Anti-blocking switching valve of continuous flow polypeptide synthesis pipeline

Abstract

The utility model relates to the technical field of valves, and discloses an anti-blocking switching valve of a continuous flow polypeptide synthesis pipeline, which comprises a first valve body and a second valve body, the second valve body is arranged on one side of the first valve body, and the first valve body is provided with a liquid inlet channel corresponding to a liquid inlet. The first valve body is provided with a purging channel used for purging impurities, and the purging channel communicates with the liquid inlet, the control outlet, the adjusting inlet and the adjusting outlet. The through first containing cavity is formed in the first valve body, the adjusting sleeve is fixedly installed in the first containing cavity, and the adjusting valve element is slidably connected into the adjusting sleeve, so that the adjusting valve element can flexibly move in the cavity, and accurate adjustment of a fluid channel is achieved; the interior of each fluid channel can be quickly purged and cleaned through the purging channels, impurities or residues possibly deposited in the channels are removed in time, the risks of material accumulation and channel blockage are remarkably reduced, and therefore the continuity and stability of continuous flow reaction are guaranteed.

Description

TECHNICAL FIELD

[0001] The utility model relates to valve technical field, concretely to a kind of anti-blocking switching valve of continuous flow polypeptide synthesis pipeline. BACKGROUND

[0002] With the rapid development of biological medicine industry, especially the research and development process of polypeptide drug and protein drug accelerates, continuous flow polypeptide synthesis technology gradually becomes important means of polypeptide production. Compared with traditional batch reaction method, continuous flow technology has significant advantages in improving reaction efficiency, shortening synthesis period and reducing impurity generation. The technology makes the synthesis process more controllable and stable by accurately controlling reaction conditions, flow rate and reaction time, so it is favored by more and more biological pharmaceutical fields. At the same time, with the continuous progress of technology, the requirements for reaction equipment, especially fluid control components, are also increasing. In the process of polypeptide synthesis, clogging phenomenon inevitably occurs in fluid system, especially in high-concentration chemical reaction and solvent transmission process, clogging phenomenon is prone to occur, which affects the synthesis efficiency and product quality.

[0003] In the existing polypeptide synthesis system, the traditional switching valve mainly relies on mechanical structure control mode, usually adopts on-off control or pressure difference control, however, in the process of realizing basic fluid switching, material accumulation or impurity deposition cannot be effectively prevented, thereby causing valve clogging, and since polypeptide synthesis liquid usually has high viscosity and contains many impurities, the valve is prone to clogging during use, thereby causing fluid channel obstruction, which seriously affects the stability of reaction system and the synthesis efficiency of product.

[0004] Therefore, it is necessary to provide an anti-blocking switching valve of continuous flow polypeptide synthesis pipeline to solve the problem that the existing switching valve cannot effectively prevent material accumulation or impurity deposition from causing valve clogging. UTILITY MODEL CONTENT

[0005] The main purpose of the utility model is to provide an anti-blocking switching valve of continuous flow polypeptide synthesis pipeline, which aims to solve the technical problems mentioned in the background technology.

[0006] The utility model adopts the following technical solutions:

[0007] An anti-blocking switching valve of continuous flow polypeptide synthesis pipeline comprises:

[0008] A first valve body, opposite ends of the first valve body are provided with a first accommodating cavity, an adjusting sleeve is fixedly arranged in the first accommodating cavity, and an adjusting valve core is slidably connected in the adjusting sleeve;

[0009] A second valve body is arranged at one side of the first valve body, a control assembly for controlling liquid on-off is arranged in the second valve body, and a liquid inlet and a plurality of control outlets are arranged at one end of the second valve body facing the first valve body, and a plurality of adjusting inlets and a plurality of adjusting outlets are respectively communicated with the control outlets corresponding to the opposite sides of the first valve body.

[0010] The first valve body is provided with a liquid inlet channel corresponding to the liquid inlet, and a purging channel for purging impurities is arranged in the first valve body, and the purging channel is communicated with the liquid inlet, the control outlet, the adjusting inlet and the adjusting outlet.

