Isolated organ perfusion preservation device
By designing an ex vivo organ perfusion preservation device, the temperature of the perfusion fluid can be monitored and adjusted in real time, solving the problems of untimely temperature adjustment and low monitoring accuracy, and realizing the safety, reliability and functional protection of ex vivo organs during transportation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-08
- Publication Date
- 2026-04-07
AI Technical Summary
Existing ex vivo organ perfusion and transport systems suffer from problems such as untimely temperature regulation and low temperature monitoring accuracy, leading to irreversible damage to ex vivo organs during transport.
An ex vivo organ perfusion preservation device was designed, including an organ preservation component, a perfusion circulation component, a temperature control component, and a control component. The temperature of the perfusion fluid is monitored and adjusted in real time through a temperature sensor and a temperature control unit. Combined with PID control technology, the stability and accuracy of the perfusion fluid temperature are ensured.
It effectively removes metabolic products generated during the transport of organs from outside the body, ensuring organ function during transport, avoiding irreversible damage, improving the accuracy of temperature monitoring, and ensuring the safety and reliability of organs during transport.
Smart Images
Figure CN224084542U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of medical device technology, and in particular to an ex vivo organ perfusion preservation device. Background Technology
[0002] Lung transplantation is the only effective and ultimate treatment for end-stage lung disease. As a special hollow organ, the success of lung transplantation is constrained by a variety of factors, among which the quality of the donor lung is one of the decisive factors. Improving the quality of donor lungs is also the most direct and effective way to expand the source of donors and reduce the difficulty of postoperative treatment. As a technical carrier for donor lung pretreatment, extracorporeal lung perfusion technology can make donor lungs that are not in good condition, close to unusable, or do not meet the transplantation standards suitable for clinical lung transplantation.
[0003] In existing technologies, lung transplantation surgery requires the removal of an isolated lung. After removal, the isolated lung is perfused with perfusion fluid and placed in an isolated lung transport box, which is then transported to its destination. Typically, the transport time for an isolated lung can be 6-7 hours or even longer. However, during transport, because perfusion cannot be performed within the transport box, metabolic waste products from the isolated lung cannot be eliminated. After transplantation, these metabolic products enter the recipient's bloodstream through the body's circulation, potentially causing severe reactions in the recipient.
[0004] During ex vivo lung perfusion, the protection of the donor lung is highly sensitive to the temperature of the perfusion fluid. Temperatures that are too high or too low can significantly impact the function of the donor lung, and unstable perfusion fluid temperature can lead to irreversible damage caused by ex vivo lung perfusion. Currently, traditional ex vivo lung perfusion systems typically suffer from untimely temperature regulation and low accuracy in temperature monitoring.
[0005] Besides isolated lungs, the preservation and transport of isolated organs such as liver and kidneys also face similar challenges.
[0006] It should be noted that the above introduction to the technical background is only for the purpose of providing a clear and complete explanation of the technical solutions of this utility model and facilitating understanding by those skilled in the art. It should not be assumed that these technical solutions are known to those skilled in the art simply because they have been described in the background section of this utility model. Utility Model Content
[0007] In view of the shortcomings of the prior art described above, the purpose of this utility model is to provide an ex vivo organ perfusion preservation device to solve the problems of untimely temperature regulation and low temperature monitoring accuracy in existing ex vivo organ perfusion and transport systems.
[0008] To achieve the above and other related objectives, this utility model provides an ex vivo organ perfusion preservation device, comprising an organ preservation component, a perfusion circulation component, a temperature control component, and a control component. The organ preservation component includes a preservation tank with a top cover, an organ tray, and a side plate support frame. The preservation tank includes an inner layer and an outer layer surrounding the inner layer for containing a temperature control fluid. The organ tray and the side plate support frame are both disposed within the inner layer of the preservation tank, and the side plate support frame is circumferentially connected to the organ tray, which supports the ex vivo organ. The perfusion circulation component includes a perfusion fluid container, a gas separator, and a filter remover. The perfusion fluid container includes an inner layer for containing the perfusion fluid and an outer layer surrounding the inner layer for containing a temperature control fluid. The outer layer, which contains the temperature-regulating liquid, is located around the inner layer of the filling liquid container. The inner layer of the filling liquid container is connected to the inner layer of the storage tank via a filling liquid pipeline. The gas separator and filter remover are installed on the filling liquid pipeline connecting the filling liquid container and the storage tank. The temperature regulation component includes a temperature-regulating liquid container, a temperature sensor for monitoring the temperature of the temperature-regulating liquid in the container, and a temperature control unit for adjusting the temperature. The temperature-regulating liquid container, the outer layer of the storage tank, and the outer layer of the filling liquid container are interconnected. The control component is connected to the temperature regulation component and includes a filtering unit for filtering data from the temperature regulation component and a PID control unit for PID adjustment of the filtered data with target data.
