Fluid treatment device and biochemical substance analysis system

Abstract

The utility model relates to a fluid treatment device and a biochemical substance analysis system, the fluid treatment device comprises a cavity module, a liquid inlet module, a liquid outlet module, a gas circuit module and a control module, the cavity module is provided with a plurality of cavities; the liquid inlet module and the liquid outlet module are communicated with each cavity and are arranged on the two opposite sides of the cavity module respectively, the gas circuit module is communicated with each cavity and is communicated with the power source to provide first driving force and second driving force for each cavity, the first driving force is used for enabling fluid to enter the cavity through the liquid inlet module, and the second driving force is used for enabling fluid to enter the cavity through the liquid outlet module. The second driving force is used for discharging the fluid in the cavity through the liquid outlet module; and the control module is used for controlling the synergistic effect among the modules. According to the fluid treatment device, a plurality of modules are integrated, the structure is compact, debugging is convenient, pipeline connection is not needed in the device, and installation and maintenance are convenient; the integration level and the space utilization rate are high; the fluid treatment device can be directly connected into a fluid using module, and the liquid adding efficiency is improved.

Description

Technical Field

[0001] This application relates to the field of instruments and equipment for biochemical reactions, and in particular to a fluid processing device and a biochemical substance analysis system. Background Technology

[0002] In fields such as biology, chemistry, and medicine, such as gene sequencing, pretreatment of biochemical reagents is often required, including operations such as degassing, mixing, and transfer. These pretreatment operations are crucial for detection accuracy and quality. However, existing reagent pretreatment devices have complex tubing, are bulky, and require complex debugging of various components, which is not conducive to production assembly and product maintenance, and is also costly. Utility Model Content

[0003] In view of this, in order to solve at least one of the above defects, it is necessary to propose a fluid processing device.

[0004] Additionally, this application also provides a biochemical substance analysis system based on the aforementioned fluid processing device.

[0005] In a first aspect, embodiments of this application provide a fluid processing device, comprising: a cavity module, a liquid inlet module, a liquid outlet module, a gas path module, and a control module. The cavity module has multiple cavities; the liquid inlet module is disposed on one side of the cavity module and communicates with each of the cavities, and is used to communicate with a fluid storage module; the liquid outlet module is disposed on the side of the cavity module opposite to the liquid inlet module and communicates with each of the cavities; the gas path module is communicated with each of the cavities and is used to communicate with a power source to provide a first driving force and a second driving force to each cavity, the first driving force being used to cause fluid in the fluid storage module to enter the cavity via the liquid inlet module, and the second driving force being used to cause fluid in the cavity to be discharged via the liquid outlet module; the control module is used to control the cooperative action between the liquid inlet module, the liquid outlet module, and the gas path module.

[0006] In some possible embodiments, the liquid inlet module includes a liquid inlet assembly having multiple sets of liquid inlet channels, one end of each set of liquid inlet channels being connected to one of the cavities, and the end of each set of liquid inlet channels away from the cavity being respectively used to communicate with the fluid storage module; and / or, the liquid outlet module includes a liquid outlet assembly having multiple sets of liquid outlet channels, one end of each set of liquid outlet channels being connected to one of the cavities.

[0007] In some possible embodiments, the liquid inlet module further includes multiple liquid inlet valves, each group of liquid inlet channels is connected to one liquid inlet valve, each liquid inlet channel is provided with at least one liquid inlet corresponding to the liquid inlet valve, and each liquid inlet valve is signal-connected to the control module; and / or, the liquid outlet module further includes multiple liquid outlet valves, each group of liquid outlet channels is connected to one liquid outlet valve, and each liquid outlet channel is provided with at least one liquid outlet corresponding to the liquid outlet valve.

[0008] In some possible embodiments, the cavity module includes a cavity assembly, which has a plurality of cavities arranged side by side along a first direction. A plurality of inlet channels and a plurality of outlet channels are also arranged side by side along the first direction. Along a second direction perpendicular to the first direction, each cavity has a set of inlet channels and a set of outlet channels on opposite sides.

[0009] In some possible embodiments, the liquid inlet module, the liquid outlet module, the control module, the gas path module, and the cavity module are integrated.

[0010] In some possible embodiments, the fluid processing device further includes a liquid level detection module disposed outside the cavity module. The liquid level detection module includes a first liquid level detection component and a second liquid level detection component. Both the first liquid level detection component and the second liquid level detection component are signal connected to the control module. The first liquid level detection component is used to detect the lowest liquid level in each cavity, and the second liquid level detection component is used to detect the highest liquid level in each cavity.

