Liquid supply device, liquid drop generation system and detection equipment

Abstract

The utility model relates to a liquid supply device, a liquid drop generation system and detection equipment. The liquid drop generation system and the detection equipment respectively comprise a liquid supply device, wherein the liquid supply device comprises a container, a liquid nozzle which can be driven to move along a preset path and is provided with a first position and a second position, and a locking device for keeping the liquid nozzle at the first position; the liquid supply device has a first state and a second state; in the first state, the liquid nozzle is located at a first position and is tightly connected with the container, and an internal channel of the liquid nozzle is communicated with the liquid outlet part of the container; in the second state, the liquid nozzle is located at the second position, the liquid nozzle is separated from the container, the internal channel of the liquid nozzle is disconnected from the liquid outlet part of the container, and the detection equipment can be PCR equipment specifically. According to the liquid supply device, the detection equipment and the liquid drop generation system provided by the utility model, the liquid container can be conveniently disassembled and assembled, and meanwhile, the liquid can be prevented from being scattered during disassembly and replacement, so that the detection efficiency is effectively improved.

Description

Technical Field

[0001] This utility model relates to a PCR device and other testing equipment, and particularly to a liquid supply device and a droplet generation system for the testing equipment. Background Technology

[0002] In testing equipment such as digital PCR devices, a liquid supply device is used to supply liquids (such as formulated oils) to generate droplets. Taking digital PCR devices as an example, the liquid supply device in existing digital PCR devices generally includes a container with a liquid holding space, a removable cap, and an infusion tube. The infusion tube runs from inside the container to the outside and is used to connect to a rear-end mechanism outside the container. With this structure, when disassembling to replace the container, the cap needs to be opened and the infusion tube pulled out of the container. During this process, the pulled-out infusion tube carries some liquid out of the container, causing liquid spillage and contamination of the work area. Furthermore, the installation of this structure requires inserting the infusion tube into the container, making quick and convenient assembly difficult. Summary of the Invention

[0003] The technical problem to be solved by this utility model is to provide an improved liquid supply device that can be easily replaced and can prevent liquid spillage.

[0004] To solve the above technical problems, the present invention adopts the following technical solution:

[0005] A liquid supply device includes a container having a liquid holding space and a liquid outlet, a nozzle capable of being driven to move along a preset path and having a first position and a second position, and a locking device for holding the nozzle in the first position. The nozzle has an internal channel. The liquid supply device has a first state and a second state. When in the first state, the nozzle is in the first position, the nozzle is tightly connected to the container, and the internal channel of the nozzle communicates with the liquid outlet of the container. When in the second state, the nozzle is in the second position, the nozzle is separated from the container, and the internal channel of the nozzle is disconnected from the liquid outlet of the container.

[0006] According to one specific embodiment of the present invention, the liquid supply device includes a support, the support having a first mounting portion, and a liquid nozzle disposed on the first mounting portion. In another specific embodiment, the support has both a first mounting portion and a second mounting portion. As described above, the liquid nozzle is disposed on the first mounting portion, and the second mounting portion is used to accommodate and / or support a container.

[0007] According to a preferred embodiment of the present invention, the preset path extends in the up-down direction, particularly vertically; when the nozzle is in the first position, the nozzle can be located above or below the container, and correspondingly, the liquid outlet is located at the top or bottom of the container; preferably, when the nozzle is located above the container, the container also has a conduit, and one end of the conduit is connected to the liquid outlet, and the other end extends to near the bottom of the container.

[0008] Preferably, the liquid supply device further includes a drive device for driving the liquid nozzle to move along a preset path between the first position and the second position. The drive device can be a manual drive device, an electric drive device, or a drive device that can be both manual and electric.

[0009] The locking device in this invention is not particularly limited and can be any conventional device in the art. However, according to a preferred embodiment of this invention, the locking device is provided between the driving device and the container. In a specific and preferred embodiment, the locking device includes a snap-fit ​​groove disposed on the container and a snap-fit ​​connector connected to the driving device. When in a first state, the snap-fit ​​connector is embedded in the snap-fit ​​groove.

