Reaction device for biotransformation of bilirubin

Abstract

The utility model relates to the technical field of bilirubin extraction, and discloses a reaction device for bioconversion of bilirubin, which comprises a reaction kettle body, a stirring mechanism for mixing a catalyst and a solvent is arranged at the top of an inner cavity of the reaction kettle body, and a material control mechanism for feeding the catalyst is arranged at the upper end of the reaction kettle body. A water bath heat preservation mechanism is arranged on the outer side of the reaction kettle body; the material control mechanism comprises a material barrel, and an air cylinder is arranged at the upper end of the material barrel. Through the cooperation of the reaction kettle body, the material control mechanism and the stirring mechanism, the position of a piston is adjusted through an air cylinder, and due to the sealing design of the charging barrel, a catalyst in the charging barrel can be injected into the reaction kettle along a connecting pipe under the extrusion of the piston, and the feeding amount is monitored through a flow sensor, so that the feeding amount of the catalyst can be accurately controlled; and the stability of reaction conditions is ensured, so that the conversion efficiency of the bilirubin is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of bilirubin extraction, in particular to a reaction device for biological conversion of bilirubin. BACKGROUND

[0002] Bilirubin is one of the bile pigments, and is the main color in human bile. Bilirubin is mainly the metabolic product of some compounds in the body. In the medical field, it is mainly used as an important basis for determining jaundice. However, some auxiliary materials need to be added manually for the extraction of bilirubin during the extraction process of bilirubin. The staff needs to strictly control the amount of materials when adding auxiliary materials, otherwise the concentration of the extracted bilirubin will be affected.

[0003] However, the traditional reaction device usually directly puts in the biological catalyst, and cannot well control the amount of the biological catalyst. Too much or too little catalyst will lead to a decrease in reaction efficiency, and thus affect the production efficiency of bilirubin. Therefore, we need to propose a reaction device for biological conversion of bilirubin. UTILITY MODEL

[0004] The utility model aims to provide a reaction device for biological conversion of bilirubin. Controlling the amount of biological catalyst can ensure that the concentration of catalyst in the solution is in the best range, avoiding a decrease in reaction efficiency due to too much or too little catalyst, thereby improving the conversion efficiency of bilirubin to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: a reaction device for biological conversion of bilirubin, comprising a reaction kettle body, a stirring mechanism for mixing catalyst and solvent is arranged at the top of the inner cavity of the reaction kettle body, a material control mechanism for putting in catalyst is arranged at the upper end of the reaction kettle body, and a water bath heat preservation mechanism is arranged on the outer side of the reaction kettle body.

[0006] The material control mechanism comprises a barrel, a cylinder is arranged at the upper end of the barrel, a piston is installed at the telescopic end of the cylinder and penetrates through the barrel, the piston is slidingly arranged in the inner cavity of the barrel, a tapered barrel is integrally formed at the lower end of the barrel, a connecting pipe connected with the reaction kettle is arranged at the lower end of the tapered barrel, a flow sensor is installed on the inner wall of the connecting pipe, and an electromagnetic valve is arranged at the upper end of the connecting pipe.

[0007] Preferably, the lower end of the piston is conical, a guide rod penetrating through the barrel is fixedly connected to the upper surface of the piston, a feeding pipe is arranged on the outer side of the barrel, and a control valve is arranged on the feeding pipe.

[0008] Preferably, the upper end of the reaction kettle body is provided with a pH value display for detecting pH value change of the solvent, and the outer side of the reaction kettle body is provided with a raw material inlet pipe, one end of the raw material inlet pipe is provided with an oxygen supply pipe.

[0009] Preferably, the stirring mechanism comprises a rotating shaft rotatably arranged at the top of the inner cavity of the reaction kettle body, the upper end of the rotating shaft penetrates through the reaction kettle body and is driven by a motor, and the lower end of the rotating shaft is provided with a plurality of groups of stirring blades.

[0010] Preferably, the upper end of the rotating shaft is symmetrically and fixedly connected with two groups of side rods, and the opposite ends of the two groups of side rods are fixedly connected with scraping rods, and one side of the scraping rods is slidably arranged on the inner wall of the reaction kettle body.

[0011] Preferably, the water bath heat preservation mechanism comprises a heat preservation pipe cover mounted on the outer side of the reaction kettle body, and the inner cavity of the heat preservation pipe cover is provided with a spiral water pipe, and the two ends of the spiral water pipe are respectively provided with a water inlet pipe and a water outlet pipe.

[0012] Preferably, the outer side of the reaction kettle body is provided with a controller electrically connected with the electromagnetic valve and the motor, the lower end of the reaction kettle body is provided with a discharge pipe, and the raw material inlet pipe and the oxygen supply pipe are both provided with an electric control valve.

