Library construction instrument display structure and library construction instrument
By designing a sliding frame and mounting bracket in the document builder, the main body of the display is slidably connected to the inside of the instrument's side panel, solving the problem of incompatibility between the display and the overall structure, and improving the instrument's aesthetic appearance and space utilization efficiency.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-07
- Publication Date
- 2026-03-10
Smart Images
Figure CN223987245U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of gene sequencing preprocessing technology, and in particular to the display structure of a library builder and a library builder. Background Technology
[0002] A fully automated library builder is a pre-processing device for sequencing instruments (the samples / objects tested by the sequencer are libraries). It can automate the entire process from nucleic acid preparation to library preparation and then to library mixing. Current instrument designs on the market typically involve an external display (touchscreen) mounted on a stand next to the instrument, which looks uncoordinated and detracts from the overall aesthetic appeal of the instrument's industrial design. Summary of the Invention
[0003] This application provides a library builder display structure and a library builder display structure to solve the technical problem of incompatibility between the existing library builder display structure and the overall structure of the library builder. The various technical effects of the preferred technical solutions provided in this application are detailed below.
[0004] To achieve the above objectives, this application provides a document builder display structure, including: a display body, a sliding frame, and a mounting bracket. The mounting bracket is disposed inside the side panel of the document builder, and the sliding frame is slidably disposed on the mounting bracket. The display body is connected to the sliding frame and slides along the mounting bracket with the sliding frame, thereby sliding out to be located outside the document builder or sliding in to be hidden inside the document builder.
[0005] Optionally, the mounting bracket includes a guide rail, and a guide rail slider is provided on one side of the sliding frame. The guide rail slider is connected to the guide rail so that the sliding frame is slidably connected to the mounting bracket.
[0006] Optionally, the mounting bracket further includes a guide shaft, which is arranged parallel to the guide rail, and a limiting block is provided on the other side of the sliding frame. The limiting block engages with the guide shaft and slides along the guide shaft.
[0007] Optionally, the two ends of the guide shaft are connected and fixed to the side plate through shaft mounting seats. The shaft mounting seats at both ends of the guide shaft cooperate with the limiting blocks to limit the sliding frame to the positions at both ends.
[0008] Optionally, a support plate is provided on the sliding frame, and the display body is connected to the support plate through a hinge structure, thereby enabling it to rotate relative to the support plate.
[0009] Optionally, a damping structure is provided inside the hinge structure, so that the display body can be suspended at any angle when rotating.
[0010] Optionally, the sliding frame is a box structure, and the box structure contains a control box.
[0011] Optionally, the sliding direction of the display body is horizontal, and when the display body slides out, its display screen faces the direction of the front of the document builder.
[0012] Optionally, the sliding stroke of the sliding frame allows the hinge structure to be located entirely outside the library builder.
[0013] On the other hand, this application provides a library builder, including the library builder display structure as described above, wherein a space is provided on the inner side of the side plate of the library builder to accommodate the display structure.
[0014] To make the features and advantages of this application more apparent and understandable, some embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description
[0015] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0016] Figure 1 This is a schematic diagram of the gene sequencing preprocessing system in the embodiments of this application;
[0017] Figure 2 This is a schematic diagram of the internal structure of the library builder in the embodiments of this application;
[0018] Figure 3 This is a schematic diagram of the hidden state of the display structure of the library builder in the embodiments of this application;
[0019] Figure 4 This is a schematic diagram of the display structure of the library builder in the slide-out state in the embodiments of this application;
[0020] Figure 5 This is a schematic diagram of the display structure of the library builder in the embodiment of this application when it is rotated at a certain angle while in the slide-out state;
[0021] Figure 6 This is a schematic diagram of the display structure of the library builder in this embodiment of the application.
[0022] In the diagram: 10. Nucleic acid extraction system; 20. Library construction instrument; 21. PCR instrument; 22. Actual container for document construction; 23. Shaking and heating assembly; 24. Magnet assembly; 25. Working area of the puncture assembly; 26. Waste container; 27. Large-capacity reagent container; 28. Display structure; 281. Display frame; 282. Display screen; 283. Support plate; 284. Hinge structure; 285. Guide rail slider; 286. Guide rail; 287. Shaft mounting base; 288. Guide shaft; 289. Limiting block; 2810. Sliding frame; 29. Side plate; 30. Quality control system; 40. Electrical control system; 50. Host computer. Detailed Implementation
[0023] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions of this application will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other implementation methods obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0024] It should be noted that when a component is referred to as "fixed to" or "set on" another component, it can be directly on the other component or may have an intervening component present. When a component is referred to as "connected to" another component, it can be directly connected to the other component or may have an intervening component present.