[0010] Furthermore, the driving device includes a rotatable driving member and an actuating ring formed on the outer periphery of the nozzle. When the driving member rotates, it drives the nozzle to move linearly by abutting the actuating ring.

[0011] Furthermore, the liquid supply device includes a support, the support having a first mounting portion, a liquid nozzle disposed on the first mounting portion, a drive member having a drive arm and a connecting portion rotatably connected to the first mounting portion, and an actuating ring including an upper actuating ring and a lower actuating ring spaced apart and respectively located on both sides of the drive arm.

[0012] Preferably, the driving device further includes an operating handle connected to the driving component, and the locking device includes a snap-fit ​​groove disposed on the container and a snap-fit ​​connector formed at one end of the operating handle. When in the first state, the snap-fit ​​connector is embedded in the snap-fit ​​groove.

[0013] When the driving device is an electric driving device or a driving device that can be operated manually or electrically, the driving device further includes an electric push rod connected to the driving member.

[0014] According to a specific embodiment of the present invention, the liquid outlet includes a liquid outlet hole and a sealing ring disposed on the hole wall of the liquid outlet hole.

[0015] Preferably, the nozzle includes a liquid tube having the internal channel, the liquid tube being opposite to the sealing ring, and the end of the liquid tube facing the sealing ring having a bevel; the end face of the sealing ring facing the liquid tube also has a bevel; when in the first state, the bevel of the liquid tube is pressed against the bevel of the sealing ring.

[0016] Furthermore, the container has an installation hole, a container cap is fixed in the installation hole, and a liquid outlet is opened on the container cap.

[0017] Preferably, the container lid is also provided with vent holes.

[0018] Preferably, the edge of the mounting hole is provided with a hole wall located outside the container, and the outer periphery of the container lid is provided with a protruding edge that abuts against the end face of the hole wall.

[0019] Preferably, the liquid supply device further includes a guide seat for guiding the movement of the liquid nozzle along a preset path, the guide seat being disposed around the liquid nozzle.

[0020] Another aspect of the present invention provides a droplet generation system, which includes the liquid supply device as described above.

[0021] In another aspect, the present invention provides a detection device having a liquid passage and a liquid supply device as described above for supplying liquid to said liquid passage.

[0022] Preferably, the detection device is a PCR device, and the liquid supply device is an oil supply device.

[0023] Due to the application of the above technical solution, this utility model has the following advantages compared with the prior art: This utility model adopts an improved liquid supply device, which can not only facilitate the disassembly and installation of the liquid supply container during the container replacement process, but also avoid problems such as liquid spillage during disassembly and replacement, which helps to ensure the smooth progress of testing and promote work efficiency. Attached Figure Description

[0024] Appendix Figure 1 A schematic diagram of the overall structure of a digital PCR device.

[0025] Appendix Figure 2 This is a partial front view schematic diagram of the testing equipment of this utility model.

[0026] Appendix Figure 3 This is a schematic AA cross-sectional view of the detection device of this utility model in its first state.

[0027] Appendix Figure 4 This is an enlarged schematic diagram of part B of the testing equipment of this utility model.

[0028] Appendix Figure 5 This is a schematic AA cross-sectional view of the detection device of this utility model in the second state.

[0029] Appendix Figure 6 This is an enlarged schematic diagram of part C of the testing equipment of this utility model.

[0030] In the attached diagrams: 1. Container; 2. Nozzle; 3. Support; 4. First mounting part; 5. Second mounting part; 6. Conduit; 7. Discharge part; 8. Drive arm; 9. Upper drive ring; 10. Lower drive ring; 11. Operating handle; 12. Snap-fit ​​groove; 13. Snap-fit ​​connector; 14. Sealing ring; 15. Discharge hole; 16. Container cap; 17. Guide seat; 18. X-axis slide rail; 19. Y-axis slide rail; 20. Base; 21. Moving detection platform; 22. Microdroplet generation unit; 23. Optical detection unit; 24. Moving support platform; 25. Thermal circulation unit; 26. Drive device; 27. Drive screw; 28. Oil supply device; 29. ​​Flow-stabilizing sample injection device. Detailed Implementation

[0031] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of the present invention.