[0011] In some possible embodiments, the first liquid level detection component includes a plurality of first transmitters and a plurality of first receivers, with one first transmitter disposed on the side of each cavity near the liquid inlet module and one first receiver disposed on the side of each cavity near the liquid outlet module; the second liquid level detection component includes a plurality of second transmitters and a plurality of second receivers, with one second transmitter disposed on the side of each cavity near the liquid inlet module and one second receiver disposed on the side of each cavity near the liquid outlet module.

[0012] In some possible embodiments, the air path module includes an air path assembly, which has a main air path and a plurality of branch air paths communicating with the main air path. The main air path is used to communicate with the power source, and each of the branch air paths is communicated with a cavity.

[0013] In some possible embodiments, the connection points between the cavity and the liquid inlet module, the liquid outlet module, and the gas path module are all provided with seals.

[0014] Secondly, embodiments of this application provide a biochemical substance analysis system, including a fluid storage module, a fluid processing device, a fluid usage module, and a power source. The fluid processing device is the fluid processing device described above. The fluid storage module is connected to the liquid inlet module, the fluid usage module is connected to the liquid outlet module, and the power source is connected to the gas path module.

[0015] The fluid processing device provided in this application integrates multiple modules such as a cavity module, a liquid inlet module, a liquid outlet module, a gas path module, a control module, and a liquid level detection module. The overall structure is compact, easy to debug, and requires no internal piping connections, making installation and maintenance convenient. This fluid processing device has a high degree of integration, which helps to improve space utilization and reduce volume. This fluid processing device can be directly connected to the fluid use module. After the fluid (e.g., reagent) has been pretreated in the cavity, it can be directly added to the fluid use module, improving the liquid addition efficiency and increasing the biochemical reaction rate. Attached Figure Description

[0016] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings used in the embodiments of this application will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a module architecture diagram of a biochemical substance analysis system according to an embodiment of this application.

[0018] Figure 2 This is a schematic diagram of the structure of a fluid processing device according to an embodiment of this application.

[0019] Figure 3 for Figure 2 A partial structural diagram of a fluid processing device.

[0020] Figure 4 for Figure 2 Cross-sectional view along IV-IV.

[0021] Figure 5 for Figure 4 Enlarged view of section A.

[0022] Figure 6 for Figure 2 A schematic diagram of the structure of the middle cavity module.

[0023] Figure 7 for Figure 6 Sectional view along VII-VII.

[0024] Figure 8 for Figure 2A schematic diagram of the liquid inlet module.

[0025] Figure 9 for Figure 2 A schematic diagram of the liquid outlet module.

[0026] Figure 10 for Figure 2 Cross-sectional view of the assembled gas path module and cavity module.

[0027] Explanation of main component symbols

[0028]

[0029]

[0030] The following detailed description, in conjunction with the accompanying drawings, will further illustrate this application. Detailed Implementation

[0031] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments.

[0032] It should be noted that when a component is described as "fixed to" or "mounted to" another component, it can be directly on the other component or may be interspersed with an intermediate component. When a component is described as "set to" another component, it can be directly set on the other component or may be interspersed with an intermediate component. The term "and / or" as used herein includes all and any combination of one or more of the associated listed items.

[0033] In the field of gene sequencing, liquid reagents are typically contained in reagent bottles and sealed with caps. Due to their specific application, these reagent bottle caps differ from conventional caps; they have a through-hole structure in the center to allow the reagent probe to penetrate the bottle and extract the reagents during sequencing. Therefore, the requirements for the sealing and reliability of these reagent bottles and caps used in gene sequencing are higher during production, storage, and transportation.

[0034] Please see Figure 1This application provides a biochemical substance analysis system 1000, which can be used for analytical processes such as reaction and detection of biochemical substances in fields such as biology, chemistry, or medicine, for example, in gene sequencing. The biochemical substance analysis system 1000 may include a fluid processing device 100, a fluid storage module 200, a fluid usage module 300, and a power source 400. Both the fluid storage module 200 and the fluid usage module 300 are connected to the fluid processing device 100. The power source 400 is connected to the fluid processing device 100 and provides power, allowing the fluid in the fluid storage module 200 to enter the fluid processing device 100 and transferring the processed fluid to the fluid usage module 300. The fluid can be a liquid. Before performing biochemical substance analysis, the biochemical liquids used (such as various reagents and buffer solutions required for biochemical reactions) typically need to be pretreated, including degassing, mixing, and transfer. The fluid processing device 100 can perform at least one of these pretreatment operations. Driven by the power source 400, the fluid in the fluid storage module 200 enters the fluid processing device 100. After pretreatment by the fluid processing device 100, it can directly enter the fluid usage module 300. The fluid usage module 300 can realize the biochemical substance analysis process. For example, the fluid usage module 300 can be a reaction chamber or flow cell for biochemical reactions. Understandably, the fluid processed by the fluid processing device 100 can also be used independently and does not directly enter the fluid usage module 300.