[0025] Figure 1 This is a schematic diagram of the gene sequencing preprocessing system structure in this application embodiment. Further, the gene sequencing preprocessing system (or sequencing preprocessor) provided in this application embodiment includes: a nucleic acid extraction system 10, a library construction instrument 20, a quality control system 30, an electronic control system 40, and a host computer 50. Wherein:
[0026] Nucleic acid extraction system 10, configured to controllably release nucleic acid molecules (such as DNA or RNA) from biological samples;
[0027] The library builder 20 is configured to controllably prepare nucleic acid molecules (such as DNA or RNA) into libraries that can be used for sequencing.
[0028] The quality control system 30 is configured to controllably detect the concentration of nucleic acid molecules in the nucleic acid extraction product and adjust the concentration of nucleic acid molecules to a predetermined concentration range based on the detection results, and / or controllably detect the concentration of the library in the library construction product and adjust the concentration of the library to a predetermined concentration range based on the detection results.
[0029] The electrical control system 40 is configured to control the operation and function of the nucleic acid extraction system 10, the library construction instrument 20, and the quality control system 30 according to the instructions of the host computer 50.
[0030] The host computer 50 is configured to control the operation and function of the nucleic acid extraction system 10, the library construction instrument 20, and the quality control system 30 by sending control commands to the electronic control system 40.
[0031] For the nucleic acid extraction system 10, taking chemical separation and magnetic bead purification as an example, the nucleic acid extraction system 10 includes at least a nucleic acid extraction platform and a magnetic rod / magnetic rod sleeve assembly. The nucleic acid extraction platform is equipped with an extraction operation container (e.g., a single reagent strip or deep-well plate) and a heating device (e.g., a heating block). The extraction operation container can hold one or more reagents required for nucleic acid extraction (e.g., cell lysis buffer, washing buffer, elution buffer), as well as biological samples and magnetic particles (e.g., magnetic beads), and provides reaction space for various chemical reactions during the nucleic acid extraction process (e.g., lysis reaction, washing reaction, elution reaction). The heating device provides suitable reaction temperature and conditions for various chemical reactions occurring in the extraction operation container. The magnetic rod sleeve is fitted onto the magnetic rod to prevent direct contact and corrosion of the magnetic rod with the nucleic acid extraction reagent. When the magnetic rod / magnetic rod sleeve assembly enters the extraction operation container via a moving mechanism, it provides the necessary magnetic field environment for the washing and elution reactions during the nucleic acid extraction process.
[0032] It should be noted that the nucleic acid extraction system 10 can perform nucleic acid extraction processing on multiple biological samples in batches.
[0033] For Library Builder 20, such as Figure 2 The diagram shows the internal structure of a library construction instrument. The library construction instrument 20 includes at least a PCR instrument 21 and a library construction manipulator assembly. Figure 2 Only its working area is shown in the image), library construction pipetting assembly ( Figure 4 Only the working area is shown in the diagram, along with the library construction reagent container 22, the shaking and heating assembly 23, and the magnet assembly 24. It should be noted that... Figure 2 This is merely illustrative and should not be interpreted as a limitation on the location of any part. Furthermore, its external contour structure and display structure are as follows: Figures 3-5 As shown.
[0034] The library construction reagent container 22 (e.g., a reagent kit) can hold one or more reagents required for library construction. The library construction reagent container 22, the shaking and heating assembly 23, and the magnet assembly 24 are each located in their respective storage areas, which are all within the working areas of the library construction manipulator assembly and the library construction pipetting assembly. The storage area of the library construction reagent container 22 generally needs to be in a low-temperature refrigerated environment to facilitate the low-temperature refrigeration of the library construction reagents. The shaking and heating assembly 23 is equipped with a purification container (e.g., a deep-well plate) and a shaking and heating device. The purification container provides the reaction space for magnetic bead purification during the library construction process, the shaking and heating device provides suitable reaction temperature and conditions for magnetic bead purification, and the magnet assembly 24 provides the necessary magnetic field environment for magnetic bead purification.
