Raw material mixing and heating device for preparing ramelteon

Abstract

The utility model relates to the technical field of mixing and heating, in particular to a mixing and heating device for ramelteon preparation raw materials. According to the technical scheme, the device comprises a mixing tank, a tank cover is fixedly installed on the upper surface of the mixing tank, a stirring shaft is rotatably installed at the axis position of the lower surface of the tank cover, a plurality of stirring blades are evenly and fixedly installed on the outer surface of the stirring shaft, and a plurality of penetrating openings are evenly formed in the outer surface of the mixing tank; a through opening is formed in the mixing tank, a heat conducting plate is welded in each through opening, the two ends of each heat conducting plate are located inside and outside the mixing tank respectively, a jacket is fixedly installed on the outer surface of the mixing tank, a heating cavity is formed between the jacket and the mixing tank, and a liquid inlet valve and a liquid outlet valve are fixedly connected to the two sides of the outer surface of the jacket respectively. According to the utility model, the heat exchange area of the ramelteon preparation raw material and the heating medium in the heating jacket can be effectively increased, and the mixing and heating efficiency of the ramelteon preparation raw material is improved.

Description

Technical Field

[0001] This utility model relates to the field of mixed heating technology, specifically to a mixed heating device for preparing ramelteline raw materials. Background Technology

[0002] Rametamide is the world's first approved melatonin receptor agonist hypnotic drug. It appears as a white to off-white crystalline powder. It primarily works by specifically activating melatonin MT1 and MT2 receptors, effectively regulating the body's biological clock to promote sleep. It can significantly shorten sleep onset time, prolong sleep duration, and improve sleep quality, unlike traditional benzodiazepines. Unlike other hypnotics, ramelteamide is non-addictive, has no withdrawal symptoms, and does not produce daytime residual effects. It has good safety and tolerability, providing a safe and effective new treatment option for insomnia patients, especially those with difficulty falling asleep. In the preparation of ramelteamide, the mixing and heating of raw materials is a key operation in multiple reaction steps. It can increase the activity of reactants, accelerate molecular motion, increase collision frequency, and allow more molecules to reach the activation energy. At the same time, it promotes full contact between molecules, helps overcome the activation energy barrier of the reaction, and allows the reaction to proceed smoothly. It can also improve the selectivity of the reaction to obtain a higher yield and purity of the target product.

[0003] Currently, jacket heating is commonly used in the mixing and heating process of ramelteline preparation raw materials. However, the heat exchange area between the ramelteline preparation raw materials and the heating medium inside the jacket is limited during the heating process, which is not conducive to improving the mixing and heating efficiency. Therefore, we propose a mixing and heating device for ramelteline preparation raw materials. Utility Model Content

[0004] The purpose of this invention is to provide a mixing and heating device for ramelteline preparation raw materials, which has the advantage of effectively increasing the heat exchange area between the ramelteline preparation raw materials and the heating medium inside the heating jacket, thereby improving the mixing and heating efficiency of the ramelteline preparation raw materials. This solves the problem that in the current process of mixing and heating ramelteline preparation raw materials, the jacket heating method is often used, but the heat exchange area between the ramelteline preparation raw materials and the heating medium inside the jacket is limited, which is not conducive to improving the mixing and heating efficiency.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a mixing and heating device for preparing ramelteline raw materials, comprising a mixing tank, a tank cover fixedly installed on the upper surface of the mixing tank, a stirring shaft rotatably installed at the axial position of the lower surface of the tank cover, a plurality of stirring blades uniformly fixedly installed on the outer surface of the stirring shaft, a plurality of through-holes evenly distributed on the outer surface of the mixing tank, a heat-conducting plate welded inside each through-hole, and the two ends of each heat-conducting plate being located inside and outside the mixing tank respectively, a jacket fixedly installed on the outer surface of the mixing tank, and a heating chamber provided between the jacket and the mixing tank, and an inlet valve and an outlet valve fixedly connected to both sides of the outer surface of the jacket respectively.

[0006] Preferably, a stirring motor is fixedly installed at the axial center position on the upper surface of the mixing tank, and the end of the output shaft of the stirring motor is fixedly connected to the top of the stirring shaft.

[0007] Preferably, a liquid addition pipe is fixedly connected to the upper surface of the tank cover, and a liquid drain valve is fixedly connected to the lower surface of the mixing tank.

[0008] Preferably, each of the heat-conducting plates has a cavity inside.

[0009] Preferably, a number of support legs are fixedly installed in a ring array at equal intervals on the lower surface of the mixing tank near the edge.

