two symmetrically arranged support columns 120. The support columns 120 are located at the left end of the base 100, and the drive mechanism 400 is located on the side away from the support columns 120. The tail of the incubation component 200 faces the drive mechanism 400.

[0070] The tilting mechanism 300 may include a second drive member 321 and a support plate 310. A first connecting hole 311 and a second connecting hole 312 are provided at the center of the support plate 310. A shaft 121 is provided on the inner support column 120, and the shaft 121 can pass through and rotate within the first connecting hole 311. A through hole is provided on the outer support column 120, and the second drive member 321 is connected to the support column 120. The drive shaft of the second drive member 321 passes through the through hole and is connected to the second connecting hole 312. The second drive member 321 may be a geared stepper motor or a servo motor. The second drive member 321 can drive the support plate 310 to rotate along the shaft 121 to adjust the tilt of the support plate 310 relative to the horizontal plane. The axis of the shaft 121 is the same as the axis of the drive shaft of the second drive member 321.

[0071] A support plate 130130 is provided on the base 100. The support plate 130130 is located on the side of the support plate 310. An arc groove 131 is provided on the support plate 130130. An outwardly extending guide rod 313 is provided on the support plate 310. The guide rod 313 can slide in the arc groove 131. The arc groove 131 is used to limit the distance of the support plate 310 swinging up and down.

[0072] A drive mechanism 400 is connected to one end of the tray 310. The drive mechanism 400 may include a third drive component 410 and a connecting block 420. The third drive component 410 may be an eccentric wheel motor. The third drive component 410 is connected to the connecting block 420, and the connecting block 420 is indirectly connected to the cover plate 220 (for specific connection methods, please refer to the description of the incubation component 200 below). When the third drive component 410 drives the connecting block 420 to move back and forth, the connecting block 420 can drive the cover plate 220 to move relative to the slide 230, thereby accelerating the reaction speed between the sample and the reagent and improving detection efficiency.

[0073] The working process of this slide specimen incubation device can be as follows:

[0074] In the initial state, the tray 310 is parallel to the horizontal plane and is supported by two support columns 120 and support plates 130. At this time, liquid can be added to the gap between the cover plate 220 and the carrier plate 230.

[0075] When transitioning from the initial state to the incubation state, the output end of the second drive unit 321 rotates clockwise, and the tray 310 swings downward along the shaft 121. Correspondingly, the incubation assembly 200 swings downward synchronously. When the incubation assembly 200 swings downward to the incubation state, the second drive unit 321 stops driving. At this time, the tilt angle of the slide 230 with the horizontal plane decreases to reduce the risk of reagent leakage from the bottom of the gap between the cover plate 220 and the slide 230.

[0076] After the second driving component 321 stops driving, the driving mechanism 400 can be started to work, so that the cover plate 220 moves relative to the slide 230, so that the specimen and reagent between the cover plate 220 and the slide 230 are mixed.

[0077] After the mixing is completed, the drive mechanism 400 stops working, and the output end of the second drive component 321 rotates counterclockwise to drive the incubation component 200 to swing upward. When the tray 310 is parallel to the horizontal plane, the second drive component 321 stops driving.

[0078] refer to Figure 7 , Figure 8 and Figure 14 The incubation component 200 enables the reagents and tissue samples on the slide 230 to react more quickly, improving detection efficiency, sensitivity, and accuracy. In particular, the cover plate 220 is easy to install and remove, facilitating replacement and cleaning.

[0079] The incubation assembly 200 may include a base plate 240, a carrier plate 230, a cover plate 220, a support 210, and a push rod 250. The base plate 240 is used to load the carrier plate 230. The cover plate 220 is correspondingly disposed above the base plate 240, and the carrier plate 230 is located between the base plate 240 and the cover plate 220. The cover plate 220 has outwardly extending protrusions 221 on both sides.

[0080] The bracket 210 includes a pair of side plates 211, and a base plate 240 is provided between the pair of side plates 211. The base plate 240 and the pair of side plates 211 can be connected by a pin. A pair of push rods 250 are slidably connected to the pair of side plates 211 respectively. A groove 251 is provided downward along the top surface of the push rod 250, and a protrusion 221 is provided in the groove 251.

[0081] Driven by an external force, the push rod 250 can move the cover plate 220 to agitate the reagents and tissue samples between the cover plate 220 and the slide 230. The top of the groove 251 has a groove opening, and the protrusion 221 can enter and exit the groove 251 through the groove opening.