[0009] Optionally, the organ tray is a conical shape with a central depression and has multiple vent holes on its surface.
[0010] Optionally, the storage tank is a transparent cylindrical tank, and the top cover is hemispherical and can be detachably placed on the storage tank.
[0011] Optionally, the top cover is provided with a first interface for allowing the infusion liquid to flow into the isolated organ, a second interface for allowing the isolated organ to be ventilated, and a third interface for allowing the infusion liquid to leave the storage tank.
[0012] Optionally, the support surface of the side plate support frame is provided with a drain pipe and a drain channel.
[0013] Optionally, the gas separator includes a plurality of vent holes disposed on the perfusion fluid pipeline and a water-resistant and gas-permeable membrane disposed within the vent holes, and the filter remover includes an adsorption filter membrane capable of adsorbing and separating metabolic products.
[0014] Optionally, the adsorption filter membrane is provided with a medical adsorbent, which includes medical carbon powder.
[0015] Optionally, a liquid injection port is also provided at the bottom of the gas separator.
[0016] Optionally, the temperature-regulating liquid includes sterile deionized water and / or refrigerant.
[0017] Optionally, the temperature control unit further includes a thermometer for measuring the temperature of the temperature-regulating liquid inside the outer layer of the storage tank and / or for measuring the temperature of the temperature-regulating liquid inside the outer layer of the filling liquid container.
[0018] As described above, the ex vivo organ perfusion preservation device provided by this utility model, through the ingenious design and mutual cooperation of the organ preservation component, perfusion circulation component, temperature regulation component, and control component, can effectively achieve the cleaning and perfusion of ex vivo organs during transportation, effectively remove metabolic products generated during transportation, ensure the respiratory and circulatory function of ex vivo organs during transportation, and ensure the functional and safe transport process. Furthermore, this utility model acquires temperature data measured by the temperature control unit in real time, and through sequential data filtering and PID adjustment processing of the temperature data, it can maintain a constant temperature of the perfusion fluid after reaching a preset value. This avoids irreversible damage to ex vivo organs caused by unstable perfusion fluid temperature, improves the vital signs of ex vivo organs, and achieves real-time temperature regulation of the perfusion fluid during ex vivo organ perfusion, improving the accuracy of temperature monitoring. Attached Figure Description
[0019] Figure 1 The diagram shows the connection relationship of the components of the ex vivo organ perfusion preservation device provided by this utility model.
[0020] Figure 2 The image shown is a front view of the organ preservation component of the ex vivo organ perfusion preservation device provided by this utility model.
[0021] Figure 3 The image shown is a front view of the perfusion fluid container of the ex vivo organ perfusion preservation device provided by this utility model.
[0022] Figure 4 The diagram shown is an exemplary plan view of the perfusion circulation component of the ex vivo organ perfusion preservation device provided by this utility model.
[0023] Figure 5 The diagram shown is an exemplary cross-sectional view of the perfusion circulation component of the ex vivo organ perfusion preservation device provided by this utility model. Detailed Implementation
[0024] The following specific examples illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. This utility model can also be implemented or applied through other different specific embodiments, and various details in this specification can be modified or changed based on different viewpoints and applications without departing from the spirit of this utility model. For ease of explanation, when detailing the embodiments of this utility model, the cross-sectional views showing the device structure may be partially enlarged without adhering to the general scale, and the schematic diagrams are merely examples and should not limit the scope of protection of this utility model. Furthermore, in actual manufacturing, the three-dimensional spatial dimensions of length, width, and depth should be included.
[0025] For ease of description, spatial relation terms such as “below,” “under,” “lower than,” “below,” “above,” and “upper” may be used herein to describe the relationship between one element or feature shown in the accompanying drawings and other elements or features. It will be understood that these spatial relation terms are intended to include directions other than those depicted in the drawings for devices in use or operation. Furthermore, when a layer is referred to as being “between” two layers, it may be the only layer between the two layers, or there may be one or more layers in between.
[0026] In the context of this invention, the described structure of the first feature "above" the second feature may include embodiments in which the first and second features are formed in direct contact, or embodiments in which additional features are formed between the first and second features, such that the first and second features may not be in direct contact.