[0032] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0033] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0034] As attached Figure 1The digital PCR device shown includes a base 20 with an X-axis slide rail 18 and a Y-axis slide rail 19, a movable detection platform 21 slidably mounted on the base 20 via the X-axis slide rail 18, a drive device 26 for moving the movable detection platform 21, a microdroplet generation unit 22 mounted on the movable detection platform 21, an optical detection unit 23 mounted on the movable detection platform 21, a movable support platform 24 mounted within the base 20 via the Y-axis slide rail 19, a drive screw 27 for driving the movable support platform 24, and multiple thermal circulation units 25 mounted on the movable support platform 24. The microdroplet generation unit 22 for microdropletizing samples includes an oil supply device 28 for providing formulated oil and a steady-flow injection device 29 for aspirating samples and injecting them into the formulated oil to form microdroplets. The oil supply device 28 is connected to the injection microtube in the steady-flow injection device 29 via a tubing, thereby allowing the formulated oil to be introduced into the injection microtube to purge any gas.

[0035] In the aforementioned digital PCR device, the oil supply device 28 employs a liquid supply device having a liquid passage and a liquid supply device for supplying liquid to the liquid passage.

[0036] As attached Figure 2 To be continued Figure 6 As shown, the liquid supply device includes a container 1 with a liquid holding space and a liquid outlet 7. The liquid holding space contains the required liquid, such as oil. The liquid outlet 7 connects the inside and outside of the container 1, allowing the liquid inside the container 1 to be discharged outside. The liquid supply device also includes a nozzle 2 with an internal channel. The nozzle 2 is movably disposed outside the container 1 and can be driven to move along a preset path. The nozzle 2 also has a first position and a second position, which can be switched between when the nozzle 2 moves along the preset path. The liquid supply device also includes a locking device that holds the nozzle 2 in the first position when it reaches that position. The nozzle 2 is used to connect to a downstream liquid circuit system to deliver oil.

[0037] The liquid supply device has the following features: Figure 3 and attached Figure 4 The first state shown and as attached Figure 5 and attached Figure 6 The second state is shown. In the first state, the nozzle 2 is in the first position, the nozzle 2 is tightly connected to the container 1, and the internal channel of the nozzle 2 is connected to the liquid outlet 7 of the container 1. In the second state, the nozzle 2 is in the second position, the nozzle 2 is separated from the container 1, and the internal channel of the nozzle 2 is disconnected from the liquid outlet 7 of the container 1.

[0038] The locking device includes a matching locking groove 12 and a locking connector 13. The locking groove 12 is disposed on the container 1, and the locking connector 13 is connected to the drive device. When the liquid supply device is in the first state, the locking connector 13 is embedded in the locking groove 12, and the drive device cannot move freely, thereby keeping the nozzle 2 in the first position by restricting the drive device.

[0039] The testing equipment includes a support 3 for supporting and mounting the various components. The support 3 has a first mounting portion 4 on which a liquid nozzle 2 is disposed and movable relative to the first mounting portion 4. The first mounting portion 4 may be plate-shaped with a through hole through which the liquid nozzle 2 passes. The support 3 may also have a second mounting portion 5 in addition to the first mounting portion 4, the second mounting portion 5 for receiving and / or supporting the container 1.

[0040] The nozzle 2 moves along a preset path in the vertical direction, meaning it can move vertically. The nozzle 2 includes a liquid tube with an internal channel, the axis of which is aligned with the direction of movement of the nozzle 2, i.e., vertically. When the nozzle 2 is in the first position, it is located above or below the container 1, and correspondingly, the liquid outlet 7 is located at the top or bottom of the container 1. In this embodiment, the nozzle 2 is positioned above the container 1. In this case, a conduit 6 is also provided inside the container 1. One end (upper end) of the conduit 6 communicates with the liquid outlet 7 of the container 1, while the other end (lower end) extends to the lower half of the container 1, near the bottom, and preferably has an inclined end face that contacts the bottom of the container 1. The lower end of the nozzle 2 is used to connect to the container 1, and the upper end is used to connect to the downstream liquid system. For example, a connection bayonet is provided at the upper end of the nozzle 2, where a flexible hose can be used to connect to the downstream liquid system.