[0035] After nucleic acid extraction quality control is completed, the library construction manipulator is responsible for removing the construction reaction container (with nucleic acid extraction product added) from the quality control system 30 and placing it in a specific storage area of the library construction instrument 20. In this storage area, various reaction reagents are added to the construction reaction container. For ease of description, this storage area can be called the reagent addition area. Since the construction reaction container contains nucleic acid, the reagent addition area generally needs to be kept in a low-temperature refrigeration environment to facilitate the low-temperature refrigeration of nucleic acid. Since the entire library construction process includes multiple reaction steps, for each reaction step, the library construction pipetting component is first responsible for aspirating the corresponding reaction reagent from the library construction reagent container 22 and adding it to the construction reaction container (with nucleic acid extraction product added). The library construction manipulator is then responsible for placing the construction reaction container (with nucleic acid extraction product and corresponding reaction reagents added sequentially) into the PCR instrument 21 for reaction. After the reaction is completed, the library construction manipulator removes the construction reaction container from the PCR instrument 21 and returns it to the specific area to wait for the addition of reaction reagents for the next reaction, and repeats the above process.
[0036] During library construction, after ligating adapters to both ends of the nucleic acid fragments, the ligation products need to be purified to obtain a pure library. Additionally, since the amount of library obtained at this stage is relatively small, library amplification is usually required. Similarly, the amplification products need to be purified to obtain a pure library. If magnetic bead purification is used, the library construction reagent container 22 can hold one or more reagents required for library construction (including washing and elution buffers required for magnetic bead purification), as well as magnetic beads or other magnetic particles. In the magnetic bead purification reaction of the ligation or amplification products, the library construction pipetting assembly first aspirates the ligation / amplification products from the construction reaction container and adds them to the purification container of the shaking and heating assembly 23. Then, it aspirates magnetic beads from the library construction reagent container 22 and adds them to this purification container (which already contains the ligation / amplification products). After a certain reaction time, the library construction manipulator assembly transfers the purification container (with the library adsorbed on the surface of the magnetic beads) to the magnet assembly 24. Under the influence of the magnetic field, the magnetic beads adsorbed with the library separate from the solution. The library construction pipetting assembly then aspirates the supernatant from the purification container, leaving the magnetic beads adsorbed with the library. The library construction pipetting assembly continues to aspirate washing solution from the library construction reagent container 22 and add it to the purification container. After a certain reaction time, the supernatant is aspirated again. According to experimental needs, the library construction pipetting assembly can be repeatedly operated to perform multiple washes. After washing, the library construction manipulator transfers the purification container to the shaking and heating assembly 23. The library construction pipetting assembly continues to draw eluent from the library construction reagent container 22 and add it to the purification container. After a certain reaction time, the library and magnetic beads are deadsorbed. The library construction pipetting assembly then draws out the supernatant (i.e., the library construction product) from the purification container and adds it to the construction reaction container.
[0037] Typically, the upper surface of the library construction reagent container 22 is covered with a sealing film to facilitate the preservation and transportation of the internal reagents. After the reagent container is loaded into the sequencing preprocessor, it needs to be punctured (…). Figure 2 (Only the working area is shown in the image) After the sealing film is punctured, the corresponding pipetting component can draw reagents from the library file reagent container 22, and the storage area of the library construction reagent container 22 is located within the working area 25 of the puncturing component.
[0038] In addition, considering that the magnetic beads, washing solution and elution solution required in the magnetic bead purification process are in large quantities and do not need to be in a low-temperature refrigeration environment, in addition to the library construction reagent container 22, the library construction instrument 20 can also be further equipped with a large-capacity reagent container 27 to store large-capacity reagents such as magnetic beads, washing solution and elution solution.
[0039] It should be noted that the library construction manipulator and the library construction pipetting assembly can be set up independently. However, considering that the library construction manipulator and the library construction pipetting assembly do not need to work in parallel, they can also be integrated into one unit to save space. In addition, the library construction instrument 20 can perform batch library construction processing on nucleic acid extraction products from multiple biological samples.
[0040] In one possible implementation, the library pipetting assembly can be a pipetting pump, which, in conjunction with the operation of the pipetting pump, also needs to be equipped with pipetting tips. At the start of pipetting, the pipetting pump places the pipetting tip onto its end; after the pipetting is completed, the pipetting pump detaches the pipetting tip from its end. Correspondingly, the library builder 20 also includes a pipetting tip storage area, where used pipetting tips are disposed of in the waste container 26, such as... Figure 2 As shown.