[0027] It should be noted that the illustrations provided in this embodiment are only schematic representations of the basic concept of this utility model. Therefore, the drawings only show components related to this utility model and are not drawn according to the actual number, shape, and size of the components in the actual implementation. In the actual implementation, the form, quantity, and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex. To keep the illustrations as concise as possible, not all structures are indicated in the drawings.
[0028] like Figure 1 As shown, this utility model provides an ex vivo organ perfusion preservation device, which includes an organ preservation component 1, a perfusion circulation component 2, a temperature control component 3, and a control component 4.
[0029] The organ preservation component 1 is mainly used to preserve ex vivo organs, such as ex vivo lungs, ex vivo livers, kidneys, and other human organs used for transplantation. The structure of the organ preservation component 1 can be referenced... Figure 2As shown, the storage container 12 includes a top cover 11, an organ tray 13, and a side support frame 14. The storage container 12 includes an inner layer 121 for storing excised organs and an outer layer 122 surrounding the inner layer 121 for containing a temperature-regulating liquid. The organ tray 13 and the side support frame 14 are both located within the inner layer 121 of the storage container 12, and the side support frame 14 is circumferentially connected to the organ tray 13. That is, the storage container 12 has a double-layer structure with a double outer shell and a gap between the inner and outer shells. This gap serves as a space for containing the temperature-regulating liquid, which can regulate the temperature of the organs placed in the inner layer 121. For this purpose, the outer layer 122 (or outer container) of the storage container 12 is provided with a temperature-regulating liquid inlet / outlet end 123, which can be single or multiple. For example, in this embodiment, one port is located on the upper part of the outer layer 122 as the inlet of the temperature-regulating liquid, and another port is located on the lower part of the outer layer 122 as the outlet of the temperature-regulating liquid. The temperature-regulating liquid enters the shell of the outer layer 122 of the storage tank 12 through the temperature-regulating liquid inlet and outlet. By flowing through the temperature-regulating liquid channels of the inner and outer double walls, the heat of the temperature-regulating liquid is exchanged with the perfusion liquid, thereby achieving temperature regulation of the perfusion liquid. This allows the perfusion liquid to be transferred to the excised organ, such as the lung, through the perfusion liquid channels.
[0030] In a preferred embodiment of this invention, the storage container 12 is a cylindrical container, preferably a transparent container, such as a glass container or a polymer container, to facilitate observation of the contents from the outside. When the storage container 12 is cylindrical, the top cover 11 can be correspondingly designed as a hemispherical shape, making the overall appearance of the storage container 12 more concise and aesthetically pleasing. The top cover 11 is detachably attached to the storage container 12, providing a sealable connection to the outer wall of the storage container 12. The top cover 11 may have several interfaces 111. For example, if used for storing lungs, a first interface for allowing perfusion fluid to flow into the lungs, a second interface for allowing ventilation of the lungs, and a third interface for allowing perfusion fluid to flow out of the lungs can be provided. During the transport of the donor lung, the donor lung requires oxygen and blood circulation to maintain its activity in the ex vivo state. To maintain a sterile environment outside the donor lung, multiple sets of tubing are needed to connect the ventilator and blood circulation equipment to the donor lung. These tubing can pass through the interface 111 hole of the top cover 11, which makes the external lung protection box look aesthetically pleasing and also facilitates the centralized processing of multiple sets of tubing.
[0031] The organ tray 13 is used to support the excised organ, and its bottom is preferably at a certain distance from the bottom surface of the storage container 12. In some examples, the depth of the organ tray 13 is adjustable to adjust the contact area with the organ according to the different organs to be stored. For example, the organ tray 13 may be a partially foldable structure. To better support the excised organ and prevent local compression, the organ tray 13 may adopt a conical structure with a central concave shape. The main body of the organ tray 13 may be made of a high-molecular polymer material to ensure that it has a certain supporting strength. The surface of the organ tray 13 in contact with the excised organ may be covered with a skin-friendly material layer such as a silicone membrane. The multiple vent holes spaced apart on the surface of the organ tray 13 not only reduce the contact area between the organ tray 13 and the excised organ, preventing lesions on the organ surface due to prolonged contact, but also provide a gas exchange channel between the storage container 12 and the organ tray 13 to keep the excised organ moist. In addition, the liquid drained from the excised organ (e.g., perfusion fluid that has completed blood oxygen exchange) can also be drained through these vent holes. The side plate support frame 14 is connected to the organ tray 13 to secure the organ tray 13 within the inner layer of the preservation tank 12. In some examples, the support surface of the side plate support frame 14 defines a drain pipe and a drain channel, and the space formed can also hold sterile saline solution to maintain humidity within the preservation tank 12 and improve the preservation capability of the ex vivo organ. The organ preservation assembly 1 with the above-described structure can provide a sealed, sterile environment for the donor organ (e.g., a lung) in its ex vivo state, reducing the possibility of damage to the ex vivo organ due to unsuitable environmental conditions.