[0011] Further, the first adjusting end cover is arranged at one end of the adjusting sleeve, and the pressure chamber is arranged between the adjusting sleeve and the second adjusting end cover, and the adjusting valve core is in sliding connection with the first adjusting end cover and the second adjusting end cover.

[0012] Further, the pressure adjusting holes are arranged at opposite ends of the adjusting valve core, and the pressure through hole is arranged in the adjusting valve core along the axial direction, and the pressure through hole is communicated with the pressure adjusting holes and the pressure chamber.

[0013] Further, the adjusting sleeve is provided with a plurality of adjusting through holes corresponding to the adjusting inlets and the adjusting outlets, and the adjusting through holes are arranged along the radial direction of the adjusting sleeve.

[0014] The recessed adjusting part is arranged on the outer surface of the adjusting valve core, and the recessed adjusting part is used for cooperating with the adjusting through holes to adjust the communication of the plurality of adjusting inlets and the plurality of adjusting outlets.

[0015] Further, the second valve body is provided with a second containing cavity penetrating through the opposite end surfaces of the second valve body, the control assembly is arranged in the second containing cavity, the electromagnet and the control end cover are respectively arranged at the opposite ends of the second containing cavity, and the second containing cavity is communicated with the liquid inlet channel.

[0016] Further, the control assembly comprises a control sleeve fixedly connected with the second containing cavity, and a control valve core is in sliding connection with the control sleeve.

[0017] The control sleeve is provided with a plurality of control through holes corresponding to the control outlets, and the recessed control part is arranged on the outer surface of the control valve core, and the recessed control part is used for cooperating with the control through holes to adjust the communication of the liquid inlet and the plurality of control outlets.

[0018] Further, the control valve core is provided with an adjusting flow channel in the axial direction, a shunt cap is arranged at one end of the adjusting flow channel close to the electromagnet, a plurality of shunt through holes are arranged in the shunt cap, a compression spring is arranged at one end of the adjusting flow channel away from the shunt cap, and the two ends of the compression spring are fixedly connected with the control valve core and a control end cover.

[0019] Further, the control end cover is provided with a pressure regulating flow channel, and the pressure regulating flow channel is communicated with the adjusting flow channel and the pressure cavity.

[0020] Further, the first adjusting end cover is provided with a liquid supply port communicated with the liquid inlet channel, and the second adjusting end cover is provided with a blowing port communicated with the blowing channel.

[0021] Beneficial effects:

[0022] The utility model provides a kind of anti-blocking switching valve of continuous flow polypeptide synthesis pipeline, by being provided with the first containing cavity of first valve body penetration, and adjusting sleeve is fixedly installed in the first containing cavity, adjusting sleeve is slidably connected adjusting valve core, so that adjusting valve core can be flexibly moved in cavity, realize accurate adjustment to fluid passage.Meanwhile, the control component for controlling liquid on-off of second valve body, liquid inlet and a plurality of control outlet cooperate with the adjusting inlet and adjusting outlet corresponding connection of the two sides of first valve body, form flexible fluid switching and distribution mechanism, guarantee the pressure balance and stability in fluid conveying process.In addition, blowing channel is opened in first valve body, and it is communicated liquid inlet, control outlet, adjusting inlet and adjusting outlet, the inside of each fluid passage can be rapidly blown and cleaned by blowing channel, and the impurities or residues possibly deposited in passage are promptly removed, the risk of material accumulation and channel blockage is significantly reduced, so that the continuity and stability of continuous flow reaction are guaranteed. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is the overall structure schematic diagram of the anti-blocking switching valve of continuous flow polypeptide synthesis pipeline of the utility model;

[0024] Figure 2 It is the section structure schematic diagram of the utility model;

[0025] Figure 3 It is the explosion structure schematic diagram of the utility model;

[0026] Figure 4 It is the section structure schematic diagram of the first valve body of the utility model;

[0027] Figure 5 It is the section structure schematic diagram of the second valve body of the utility model;

[0028] Wherein: 1, first valve body; 101, first containing cavity; 102, adjusting import; 103, adjusting export; 104, liquid inlet channel; 105, purging channel; 2, adjusting sleeve; 201, adjusting through hole; 3, adjusting valve core; 301, pressure adjusting hole; 302, pressure through hole; 303, recessed adjusting part; 4, second valve body; 401, liquid inlet; 402, control export; 403, second containing cavity; 5, control assembly; 510, control sleeve; 511, control through hole; 520, control valve core; 521, recessed control part; 522, adjusting flow passage; 6, first adjusting end cover; 601, liquid supply port; 7, second adjusting end cover; 701, gas blowing port; 8, pressure cavity; 9, electromagnet; 10, control end cover; 11, shunt cap; 12, compression spring.