[0035] Please see Figures 2 to 5 As shown, please refer to the following: Figure 1 As shown, the fluid processing device 100 provided in this embodiment includes: a cavity module 1, a liquid inlet module 2, a liquid outlet module 3, a gas path module 4, and a control module 5. The cavity module 1 has multiple cavities 11; the liquid inlet module 2 is located on one side of the cavity module 1, and the liquid outlet module 3 is located on the side of the cavity module 1 opposite to the liquid inlet module 2, i.e., the liquid outlet module 3 and the liquid inlet module 2 are respectively located on opposite sides of the cavity module 1. Both the liquid inlet module 2 and the liquid outlet module 3 are connected to each cavity 11. The liquid inlet module 2 is also connected to a fluid storage module 200, and the liquid outlet module 3 is also connected to a fluid usage module 300. The gas path module 4 is connected to a power source 400 and to each cavity 11. The power source 400 can provide a first driving force and a second driving force to each cavity 11 through the gas path module 4. The first driving force enables the fluid in the fluid storage module 200 to enter the cavity 11 through the liquid inlet module 2, and the second driving force enables the fluid in the cavity 11 to be discharged through the liquid outlet module 3, for example, directly into the fluid usage module 300. The control module 5 is used to control the coordinated action between the liquid inlet module 2, the liquid outlet module 3, and the gas path module 4 to achieve fluid pretreatment.

[0036] Please see Figure 6 and Figure 7 As shown, please refer to the following: Figure 4 and Figure 5 As shown, the cavity module 1 includes a cavity integration component 12, within which multiple cavities 11 are arranged side-by-side along a first direction X. Specifically, the cavity integration component 12 is a one-piece molded structure, with the multiple cavities 11 directly molded within it and arranged in a row along the first direction X. The liquid inlet module 2 and the liquid outlet module 3 are located on opposite sides of the cavity integration component 12 along a second direction Y perpendicular to the first direction X, and are connected to each cavity 11. Integrating multiple cavities 11 within the same cavity integration component 12 facilitates the installation layout of the multiple cavities 11 and the connection layout with the liquid inlet module 2 and the liquid outlet module 3, thereby improving the integration of the cavity module 1.

[0037] like Figure 4 , Figure 5 and Figure 7 As shown, in some embodiments, along the third direction Z, the cavity assembly 12 includes a first end 13 and a second end 14 disposed opposite to each other. The third direction Z is perpendicular to the first direction X and the second direction Y, and the three constitute a three-dimensional coordinate system. Each cavity 11 extends along the third direction Z, and the opening of the cavity 11 is located at the first end 13 and communicates with the gas path module 4. The second end 14 includes a first sidewall 15 and a second sidewall 16 disposed opposite to each other. The first sidewall 15 is disposed near the liquid inlet module 2, and the second sidewall 16 is disposed near the liquid outlet module 3. The first sidewall 15 is provided with a liquid inlet hole 151 for each cavity 11, and each liquid inlet hole 151 communicates with the corresponding cavity 11 and the liquid inlet module 2. The second sidewall 16 is provided with a liquid outlet hole 161 for each cavity 11, and each liquid outlet hole 161 communicates with the corresponding cavity 11 and the liquid outlet module 3. Both the inlet hole 151 and the outlet hole 161 are located at the second end 14 (i.e. the bottom end of the cavity 11), which facilitates the connection layout of the inlet module 2 and the outlet module 3, and also facilitates the inlet and outlet of liquids, while reducing liquid loss.