[0082] In this embodiment, a protrusion 221 is disposed within a groove 251 formed downwards along the top surface of the push rod 250, and the top of the groove 251 has a slot opening, allowing the protrusion 221 to enter and exit the groove 251 through the slot opening. This allows for simple assembly and disassembly of the cover plate 220 in the slide specimen incubation device, facilitating replacement and cleaning of the cover plate 220 and preventing wear and tear from prolonged use, which could lead to the adhesion of previous reagents and tissue samples, thus affecting the accuracy of subsequent tests. Furthermore, the base plate 240 and the pair of side plates 211 are connected by pins, a simple, reliable, and robust connection structure that reduces production costs.

[0083] refer to Figure 7 , Figure 8 and Figure 14 The bracket 210 may include a pair of side plates 211, a pair of cross plates 218 and a crossbar 219.

[0084] A pair of side plates 211 are arranged parallel to each other and perpendicular to the horizontal plane. A pair of horizontal plates 218 are respectively arranged on the front and rear sides of the side plates 211 and are located between the pair of side plates 211. The horizontal plates 218 are perpendicular to the side plates 211 and are used to support the pair of side plates 211, so that the pair of side plates 211 form a stable structure.

[0085] A crossbar 219 can be installed on the rear side of a pair of side plates 211, and the crossbar 219 can be connected to the pair of side plates 211 by screws. At the same time, a pair of cross plates 218 can also be connected to the pair of side plates 211 by screws, making the bracket 210 structure more stable and reliable.

[0086] refer to Figures 7 to 19 The slide specimen incubation device may include multiple base plates 240 and multiple cover plates 220, with each base plate 240 corresponding to a cover plate 220.

[0087] Multiple base plates 240 are arranged sequentially along a first direction A. Each base plate 240 is perpendicular to a pair of side plates 211. The base plates 240 are inclined relative to the horizontal plane and are parallel to each other in pairs. Two receiving slots 241 are provided on each base plate 240, and each receiving slot 241 can hold a carrier plate 230. Inwardly extending limiting blocks 242 are provided on both side walls forming the receiving slots 241. The limiting blocks 242 can be rectangular, square, etc., and can restrict the carrier plate 230 within the receiving slots 241, preventing the carrier plate 230 from moving in the direction perpendicular to the base plates 240. The limiting blocks 242 can restrict the position of the carrier plate 230. An inclined surface (not shown in the figure) can be provided on the top of the limiting block 242, which guides the carrier plate 230 into the receiving slot 241.

[0088] The base plate 240 is provided with two receiving slots 241, each receiving slot 241 is used to load a carrier piece 230, and each side wall of the receiving slot 241 is provided with an inwardly extending limiting block 242, which is used to limit the movement of the carrier piece 230 in a direction perpendicular to the base plate 240.

[0089] refer to Figures 7 to 19Multiple cover plates 220 are respectively disposed above multiple base plates 240. Two slides 230 can be inserted into each base plate 240, and the slides 230 are located between the cover plate 220 and the base plate 240. Tissue samples can be loaded on the upper surface of the slides 230. There is always a partial contact between the cover plate 220 and the slides 230, and reagents are dropped between the slides 230 and the cover plate 220.

[0090] The push rod 250 drives the cover plate 220 to move relative to the slide 230, thereby agitating the reagents and tissue samples between the cover plate 220 and the slide 230, enabling dynamic incubation of the reagents and tissue samples and accelerating the reaction. The upper part of the cover plate 220 is provided with an outwardly extending protrusion 221. The protrusion 221 can be a cylinder. The width of the limiting groove 213, the guide groove 216, and the groove 251 is all greater than the diameter of the cylinder, allowing the cylinder to move freely within the limiting groove 213, the guide groove 216, and the groove 251.

[0091] In one embodiment, reference Figures 8 to 13 The cover plate 220 is an arc-shaped plate 222.

[0092] Driven by external force, the push rod 250 slides in the first direction A, forcing the protrusion 221 to move along the first end 214 of the limiting groove 213 to the second end 215. The upper part of the arc plate 222 gradually separates from the carrier plate 230, while the lower part of the cover plate 220 will make opposite contact movements in a seesaw manner. The cover plate 220 always has a part of its position in contact with the carrier plate 230.