[0013] Compared with the prior art, the beneficial effects of the utility model are:

[0014] The utility model mainly through the cooperation between reaction kettle body, control material mechanism and stirring mechanism, through the position adjustment of piston by air cylinder, and because of the sealing design of material cylinder, the catalyst in the material cylinder can be injected into the reaction kettle along the connecting pipe under the extrusion of piston, and the amount of input is monitored by using the flow sensor, the amount of catalyst input can be accurately controlled, the excessive or insufficient is avoided, the stability of reaction condition is guaranteed, and the efficiency of bilirubin conversion is improved. BRIEF DESCRIPTION OF DRAWINGS

[0015] Fig. 1 It is the whole structure schematic view of the utility model;

[0016] Fig. 2 It is the internal structure schematic view of the reaction kettle body of the utility model;

[0017] Fig. 3 It is the control material mechanism structure schematic view of the utility model.

[0018] As shown in the figure: 1, the reactor body; 2, the controller; 3, the water bath insulation mechanism; 31, the insulation pipe cover; 32, the spiral water pipe; 33, the water inlet pipe; 34, the water outlet pipe; 4, the stirring mechanism; 41, the motor; 42, the rotating shaft; 43, the stirring blade; 44, the side rod; 45, the scraper; 5, the material control mechanism; 51, the barrel; 52, the air cylinder; 53, the guide rod; 54, the piston; 55, the cone barrel; 56, the feeding pipe; 57, the connecting pipe; 58, the electromagnetic valve; 59, the flow sensor; 6, the pH value display; 7, the raw material inlet pipe; 8, the oxygen supply pipe; 9, the discharge pipe. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the utility model.

[0020] Please refer to Figs. 1-3 The utility model provides a kind of technical scheme: a kind of reaction device of biological conversion bilirubin, including reactor body 1, the inner chamber top of reactor body 1 is provided with the stirring mechanism 4 for mixing catalyst with solvent, the upper end of reactor body 1 is provided with the material control mechanism 5 for catalyst feeding, the outer side of reactor body 1 is provided with water bath insulation mechanism 3;

[0021] Material control mechanism 5 includes barrel 51, the upper end of barrel 51 is provided with air cylinder 52, the telescopic end of air cylinder 52 is connected and is equipped with piston 54, piston 54 is slidably arranged in the inner chamber of barrel 51, the lower end of barrel 51 is integrally formed with cone barrel 55, the lower end of cone barrel 55 is provided with connecting pipe 57 connected with reactor, flow sensor 59 is installed on the inner wall of connecting pipe 57, and the upper end of connecting pipe 57 is provided with electromagnetic valve 58.

[0022] The lower end of piston 54 is conical, the upper surface of piston 54 is fixedly connected with guide rod 53 penetrating barrel 51, the outer side of barrel 51 is provided with feeding pipe 56, and control valve is arranged on feeding pipe 56. Through the structural design of piston 54, it is convenient to adhere to the inner wall of cone barrel 55, additives in barrel 51 are conveniently pushed out, and catalyst attached to the inner wall of barrel 51 is reduced.

[0023] The upper end of the reactor body 1 is equipped with a pH display 6 for detecting changes in the pH value of the solvent. The outside of the reactor body 1 is equipped with a raw material inlet pipe 7, and one end of the raw material inlet pipe 7 is equipped with an oxygen supply pipe 8. The pH display 6 monitors the pH value of the reaction system in real time, and when the pH value deviation is large, it transmits a signal to the controller 2, so that the controller 2 controls the addition of catalyst and introduces oxygen through the oxygen supply pipe 8 to meet the oxygen demand conditions of the bioconversion reaction.

[0024] The stirring mechanism 4 includes a rotating shaft 42 rotatably mounted on the top of the inner cavity of the reactor body 1. The upper end of the rotating shaft 42 passes through the reactor body 1 and is driven by a motor 41. The lower end of the rotating shaft 42 is provided with multiple sets of stirring blades 43. The multiple sets of stirring blades 43 increase the stirring range of the solution, thereby improving the efficiency of uniform mixing of the catalyst and the solvent.

[0025] Two sets of side rods 44 are symmetrically fixedly connected to the upper end of the rotating shaft 42. Each set of side rods 44 has a scraper 45 fixedly connected to one end opposite to the other. One side of the scraper 45 is slidably disposed on the inner wall of the reactor body 1. The solution on the inner wall of the reactor body 1 can be scraped off by the side rods 44, which facilitates the next use of the reactor body 1.

[0026] The water bath insulation mechanism 3 includes an insulation pipe cover 31 installed on the outside of the reactor body 1. The inner cavity of the insulation pipe cover 31 is provided with a spiral water pipe 32. The two ends of the spiral water pipe 32 are respectively provided with an inlet pipe 33 and an outlet pipe 34. Warm water is injected through the inlet pipe 33 and heat is exchanged inside the reactor body 1 under the action of the spiral water pipe 32, so as to ensure the stability of the ambient temperature when the solution and catalyst are mixed inside the reactor body 1 and to ensure the uniformity of the mixing of the solution and catalyst.