[0029] The realization, functional features and advantages of the utility model will be further explained in combination with embodiments and with reference to the drawings. DETAILED DESCRIPTION

[0030] It should be understood that the specific embodiments described herein merely exemplify the utility model and are not intended to limit the utility model.

[0031] In the description of the utility model, it should be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the utility model and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the utility model. In addition, the terms "first" and "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the utility model, the meaning of "multiple" is two or more, unless otherwise specifically limited.

[0032] In the description of the utility model, it should be noted that, unless otherwise specifically specified and limited, the terms "mounting", "connection" and "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, it can be directly connected, or indirectly connected through an intermediate medium, it can be the communication between two elements or the interaction relationship between two elements. For ordinary skilled persons in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0033] In the utility model, unless another definite provision and limitation, first feature is in second feature "on" or "under" can include that first and second features are in direct contact, also can include that first and second features are not in direct contact but contact through other feature between them. Moreover, first feature is in second feature "on", "above" and "upper surface" include that first feature is in second feature directly above and obliquely above, or only indicate that first feature horizontal height is higher than second feature. First feature is in second feature "under", "below" and "under surface" include that first feature is in second feature directly below and obliquely below, or only indicate that first feature horizontal height is less than second feature.

[0034] Referring to Figures 1 to 5 The utility model proposes a kind of continuous flow polypeptide synthesis pipeline's anti-blocking switch valve, comprising: first valve body 1, the opposite two end surfaces of first valve body 1 are provided with first containing cavity 101, adjusting sleeve 2 is fixedly arranged in first containing cavity 101, adjusting valve core 3 is slidably connected in adjusting sleeve 2;

[0035] Second valve body 4, the second valve body 4 is arranged in one side of the first valve body 1, control assembly 5 for controlling liquid on-off is arranged in the second valve body 4, and the second valve body 4 is provided with liquid inlet 401 and a plurality of control outlet 402 towards one end of the first valve body 1, and a plurality of adjusting inlet 102 and a plurality of adjusting outlet 103 are communicated with the control outlet 402 respectively on the opposite two sides of the first valve body 1 corresponding to the control outlet 402;

[0036] Wherein, the first valve body 1 is provided with liquid inlet channel 104 corresponding to the liquid inlet 401, and the first valve body 1 is provided with purging channel 105 for purging impurities, and the purging channel 105 is communicated with liquid inlet 401, control outlet 402, adjusting inlet 102 and adjusting outlet 103.

[0037] In the above embodiment, the first valve body 1 is provided with a first accommodating cavity 101 penetrating through the opposite two end faces, a regulating sleeve 2 is fixedly installed in the cavity, a regulating valve core 3 is slidingly connected in the regulating sleeve 2, and the regulating valve core 3 can flexibly slide in the regulating sleeve 2 in the axial direction to control the outflow channel of the fluid. The second valve body 4 is arranged on one side of the first valve body 1 and internally integrated with a control assembly 5 for controlling the on-off of the liquid. An inlet port 401 and a plurality of control outlet ports 402 are formed on the end of the second valve body 4 facing the first valve body 1. A plurality of regulating inlet ports 102 and regulating outlet ports 103 are respectively communicated with the control outlet ports 402 on the two sides of the first valve body 1, and the regulating inlet ports 102 and the regulating outlet ports 103 are communicated in the first valve body 1 itself to form a multi-channel fluid distribution network. Specifically, the control outlet ports 402 are provided as two, the regulating inlet ports 102 are provided as two, and the regulating outlet ports 103 are provided as three. The inlet port 401 realizes the liquid inlet function through the liquid inlet channel 104 formed in the first valve body 1. The sliding of the regulating valve core 3 can adjust the communication state between the regulating inlet ports 102 and the regulating outlet ports 103, so as to realize the accurate switching and distribution of the fluid. In addition, a purge channel 105 is formed in the first valve body 1, which is communicated with the inlet port 401, the control outlet port 402, the regulating inlet port 102 and the regulating outlet port 103. Through the external purge gas flow, each channel can be efficiently cleaned, and the residues or impurities possibly generated in the process of polypeptide synthesis can be timely removed.