[0041] The display structure of the library builder is currently mounted next to the instrument via a display stand, resulting in an uncoordinated appearance and negatively impacting the overall aesthetic design. Considering the overall instrument design and display support structure, integrating the display into the instrument's structural design would create a more aesthetically pleasing and harmonious look, without affecting its normal use, and would also save space. This application provides the following display structure for the library builder and the library builder itself.
[0042] like Figure 3 , Figure 4 , Figure 6 As shown, on one hand, this application provides a library builder display structure 28 including: a display body, a sliding frame 2810 and a mounting bracket. The mounting bracket is disposed inside the side plate 29 of the library builder 20. The sliding frame 2810 is slidably disposed on the mounting bracket. The display body is connected to the sliding frame 2810 and slides along the mounting bracket with the sliding frame 2810, thereby sliding out to be located outside the library builder 20 or sliding in to be hidden inside the library builder 20.
[0043] Specifically, the overall external structure of the fully automated library builder 20 is as follows: Figures 3-4 As shown, the right side is the outer frame 281 of the display body. There is a groove between the right side panel 29 and the outer frame 281 of the display (details not shown in the figure), which facilitates manually sliding the display body out for normal use. Overall, the instrument structure is symmetrical and aesthetically pleasing, without any other abrupt or discordant structures. Figure 4 With the main body of the monitor fully extended for display, the monitor body and the front of the instrument form an angle of approximately 90°. This configuration is suitable for normal use when there is insufficient space on the right side of the instrument.
[0044] As an optional implementation, the mounting bracket includes a guide rail 286, and a guide rail slider 285 is provided on one side of the sliding frame 2810. The guide rail slider 285 and the guide rail 286 are connected to each other so that the sliding frame 2810 is slidably connected to the mounting bracket.
[0045] Specifically, such as Figure 6 As shown, by setting the guide rail 286 and the guide rail slider 285, the main body of the display can move along the track direction of the guide rail 286 with the sliding frame 2810. This allows the main body of the display to switch between hidden and displayed states.
[0046] As an optional implementation, the mounting bracket also includes a guide shaft 288, which is arranged parallel to the guide rail 286. A limiting block 289 is provided on the other side of the sliding frame 2810, which engages with the guide shaft 288 and slides along the guide shaft 288.
[0047] Specifically, the guide shaft 288 is arranged parallel to the guide rail 286, so that the sliding frame 2810 slides smoothly along the guide rail 286.
[0048] As an optional implementation, the two ends of the guide shaft 288 are connected and fixed to the side plate 29 through the shaft mounting seat 287. The shaft mounting seat 287 at both ends of the guide shaft 288 cooperates with the limiting block 289 to limit the sliding frame 2810 to slide to the positions at both ends.
[0049] Specifically, the guide rail slider 285 and the limiting block 289 are respectively connected to the sliding frame 2810, which allows the sliding frame 2810 to slide along the guide rail 286 and the guide shaft 288, thus achieving the purpose of hiding the display body inside the overall structure. Figure 3 The main body of the display is on the far left. The left limiting block 289 and the left shaft mounting seat 287 are in contact, limiting the position of the main body of the display in the hidden state. At this time, the overall state of the machine is as follows. Figure 3 As shown. Figure 4 The main display unit is located on the far right. At this time, the right limit block 289 and the right shaft mounting seat 287 are in contact, limiting the position of the main display unit. The overall state of the unit is as follows. Figure 4 As shown.
[0050] As an optional implementation, a support plate 283 is provided on the sliding frame 2810, and the display body is connected to the support plate 283 through a hinge structure 284, thereby being able to rotate relative to the support plate 283.
[0051] Specifically, the support plate 283 on the sliding frame 2810 is connected to the display body through the hinge structure 284. When the display body is in the display state, the hinge is connected to the support plate 283 to realize the free rotation of the display body in the left and right directions of 90°.
[0052] As an optional implementation, the hinge structure 284 is provided with a damping structure inside, so that the display body can be suspended at any angle when rotating.