[0093] Driven by an external force, the push rod 250 slides in the opposite direction to the first direction A, forcing the protrusion 221 to move along the second end 215 of the limiting groove 213 to the first end 214. The upper part of the cover plate 220 gradually fits into the carrier plate 230, while the lower part of the cover plate 220 will move apart in the opposite way like a seesaw. The cover plate 220 always has a part of its position in contact with the carrier plate 230.

[0094] The use of the curved plate 222 facilitates greater reciprocating movement of the reagent on the slide 230, enhancing the dynamic incubation effect, shortening the incubation time, and increasing detection sensitivity. Furthermore, by controlling the distance of the reciprocating movement of the push-pull assembly with external force, the contact area between the curved plate 222 and the slide 230 can be controlled, thereby reducing the area covered by the reagent on the slide 230 and decreasing the amount of reagent used. This is especially beneficial when performing procedures such as fluorescence in situ hybridization or using other expensive reagents, resulting in cost savings.

[0095] The groove 251 can be similar to an inverted R shape. An inclined surface 252 extends downward from the groove opening of the groove 251. The inclined surface 252 can connect with the guide surface 217 of the guide groove 216, which makes it easy for the protrusion 221 to enter and exit the groove 251 and the limiting groove 213 along the guide surface 217 and the inclined surface 252.

[0096] The limiting groove 213 can be in the shape of a straight line. The straight limiting groove 213 is set horizontally. When the push rod 250 drives the protrusion 221 to reciprocate in the limiting groove 213, the upper, middle and lower parts of the arc plate 222 can contact the carrier plate 230, so that the seesaw motion effect of the arc plate 222 is better.

[0097] Furthermore, the upper, middle, and lower parts of the straight plate 223 can all contact the slide 230, resulting in better opening and closing motion between the straight plate 223 and the slide 230. This avoids situations where only a portion of the curved plate 222 slides up and down along the slide 230, or where the bottom of the straight plate 223 slides up and down along the slide 230. Such situations can easily lead to insufficient binding of reagents with tissue samples and increase the possibility of reagent leakage from the bottom, wasting reagents and increasing costs.

[0098] In one embodiment, reference Figures 14 to 19 The cover plate 220 is a straight plate 223.

[0099] Driven by an external force, push rod 250 slides in the first direction A, forcing protrusion 221 to move along the first end 214 of limiting groove 213 to the second end 215, thereby increasing the opening between cover plate 220 and carrier plate 230. Driven by an external force, push rod 250 slides in the opposite direction of the first direction A, forcing protrusion 221 to move along the second end 215 of limiting groove 213 to the first end 214, thereby decreasing the opening between cover plate 220 and carrier plate 230.

[0100] The groove 251 can be similar to an inverted right trapezoid, with an inclined surface 252 extending downward from the groove opening. The limiting groove 213 can be in the shape of a straight line, and the straight limiting groove 213 is inclined relative to the horizontal plane.

[0101] refer to Figure 12 , Figure 13 , Figure 18 and Figure 19 The cover plate 220 is provided with a protrusion 225, which presses against the carrier plate 230, and a gap is formed between the cover plate 220 and the carrier plate 230.

[0102] The base plate 240 has two receiving grooves 241, and the corresponding cover plate 220 can have two capillary planes 226. Raised strips 225 are provided on both sides of the capillary planes 226, extending from the top to the bottom. There is a height difference between the lower surface of the raised strips 225 and the capillary planes 226, which can be 0.01-2 mm. The lower surface of the raised strips 225 refers to the surface that can contact the surface of the substrate 230. When the lower surface of the raised strips 225 is in contact with the substrate 230, a gap is formed between the capillary planes 226 and the substrate 230.

[0103] An isolation section 224 is provided between the two capillary planes 226 to prevent reagents on adjacent slides 230 from flowing across the boundary, effectively avoiding cross-contamination of reagents and improving the accuracy of detection.

[0104] refer to Figure 7 , Figure 8 , Figure 9 , Figure 10 , Figure 14 , Figure 15 and Figure 16 The push rod 250 is slidably connected to a pair of side plates 211.

[0105] A connecting plate 253 is connected to one end of a pair of push rods 250. The connecting plate 253 can be a magnetic metal. By pushing the connecting plate 253, the pair of push rods 250 can move synchronously in the first direction A. Each push rod 250 can include multiple grooves 251, each groove 251 having an opening at its top. The push rod 250 can drive the cover plates 220 to move synchronously. It should be noted that the connecting block 420 on the drive mechanism 400 is also magnetic, and the connecting plate 253 and the connecting block 420 can be attracted together by magnetic force. Driven by the third drive member 410, the connecting block 420 drives the connecting plate 253 to move back and forth, so that the push rods 250 can reciprocate in the first direction A.