[0038] Specifically, along the third direction Z, the cavity 11 includes a first cavity 111 and a second cavity 112 connected to each other. The second cavity 112 is located near the second end 14, and its size decreases sequentially along the direction away from the first cavity 111, forming a conical structure. In this case, the liquid inlet 151 is located at the end of the first cavity 111 near the second cavity 112, and the liquid outlet 161 is located at the bottom of the second cavity 112. By placing the liquid outlet 161 at the bottom of the second cavity 112, all the liquid in the cavity 11 can be transferred out through the liquid outlet 161, reducing the risk of liquid residue in the cavity 11 and minimizing liquid loss.

[0039] Please see Figure 8As shown, please refer to the following: Figure 1 , Figure 4 and Figure 5 As shown, the liquid inlet module 2 includes a liquid inlet assembly 21, which contains multiple sets of liquid inlet channels 22. One end of each set of liquid inlet channels 22 is connected to a cavity 11, and the end of each set of liquid inlet channels 22 away from the cavity 11 is connected to the fluid storage module 200. In some embodiments, the liquid inlet assembly 21 is a one-piece molded structure, that is, the multiple sets of liquid inlet channels 22 are directly molded within the liquid inlet assembly 21, which improves the integration of the liquid inlet module 2. The liquid inlet module 2 and the cavity module 1 do not require separate pipelines for connection, making installation and maintenance more convenient. In some embodiments, the multiple sets of liquid inlet channels 22 are arranged side-by-side along a first direction X, and the multiple sets of liquid inlet channels 22 correspond one-to-one with multiple cavities 11.

[0040] In some embodiments, the liquid inlet module 2 further includes a plurality of liquid inlet valves 23, with one liquid inlet valve 23 connected to each group of liquid inlet channels 22. The liquid inlet channel 22 is provided with at least one liquid inlet port 24 corresponding to the liquid inlet valve 23. That is, the number of liquid inlets 24 in the liquid inlet channel 22 can be flexibly set according to the number of liquid inlet ends of the liquid inlet valve 23. For example, when the liquid inlet valve 23 includes one liquid inlet end, the liquid inlet channel 22 is designed with one liquid inlet port 24 and can communicate with one type of fluid in the fluid storage module 200. For example, the liquid inlet valve 23 can be a two-way valve. When the liquid inlet valve 23 includes multiple liquid inlet ends, the liquid inlet channel 22 is designed with multiple liquid inlets 24 and can communicate with multiple types of fluids in the fluid storage module 200. Multiple liquids can be injected into the same cavity 11 to realize the mixing process of different liquids. For example, the liquid inlet valve 23 can be a three-way valve or a rotary valve, etc. In addition, each inlet valve 23 is connected to the control module 5 via a signal. The control module 5 can control the opening and closing of each inlet valve 23, thereby controlling the opening and closing of the inlet module 2, so as to realize the connection or disconnection between the fluid storage module 200 and each cavity 11.

[0041] In some embodiments, the liquid inlet module 2 further includes a plurality of liquid inlet connectors 25, with each liquid inlet port 24 having a liquid inlet connector 25. The liquid inlet connector 25 can achieve sealed communication with the fluid storage module 200, making the connection more convenient.

[0042] Please see Figure 9 As shown, please refer to the following: Figure 1 , Figure 4 and Figure 5As shown, the liquid outlet module 3 includes a liquid outlet integration component 31, which has multiple sets of liquid outlet channels 32. One end of each set of liquid outlet channels 32 is connected to a cavity 11, and the end of each set of liquid outlet channels 32 away from the cavity 11 is connected to the fluid use module 300. In some embodiments, the liquid outlet integration component 31 is a one-piece molded structure, that is, the multiple sets of liquid outlet channels 32 are directly molded in the liquid outlet integration component 31, which improves the integration of the liquid outlet module 3. The liquid outlet module 3 and the cavity module 1 do not need to be connected by a separate pipeline, making installation and maintenance more convenient. In some embodiments, the multiple sets of liquid outlet channels 32 are arranged side by side along the first direction X, and the multiple sets of liquid outlet channels 32 are arranged one-to-one with multiple cavities 11. Along the second direction Y, each cavity 11 has a set of inlet channels 22 and a set of outlet channels 32 on its opposite sides. That is, multiple sets of inlet channels 22 and multiple sets of outlet channels 32 are arranged one-to-one with multiple cavities 11 to realize the inlet and outlet of each cavity 11.