[0038] The close cooperation between the first valve body 1 and the second valve body 4 realizes the flexible distribution and pressure balance of the fluid among the multi-channels through the synergistic effect of the regulating valve core 3 and the control assembly 5, thereby ensuring the stability of fluid delivery in the process of continuous flow polypeptide synthesis. The structure that the purge channel 105 is communicated with each fluid channel makes the purge gas flow fully cover the path from the inlet port 401 to the regulating outlet port 103, effectively prevents material accumulation or channel blockage, significantly improves the anti-blocking performance of the pipeline, optimizes the process stability of continuous flow polypeptide synthesis, prolongs the equipment maintenance period, and provides reliable guarantee for efficient and stable polypeptide production.

[0039] Reference Figures 1 to 3 In an embodiment, the opposite two ends of the first accommodating cavity 101 are respectively provided with a first regulating end cover 6 and a second regulating end cover 7. One end of the first regulating end cover 6 abuts against the regulating sleeve 2. A pressure cavity 8 is arranged between the regulating sleeve 2 and the second regulating end cover 7. The regulating valve core 3 is slidingly connected with the first regulating end cover 6 and the second regulating end cover 7.

[0040] In the above embodiment, the first accommodating cavity 101 is fixedly installed with the first adjusting end cover 6 and the second adjusting end cover 7 at both ends respectively, forming a cavity structure. The first adjusting end cover 6 is in close abutment with the end face of the adjusting sleeve 2 at one end to prevent axial displacement. The adjusting sleeve 2 and the second adjusting end cover 7 form a pressure chamber 8 therebetween for accommodating fluid or gas pressure to control the sliding of the adjusting valve core 3. The adjusting valve core 3 is in sliding connection with the inner walls of the first adjusting end cover 6 and the second adjusting end cover 7 through its outer surface, and keeps axial stable movement during sliding, with low friction resistance, to ensure the accuracy of fluid passage switching. The pressure chamber 8 is connected to an external fluid source through a special control channel in the first valve body 1, realizing control over the sliding of the adjusting valve core 3, and the pressure change drives the adjusting valve core 3 to slide in the adjusting sleeve 2, thereby regulating the communication state of the adjusting inlet 102 and the adjusting outlet 103.

[0041] Reference Figure 2 In an example, the adjusting valve core 3 is provided with pressure adjusting holes 301 at opposite ends, and the adjusting valve core 3 is provided with a pressure through hole 302 in the axial direction, which is in communication with the pressure adjusting holes 301 and the pressure chamber 8.

[0042] In the above embodiment, the adjusting valve core 3 is provided with pressure adjusting holes 301 at both ends, and a pressure through hole 302 is provided in the axial direction. The pressure through hole 302 is in communication with the pressure adjusting holes 301 at both ends, and is in communication with the pressure chamber 8 at one end, forming a complete pressure conduction path. The pressure adjusting holes 301 are located at the end faces of the adjusting valve core 3, ensuring that the fluid or gas pressure enters the pressure through hole 302 uniformly, and the pressure through hole 302 extends in the axial direction of the adjusting valve core 3. The adjusting valve core 3 is driven by fluid or gas pressure in the pressure chamber 8 and slides in the axial direction to regulate the communication state of the adjusting inlet 102 and the adjusting outlet 103. The arrangement of the pressure through hole 302 and the pressure adjusting hole 301 enables the adjusting valve core 3 to dynamically respond to pressure changes, achieving precise control of fluid distribution.

[0043] In an embodiment, the adjusting sleeve 2 is provided with a plurality of adjusting through holes 201 corresponding to the adjusting inlet 102 and the adjusting outlet 103, and the adjusting through holes 201 are arranged in the radial direction of the adjusting sleeve 2.