[0041] The nozzle 2 can move along a preset path between a first position and a second position. To facilitate stable and controllable movement of the nozzle, the liquid supply device also includes a drive device to drive the nozzle 2. This drive device can be a manual drive device, an electric drive device, or a drive device that can be both manual and electric.

[0042] In this embodiment, the driving device includes a driving component 8, an actuating ring, and an operating handle 11. The driving component 8 is movably configured to drive the nozzle 2 when it moves. In this embodiment, the driving component 8 is rotatably connected to the first mounting portion 4 of the support 3 via a rotating shaft. The driving component 8 includes a connecting portion rotatably connected to the first mounting portion 4 at one end and a driving arm connected to the other end of the connecting portion. The axis of the connecting portion forms a certain angle with the axis of the driving arm. In this embodiment, the axis of the connecting portion is approximately perpendicular to the axis of the driving arm, thus forming a bent arm. The rotating shaft and the connecting portion are located on one side of the nozzle 2, while the driving arm extends from both sides of the middle of the nozzle 2 to the other side of the nozzle 2. Two parallel ribs can be provided on the first mounting portion 4 for mounting the rotating shaft so that the driving component 8 can be rotatably mounted. The actuating ring is disposed on the outer periphery of the nozzle 2 and can contact the driving component 8, specifically the driving arm of the driving component 8, so that when the driving component 8 rotates, it can push the actuating ring and thus drive the nozzle 2 to move. The actuating rings include an upper actuating ring 9 disposed on one side of the driving member 8 and a lower actuating ring 10 disposed on the other side of the driving member 8. The two actuating rings 9 and 10 are spaced apart and are used to realize the movement of the nozzle 2 in two directions, up and down. When the driving member 8 rotates upward, it pushes the upper actuating ring 9 from below, causing the nozzle 2 to move upward; when the driving member 8 rotates downward, it pushes the lower actuating ring 10 from above, causing the nozzle 2 to move downward. The movement of the driving member 8 can be manually driven by a person or electrically driven. In this embodiment, the driving device is a manual driving device, which further includes an operating handle 11. The operating handle 11 is connected to the driving arm of the driving member 8, so the driving member 8 can be operated by operating the operating handle 11. One end of the operating handle 11 is fixedly connected to the driving member 8, and a protrusion for applying force by a person can be provided in the middle of the operating handle 11. Based on this scheme including the operating handle 11, the locking connector 13 in the locking device is formed at one end of the operating handle 11. When in the first state, the operating handle 11 is rotated in the direction of the container 1, causing the locking connector 13 at one end to engage with the locking groove 12 on the container 1. The surface of the locking groove 12 that contacts the locking connector 13 is inclined, making it difficult for the locking connector 13 to slide freely out of the locking groove 12 under the action of the inclined surface. Instead, a certain amount of external force is required to allow it to slide out of the locking groove 12 and unlock.

[0043] In order to ensure that the nozzle 2 moves along the preset path and reduce deviation, the detection device also includes a guide seat 17 for guiding the movement of the nozzle 2 along the preset path. The guide seat 17 is arranged around the nozzle 2 and can be installed on the first mounting part 4.

[0044] When the drive device is an electric drive device or a drive device that can be operated manually or electrically, the drive device also includes an electric push rod connected to the drive member 8. The two ends of the electric push rod can be hinged to the first mounting part 4 and the drive member 8, respectively. When the electric push rod extends or retracts, it can drive the drive member 8 to rotate.

