Filter pressing device for extracting heparin sodium

Abstract

The utility model discloses a filter pressing device for extracting heparin sodium, which is characterized in that a filter pressing cylinder is arranged on a support frame, an outer cylinder body is arranged on the outer side of the filter pressing cylinder, an interlayer is arranged between the outer cylinder body and the filter pressing cylinder, and a cold water inlet pipe and a cold water outlet pipe are arranged on the outer cylinder body; a pressure detection assembly is arranged between the filter pressing block and the electric push rod, a liquid outlet pipe is arranged at the bottom of the filter pressing cylinder, a turbidity meter for detecting the turbidity of filter pressing liquid is arranged on the liquid outlet pipe, a liquid collecting cylinder is installed at the bottom of the liquid outlet pipe, the filter pressing device further comprises a PLC, and the pressure detection assembly, the PLC and the turbidity meter are connected with the PLC. According to the utility model, the filter pressing is carried out at low temperature, so that the reduction of the activity of heparin sodium caused by over-high temperature is avoided, and when the turbidity meter detects that the turbidity of the filter pressing liquid is higher, the PLC controls the electric push rod to retract, so that the filter pressing pressure is reduced, and the reduction of the filter pressing effect caused by over-high pressure is avoided.

Description

Technical Field

[0001] This utility model relates to the technical field of heparin sodium extraction, specifically a pressure filtration device for heparin sodium extraction. Background Technology

[0002] Heparin is a sulfated glucosamine polysaccharide compound widely found in animal organs and tissues (such as the small intestinal mucosa and lungs), possessing various biological functions including anticoagulation, anti-inflammation, anti-allergy, antiviral, anticancer, and lipid-lowering effects. Low molecular weight heparin, obtained from ordinary heparin through physical, chemical, or enzymatic hydrolysis, has a molecular weight range of 3000–8000. It exhibits superior antithrombotic activity compared to heparin, and compared to heparin, it has fewer bleeding side effects, higher bioavailability, a longer half-life, and predictable anticoagulant effects that do not require laboratory monitoring. However, the preparation and extraction of heparin sodium requires purification using a pressure filtration device. Existing pressure filtration devices lack cooling mechanisms, which can easily lead to over-purification of the heparin sodium. Furthermore, the pressure is not adjustable, which can cause increased turbidity of the filtrate due to pressure fluctuations. Utility Model Content

[0003] To address the shortcomings of existing technologies, such as the large size of the baskets, which occupy a lot of space when not in use and are inconvenient to store, this utility model provides a pressure filtration device for extracting heparin sodium.

[0004] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0005] This utility model discloses a pressure filtration device for extracting heparin sodium, including a support frame, a filter cylinder on the support frame, an outer cylinder on the outside of the filter cylinder, an interlayer between the outer cylinder and the filter cylinder, and a cold water inlet pipe and a cold water outlet pipe on the outer cylinder.

[0006] The bottom of the filter press cylinder is provided with a support block, and a mesh cylinder is provided inside the filter press cylinder. The upper and lower ends of the mesh cylinder are provided with sliding blocks for moving the inner cavity of the filter press cylinder. The support frame is provided with a vertically downward electric push rod mounted on a fixed frame. The inner wall of the mesh cylinder is provided with a filter cloth layer, and the electric push rod is provided with a filter block for pressing and filtering the mixture inside the mesh cylinder.

[0007] A pressure detection component is provided between the filter press block and the electric push rod. A liquid outlet pipe is provided at the bottom of the filter press cylinder, and a turbidity meter for detecting the turbidity of the filter liquid is provided on the liquid outlet pipe. A liquid collection cylinder is installed at the bottom of the liquid outlet pipe. The system also includes a PLC controller. The pressure detection component, the PLC controller, and the turbidity meter are connected to the PLC controller.

[0008] In a preferred embodiment of this invention, a three-way valve is provided at the bottom of the outlet pipe. One end of the three-way valve is connected to the inlet end of the liquid collecting cylinder, and the other end is connected to a buffer tank. The three-way valve is also connected to a PLC controller.

[0009] As a preferred technical solution of this utility model, the bottom of the support frame is provided with a cooling base, and the liquid collecting cylinder and the buffer tank are both placed on the cooling base. The cooling base is provided with a positioning groove for positioning the liquid collecting cylinder and the buffer tank.

[0010] As a preferred embodiment of this utility model, the cooling base is provided with a water cavity, and the cooling base is provided with a water inlet pipe communicating with the water cavity. The cold water inlet pipe, the cold water outlet pipe and the water inlet pipe are connected to a cooling water circulation device.

[0011] As a preferred technical solution of this utility model, the bottom of the support frame is provided with a cooling base, and the liquid collecting cylinder and the buffer tank are both placed on the cooling base. The cooling base is provided with a positioning groove for positioning the liquid collecting cylinder and the buffer tank.

