Multi-electrode cell electrical stimulation device

Abstract

The utility model provides a multi-electrode cell electrical stimulation device which comprises a multi-electrode plate, the multi-electrode plate comprises a flexible substrate and electrodes, the flexible substrate is provided with a first electrode area and a second electrode area, six electrodes are respectively arranged in the first electrode area and the second electrode area, one end of each electrode is provided with a wire connecting end, and the other end of each electrode is provided with a wire connecting end. The wire connecting end is connected with an external wire, the external wire is communicated with the wire connecting end to complete access operation of the electrode operation end, the multi-electrode plate, the resistor and the waveform function generator are sequentially connected in series to form a series electric control circuit, and the two ends of the series electric control circuit are connected with an external power source to form the electrical stimulation device. Two rows of twelve electrode arrays are arranged, multi-path and multi-direction electrical stimulation scheme adjustment is achieved by controlling the electrodes on the two sides to discharge, growth of nerve axons can be promoted, re-myelination of the axons can be promoted, recovery of nerve functions is accelerated, and popularization and application are facilitated.

Description

Technical Field

[0001] This invention belongs to the technical field of electrical stimulation devices, specifically relating to a multi-electrode cell electrical stimulation device. Background Technology

[0002] Electrical stimulation (ES) is a technique that uses electrical pulses to affect biological tissues, promoting neuromuscular function recovery and improving blood circulation. It can be used to relieve intractable neuropathic pain, helping patients restore bodily functions and alleviate pain. Studies have found that Schwann cells have a significant remyelination effect on central nervous system axons after damage to the central nervous system in rodents, non-human primates, and humans, most notably on the dorsal side of the spinal cord. ES can effectively regulate various biological properties of many cells, especially nerve cells and cardiomyocytes, including apoptosis, adhesion, extension, and migration. It can promote axonal growth and remyelination, thereby accelerating the recovery of nerve function.

[0003] Based on this, a multi-electrode cell electrostimulation device is proposed. Utility Model Content

[0004] The technical problem to be solved by this utility model is to provide a multi-electrode cell electrical stimulation device to address the shortcomings of the prior art mentioned above.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is: a multi-electrode cell electrostimulation device, including a multi-electrode plate, the multi-electrode plate including a flexible substrate and electrodes, a first electrode area and a second electrode area are provided on the flexible substrate, six electrodes are respectively provided in the first electrode area and the second electrode area, one end of the electrode is provided with a wire connection end, the wire connection end is connected to an external wire, and the other end of the electrode is provided with an electrode working end, the electrode working end is connected to the wire connection end through the external wire to complete the path operation of the electrode working end;

[0006] The multi-electrode plate, resistor, and waveform function generator are connected in series to form a series electronic control circuit, and an external power supply is connected to both ends of the series electronic control circuit to form an electrical stimulation device.

[0007] As a further explanation of this utility model, the flexible substrate is made of polydimethylsiloxane, and the electrode is made of titanium alloy.

[0008] As a further explanation of this utility model, the multi-electrode plate is placed in a cell culture dish during use, and PBS buffer is placed in the cell culture dish.

[0009] As a further explanation of this utility model, the resistance value of the resistor is 1Ω, and an oscilloscope is connected to both ends of the resistor to measure the voltage across the resistor.

[0010] This utility model has the following advantages compared with the prior art:

[0011] The multi-electrode cell electrical stimulation device of this invention consists of a series electrical control circuit composed of a multi-electrode plate, a resistor and a waveform function generator connected in series, and an external power supply. The device has two rows of twelve electrode arrays. By controlling the discharge of the electrodes on both sides, the electrical stimulation scheme can be adjusted in multiple paths and directions. It can not only promote the growth of nerve axons, but also promote the remyelination of axons, thereby accelerating the recovery of nerve function and facilitating its widespread use. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the multi-electrode plate structure of this utility model.

[0013] Explanation of reference numerals in the attached figures:

[0014] 11-Flexible substrate; 12-First electrode region; 13-Second electrode region; 14-Electrode; 15-Wire connection end; 16-Electrode working end. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] like Figure 1 As shown, this utility model provides a technical solution: a multi-electrode cell electrostimulation device includes a multi-electrode plate, the multi-electrode plate includes a flexible substrate 11 and an electrode 14, the flexible substrate 11 is made of polydimethylsiloxane, and the electrode 14 is made of titanium alloy.

[0017] The flexible substrate 11 is provided with a first electrode region 12 and a second electrode region 13. Six electrodes 14 are respectively provided in the first electrode region 12 and the second electrode region 13. One end of the electrode 14 is provided with a wire connection end 15, which is connected to an external wire. The other end of the electrode 14 is provided with an electrode working end 16. The electrode working end 16 is connected to the wire connection end 15 through the external wire to complete the passage operation of the electrode working end 16.

[0018] The multi-electrode plate, resistor, and waveform function generator are connected in series to form a series electronic control circuit, and an external power supply is connected to both ends of the series electronic control circuit to form an electrical stimulation device.

[0019] The multi-electrode plate is placed in a cell culture dish during use, and PBS buffer is placed in the cell culture dish.

[0020] The resistor has a resistance of 1Ω, and an oscilloscope is connected to both ends of the resistor to measure the voltage across the resistor.

[0021] When using, place the multi-electrode plate in a culture dish and add PBS buffer to the culture dish until the multi-electrode plate is completely immersed in the PBS buffer;

[0022] Then, the multi-electrode plate, resistor, and waveform function generator are respectively connected in series to form an electronic control circuit. The voltage across the resistor is measured using an oscilloscope. The measured voltage signal is the actual electrical stimulation voltage signal that the cells in the culture dish experience during the application of electrical stimulation.

[0023] During the test, when the waveform function generator was set to a 100Hz frequency and a 5Vp-p sinusoidal electrical stimulation signal, the oscilloscope observed that the voltage across the 1Ω resistor was 10±0.5mV. By controlling the paths of different electrodes 14, the control operation of the multi-electric control system can be completed.

[0024] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0025] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A multi-electrode cell electrical stimulation device, characterized in that: The device includes a multi-electrode plate, which includes a flexible substrate (11) and electrodes (14). The flexible substrate (11) is provided with a first electrode region (12) and a second electrode region (13). Six electrodes (14) are respectively provided in the first electrode region (12) and the second electrode region (13). One end of the electrode (14) is provided with a wire connection end (15), which is connected to an external wire. The other end of the electrode (14) is provided with an electrode working end (16). The electrode working end (16) is connected to the wire connection end (15) through the external wire to complete the passage operation of the electrode working end (16). The multi-electrode plate, resistor, and waveform function generator are connected in series to form a series electronic control circuit, and an external power supply is connected to both ends of the series electronic control circuit to form an electrical stimulation device.

2. The multi-electrode cell electrical stimulation device according to claim 1, characterized in that, The flexible substrate (11) is made of polydimethylsiloxane, and the electrode (14) is made of titanium alloy.

3. The multi-electrode cell electrical stimulation device according to claim 1, characterized in that, The multi-electrode plate is placed in a cell culture dish during use, and PBS buffer is placed in the cell culture dish.

4. The multi-electrode cell electrical stimulation device according to claim 1, characterized in that, The resistor has a resistance of 1Ω, and an oscilloscope is connected to both ends of the resistor to measure the voltage across the resistor.

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