[0045] The liquid outlet 7 of container 1 includes a liquid outlet hole 15 and a sealing ring 14, with the sealing ring 14 disposed on the wall of the liquid outlet hole 15. In this embodiment, an installation hole is provided on container 1, and a container cap 16 is fixed at the installation hole, while the liquid outlet hole 15 is provided on the container cap 16. More specifically, a hole wall located outside container 1 is provided at the edge of the installation hole, and a protrusion abutting against the end face of the hole wall is provided on the outer periphery of the container cap 16, thereby achieving the installation of the container cap 16 through the cooperation of the protrusion and the end face of the hole wall. The container cap 16 has a large thickness, and the axial length of the liquid outlet hole 15 provided on it is greater than the axial length of the sealing ring 14. The sealing ring 14 is fixed to the hole wall in the middle of the liquid outlet hole 15 by a stepped structure. Above the liquid outlet hole 15 and the sealing ring 14, the end of the liquid tube of the nozzle 2 facing the sealing ring 14 of container 1 has a bevel, and the end face of the sealing ring 14 facing the nozzle 2 also has a bevel. In the first state, the inclined surface of the liquid pipe presses against the inclined surface of the sealing ring 14, causing the sealing ring 14 to undergo elastic deformation, achieving an axial and circumferential sealing connection. The container lid 16 also has vent holes to connect the inside and outside of the container 1; a pair of vent holes can be opened on opposite sides of the liquid outlet 15. For unused containers 1, a sealing film covering the liquid outlet 15 and the vent holes is provided on the container lid 16 to ensure the unused container 1 is sealed during transportation and prevent liquid spillage.

[0046] The process of replacing container 1 in the above-mentioned liquid supply device is as follows: Unlock the locking device, manually or electrically rotate the drive component 8 upwards, and during this process, the upper actuating ring 9 drives the nozzle 2 to move upwards under the guidance of the guide seat 17, so that the lower end of the nozzle 2 is separated from the liquid outlet 7 of container 1. Peel off the sealing film on the container cap 16 of the unused container 1 and place the container 1 in the designated position on the support 3. Manually or electrically rotate the drive component 8 downwards, and during this process, the lower actuating ring 10 drives the nozzle 2 to move upwards under the guidance of the guide seat 17 until the limit position, so that the lower end of the nozzle 2 enters the liquid outlet 15 and makes tight contact with the sealing ring 14 to achieve a tight connection with the container 1. At this time, the internal channel of the nozzle 2 is connected to the liquid outlet 15 of the liquid outlet 7 of the container 1, and the snap connector 13 at the end of the operating handle 11 is inserted into the snap slot 12 to lock the position of the nozzle 2. At this point, the gas in the nozzle 2 and the internal conduit 6 of container 1 can be vented to the inside of container 1 through the rear liquid circuit system, and then oil can be injected into the rear. The vent on container 1 can replenish the pressure inside container 1 in a timely manner, so that the pressure inside and outside container 1 is equal. During the above process of replacing container 1, the liquid inside container 1 will not spill and contaminate the testing environment, and the process is convenient and takes little time.

[0047] In the aforementioned liquid supply device, the container 1 has a built-in bottom-contact conduit 6, which maximizes liquid utilization and reduces liquid residue and waste. The sealing ring 14 is embedded in the wall of the liquid outlet hole 15 on the container cap 16 or is formed by secondary injection molding in the liquid outlet hole 15. The sealing connection between the liquid outlet 2 and the container 1 is achieved through the cooperation between the inclined surface on the sealing ring 14 and the inclined surface on the liquid nozzle 2.

[0048] The same testing equipment can be equipped with multiple (e.g., two) of the above-mentioned liquid supply devices to realize the supply function of different liquids or to realize the supply and backup function of the same liquid.

[0049] The aforementioned liquid supply device is not limited to digital PCR equipment, but can also be applied to other detection equipment that requires a liquid supply device.

[0050] The above embodiments are only for illustrating the technical concept and features of this utility model, and are intended to enable those skilled in the art to understand the content of this utility model and implement it accordingly. They should not be construed as limiting the scope of protection of this utility model. All equivalent changes or modifications made in accordance with the spirit and essence of this utility model should be included within the scope of protection of this utility model.