[0027] A controller 2, which is electrically connected to a solenoid valve 58 and a motor 41, is installed on the outside of the reactor body 1. A discharge pipe 9 is installed at the lower end of the reactor body 1. Electrically controlled valves are installed on both the raw material inlet pipe 7 and the oxygen supply pipe 8. The electrically controlled valves are electrically connected to the controller 2 to facilitate the control of the injection of oxygen and solution.

[0028] In use, the catalyst is injected into the feed cylinder 51 through the feed pipe 56, and the solvent is injected into the reactor body 1 through the raw material inlet pipe 7. The reactor body 1 is heated by the water bath heat preservation mechanism 3, and then the cylinder 52 and motor 41 are started. The motor 41 drives the rotating shaft 42 to stir the solvent with the stirring blades 43. After the solenoid valve 58 is opened, the cylinder 52 drives the piston 54 to descend, pressurizing the catalyst in the feed cylinder 51, so that the catalyst is injected into the reactor body 1 through the connecting pipe 57. The amount injected is monitored by the flow sensor 59 so as to close the solenoid valve 58 in time to avoid adding too much or too little catalyst. Under the action of the stirring mechanism 4, the catalyst is mixed evenly with the solvent, which improves the extraction efficiency of bilirubin in the solvent. After extraction, the evenly mixed solution is collected through the discharge pipe 9.

[0029] While the embodiments of the present application have been illustrated and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the spirit and scope of the application, which is defined by the appended claims and their equivalents.

Claims

1. A reaction device for biotransformation of bilirubin comprising a reaction vessel body (1), characterized in that: The inner cavity top of the reaction kettle body (1) is provided with a stirring mechanism (4) for mixing catalyst and solvent, the upper end of the reaction kettle body (1) is provided with a material control mechanism (5) for catalyst feeding, and the outer side of the reaction kettle body (1) is provided with a water bath insulation mechanism (3); The material control mechanism (5) comprises a barrel (51), the upper end of the barrel (51) is provided with a pneumatic cylinder (52), the telescopic end of the pneumatic cylinder (52) is penetrated and communicated and is provided with a piston (54), the piston (54) is slidingly arranged in the inner cavity of the barrel (51), the lower end of the barrel (51) is integrally formed with a tapered barrel (55), the lower end of the tapered barrel (55) is provided with a connecting pipe (57) communicated with the reaction kettle, the inner wall of the connecting pipe (57) is provided with a flow sensor (59), and the upper end of the connecting pipe (57) is provided with an electromagnetic valve (58); The stirring mechanism (4) comprises a rotating shaft (42) rotatingly arranged at the top of the inner cavity of the reaction kettle body (1), the upper end of the rotating shaft (42) penetrates the reaction kettle body (1) and is driven by a motor (41), and the lower end of the rotating shaft (42) is provided with a plurality of groups of stirring blades (43); The upper end of the rotating shaft (42) is fixedly connected with two groups of side rods (44) in symmetry, and the opposite ends of the two groups of side rods (44) are fixedly connected with scraping rods (45), respectively; and one side of the scraping rod (45) is slidingly arranged on the inner wall of the reaction kettle body (1). The water bath insulation mechanism (3) comprises a heat preservation pipe cover (31) arranged on the outer side of the reaction kettle body (1), and the inner cavity of the heat preservation pipe cover (31) is provided with a spiral water pipe (32); the two ends of the spiral water pipe (32) are provided with water inlet pipes (33) and water outlet pipes (34), respectively.

2. The reaction device for biotransformation of bilirubin according to claim 1, characterized in that: The lower end of the piston (54) is conical, the upper surface of the piston (54) is fixedly connected with a guide rod (53) penetrating the barrel (51), the outer side of the barrel (51) is provided with a feeding pipe (56), and the feeding pipe (56) is provided with a control valve.

3. The reaction device for biotransformation of bilirubin according to claim 2, characterized in that: The upper end of the reaction kettle body (1) is provided with a pH value display (6) for detecting the pH value change of the solvent, the outer side of the reaction kettle body (1) is provided with a raw material inlet pipe (7), and one end of the raw material inlet pipe (7) is provided with an oxygen supply pipe (8).

4. The reaction device for biotransformation of bilirubin according to claim 3, characterized in that: The outer side of the reaction kettle body (1) is provided with a controller (2) electrically connected with the electromagnetic valve (58) and the motor (41), the lower end of the reaction kettle body (1) is provided with a discharge pipe (9), and the raw material inlet pipe (7) and the oxygen supply pipe (8) are provided with electric control valves, respectively.

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