[0012] As a preferred embodiment of this utility model, the cooling base is provided with a water cavity, and the cooling base is provided with a water inlet pipe communicating with the water cavity. The cold water inlet pipe, the cold water outlet pipe and the water inlet pipe are connected to a cooling water circulation device.

[0013] As a preferred embodiment of this invention, the temperature of the cooling water introduced into the interlayer is between 4 and 8 degrees Celsius.

[0014] The beneficial effects of this utility model are:

[0015] This heparin sodium extraction pressure filter device features a jacket between the outer cylinder and the filter cylinder, through which cooling water is circulated. This allows the heparin sodium extraction and filtration process to operate in a low-temperature environment, as heparin sodium is highly sensitive to temperature. Low-temperature filtration prevents excessively high temperatures from reducing the activity of the heparin sodium. Furthermore, a pressure detection component is installed between the filter block and the electric push rod, and a turbidimeter is installed on the outlet pipe to detect the turbidity of the filtrate. If the turbidimeter detects high turbidity in the filtrate, the PLC controller will retract the electric push rod to reduce the filtration pressure, thus preventing excessive pressure and reduced filtration efficiency. Attached Figure Description

[0016] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0017] Figure 1 This is a schematic diagram of the structure of a pressure filtration device for extracting heparin sodium according to this utility model;

[0018] Figure 2 This is a schematic diagram of the filter cylinder of a pressure filter device for extracting sodium heparin according to this utility model;

[0019] Figure 3 This is a schematic diagram of the filter cloth layer of a filter press device for extracting sodium heparin according to this utility model;

[0020] Figure 4 This is a control system block diagram of a pressure filtration device for extracting heparin sodium according to this utility model;

[0021] Figure 5 This is a schematic diagram of the cooling base of a pressure filtration device for extracting sodium heparin according to this utility model.

[0022] In the diagram: 1. Support frame; 2. Filter press cylinder; 3. Outer cylinder; 4. Jacket; 5. Cold water inlet pipe; 6. Cold water outlet pipe; 7. Support block; 8. Screen cylinder; 9. Sliding block; 10. Fixing frame; 11. Electric push rod; 12. Filter press cloth layer; 13. Filter press block; 14. Turbidity meter; 15. PLC controller; 16. T-connector; 17. Buffer tank; 18. Solenoid valve; 19. Refrigeration base; 20. Positioning groove; 21. Water chamber; 22. Water inlet pipe; 23. Liquid outlet pipe; 24. Liquid collection cylinder. Detailed Implementation

[0023] The preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0024] Example: Figure 1-5 As shown, the present invention provides a pressure filtration device for extracting heparin sodium, including a support frame 1, a filter cylinder 2 on the support frame 1, an outer cylinder 3 on the outside of the filter cylinder 2, an interlayer 4 between the outer cylinder 3 and the filter cylinder 2, and a cold water inlet pipe 5 and a cold water outlet pipe 6 on the outer cylinder 3.

[0025] The bottom of the filter press cylinder 2 is provided with a support block 7, and the filter press cylinder 2 is provided with a mesh cylinder 8. The upper and lower ends of the mesh cylinder 8 are provided with sliding blocks 9 for moving the inner cavity of the filter press cylinder 2. The support frame 1 is provided with a vertically downward electric push rod 11 installed on the fixing frame 10. The inner wall of the mesh cylinder 8 is provided with a filter cloth layer 12, and the electric push rod 11 is provided with a filter block 13 for pressing and filtering the mixture in the mesh cylinder 8.

[0026] A pressure detection component is provided between the filter press block 13 and the electric push rod 11. The pressure detection component is an existing technology product used to detect the pressure between the filter press block and the electric push rod, thereby realizing the detection of the filter press block's pressure on the mixture. The bottom of the filter press cylinder 2 is provided with a liquid outlet pipe 23, and a turbidity meter 14 for detecting the turbidity of the filtrate is provided on the liquid outlet pipe 23. A liquid collection cylinder 24 is installed at the bottom of the liquid outlet pipe 23. The system also includes a PLC controller 15. The pressure detection component, the PLC controller 15, and the turbidity meter 14 are connected to the PLC controller 15. By providing a jacket 4 between the outer cylinder 3 and the filter press cylinder 2, and by circulating cooling water through the jacket 4, the process of extracting and filtering heparin sodium is carried out in a low-temperature environment. Since heparin sodium is sensitive to temperature, filtering at a low temperature avoids the reduction of heparin sodium activity due to excessively high temperatures. Furthermore, a pressure detection component is provided between the filter press block 13 and the electric push rod 11, and a turbidimeter 14 is provided on the outlet pipe 23 to detect the turbidity of the filter liquid. If the turbidimeter 14 detects that the turbidity of the filter liquid is high, the PLC controller will control the electric push rod 11 to retract, thereby reducing the filter pressure. This avoids excessive pressure, which would reduce the filter effect.