[0032] The filling circulation assembly 2 includes a filling liquid container 21, a gas separator 22, and a filter remover 23. The filling liquid container 21 includes an inner layer 211 for containing the filling liquid and an outer layer 212 surrounding the inner layer 211 for containing a temperature-regulating liquid. That is, the filling liquid container 21 also has a double-layer structure. The inner layer 211 is used to contain the filling liquid, and there is a gap between the inner layer 211 shell and the outer layer 212 shell. The space between the gap is the space for containing the temperature-regulating liquid, or the temperature-regulating liquid flow channel. The temperature-regulating liquid regulates the temperature of the filling liquid in the inner layer 211 through heat exchange. In some examples, the filling liquid container 21 can adopt a structure that is substantially the same as that of the storage tank 12. For example, it can also be a transparent cylindrical tank, with a temperature-regulating liquid inlet / outlet 213, and is also covered by a detachable hemispherical top cover 214, which can also be provided with several interfaces 215. Besides further simplifying and optimizing the overall structure of the preservation device, this design allows the perfusion container 21 to be used as the preservation tank 12 in emergencies, enhancing overall safety. The inner layer 211 of the perfusion container 21 is connected to the inner layer 121 of the preservation tank 12 via a perfusion pipeline. After undergoing necessary oxygenation and temperature regulation in the perfusion container 21, the perfusion fluid is transported (e.g., via a peristaltic pump) to the isolated organ within the inner layer 121 of the preservation tank 12. For example, perfusion fluid meeting the required blood oxygen concentration enters the isolated organ through its aorta, completes blood oxygen exchange within the organ, flows out from the vein, and after further processing, returns to the perfusion container 21, thus achieving the recycling of the perfusion fluid.
[0033] The gas separator 22 is disposed on the perfusion fluid pipeline connecting the inlet of the perfusion fluid container 21 and the inlet of the storage tank 12, or connected to the inlet pipe 24 of the perfusion fluid container 21. The filter remover 23 is disposed on the perfusion fluid pipeline connecting the outlet of the perfusion fluid container 21 and the outlet of the storage tank 12, or connected to the outlet pipe 25 of the perfusion fluid container 21. For example, when the excised organ is an excised lung, the perfusion circulation assembly 2 is adapted and connected to the pulmonary artery and pulmonary vein of the excised lung to continuously transfer perfusion fluid to the excised lung, and can remove metabolic products produced by the excised lung during the perfusion process, and perform heat exchange between the temperature-regulating liquid and the perfusion fluid. The perfusion fluid container 21 contains the perfusion fluid, which can be placed in the perfusion fluid container 21 by pre-filling or filling. The perfusion fluid is a liquid available for perfusing isolated organs. Its specific composition varies depending on the organ; however, this is well-known to those skilled in the art and will not be elaborated upon here. One end of the outer layer of the perfusion fluid container 21 is connected to the liquid outlet of the temperature-regulating liquid container 31 of the temperature-regulating component 3, and the other end is connected to the liquid inlet of the temperature-regulating liquid container 31. The gas separator 22 includes several vent holes 221 disposed on the perfusion inlet pipe 24 and a water-resistant and gas-permeable membrane 222 disposed within the vent holes 221. The filter remover 23 includes an adsorption filter membrane 231 capable of adsorbing and separating metabolic products.
[0034] Specifically, the gas separator 22 includes a gas separation container that can communicate with the injection inlet pipe 24. Several vent holes 221 are provided on the gas separation container, and a water-resistant and breathable membrane 222 is installed in each vent hole 221. The injection liquid entering the injection liquid container 21 through the tubular inlet pipe first enters the gas separation container. When gas is present in the injection liquid, the gas can be discharged through the water-resistant and breathable membrane 222, which prevents the injection liquid from following the gas out of the vent holes 221. After the gas is discharged, the injection liquid re-enters the injection container. As injection continues, the gas is effectively discharged, avoiding the problem of air embolism caused by the presence of gas in the injection liquid. In some examples, a liquid injection port 223 can be provided at the bottom of the gas separation container. The required liquid, such as physiological saline or perfusion fluid, can be injected into the gas separation container through the liquid injection port 223. The injected liquid can mix with the perfusion fluid in the gas separation container and follow the perfusion circulation of the perfusion fluid.