Claims

1. A liquid supply apparatus including a container having a liquid containing space and a liquid outlet, characterized by: The liquid supply device further comprises a liquid nozzle capable of being driven to move along a preset path and having a first position and a second position, and a locking device for keeping the liquid nozzle in the first position, the liquid nozzle having an internal passage; the liquid supply device has a first state and a second state; When in the first state, the liquid nozzle is in the first position, the liquid nozzle is tightly connected with the container, and the internal passage of the liquid nozzle is in communication with the liquid outlet of the container; when in the second state, the liquid nozzle is in the second position, the liquid nozzle is separated from the container, and the internal passage of the liquid nozzle is disconnected from the liquid outlet of the container.

2. The liquid supply apparatus according to claim 1, wherein: The liquid supply device comprises a support, the support having a first mounting portion on which the liquid nozzle is arranged, or the support simultaneously having the first mounting portion and a second mounting portion for accommodating and / or supporting the container.

3. The liquid supply apparatus according to claim 1, wherein: The preset path extends in the up-down direction; when the liquid nozzle is in the first position, the liquid nozzle is located above or below the container, and correspondingly, the liquid outlet is arranged on the top or bottom of the container; when the liquid nozzle is located above the container, the container further has a guide pipe therein, one end of the guide pipe being in communication with the liquid outlet and the other end extending to the vicinity of the bottom of the container.

4. The liquid supply apparatus according to claim 1, wherein: The liquid supply device further comprises a driving device for driving the liquid nozzle to move along the preset path between the first position and the second position, the driving device being a manual driving device or an electric driving device or a driving device capable of being driven manually or electrically.

5. The liquid supply apparatus according to claim 4, wherein: The locking device comprises a clamping groove arranged on the container and a clamping head connected with the liquid nozzle or the driving device, the clamping head being embedded in the clamping groove when in the first state.

6. The liquid supply apparatus according to claim 4, wherein: The driving device comprises a driving member capable of being rotatably arranged and a touch ring formed on the outer periphery of the liquid nozzle, the driving member driving the liquid nozzle to move linearly by abutting against the touch ring when the driving member rotates.

7. The liquid supply apparatus according to claim 6, wherein: The liquid supply device comprises a support, the support having a first mounting portion on which the liquid nozzle is arranged, the driving member having a driving arm and a connecting portion rotatably connected with the first mounting portion, and the touch ring comprising an upper touch ring and a lower touch ring arranged at intervals and located on the two sides of the driving arm respectively.

8. The liquid supply apparatus according to claim 6, wherein: The driving device further comprises an operating handle connected with the driving member, and the locking device comprises a clamping groove arranged on the container and a clamping head formed on one end of the operating handle, the clamping head being embedded in the clamping groove when in the first state.

9. The liquid supply apparatus according to claim 1, wherein: The liquid outlet comprises a liquid outlet hole and a sealing ring arranged on the hole wall of the liquid outlet hole.

10. The liquid supply apparatus according to claim 9, wherein: The liquid nozzle comprises a liquid pipe having the internal passage, the liquid pipe being opposite to the sealing ring, and one end of the liquid pipe towards the sealing ring having a bevel; one side end surface of the sealing ring towards the liquid pipe also has a bevel; when in the first state, the bevel of the liquid pipe is pressed against the bevel of the sealing ring.

11. The liquid supply apparatus according to claim 9, wherein: The container has a mounting hole formed thereon, a container cover being fixedly arranged in the mounting hole, and the liquid outlet hole being formed on the container cover.

12. The liquid supply apparatus according to claim 11, wherein: The container cover is further provided with a ventilation hole; and / or, the edge of the mounting hole is provided with a hole wall outside the container, and the outer periphery of the container cover is provided with a protruding edge abutting against the end surface of the hole wall.

13. The liquid supply apparatus according to claim 1, wherein: The liquid supply device further comprises a guide seat for guiding the movement of the liquid nozzle along a preset path, and the guide seat is arranged around the liquid nozzle.

14. A droplet generation system comprising a liquid supply device, characterised in that: The liquid supply device is as claimed in any one of claims 1 to 13.

15. A testing apparatus having a liquid passage and a liquid supply device for supplying a liquid to the liquid passage, characterized by: The liquid supply device is as claimed in any one of claims 1 to 13.

16. The detection device of claim 15, wherein: The detection device is a PCR device, and the liquid supply device is an oil supply device.

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