[0044] The outer surface of the adjusting valve core 3 is provided with a recessed adjusting part 303 for cooperating with the adjusting through holes 201 to adjust the communication of a plurality of adjusting inlets 102 and a plurality of adjusting outlets 103.

[0045] In the above embodiment, the adjusting sleeve 2 is provided with a plurality of adjusting through holes 201 corresponding to the positions of the adjusting inlets 102 and the adjusting outlets 103, which are uniformly distributed along the radial direction of the adjusting sleeve 2. The outer surface of the adjusting valve core 3 is processed with a recessed adjusting part 303, which is designed as an annular or arc-shaped groove with a precise depth and width to cooperate with the adjusting through holes 201. When the adjusting valve core 3 slides axially in the adjusting sleeve 2, the recessed adjusting part 303 can be partially or completely aligned with the adjusting through holes 201, so as to regulate the communication state between the two adjusting inlets 102 and the three adjusting outlets 103, and realize the precise distribution of fluid.

[0046] In an embodiment, opposite end faces of the second valve body 4 are provided with a second accommodating cavity 403, the control assembly 5 is arranged in the second accommodating cavity 403, opposite ends of the second accommodating cavity 403 are respectively provided with an electromagnet 9 and a control end cover 10, and the second accommodating cavity 403 is communicated with the liquid inlet channel 104.

[0047] The control assembly 5 comprises a control sleeve 510 fixedly connected with the second accommodating cavity 403, and a control valve core 520 slidingly connected in the control sleeve 510.

[0048] The control sleeve 510 is provided with a plurality of control through holes 511 corresponding to the control outlets 402, and the outer surface of the control valve core 520 is provided with a recessed control part 521 for cooperating with the control through holes 511 to adjust the communication between the liquid inlet 401 and the control outlets 402.

[0049] In the above embodiment, the second valve body 4 has a second accommodating cavity 403 passing through both ends, and the control assembly 5 is installed in the second accommodating cavity 403 to control the on-off of the liquid. One end of the second accommodating cavity 403 is fixedly installed with an electromagnet 9, and the other end is installed with a control end cover 10. The electromagnet 9 provides driving force, and the control end cover 10 seals the cavity and restricts the movement of the control assembly 5. The second accommodating cavity 403 is communicated with the adjusting inlet 102 of the first valve body 1 through the liquid inlet channel 104, ensuring that the fluid enters from the liquid inlet 401 and is distributed on-off. The control assembly 5 includes a control sleeve 510 and a control valve core 520. The control sleeve 510 is fixed to the inner wall of the second accommodating cavity 403, and the control valve core 520 slides in the control sleeve 510 to control the fluid passage. The adjusting valve core 3 in the first accommodating cavity 101 cooperates with the control valve core 520 in the second accommodating cavity 403 to realize the distribution of the fluid among multiple channels. The purge channel 105 communicates the second accommodating cavity 403 and the adjusting outlet 103 of the first valve body 1. The external purge gas flow enters the second accommodating cavity 403 through the liquid inlet channel 104 to clean the residues in the control assembly 5 and the channel. The electromagnet 9 drives the control valve core 520 to slide by accurately controlling the current, ensuring that the communication state of the liquid inlet 401 and the control outlet 402 quickly responds to the process requirements. Through the cooperation of the electromagnet 9 and the control assembly 5, combined with the cleaning function of the purge channel 105, not only the stable switching of the fluid is realized, but also the anti-blocking performance of the pipeline is significantly improved, prolonging the service life of the equipment.

[0050] The control sleeve 510 has a plurality of control through holes 511 corresponding to the two control outlets 402 and distributed in the radial direction. The outer surface of the control valve core 520 is provided with a recessed control part 521 in an arc-shaped groove design, which cooperates with the control through hole 511 to control the communication state of the liquid inlet 401 and the control outlet 402. The control valve core 520 slides axially along the control sleeve 510 under the drive of the electromagnet 9. The alignment degree of the recessed control part 521 and the control through hole 511 determines the opening and closing ratio of the fluid passage, realizing accurate fluid distribution. The second accommodating cavity 403 is communicated with the adjusting inlet 102 of the first valve body 1 through the liquid inlet channel 104. The sliding of the control valve core 520 cooperates with the movement of the adjusting valve core 3 in the first accommodating cavity 101, ensuring the stability of the multi-channel fluid network.