[0043] In some embodiments, the liquid dispensing module 3 further includes multiple liquid dispensing valves 33, with one liquid dispensing valve 33 connected to each group of liquid dispensing channels 32. The number of liquid outlets 34 in the liquid dispensing channels 32 can be flexibly set according to the number of liquid dispensing ends of the liquid dispensing valves 33. For example, when the liquid dispensing valve 33 includes one liquid dispensing end, the liquid dispensing channel 32 is designed with one liquid outlet 34 and can communicate with one inlet in the fluid use module 300. For example, the liquid dispensing valve 33 can be a two-way valve. When the liquid dispensing valve 33 includes multiple liquid dispensing ends, the liquid dispensing channel 32 is designed with multiple liquid outlets 34 and can communicate with multiple inlets in the fluid use module 300, which can inject liquid from the cavity 11 into multiple reaction vessels in the fluid use module 300, improving the liquid addition efficiency. For example, the liquid dispensing valve 33 can be a three-way valve or a rotary valve, etc. Figure 9 The liquid outlet module 3 shown is equipped with a three-way valve. In addition, each liquid outlet valve 33 is connected to the control module 5 by signal. The control module 5 can control the opening and closing of each liquid outlet valve 33, thereby controlling the opening and closing of the liquid outlet module 3, so as to realize the connection or disconnection between each cavity 11 and the fluid use module 300.

[0044] In some embodiments, the liquid outlet module 3 further includes a plurality of liquid outlet connectors 35, with each liquid outlet 34 having a liquid outlet connector 35. The liquid outlet connector 35 can achieve sealed communication with the fluid use module 300, making the connection more convenient.

[0045] Please refer to it again. Figures 3 to 5As shown, the fluid processing device 100 also includes a liquid level detection module 6 located outside the cavity module 1 and connected to the control module 5. Depending on whether liquid is present in the cavity 11, the liquid level detection module 6 will generate different signals, thereby enabling the detection of the liquid level height in each cavity 11. The liquid level detection module 6 includes a first liquid level detection component 61 and a second liquid level detection component 62. Both the first liquid level detection component 61 and the second liquid level detection component 62 are connected to the control module 5. The first liquid level detection component 61 can detect the lowest liquid level in each cavity 11, and the second liquid level detection component 62 can detect the highest liquid level in each cavity 11, thereby achieving real-time monitoring of the liquid level in the cavity 11.

[0046] In some embodiments, the first liquid level detection component 61 includes a plurality of first transmitting ends 63 and a plurality of first receiving ends 64. Each cavity 11 has one first transmitting end 63 near the liquid inlet module 2 and one first receiving end 64 near the liquid outlet module 3. The first transmitting end 63 acts as a signal transmitter, capable of generating a signal (e.g., an infrared signal), and the first receiving end 64 acts as a signal receiver, capable of receiving the signal emitted by the first transmitting end 63. Depending on whether the liquid level in the cavity 11 reaches the lower limit, the first liquid level detection component 61 will generate different signals, thereby enabling the detection of the lower limit of the liquid level in the cavity 11. The first transmitting end 63 and the first receiving end 64 are both located at the bottom of the cavity 11 (i.e., near the second end 14) for detecting the lowest liquid level in the cavity 11. Specifically, the first transmitting end 63 and the first receiving end 64 are located above the liquid inlet 151.

[0047] Similarly, the second liquid level detection component 62 includes multiple second transmitting ends 65 and multiple second receiving ends 66. Each cavity 11 has one second transmitting end 65 near the liquid inlet module 2 and one second receiving end 66 near the liquid outlet module 3. The second transmitting end 65 acts as a signal transmitter, capable of generating signals (e.g., infrared signals), and the second receiving end 66 acts as a signal receiver, capable of receiving signals emitted by the second transmitting end 65. Depending on whether the liquid level in the cavity 11 reaches the upper limit, the second liquid level detection component 62 will generate different signals, thereby enabling the detection of the upper limit of the liquid level in the cavity 11. The second transmitting end 65 and the second receiving end 66 are both located at the top of the cavity 11 (i.e., near the first end 13) for detecting the highest liquid level in the cavity 11.

[0048] like Figures 3 to 5As shown, the first transmitting end 63 and the second transmitting end 65 are integrated on the first liquid level detection circuit board 71, and the first receiving end 64 and the second receiving end 66 are integrated on the second liquid level detection circuit board 72. The first liquid level detection circuit board 71 and the second liquid level detection circuit board 72 are respectively installed on the opposite side walls of the cavity integration component 12, making installation and maintenance more convenient and improving the integration of the fluid processing device 100.