[0010] Preferably, a PLC controller and a temperature sensor are fixedly installed on the upper surface of the can lid, and both the inlet valve and the outlet valve are electric valves, and the inlet valve, the outlet valve and the temperature sensor are all electrically connected to the PLC controller.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0012] 1. This utility model, by setting up a mixing tank, jacket, heating chamber, through port, heat-conducting plate, inlet valve, outlet valve, stirring shaft, and stirring blades, effectively increases the heat exchange area between the rameltein amine preparation raw material and the heating medium inside the heating jacket, thereby improving the mixing and heating efficiency of the rameltein amine preparation raw material. The stirring motor drives the stirring blades to rotate, stirring the rameltein amine preparation raw material inside the mixing tank. The heating medium enters the jacket through the inlet valve and flows inside the heating chamber to heat the rameltein amine preparation raw material inside the mixing tank. After heat exchange, the heating medium is discharged from the outlet valve. The heat-conducting plate inside the mixing tank hinders the flow of the rameltein amine preparation raw material, causing turbulence in the liquid inside the mixing tank, improving the mixing efficiency. It also increases the heat exchange area between the rameltein amine preparation raw material and the heating medium, improving the heating efficiency, thereby improving the mixing and heating efficiency of the rameltein amine preparation raw material.

[0013] 2. By setting up a cavity, this utility model achieves the effect of further increasing the contact area between the heating medium inside the jacket and the heat-conducting plate, thereby improving the heating efficiency of the raw materials for rameltemine preparation. The cavity allows the heating medium inside the heating chamber to enter the interior of the heat-conducting plate, increasing the contact area between the heat-conducting plate and the heating medium, thereby improving the efficiency of transferring the heat inside the heating medium to the raw materials for rameltemine preparation inside the mixing tank through the heat-conducting plate.

[0014] 3. This utility model achieves the effect of automatically controlling the temperature of the raw materials for rameltein preparation inside the mixing tank by setting a PLC controller and a temperature sensor. The temperature sensor monitors the temperature of the raw materials for rameltein preparation inside the mixing tank, and the temperature signal is transmitted to the PLC controller. The PLC controller controls the opening of the inlet valve and outlet valve according to the temperature signal to adjust the flow rate of the heating medium inside the heating chamber, thereby keeping the temperature of the raw materials for rameltein preparation inside the mixing tank within the set range. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0016] Figure 2 This is a partial three-dimensional structural diagram of the can lid of this utility model;

[0017] Figure 3 This is a partial three-dimensional structural diagram of the mixing tank of this utility model;

[0018] Figure 4 This is a schematic diagram of the main cross-sectional structure of this utility model.

[0019] Reference numerals: 1. Support leg; 2. Mixing tank; 3. Inlet valve; 4. Jacket; 5. Tank cover; 6. Outlet valve; 7. Stirring blade; 8. Stirring shaft; 9. Adding pipe; 10. Stirring motor; 11. PLC controller; 12. Temperature sensor; 13. Through port; 14. Heat-conducting plate; 15. Cavity; 16. Drain valve; 17. Heating chamber. Detailed Implementation

[0020] The technical solution of this utility model will be further described below with reference to the accompanying drawings and specific embodiments.

[0021] Example 1

[0022] like Figures 1-4As shown, the present invention proposes a mixing and heating device for ramelteline preparation raw materials, comprising a mixing tank 2, a tank cover 5 fixedly installed on the upper surface of the mixing tank 2, a liquid addition pipe 9 fixedly connected to the upper surface of the tank cover 5, the ramelteline preparation raw materials being added to the mixing tank 2 through the liquid addition pipe 9, a drain valve 16 fixedly connected to the lower surface of the mixing tank 2, the heated and mixed ramelteline preparation raw materials being discharged through the drain valve 16, a stirring shaft 8 rotatably installed at the axial position of the lower surface of the tank cover 5, a stirring motor 10 fixedly installed at the axial position of the upper surface of the mixing tank 2, the end of the output shaft of the stirring motor 10 being fixedly connected to the top of the stirring shaft 8, a plurality of stirring blades 7 being uniformly fixedly installed on the outer surface of the stirring shaft 8, the stirring motor 10 driving the stirring shaft 8 and the stirring blades 7 to rotate and stir and mix the ramelteline preparation raw materials inside the mixing tank 2.

[0023] The outer surface of the mixing tank 2 is evenly provided with several through-holes 13. A heat-conducting plate 14 is welded inside each through-hole 13, and the two ends of each heat-conducting plate 14 are located inside and outside the mixing tank 2, respectively. A cavity 15 is provided inside each heat-conducting plate 14. A jacket 4 is fixedly installed on the outer surface of the mixing tank 2, and a heating chamber 17 is provided between the jacket 4 and the mixing tank 2. The cavity 15 and the heating chamber 17 are connected. The arrangement of the cavity 15 allows the heating medium inside the heating chamber 17 to enter the interior of the heat-conducting plate 14. The increased contact area between the heat-conducting plate 14 and the heating medium improves the efficiency of transferring heat from the heating medium to the raw material for rameltein preparation in the mixing tank 2. An inlet valve 3 and an outlet valve 6 are fixedly connected to both sides of the outer surface of the jacket 4. The heating medium enters the heating chamber 17 from the inlet valve 3 and then exits from the outlet valve 6. Several support legs 1 are fixedly installed in a ring array at equal intervals near the edge of the lower surface of the mixing tank 2. The number of support legs 1 is greater than or equal to three.