[0051] Reference Figure 2 and Figure 3 In an embodiment, the control valve core 520 is provided with an adjusting flow channel 522 in the axial direction. A split cap 11 is arranged at one end of the adjusting flow channel 522 close to the electromagnet 9. A plurality of split through holes are arranged in the split cap 11. A compression spring 12 is arranged at the other end of the adjusting flow channel 522 away from the split cap 11. The two ends of the compression spring 12 are fixedly connected with the control valve core 520 and the control end cover 10.

[0052] In the above embodiment, the middle part of the control valve core 520 is provided with an adjusting flow channel 522 in the axial direction. The flow channel is provided with a flow distribution cap 11 at one end close to the electromagnet 9. The flow distribution cap 11 is provided with a plurality of flow distribution holes which are distributed radially to ensure uniform distribution of the fluid. The adjusting flow channel 522 is provided with a compression spring 12 at the other end away from the flow distribution cap 11. The two ends of the spring are fixedly connected with the control valve core 520 and the control end cover 10 respectively to provide a restoring force to assist the sliding of the control valve core 520. The electromagnet 9 drives the control valve core 520 to slide in the control sleeve 510 through current control to realize the communication regulation between the liquid inlet 401 and the control outlet 402.

[0053] In an embodiment, the control end cover 10 is provided with a pressure regulating flow channel which communicates with the adjusting flow channel 522 and the pressure chamber 8.

[0054] In the above embodiment, the control end cover 10 is provided with a pressure regulating flow channel which communicates with the adjusting flow channel 522 of the control valve core 520 and the pressure chamber 8 of the first valve body 1 to form a pressure balance network. The pressure regulating flow channel adopts a fine diameter channel to ensure the stability of pressure transmission and improve the opening and closing precision of the control valve core 520 and the self-regulating function.

[0055] In an embodiment, the first adjusting end cover 6 is provided with a liquid supply port 601 which communicates with the liquid inlet channel 104. The second adjusting end cover 7 is provided with a gas blowing port 701 which communicates with the purge channel 105.

[0056] In the above embodiment, the first adjusting end cover 6 is provided with a liquid supply port 601 which communicates with the liquid inlet channel 104 of the first valve body 1 through a pipeline to ensure that the fluid enters the multi-channel network stably from an external source. The second adjusting end cover 7 is provided with a gas blowing port 701 which communicates with the purge channel 105 for introducing an external purge gas stream. The purge gas stream can enter the pressure chamber 8 through the indirect communication between the gas blowing port 701 and the purge channel 105 to assist in cleaning the residues on the surface of the adjusting valve core 3. The first valve body 1 and the second valve body 4 are connected by bolts. The control assembly 5 of the second valve body 4 cooperates with the adjusting valve core 3 to realize the distribution of the fluid among the multiple channels. The purge channel 105 communicates with the liquid supply port 601, the gas blowing port 701 and the adjusting outlet 103. The purge gas stream enters through the gas blowing port 701 and covers all the channels, efficiently removing the by-products in the polypeptide synthesis. The provision of the liquid supply port 601 and the gas blowing port 701 optimizes the efficiency of fluid input and channel cleaning, significantly improves the anti-blocking performance of the pipeline and ensures the process stability of continuous flow polypeptide synthesis.

[0057] The above merely describes preferred embodiments of the present application, and does not limit the patent scope of the present application, and any equivalent structure or equivalent process transformation, or direct or indirect application in other related technical fields, which are made by using the content of the present application specification and drawings, are also included in the patent protection scope of the present application.