[0053] Specifically, the damping effect of the hinge structure 284 allows the monitor body to hover at any angle during rotation, making it easy for users to position the monitor body according to space and usage habits. Figure 5 As shown, the main body of the display and the front of the instrument are at an angle of about 130°, and the maximum angle can be about 180° with the front of the instrument. This position can be adapted to situations where there is enough space on the right side of the instrument, and this angle can be freely adjusted by the user.
[0054] As an optional implementation, the display body includes a display frame 281 and a display screen 282 disposed within the display frame 281.
[0055] Specifically, the display frame 281 of the main body of the display is connected to the support plate 283 through a hinge structure 284. The display frame 281 also provides support and protection for the display, and the display screen can be set as a touch screen.
[0056] As an optional implementation, the sliding frame 2810 is a box structure, which houses a control box.
[0057] Specifically, the main body of the display has a control box composed of electronic components such as an electronic control board, connecting wires, and converters to control its normal operation. In order to save space, the sliding frame 2810 is set as a box structure with internal accommodating space, and the control box and other structures of the main body of the display are set inside the box structure. This achieves both space saving and allows the control box to slide with the main body of the display, which facilitates the electrical connection between the control box and the main body of the display.
[0058] As an optional implementation, the sliding direction of the display body is horizontal, and when the display body slides out, its display screen 282 faces the direction of the front of the document builder 20.
[0059] Specifically, such as Figure 4 As shown, the display screen 282 slides out towards the front of the document builder 20 for easy operation by the user.
[0060] As an optional implementation, the sliding stroke of the sliding frame 2810 allows the hinge structure 284 to be completely located outside the document builder 20.
[0061] Specifically, when the main body of the display is fully displayed, the hinge structure 284 is also located on the outside of the instrument, so that the main body of the display can rotate freely 90° to the left and right.
[0062] On the other hand, this application provides a library builder 20, including the display structure 28 of the library builder 20 as described above, and a space for accommodating the display structure 28 is provided inside the side plate 29 of the library builder 20.
[0063] The technical solution of this application has the advantages of simple structure and easy assembly and manufacturing. It also satisfies the aesthetic requirements of the overall industrial design of the document library builder. Furthermore, it saves space by retracting the display inside the instrument when not in use.
[0064] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.
[0065] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0066] The above are merely specific embodiments of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.
Claims
1. A library construction instrument display structure, characterized by, The display body, the sliding frame and the mounting bracket, the mounting bracket is arranged inside the side plate of the library construction instrument, the sliding frame is slidably arranged on the mounting bracket, the display body is connected with the sliding frame, and the display body slides out of the library construction instrument or slides into the library construction instrument along with the sliding frame sliding along the mounting bracket. The mounting bracket comprises a guide rail, one side of the sliding frame is provided with a guide rail slider, and the guide rail slider is connected with the guide rail in a matched mode so that the sliding frame is slidably connected with the mounting bracket.
2. The library constructor display structure of claim 1, wherein, The mounting bracket further comprises a guide shaft which is arranged in parallel with the guide rail, and the other side of the sliding frame is provided with a limiting block which is clamped with the guide shaft and slides along the guide shaft.
3. The library constructor display structure of claim 2, wherein, Both ends of the guide shaft are connected and fixed with the side plate through shaft mounting seats, and the shaft mounting seats at both ends of the guide shaft are matched with the limiting block to respectively limit the positions of the sliding frame sliding to both ends.
4. The library constructor display structure of claim 3, wherein, The sliding frame is provided with a support plate, and the display body is connected with the support plate through a hinge structure so as to be capable of rotating relative to the support plate.
5. Library construction instrument display structure according to one of claims 1-4, characterized in that, The hinge structure is internally provided with a damping structure so that the display body can be suspended at any angle when rotating.
6. The library constructor display structure of claim 5, wherein, The sliding frame is a box body structure, and the box body structure internally accommodates a control box.
7. The library constructor display structure of claim 6, wherein, The sliding direction of the display body is a horizontal direction, and when the display body slides out, the display screen direction is directed to the direction where the front face of the library construction instrument is located.
8. The library constructor display structure of claim 7, wherein, The sliding stroke of the sliding frame enables the hinge structure to be completely located outside the library construction instrument.
9. The library constructor display structure of claim 8, wherein, The library construction instrument display structure comprises the library construction instrument display structure according to any one of claims 1-9, and the space for accommodating the display structure is arranged inside the side plate of the library construction instrument.
10. A library construction instrument, characterized in that,