Component detection device for enteric-coated tablets

Abstract

The utility model relates to a component detection device for an enteric-coated tablet, and aims to solve the technical problems that pollution is easily caused in the process of transferring the ground enteric-coated tablet at present, and thiamphenicol in the enteric-coated tablet is easily decomposed when being transferred and ground due to the fact that the thiamphenicol is easily decomposed when being exposed to light, so that the component detection result of the enteric-coated tablet is influenced. Comprising a grinding pipe, an extraction pipe, a filter pipe and a storage pipe, the grinding pipe, the extraction pipe, the filter pipe and the storage pipe are sequentially connected from top to bottom, the top of the grinding pipe is connected with a cover plate through a bolt, a driving motor is installed on the cover plate, a grinding mechanism is arranged in the grinding pipe and connected with the driving end of the driving motor, and the driving end of the driving motor is connected with the extraction pipe. According to the utility model, the grinding, extracting and filtering of the enteric-coated tablet can be continuously completed in a sealed space, and the treated sample does not need to be transferred, so that the influence on the component detection result of the enteric-coated tablet caused by pollution and photolysis of thiamphenicol in the enteric-coated tablet in the transferring process is avoided.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of enteric -coated tablet component detection, concretely to a kind of enteric -coated tablet component detection device. BACKGROUND

[0002] Enteric-coated tablet refers to not disintegration in gastric juice, but can disintegration and absorption in intestinal juice one kind of tablet, it is usually wrapped with a layer of enteric-coated on ordinary tablet, and its main component is thiamphenicol, thiamphenicol is the derivative of florfenicol, and its antibacterial effect is similar to chloramphenicol. Since chloramphenicol drug has serious side effects, the international successively prohibits or strictly restricts the use of chloramphenicol, so that after the production of enteric-coated tablet, the thiamphenicol component in it needs to be detected.

[0003] When enteric-coated tablet component is detected, enteric-coated tablet is ground, extracted and filtered, which is designed separately, then after the filtered solution is obtained, its components are detected by high performance liquid chromatography, in the process of transferring the ground enteric-coated tablet, pollution is easily caused, and thiamphenicol in enteric-coated tablet is easily decomposed by light, so that it is easily decomposed by light when transferring and grinding, thereby affecting the result of enteric-coated tablet component detection. Therefore, a new technical solution needs to be designed to solve the problem. UTILITY MODEL CONTENT

[0004] The utility model aims at overcoming the deficiency of prior art, adapting to reality needs, provide a kind of enteric -coated tablet component detection device to solve the technical problem that the process of transferring the ground enteric-coated tablet in current, easily cause pollution, and thiamphenicol in enteric-coated tablet is easily decomposed by light, so that it is easily decomposed by light when transferring and grinding, thereby affecting the result of enteric-coated tablet component detection.

[0005] In order to realize the purpose of the utility model, the technical scheme adopted by the utility model is as follows: a kind of enteric -coated tablet component detection device is designed, including grinding tube, extraction tube, filter tube and storage tube, the grinding tube, extraction tube, filter tube and storage tube are sequentially connected from top to bottom, the top of the grinding tube is connected with cover plate by bolt, the cover plate is installed with drive motor, the grinding mechanism is arranged in the grinding tube, and is connected with the driving end of drive motor, the inner wall of the extraction tube is installed with first hopper, the bottom of the first hopper is communicated with liquid outlet pipe, the bottom of the liquid outlet pipe is connected with connecting plate, the bottom of the grinding mechanism is connected with connecting shaft, the bottom of the connecting shaft is rotatably connected with connecting plate, the outer side of the connecting shaft in the liquid outlet pipe of the first hopper is installed with rubber spiral blade, the inner wall of the filter tube is installed with fixed ring, the inner side of the fixed ring is installed with filter membrane, the bottom of the fixed ring is installed with second hopper.