Claims

1. A continuous flow polypeptide synthesis pipeline anti-jamming switching valve, characterized in that, The utility model relates to a valve, including: First valve body (1), the opposite both ends of first valve body (1) are provided with first containing cavity (101) through, the fixed setting of first containing cavity (101) is provided with adjusting sleeve (2), the sliding connection of adjusting sleeve (2) is provided with adjusting valve core (3) in; Second valve body (4), the one side of first valve body (1) is provided with second valve body (4), the control assembly (5) of control liquid on-off is provided in second valve body (4), and the one end of second valve body (4) is provided with liquid inlet (401) and a plurality of control outlet (402) towards first valve body (1), and the opposite both sides of first valve body (1) are communicated with a plurality of adjusting inlet (102) and a plurality of adjusting outlet (103) respectively corresponding control outlet (402); Wherein, first valve body (1) is opened with liquid inlet channel (104) corresponding liquid inlet (401), and first valve body (1) is opened with the purging channel (105) for purging impurities, and the purging channel (105) is communicated liquid inlet (401), control outlet (402), adjusting inlet (102) and adjusting outlet (103).

2. A continuous flow polypeptide synthesis conduit anti-jamming switching valve according to claim 1, wherein, The opposite both ends of first containing cavity (101) are respectively installed with first adjusting end cover (6) and second adjusting end cover (7), and one end of first adjusting end cover (6) is abutted to adjusting sleeve (2), and pressure cavity (8) is arranged between adjusting sleeve (2) and second adjusting end cover (7), and adjusting valve core (3) is slidably connected with first adjusting end cover (6) and second adjusting end cover (7).

3. A continuous flow polypeptide synthesis conduit anti-jamming switching valve according to claim 2, wherein, The opposite both ends of adjusting valve core (3) are provided with pressure regulating hole (301), and adjusting valve core (3) is provided with pressure through-hole (302) along the axial direction, and pressure through-hole (302) is communicated with pressure regulating hole (301) and pressure cavity (8).

4. The anti-jamming switching valve of a continuous-flow polypeptide synthesis pipeline according to claim 1, characterized in that, Adjusting sleeve (2) is provided with a plurality of adjusting through holes (201) corresponding adjusting inlet (102) and adjusting outlet (103), and adjusting through holes (201) are arranged along the radial direction of adjusting sleeve (2); The outer surface of adjusting valve core (3) is provided with recessed adjusting part (303), and recessed adjusting part (303) is used for cooperating with adjusting through holes (201) to adjust the communication of a plurality of adjusting inlets (102) and a plurality of adjusting outlets (103).

5. The anti-jamming switching valve of a continuous-flow polypeptide synthesis pipeline according to claim 2, characterized in that, The opposite both ends of second valve body (4) are provided with second containing cavity (403) through, control assembly (5) is arranged in second containing cavity (403), and the opposite both ends of second containing cavity (403) are respectively installed with electromagnet (9) and control end cover (10), and second containing cavity (403) is communicated with liquid inlet channel (104).

6. A continuous flow polypeptide synthesis conduit anti-jamming switching valve according to claim 5, wherein, The control assembly (5) includes control sleeve (510) fixedly connected with the second containing cavity (403), and control sleeve (510) is slidably connected with control valve core (520) in; The control sleeve (510) is provided with a plurality of control through holes (511) corresponding to the control outlets (402), and the outer surface of the control valve core (520) is provided with a recessed control part (521) for cooperating with the control through holes (511) to adjust the communication between the liquid inlet (401) and the control outlets (402).

7. A continuous flow polypeptide synthesis conduit anti-jamming switching valve according to claim 6, wherein, The control valve core (520) is provided with an adjusting flow channel (522) in the axial direction, one end of the adjusting flow channel (522) is provided with a shunt cap (11), a plurality of shunt through holes are arranged in the shunt cap (11), and the other end of the adjusting flow channel (522) is provided with a compression spring (12), and the two ends of the compression spring (12) are fixedly connected with the control valve core (520) and a control end cover (10).

8. A continuous flow polypeptide synthesis conduit anti-jamming switching valve according to claim 7, wherein, The control end cover (10) is provided with a pressure regulating flow channel, and the pressure regulating flow channel is in communication with the adjusting flow channel (522) and a pressure chamber (8).

9. The anti-jamming switching valve of a continuous-flow polypeptide synthesis pipeline according to claim 2, wherein, The first adjusting end cover (6) is provided with a liquid supply port (601), the liquid supply port (601) is in communication with the liquid inlet channel (104), and the second adjusting end cover (7) is provided with a gas blowing port (701), and the gas blowing port (701) is in communication with the purging channel (105).

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