[0035] In some examples, the filter remover 23 also includes an adsorption filter membrane 231. The perfusion fluid entering the isolated organ from the perfusion container 21 first enters the filter remover container. The perfusion fluid then comes into full contact with the adsorption filter membrane 231 within the filter remover 23, allowing the adsorption filter membrane 231 to adsorb and remove metabolic products generated by the isolated organ. The adsorption filter membrane 231 can be horizontally arranged within the filter remover container. In this arrangement, the perfusion fluid in the perfusion container 21 first enters the lower part of the adsorption filter membrane 231, and then flows out of the filter remover container through the upper part after passing through the adsorption filter membrane 231. In other examples, the adsorption filter membrane 231 can also adopt other distribution forms, as long as it achieves sufficient contact with the perfusion fluid. The adsorption filter membrane 231 can be a combination of a commonly used filter mesh and a medical adsorbent, such as medical carbon powder. The adsorption filter membrane 231 can also adopt other structural forms, as long as it can achieve the adsorption and filtration of metabolic products generated during the perfusion of isolated organs, and there are no strict restrictions on this.
[0036] The temperature control assembly 3 includes a temperature control liquid container 31, a temperature sensor 32 for monitoring the temperature of the temperature control liquid in the container 31, and a temperature control unit (not shown) for regulating the temperature of the liquid. The temperature control liquid container 31, the outer layer of the storage tank 12, and the outer layer of the filling liquid container 21 are interconnected. Therefore, after the temperature control liquid reaches the required temperature in the container 31, it is transported to the filling liquid container 21 and the storage tank 12. After completing the corresponding heat exchange in the corresponding areas, the liquid returns to the container 31 for further temperature control. The temperature control assembly 3 can heat the liquid to raise its temperature or cool it as needed. For example, different temperature control operations can be performed on the liquid at different stages of storage. Therefore, the temperature control assembly 3 has heating and cooling units, such as heating resistance wires and semiconductor cooling chips. These heating and cooling units can be located inside and / or outside the container 31. The temperature control unit includes a temperature sensor 32, which is used to collect temperature data of the temperature-regulating liquid in real time or periodically. There may be more than one temperature sensor 32. For example, in some examples, in addition to the temperature sensor 32 used to collect the temperature of the temperature-regulating liquid in the temperature-regulating liquid container 31, thermometers can also be used to measure the temperature of the temperature-regulating liquid inside the outer layer of the storage tank 12 and / or to measure the temperature of the temperature-regulating liquid inside the outer layer of the filling liquid container 21. The data collected by these thermometers will be uploaded to the control component 4 for processing. The control component 4 is a device with data processing and data transmission functions, connected to the temperature-regulating component 3 to control the temperature regulation operation of the temperature-regulating component 3. If the filling circulation component 2 is equipped with an electronic control unit such as a peristaltic pump, the control component 4 will also be connected to these electronic control units to control the operation of the corresponding component. In this embodiment, the control component 4 includes, in addition to units with logic storage functions such as a microcontroller, a filtering unit (e.g., a filter) for filtering data from the temperature-regulating component 3, and a PID control unit (e.g., a PID controller) for PID adjustment of the filtered data with the target data. The filtering unit and the PID control unit can be physically separate or integrated into one place; in this embodiment, they are preferably integrated into one place. The control component 4 acquires the temperature data collected by the temperature sensor 32, performs digital filtering on the temperature data to obtain filtered temperature data, and then performs PID control processing on the filtered temperature data and the target temperature to obtain the processing result. Based on the processing result, the temperature of the temperature control component 3 is adjusted. As a dynamic control unit, the PID control unit has many advantages such as simple structure, convenient adjustment, and good robustness, which helps to improve the speed and accuracy of temperature control.
[0037] In addition, control component 4 may also include a display screen to display relevant monitored data in real time. For example, it can display the perfusion fluid volume, temperature control fluid, and perfusion fluid oxygenation value in each component in real time.
[0038] As an example, the temperature-regulating fluid can be sterile deionized water, a refrigerant, or a combination of both. Alternatively, the temperature-regulating fluid can also be a gas-liquid mixture.