[0006] Preferably, the grinding mechanism comprises a female grinding head mounted on the inner wall of the grinding pipe, the inner side of the female grinding head is provided with a male grinding head, and the driving end of the driving motor is connected with the top of the male grinding head through the rotation of the penetrating cover plate.

[0007] Preferably, the male grinding head and the female grinding head are both made of ceramic material, the surface of the male grinding head is provided with a storage groove, the top of the storage groove is provided with a sealing plate, the surface of the sealing plate is arc-shaped and protruding, the sealing plate is connected with the driving end of the driving motor, the bottom of the sealing plate is fixedly connected with two inserting rods, the male grinding head on the two sides of the storage groove is provided with an inserting hole, and the two inserting holes are correspondingly matched with the two inserting rods.

[0008] Preferably, the filter pipe is provided with a screw rod and a sliding rod between the inner cavities of the two sides of the filter pipe below the second funnel, the sliding rod is fixedly connected with the inner wall of the filter pipe, the screw rod is rotatably connected with the inner wall of the filter pipe, one end of the screw rod is rotatably penetrated to the outside of the filter pipe, the screw rod and the sliding rod are provided with an adjusting plate, the screw rod is threadedly rotated with the adjusting plate, the adjusting plate is slidably sleeved with the outside of the sliding rod, and the adjusting plate is provided with two through holes, and the bottom of one of the through holes is provided with a collecting pipe.

[0009] Preferably, the connecting shaft outside the rubber spiral blade is provided with a plurality of stirring rods, and the plurality of stirring rods are equidistantly distributed on the outside of the connecting shaft.

[0010] Preferably, the end of the adjusting plate close to the second funnel is provided with a sealing gasket, and the size of the through hole is matched with the size of the bottom pipe of the second funnel.

[0011] Preferably, the grinding pipe, the extraction pipe, the filter pipe and the storage pipe are movably connected through threads.

[0012] Compared with the prior art, the utility model has the advantages that:

[0013] 1. The grinding pipe, the extraction pipe, the filter pipe, the storage pipe, the grinding mechanism, the driving motor, the connecting shaft, the rubber spiral blade, the first funnel, the second funnel and the filter membrane are combined, so that the grinding, extraction and filtration of enteric-coated tablets are continuously completed in a sealed space, the sample to be treated does not need to be transferred, and the pollution and decomposition caused by sulfamethoxazole in the enteric-coated tablets in the transfer process are avoided, so that the detection result of the enteric-coated tablet composition is affected.

[0014] 2. The utility model discloses a combination of storage tank, cover, plug rod and jack etc. structure, the public grinding head and female grinding head are ceramic material, thereby avoid the pollution that metal causes to enteric-coated tablet grinding, when enteric-coated tablet is added between the public grinding head and female grinding head, take ice block and put into the storage tank, then connect the cover on the public grinding head with the plug hole, thereby the ice block can cool down when the public grinding head grinds enteric-coated tablet, thereby avoid the thermal degradation of thiamphenicol when enteric-coated tablet is ground, influence the result of enteric-coated tablet component detection.

[0015] 3. The utility model discloses a combination of adjusting plate, screw rod, slide rod, through -hole and collection pipe etc. can collect the primary filtrate through the collection pipe, prevent the primary filtrate and the filtrate of the back filtration mixture, and the filter membrane is 0.45mu m nylon filter membrane, and is compatible organic solvent, reduces the adsorption of filter membrane, thereby avoid the influence of filter membrane adsorption in the component of filtrate, further improve the result of enteric-coated tablet component detection. ACCOUT OF DRAWINGS

[0016] Figure 1 It is the whole external structure schematic diagram of the utility model;

[0017] Figure 2 It is the whole internal structure schematic diagram of the utility model;

[0018] Figure 3 It is the filter pipe bottom structure schematic diagram of the utility model;

[0019] Figure 4 It is the A place enlarged view of the utility model;

[0020] Figure 5 It is the B place enlarged view of the utility model.