[0027] The bottom of the outlet pipe 23 is equipped with a three-way valve 16. One end of the three-way valve 16 is connected to the inlet end of the collection cylinder 24, and the other end is connected to a buffer tank 17. The three-way valve 16 is also connected to a PLC controller 15. When the turbidimeter 14 detects high turbidity in the filtrate, one end of the three-way valve 16 connected to the inlet end of the collection cylinder 24 closes, while the other end connected to the buffer tank 17 opens. This discharges the highly turbid filtrate into the buffer tank for storage, ensuring that the filtrate collected in the collection cylinder 24 meets production requirements.

[0028] The support frame 1 has a cooling base 19 at its bottom. The liquid collecting cylinder 24 and the buffer tank are placed on the cooling base 19. The cooling base 19 has a positioning groove 20 for positioning the liquid collecting cylinder 24 and the buffer tank. This cools the liquid collecting cylinder 24 and the buffer tank, thus avoiding excessive temperature that could reduce the activity of heparin sodium.

[0029] The cooling base 19 has a water cavity 21 inside, and a water inlet pipe 22 connected to the water cavity 21 is provided on the cooling base 19. The cold water inlet pipe 5, the cold water outlet pipe 6 and the water inlet pipe 22 are connected to a cooling water circulation device, and the cooling water is used to cool down the water. This has the characteristics of being easy to control.

[0030] The cooling water introduced into the interlayer 4 is at a temperature between 4 and 8 degrees Celsius. This avoids damage to the sodium heparin from excessively low temperatures, while also preventing the sodium heparin from becoming less active due to excessively high temperatures.

[0031] During operation, this heparin sodium extraction pressure filter device features a jacket 4 between the outer cylinder 3 and the filter cylinder 2, through which cooling water is circulated. This ensures that the heparin sodium extraction and filtration process operates in a low-temperature environment, as heparin sodium is highly sensitive to temperature. Low-temperature filtration prevents excessively high temperatures from reducing the activity of the heparin sodium. A pressure detection component is installed between the filter block 13 and the electric push rod 11, and a turbidimeter 14 is installed on the outlet pipe 23 to detect the turbidity of the filtrate. If the turbidimeter 14 detects high turbidity in the filtrate, the PLC controller controls the electric push rod 11 to retract, reducing the filtration pressure and preventing excessive pressure that could reduce the filtration efficiency.

[0032] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A filter press device for extracting sodium heparin, characterized by comprising: Including support frame (1), and the support frame (1) is equipped with filter press cylinder (2), and the outer side of filter press cylinder (2) is equipped with outer cylinder (3), and the outer cylinder (3) is equipped with interlayer (4) with filter press cylinder (2), and the outer cylinder (3) is equipped with cold water inlet pipe (5) and cold water outlet pipe (6); The bottom of the filter press cylinder (2) is provided with a supporting block (7), and the filter press cylinder (2) is provided with a mesh cylinder (8), and the upper end and the lower end of the mesh cylinder (8) are provided with a sliding block (9) moving in the inner cavity of the filter press cylinder (2), the support frame (1) is provided with a vertical downward electric push rod (11) installed through a fixed frame (10), the inner wall of the mesh cylinder (8) is provided with a filter cloth layer (12), and the electric push rod (11) is provided with a filter pressing block (13) for filtering the mixture in the mesh cylinder (8); The filter pressing block (13) and the electric push rod (11) are provided with a pressure detection assembly, the bottom of the filter press cylinder (2) is provided with a liquid outlet pipe (23), and the liquid outlet pipe (23) is provided with a turbidimeter (14) for detecting the turbidity of the filter pressing liquid, the bottom of the liquid outlet pipe (23) is provided with a liquid collecting cylinder (24), and a PLC controller (15) is further included, the pressure detection assembly, the PLC controller (15), the turbidimeter (14) and the PLC controller (15) are connected.

2. The filter press device for extracting heparin sodium according to claim 1, characterized in that, The bottom of the liquid outlet pipe (23) is provided with a three-way valve (16), one end of the discharge end of the three-way valve (16) is connected with the liquid inlet end of the liquid collecting cylinder (24), the other end of the discharge end of the three-way valve (16) is connected with a buffer tank (17), and the three-way valve (16) is connected with the PLC controller (15).

3. The filter press device for extracting heparin sodium according to claim 1, characterized in that, The bottom of the support frame (1) is provided with a refrigeration base (19), the liquid collecting cylinder (24) and the buffer tank are placed on the refrigeration base (19), and the refrigeration base (19) is provided with a positioning groove (20) for positioning the liquid collecting cylinder (24) and the buffer tank.

4. The filter press device for extracting heparin sodium according to claim 3, characterized in that, The refrigeration base (19) is provided with a water cavity (21), and the refrigeration base (19) is provided with a water inlet pipe (22) communicating with the water cavity (21), and the cold water inlet pipe (5), the cold water outlet pipe (6) and the water inlet pipe (22) are connected with a cooling water circulating device.

5. The filter press device for extracting heparin sodium according to claim 1, characterized in that, The temperature of the cooling water flowing through the interlayer (4) is between 4-8 degrees Celsius.

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