[0049] Please see Figure 10 As shown, please refer to the following: Figure 1 , Figure 3 and Figure 4 As shown, the gas path module 4 includes a gas path integration component 41, which contains a main gas path 42 and multiple branch gas paths 43 connected to the main gas path 42. The main gas path 42 can be connected to a power source 400, and each branch gas path 43 is connected to a cavity 11. The power source 400 can provide a first driving force and a second driving force. The first driving force allows the fluid in the fluid storage module 200 to enter the cavity 11 through the liquid inlet module 2 for pretreatment, and the second driving force allows the treated fluid in the cavity 11 to be discharged through the liquid outlet module 3. When the discharged fluid needs to enter the fluid use module 300, the second driving force provided by the power source 400 can also drive the fluid directly into the fluid use module 300. Specifically, the power source 400 can be a vacuum device, and the first driving force can be negative pressure, while the second driving force can be positive pressure. For example, when the power source 400 provides negative pressure (i.e., the first driving force), the cavity 11 is in a negative pressure state. At this time, the fluid in the fluid storage module 200 can enter the cavity 11 through the liquid inlet module 2. When the power source 400 provides positive pressure (i.e., the second driving force), it can drive the fluid in the cavity 11 to be discharged through the liquid outlet module 3, for example, it can directly enter the fluid use module 300.

[0050] Please refer to it again. Figure 2 As shown, from the overall layout of the fluid processing device 100, along the first direction X, multiple cavities 11 in the cavity module 1, multiple sets of inlet channels 22 in the liquid inlet module 2, and multiple sets of outlet channels 32 in the liquid outlet module 3 are all arranged side by side. At this time, the liquid inlet module 2, cavity module 1, and liquid outlet module 3 are arranged side by side along the second direction Y. In addition, along the third direction Z, the control module 5, the gas path module 4, and the cavity module 1 are stacked sequentially. The gas path module 4 is located on top of the cavity module 1, and the control module 5 is located on top of the gas path module 4. Meanwhile, the liquid inlet module 2 and the liquid outlet module 3 are located at the bottom of the cavity module 1, and the first liquid level detection circuit board 71 and the second liquid level detection circuit board 72 are integrated and installed on opposite sides of the cavity module 1. The various parts of the fluid processing device 100 are modularized and assembled using the aforementioned layout method, resulting in higher integration and space utilization, facilitating installation and maintenance, and also contributing to the miniaturization of the device.

[0051] The inlet module 2, outlet module 3, control module 5, gas path module 4, and cavity module 1 can be integrated. The entire fluid processing device 100 has a high degree of integration, small size, and can be used independently. The fluid processing device 100 can also be integrated into other instruments or systems. In some embodiments, the fluid processing device 100 further includes a mounting base 8, and the control module 5, gas path module 4, cavity module 1, inlet module 2, outlet module 3, and liquid level detection module 6 are all mounted together via the mounting base 8.

[0052] Please see Figure 4 , Figure 5 and Figure 7 As shown, sealing elements 91 are provided at the connections between the cavity 11 and the liquid inlet module 2, the liquid outlet module 3, and the gas path module 4 to achieve a sealed connection. Specifically, the outer wall of the cavity assembly 12 is provided with a mounting groove 17, and the sealing element 91 is located within the mounting groove 17 and protrudes from the mounting groove 17. Thus, when installing the liquid inlet module 2, the liquid outlet module 3, and the gas path module 4, a sealed connection can be achieved by squeezing the sealing element 91. In some embodiments, the sealing element 91 can be a rubber ring.

[0053] In some embodiments, both the inlet port 151 and the outlet port 161 are provided with sealing joints 92. When the inlet channel 22 is connected to the inlet port 151, the connection sealing performance can be improved and the risk of leakage can be reduced; similarly, when the outlet channel 32 is connected to the outlet port 161, the connection sealing performance can also be improved and the risk of leakage can be reduced.

[0054] Taking liquid as an example, the specific process of liquid treatment using the fluid treatment device 100 is explained.

[0055] 1. The transfer or degassing process of a liquid (named Liquid #1) is as follows:

[0056] Step S11, the process of liquid #1 entering cavity 11 is as follows:

[0057] Liquid #1 in the fluid storage module 200 enters the inlet channel 22 through the inlet connector 25 of the inlet module 2. At this time, the corresponding inlet valve 23 is open and the outlet valve 33 is closed. The gas path module 4 is connected to the power source 400, and the power source 400 provides the first driving force (e.g., negative pressure). Then, under the action of the first driving force, liquid #1 will flow along the inlet channel 22 of the inlet module 2, through the inlet valve 23 and the corresponding inlet hole 151, and finally enter the corresponding cavity 11. When the liquid level rises to the height of the second receiving end 66 (i.e., the upper limit), the gas path module 4 is disconnected from the power source 400, the inlet valve 23 is closed, and the action of liquid #1 entering the corresponding cavity 11 is completed.