[0021] In the drawing: 1, grinding pipe;11, cover;12, female grinding head;13, public grinding head;14, storage tank;15, cover plate;16, plug rod;17, jack;2, extraction pipe;21, first hopper;22, connecting shaft;23, stirring rod;24, liquid outlet pipe;25, rubber spiral blade;26, connecting plate;3, filter pipe;31, fixed ring;32, filter membrane;33, second hopper;4, storage pipe;5, drive motor;6, adjusting plate;61, through -hole;62, collection pipe;63, screw rod;64, slide rod. DETAILED DESCRIPTION

[0022] The utility model is further explained in connection with the drawings and examples:

[0023] Example 1: a kind of for enteric-coated tablet component detection device, refer to Figures 1 to 5The utility model provides a kind of multi-functional sample grinder, including grinding pipe 1, extraction pipe 2, filter pipe 3 and storage pipe 4, the grinding pipe 1, extraction pipe 2, filter pipe 3 and storage pipe 4 are sequentially connected from top to bottom, the top of the grinding pipe 1 is bolted with cover plate, driving motor 5 is installed on the cover plate, grinding mechanism is provided in the grinding pipe 1, and is connected with the driving end of driving motor 5, the grinding mechanism includes female grinding head 12 installed in the inner wall of grinding pipe 1, the inner side of female grinding head 12 is provided with male grinding head 13, the driving end of driving motor 5 is rotatably penetrated through cover plate and connected with the top of male grinding head 13, the inner wall of extraction pipe 2 is installed with first funnel 21, the bottom of first funnel 21 is communicated with liquid outlet pipe 24, the bottom of liquid outlet pipe 24 is connected with connecting plate 26, the bottom of connecting shaft 22 of grinding mechanism is rotatably connected with connecting plate 26, rubber helical blade 25 is installed on the outer side of connecting shaft 22 in the liquid outlet pipe 24 of first funnel 21, the inner wall of filter pipe 3 is installed with fixed ring 31, the inner side of fixed ring 31 is installed with filter membrane 32, the bottom of fixed ring 31 is installed with second funnel 33.

[0024] When working, the sample enteric-coated tablet is added into the grinding pipe 1, then the grinding pipe 1 is sealed by the cover plate 11, the male grinding head 13 is driven to rotate by the driving motor 5 to cooperate with the female grinding head 12 to grind the enteric-coated tablet, at this time, the ground enteric-coated tablet powder falls into the extraction solvent (methanol-phosphate buffer, methanol: dissolve thiamphenicol (stronger fat solubility), buffer: simulate intestinal fluid environment, promote release) in the extraction pipe 2, when the enteric-coated tablet powder is fully mixed with the extraction solvent, the driving motor 5 is started to drive the rubber helical blade 25 to rotate, so that the rubber helical blade 25 pushes the solvent to be delivered into the filter pipe 3, the filtered solvent is stored in the storage pipe 4 by the filter membrane 32, then the thiamphenicol component in the enteric-coated tablet is detected by high performance liquid chromatography, so that the grinding, extraction and filtration of the enteric-coated tablet are continuously completed in a sealed space, without transferring the processed sample, so as to avoid the thiamphenicol in the enteric-coated tablet from causing pollution and light decomposition in the transfer process, thereby affecting the detection result of the enteric-coated tablet component.