[0024] In use, the stirring motor 10 drives the stirring blades 7 to rotate, stirring the rameltein amine preparation raw materials inside the mixing tank 2. The heating medium enters the jacket 4 through the liquid inlet valve 3 and flows inside the heating chamber 17 to heat the rameltein amine preparation raw materials inside the mixing tank 2. After heat exchange, the heating medium is discharged from the liquid outlet valve 6. The heat-conducting plate 14 inside the mixing tank 2 will hinder the flow of the rameltein amine preparation raw materials, causing turbulence in the liquid inside the mixing tank 2, improving the mixing efficiency. At the same time, it also increases the heat exchange area between the rameltein amine preparation raw materials and the heating medium, improving the heating efficiency, thereby improving the mixing and heating efficiency of the rameltein amine preparation raw materials.

[0025] Example 2

[0026] like Figure 1 , Figure 2 and Figure 4As shown, the present invention proposes a mixing and heating device for preparing ramelteline raw materials. Compared with Embodiment 1, this embodiment also includes a PLC controller 11 and a temperature sensor 12 fixedly installed on the upper surface of the tank cover 5. The inlet valve 3 and the outlet valve 6 are both electric valves, and the inlet valve 3, the outlet valve 6 and the temperature sensor 12 are all electrically connected to the PLC controller 11.

[0027] In this embodiment, the temperature of the raw material for preparing rameltein amine inside the mixing tank 2 is monitored by the temperature sensor 12, and the temperature signal is transmitted to the PLC controller 11. The PLC controller 11 controls the opening of the inlet valve 3 and the outlet valve 6 according to the temperature signal to adjust the flow rate of the heating medium inside the heating chamber 17, so that the temperature of the raw material for preparing rameltein amine inside the mixing tank 2 is within the set range.

[0028] The above specific embodiments are merely several preferred embodiments of this utility model. Based on the technical solution of this utility model and the relevant teachings of the above embodiments, those skilled in the art can make various alternative improvements and combinations to the above specific embodiments.

Claims

1. A ramelteon raw material mixing and heating device comprising a mixing tank (2), characterized in that: The upper surface of the mixing tank (2) is fixedly installed with a tank cover (5), the lower surface of the tank cover (5) is rotatably installed with a stirring shaft (8) at the axial position, the outer surface of the stirring shaft (8) is uniformly fixedly installed with a plurality of stirring blades (7), the outer surface of the mixing tank (2) is equally divided to be provided with a plurality of through holes (13), each through hole (13) is welded with a heat conduction plate (14) inside, and each heat conduction plate (14) is located at the inside and outside of the mixing tank (2) at both ends respectively, the outer surface of the mixing tank (2) is fixedly installed with a jacket (4), and a heating cavity (17) is arranged between the jacket (4) and the mixing tank (2), the outer surface of the jacket (4) is fixedly connected with an inlet valve (3) and an outlet valve (6) at both sides respectively.

2. The device for mixing and heating a raw material of ramelteon according to claim 1, wherein: The upper surface of the mixing tank (2) is fixedly installed with a stirring motor (10) at the axial position, and the output shaft end of the stirring motor (10) is fixedly connected with the top end of the stirring shaft (8).

3. The device for mixing and heating a raw material of ramelteon according to claim 1, wherein: The upper surface of the tank cover (5) is fixedly connected with a liquid adding pipe (9), and the lower surface of the mixing tank (2) is fixedly connected with a liquid discharge valve (16).

4. The device for mixing and heating a raw material of ramelteon according to claim 1, wherein: Each heat conduction plate (14) is provided with a cavity (15) inside.

5. The device for mixing and heating a raw material of ramelteon according to claim 1, wherein: The lower surface of the mixing tank (2) is fixedly installed with a plurality of support legs (1) at the edge position in a ring array.

6. The device for mixing and heating a raw material of ramelteon according to claim 1, wherein: The upper surface of the tank cover (5) is fixedly installed with a PLC controller (11) and a temperature sensor (12), the inlet valve (3) and the outlet valve (6) are electric valves, and the inlet valve (3), the outlet valve (6) and the temperature sensor (12) are electrically connected with the PLC controller (11).

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