[0058] When liquid #1 reaches the preset liquid level in cavity 11 and needs to be degassed, the inlet valve 23 can be disconnected while maintaining the first driving force, so that the gas in liquid #1 in cavity 11 is separated from liquid #1 and further discharged to the outside through gas circuit module 4, thus realizing the degassed process of liquid #1.

[0059] Step S12, the process of discharging liquid #1 from cavity 11 is as follows:

[0060] With the above state unchanged, liquid #1 already exists in cavity 11. At this time, the corresponding inlet valve 23 is closed and the outlet valve 33 is open. The gas circuit module 4 is connected to the power source 400, and the power source 400 provides a second driving force (e.g., positive pressure). Then, under the push of the second driving force, liquid #1 will pass through the corresponding outlet hole 161 from cavity 11, along the internal outlet flow channel 32 of outlet module 3, and finally be discharged from the corresponding outlet connector 35. For example, the processed liquid #1 can be directly discharged into the fluid use module 300, or it can be directly discharged into a container.

[0061] 2. The pretreatment process for mixing the two liquids (named Liquid #1 and Liquid #2) is as follows (at this time, the inlet valve 23 uses a three-way valve or a rotary valve):

[0062] Step S21, the mixing process of liquid #1 and liquid #2 is as follows:

[0063] According to the liquid feeding method in step S11 above, when the liquid level of liquid #1 in the corresponding cavity 11 reaches the height of the first receiving end 64 (lower limit), switch the liquid feeding valve 23 to change the liquid connected to the liquid feeding connector 25 to liquid #2, and repeat the liquid feeding operation in step S12 above. When the liquid level of liquid #2 in the cavity 11 reaches the height of the second receiving end 66 (upper limit), the gas circuit module 4 is disconnected from the power source 400, and the liquid feeding valve 23 is closed. At this time, liquid #1 and liquid #2 both enter the cavity 11 to complete the mixing.

[0064] Understandably, to achieve uniform mixing of the two reagents, the inlet valve 23 can be switched to connect to external air. Under negative pressure, outside air enters the chamber 11, and the movement of the gas will cause liquid #1 and liquid #2 to mix uniformly. Alternatively, all of liquid #2 stored in the fluid storage module 200 can be transferred into the chamber 11. In this case, the container storing liquid #2 is connected to the outside and filled with air. The chamber 11 can be connected to the outside through the container storing liquid #2, thus eliminating the need to switch the inlet valve 23, further simplifying the operation.

[0065] It is also understandable that the fluid processing device 100 can also mix two or more liquids.

[0066] Step S22, the discharge of the mixture is the same as step S12 described above.

[0067] 3. The process of liquid buffering and transfer is as follows:

[0068] The volume of cavity 11 can also be increased to pre-extract liquid from fluid storage module 200 and inject it into cavity 11 for liquid buffering. At this time, liquid outlet module 3 is connected to fluid use module 300. When liquid needs to be added, liquid outlet valve 33 can be opened directly to add liquid to fluid use module 300, which can improve the liquid inlet speed of fluid use module 300.

[0069] The fluid processing device 100 provided in this application embodiment contains a cavity module 1 with 6 cavities 11, which can simultaneously perform pretreatment of at least 6 to 12 kinds of reagents.

[0070] The fluid processing device 100 provided in this application integrates multiple modules such as cavity module 1, liquid inlet module 2, liquid outlet module 3, gas path module 4, control module 5, and liquid level detection module 6. The overall structure is compact, easy to debug, and requires no internal pipeline connection, making installation and maintenance convenient. The fluid processing device 100 has a high degree of integration, which is beneficial to improving space utilization and reducing volume. The fluid processing device 100 can be directly connected to the fluid use module 300. After the fluid (e.g., reagent) has completed pretreatment in the cavity 11, it can be directly added to the fluid use module 300, improving the liquid addition efficiency and increasing the biochemical reaction rate.

[0071] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit it. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the spirit and scope of the technical solutions of this application.