[0025] Specifically, refer to Figure 2 and Figure 5The male grinding head 13 and the female grinding head 12 are both made of ceramic material, the surface of the male grinding head 13 is provided with a storage groove 14, the top of the storage groove 14 is provided with an enclosing plate 15, the surface of the enclosing plate 15 is arc-shaped and protruding, the enclosing plate 15 is connected with the driving end of the driving motor 5, the bottom of the enclosing plate 15 is fixedly connected with an inserting rod 16 on both sides, the male grinding head 13 on both sides of the storage groove 14 is provided with an inserting hole 17, the two inserting holes 17 are correspondingly matched with the two inserting rods 16, the male grinding head 13 and the female grinding head 12 are both made of ceramic material, so that the pollution caused by metal to the enteric-coated tablets during grinding is avoided, when the enteric-coated tablets are added between the male grinding head 13 and the female grinding head 12, the ice cubes are taken and put into the storage groove 14, then the inserting rod 16 is matched with the inserting hole 17, and the enclosing plate 15 is connected with the male grinding head 13, so that the ice cubes can cool the male grinding head 13 during grinding of the enteric-coated tablets, and the thermal degradation of thiamphenicol during grinding of the enteric-coated tablets is avoided, and the detection result of the components of the enteric-coated tablets is affected.

[0026] Further, referring to Figure 2 and Figure 3 , the two sides of the inner cavity of the filter pipe 3 below the second funnel 33 are provided with a lead screw 63 and a sliding rod 64, the sliding rod 64 is fixedly connected with the inner wall of the filter pipe 3, the lead screw 63 is rotatably connected with the inner wall of the filter pipe 3, and one end of the lead screw 63 is rotatably penetrated and arranged outside the filter pipe 3, the lead screw 63 and the sliding rod 64 are provided with an adjusting plate 6, the lead screw 63 is threadedly rotated with the adjusting plate 6, the adjusting plate 6 is slidably sleeved outside the sliding rod 64, two through holes 61 are formed in the adjusting plate 6, and a collecting pipe 62 is mounted and connected at the bottom of one of the through holes 61, when filtering, the lead screw 63 is twisted to make the collecting pipe 62 correspond to the bottom of the second funnel 33, so that the primary filtrate is collected in the collecting pipe 62, then the lead screw 63 is twisted to make the other through hole 61 correspond to the bottom of the second funnel 33, so that the filtrate filtered later is stored in the storage pipe 4, thereby preventing the primary filtrate from being mixed with the filtrate filtered later, the filter membrane 32 is a 0.45 μm nylon filter membrane 32, is compatible with organic solvents, reduces the adsorption of the filter membrane 32, thereby avoiding the influence of the adsorption of the filter membrane 32 on the components in the filtrate, and further improving the detection result of the components of the enteric-coated tablets.

[0027] It is worth noting that, referring to Figure 2 , a plurality of stirring rods 23 are mounted on the outer side of the connecting shaft 22 above the rubber spiral blade 25, and the plurality of stirring rods 23 are equidistantly distributed on the outer side of the connecting shaft 22, when the enteric-coated tablets are ground and extracted, the stirring rods 23 follow the rotation, so that the solvent can be stirred, thereby improving the extraction effect of the components of the enteric-coated tablets.

[0028] It is worth noting that, referring to Figure 2 and Figure 3The adjusting plate 6 is provided with a sealing gasket near one end of the second funnel 33, the size of the through hole 61 is matched with the size of the bottom pipe of the second funnel 33, so as to ensure the sealing of the second funnel 33, the adjusting plate 6 and the corresponding through hole 61, avoid the leakage of the primary filtrate, and affect the detection result of the enteric-coated tablet components.

[0029] It is worth mentioning that, referring to Figure 1 The grinding pipe 1, the extraction pipe 2, the filtering pipe 3 and the storage pipe 4 are connected through threads, so that the grinding pipe 1, the extraction pipe 2, the filtering pipe 3 and the storage pipe 4 can be disassembled and cleaned.

[0030] In addition, the components of the utility model are all general standard components or components known by the person skilled in the art, the structure and principle of which can be known by the person skilled in the art through a technical manual or through a conventional experimental method, and the person skilled in the art can realize it completely, and it is needless to say that the content protected by the utility model does not involve the improvement of the internal structure and method.

[0031] The utility model discloses an embodiment discloses a preferred embodiment, but is not limited to this, and the person skilled in the art, easily understands the spirit of the utility model according to the above -mentioned embodiment, and makes different extension and change, but as long as not departing from the spirit of the utility model, all are within the protection scope of the utility model.