[0039] In some examples, the control component 4 can also be equipped with an alarm unit to issue an alarm message when the monitored data is abnormal. The alarm unit can be a buzzer or a photoelectric alarm. For example, an alarm message can be issued when a large difference in the temperature of the temperature-regulating liquid at different locations is detected, reminding staff to check the condition of the excised organ.
[0040] In summary, the ex vivo organ perfusion preservation device provided by this utility model, through the ingenious design and coordinated operation of the organ preservation component, perfusion circulation component, temperature control component, and control component, can effectively achieve the cleaning and perfusion of ex vivo organs during transportation, effectively remove metabolic products generated during transportation, ensure the respiratory and circulatory function of the ex vivo organs during transportation, and ensure the functional and safe transport process. Furthermore, this utility model acquires temperature data measured by the temperature control unit in real time, and through data filtering and PID adjustment processing of the temperature data, it can maintain a constant temperature of the perfusion fluid after reaching the preset value, avoiding irreversible damage to the ex vivo organs caused by unstable perfusion fluid temperature, improving the vital signs of the ex vivo organs, and achieving real-time temperature adjustment of the perfusion fluid during the ex vivo organ perfusion process, thus improving the accuracy of temperature monitoring. This utility model can be used for the storage and transportation of various organs such as lungs, liver, and kidneys, helping to improve the success rate of organ transplantation. Therefore, this utility model effectively overcomes the various shortcomings of the prior art and has high industrial application value.
[0041] The above embodiments are merely illustrative of the principles and effects of this utility model and are not intended to limit the scope of this utility model. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this utility model. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this utility model should still be covered by the claims of this utility model.
Claims
1. An ex vivo organ perfusion preservation device, characterized in that, The ex vivo organ perfusion preservation device includes an organ preservation component, a perfusion circulation component, a temperature control component, and a control component. The organ preservation component includes a preservation tank with a top cover, an organ tray, and a side support frame. The preservation tank includes an inner layer and an outer layer surrounding the inner layer to contain a temperature-controlled liquid. The organ tray and the side support frame are both located within the inner layer of the preservation tank, and the side support frame is circumferentially connected to the organ tray. The organ tray supports the ex vivo organ. The perfusion circulation component includes a perfusion fluid container, a gas separator, and a filter remover. The perfusion fluid container includes an inner layer for containing the perfusion fluid and an outer layer surrounding the inner layer to contain the temperature-controlled liquid. The inner layer of the filling liquid container is connected to the inner layer of the storage tank via a filling liquid pipeline. The gas separator and filter remover are installed on the filling liquid pipeline connecting the filling liquid container and the storage tank. The temperature control component includes a temperature control liquid container, a temperature sensor for monitoring the temperature of the temperature control liquid in the temperature control liquid container, and a temperature control unit for temperature regulation. The temperature control liquid container, the outer layer of the storage tank, and the outer layer of the filling liquid container are interconnected. The control component is connected to the temperature control component. The control component includes a filtering unit for filtering data from the temperature control component and a PID control unit for PID adjustment of the filtered data and target data.
2. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The organ tray is a conical shape with a central depression and has multiple ventilation holes on its surface.
3. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The storage tank is a transparent cylindrical tank, and the top cover is hemispherical and can be detachably placed on the storage tank.
4. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The top cover is provided with a first interface for allowing the infusion liquid to flow into the isolated organ, a second interface for allowing the isolated organ to be ventilated, and a third interface for allowing the infusion liquid to leave the storage tank.
5. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The support surface of the side plate support frame is provided with a drain pipe and a drain channel.
6. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The gas separator includes several vent holes disposed on the perfusion fluid pipeline and a water-resistant and gas-permeable membrane disposed within the vent holes. The filter remover includes an adsorption filter membrane capable of adsorbing and separating metabolic products.
7. The ex vivo organ perfusion preservation device according to claim 6, characterized in that, The adsorption filter membrane is provided with a medical adsorbent, which includes medical carbon powder.
8. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The bottom of the gas separator is also equipped with a liquid injection port.
9. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The temperature-regulating fluid includes sterile deionized water and / or refrigerant.
10. The ex vivo organ perfusion preservation device according to claim 1, characterized in that, The temperature control unit also includes a thermometer for measuring the temperature of the temperature-regulating liquid inside the outer layer of the storage tank and / or for measuring the temperature of the temperature-regulating liquid inside the outer layer of the filling liquid container.