Claims

1. A fluid treatment device characterized by, The fluid processing device comprises: a cavity module having a plurality of cavities; a liquid inlet module arranged on one side of the cavity module, the liquid inlet module being in communication with each of the cavities, the liquid inlet module being configured to communicate with a fluid storage module; a liquid outlet module arranged on the side of the cavity module opposite to the liquid inlet module, the liquid outlet module being in communication with each of the cavities; a gas path module in communication with each of the cavities, the gas path module being configured to communicate with a power source to provide a first driving force and a second driving force for each of the cavities, the first driving force being configured to cause the fluid in the fluid storage module to enter the cavities through the liquid inlet module, and the second driving force being configured to cause the fluid in the cavities to be discharged through the liquid outlet module; and a control module configured to control the cooperation among the liquid inlet module, the liquid outlet module and the gas path module. The liquid inlet module comprises a liquid inlet integrated component, a plurality of groups of liquid inlet flow channels are arranged in the liquid inlet integrated component, one end of each group of the liquid inlet flow channels is in communication with one of the cavities, and the other end of each group of the liquid inlet flow channels is configured to communicate with the fluid storage module; and / or 2. The fluid treatment device defined in claim 1, wherein The liquid outlet module comprises a liquid outlet integrated component, a plurality of groups of liquid outlet flow channels are arranged in the liquid outlet integrated component, one end of each group of the liquid outlet flow channels is in communication with one of the cavities. The liquid inlet module further comprises a plurality of liquid inlet valves, each group of the liquid inlet flow channels is connected to one of the liquid inlet valves, at least one liquid inlet port is arranged in the liquid inlet flow channels corresponding to the liquid inlet valve, and each of the liquid inlet valves is signal connected to the control module; and / or 3. The fluid treatment device defined in claim 2, wherein The liquid outlet module further comprises a plurality of liquid outlet valves, each group of the liquid outlet flow channels is connected to one of the liquid outlet valves, and at least one liquid outlet port is arranged in the liquid outlet flow channels corresponding to the liquid outlet valve. The cavity module comprises a cavity integrated component, a plurality of the cavities are arranged in the cavity integrated component, a plurality of groups of the liquid inlet flow channels and a plurality of groups of the liquid outlet flow channels are arranged in parallel along a first direction, and along a second direction perpendicular to the first direction, each of the cavities is provided with one group of the liquid inlet flow channels and one group of the liquid outlet flow channels on opposite sides.

4. The fluid treatment device defined in claim 2, wherein The liquid inlet module, the liquid outlet module, the control module, the gas path module and the cavity module are integrally arranged.

5. The fluid treatment device defined in claim 1, wherein The fluid processing device further comprises a liquid level detection module arranged on the outside of the cavity module, the liquid level detection module comprises a first liquid level detection assembly and a second liquid level detection assembly, the first liquid level detection assembly and the second liquid level detection assembly are signal connected to the control module, the first liquid level detection assembly is configured to detect the lowest liquid level in each of the cavities, and the second liquid level detection assembly is configured to detect the highest liquid level in each of the cavities.

6. The fluid treatment device defined in claim 1, wherein The first liquid level detection assembly comprises a plurality of first transmitting ends and a plurality of first receiving ends, one of the first transmitting ends is arranged on the side of each of the cavities close to the liquid inlet module, and one of the first receiving ends is arranged on the side of each of the cavities close to the liquid outlet module.

7. The fluid treatment device defined in claim 6, wherein ​ The second liquid level detection assembly comprises a plurality of second transmitting ends and a plurality of second receiving ends, one second transmitting end is arranged near one side of each cavity close to the liquid inlet module, and one second receiving end is arranged near one side of each cavity close to the liquid outlet module.

8. The fluid treatment device defined in claim 1, wherein The gas path module comprises a gas path integrated piece, the gas path integrated piece is internally provided with a main gas path and a plurality of branch gas paths in communication with the main gas path, the main gas path is used for being in communication with the power source, and each branch gas path is in communication with one cavity.

9. The fluid treatment device defined in claim 1, wherein Sealing pieces are arranged at the connection positions of the cavities and the liquid inlet module, the liquid outlet module and the gas path module.

10. A biochemical substance analysis system, characterized in that, The fluid processing device comprises a fluid storage module, a fluid processing device, a fluid use module and a power source, the fluid processing device is the fluid processing device as claimed in any one of claims 1 to 9, the fluid storage module is in communication with the liquid inlet module, the fluid use module is in communication with the liquid outlet module, and the power source is in communication with the gas path module.

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