Claims

1. A device for detecting the components of enteric-coated tablets, comprising a grinding tube (1), an extraction tube (2), a filter tube (3), and a storage tube (4), which are connected in order from top to bottom, characterized in that, The top of the grinding pipe (1) is connected with a cover plate through bolts, a driving motor (5) is installed on the cover plate, a grinding mechanism is arranged in the grinding pipe (1) and is connected with the driving end of the driving motor (5), a first funnel (21) is installed on the inner wall of the extraction pipe (2), a liquid outlet pipe (24) is communicated with the bottom of the first funnel (21), a connecting plate (26) is connected with the bottom of the liquid outlet pipe (24), a connecting shaft (22) is connected with the bottom of the grinding mechanism, the bottom of the connecting shaft (22) is rotatably connected with the connecting plate (26), a rubber spiral blade (25) is installed on the outer side of the connecting shaft (22) in the liquid outlet pipe (24) of the first funnel (21), a fixed ring (31) is installed on the inner wall of the filter pipe (3), a filter membrane (32) is installed on the inner side of the fixed ring (31), and a second funnel (33) is installed on the bottom of the fixed ring (31).

2. The apparatus for detecting the components of enteric tablets according to claim 1, wherein The grinding mechanism comprises a female grinding head (12) installed on the inner wall of the grinding pipe (1), a male grinding head (13) arranged on the inner side of the female grinding head (12), and the driving end of the driving motor (5) rotatably penetrating the cover plate and connected with the top of the male grinding head (13).

3. The apparatus for detecting the components of enteric coated tablets according to claim 2, wherein The male grinding head (13) and the female grinding head (12) are both made of ceramic material, a storage groove (14) is formed in the surface of the male grinding head (13), an enclosing plate (15) is arranged on the top of the storage groove (14), the surface of the enclosing plate (15) is arc-shaped and protruding, the enclosing plate (15) is connected with the driving end of the driving motor (5), plug rods (16) are fixedly connected to the bottom of the enclosing plate (15) on both sides, plug holes (17) are formed in the male grinding head (13) on both sides of the storage groove (14), and the two plug holes (17) correspond to and are matched with the two plug rods (16) respectively.

4. The apparatus for detecting the components of enteric coated tablets according to claim 1, wherein A screw rod (63) and a sliding rod (64) are arranged between the inner cavities of the filter pipe (3) on both sides below the second funnel (33), the sliding rod (64) is fixedly connected to the inner wall of the filter pipe (3), the screw rod (63) is rotatably connected to the inner wall of the filter pipe (3), one end of the screw rod (63) rotatably penetrates the outer side of the filter pipe (3), an adjusting plate (6) is arranged between the screw rod (63) and the sliding rod (64), the screw rod (63) is threadedly rotatable with the adjusting plate (6), the adjusting plate (6) is slidably sleeved on the outer side of the sliding rod (64), two through holes (61) are formed in the adjusting plate (6), and a collecting pipe (62) is connected to the bottom of one of the through holes (61).

5. The apparatus for detecting the components of enteric coated tablets according to claim 1, wherein A plurality of stirring rods (23) are installed on the outer side of the connecting shaft (22) above the rubber spiral blade (25), and the plurality of stirring rods (23) are equidistantly distributed on the outer side of the connecting shaft (22).

6. The apparatus for detecting the components of enteric coated tablets according to claim 4, wherein The end of the adjusting plate (6) close to the second funnel (33) is provided with a sealing gasket, and the size of the through hole (61) is matched with the size of the bottom pipe of the second funnel (33).

7. The apparatus for detecting the components of enteric coated tablets according to claim 4, wherein The grinding pipe (1), the extraction pipe (2), the filter pipe (3) and the storage pipe (4) are connected with each other through threads.

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