[0106] In one embodiment, the side plate 211 has a sliding groove 212, and the push rod 250 is disposed in the sliding groove 212, allowing the push rod 250 to reciprocate within the sliding groove 212. A limiting groove 213 and a guide groove 216 communicating with the limiting groove 213 are provided on the side plate 211. A recess 251 is located below the guide groove 216. During the reciprocating sliding of the push rod 250 within the sliding groove 212, the recess 251 can communicate with the guide groove 216 at a certain position, allowing the protrusion 221 to be removed or placed into the limiting groove 213 and the recess 251 along the guide groove 216.

[0107] In the embodiments of the utility model, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance; the term "multiple" refers to two or more unless otherwise explicitly defined. The terms "install," "connect," "join," and "fix" should be interpreted broadly. For example, "connect" can be a fixed connection, a detachable connection, or an integral connection; "join" can be a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of the utility model according to the specific circumstances.

[0108] In the description of the utility model embodiments, it should be understood that the terms "upper", "lower", "left", "right", "front", "rear", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing the utility model embodiments and simplifying the description, and do not indicate or imply that the device or unit referred to must have a specific orientation or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the utility model embodiments.

[0109] The above are merely preferred embodiments of the utility model and are not intended to limit the utility model. For those skilled in the art, various modifications and variations can be made to the utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the utility model should be included within the protection scope of the utility model.

Claims

1. A slide specimen incubation device, characterized by, include: Base; An incubation assembly includes a support, a cover plate, and a carrier plate, wherein the cover plate and the carrier plate are fitted together and inclinedly disposed on the support; A tilting mechanism is disposed on the base and is drivenly connected to the incubation assembly. The tilting mechanism can drive the incubation assembly to swing to adjust the tilt of the cover plate and the carrier plate relative to the horizontal plane.

2. The slide specimen incubation device of claim 1, wherein, In its initial state, the incubation assembly is parallel to the horizontal plane, and the tilt angle of the slide relative to the horizontal plane ranges from 15° to 90°.

3. The slide specimen incubation device of claim 2, wherein, The tilting mechanism includes a tray and a first driving member. The two sides of the tray are hinged to the base. The first driving member is disposed on the base and connected to the bottom of the tray. The first driving member can drive the tray to swing. The incubation assembly is disposed on the tray.

4. The slide specimen incubation device of claim 2, wherein, The tilting mechanism includes a support plate and a second driving member. The support plate has a first connecting hole and a second connecting hole symmetrically arranged on both sides. The first connecting hole is hinged to the base, and the second connecting hole is driven to the second driving member. The second driving member can drive the support plate to swing downward along the axis of the first connecting hole.

5. The slide specimen incubation device of claim 4, wherein, The base is provided with a support plate located on the side of the pallet. The support plate has an arc-shaped groove. The pallet has an outwardly extending guide rod that can slide within the arc-shaped groove. The arc-shaped groove is used to limit the swing distance of the pallet.

6. The slide specimen incubation device of claim 1, wherein, The incubation assembly further includes a base plate for loading the slide, the support includes a pair of side plates, and the base plate is obliquely disposed between the pair of side plates; wherein, the cover plate is correspondingly disposed above the base plate, and the slide is located between the base plate and the cover plate, the cover plate being movable relative to the slide to agitate the reagents and tissue samples between the cover plate and the slide.

7. The slide specimen incubation device of claim 6, wherein, The incubation assembly also includes a pair of push rods, which are slidably connected to a pair of side plates respectively; the cover plate has outwardly extending protrusions on both sides; a groove is formed downward along the top surface of the push rod, and the protrusions are disposed in the grooves; the push rods can drive the cover plate to move under the drive of external force.

8. The slide specimen incubation device of claim 7, wherein, The side plate has a sliding groove and a guide groove. The push rod is disposed in the sliding groove and can reciprocate within the sliding groove. The guide groove can communicate with the groove.

9. The slide specimen incubation device of claim 8, wherein, The slide specimen incubation device further includes a drive mechanism, which is connected to the tilting mechanism and driven by a pair of push rods. The drive mechanism is used to drive the push rods to slide back and forth.

10. The slide specimen incubation device of claim 6, wherein, The cover plate is a straight plate or an arc-shaped plate, and a portion of the straight plate or the arc-shaped plate is always in contact with the carrier sheet.

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