Polypeptide synthesis kettle filtering assembly without dead angle impurity interception

Abstract

The utility model discloses a polypeptide synthesis kettle filter assembly without dead angle impurity interception, which belongs to the technical field of reaction kettles, and is characterized in that the polypeptide synthesis kettle filter assembly comprises an inner cylinder body, a screening assembly is fixedly connected in the inner cylinder body, and the top and the bottom of the inner cylinder body are respectively and movably connected with an inner upper seal head and an inner lower seal head; the problems that an existing filtering assembly is poor in drainage effect, in the actual use process, due to the fact that reasonable flow guide design is lacked, local flow velocity is uneven when materials enter a filtering box, impurities cannot be fully filtered out due to too high flow velocity in part of areas, and raw materials are accumulated and blocked due to too low flow velocity in the other area are solved. The problems that a large number of filtering dead angles are formed, impurities cannot be comprehensively intercepted, so that the purity of subsequent products is difficult to reach the standard, meanwhile, the frequent blockage problem greatly increases the equipment maintenance frequency and cost, the production efficiency and product quality of polypeptide synthesis are seriously influenced, and the practicability of the device is reduced are solved.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, and in particular to a filter component for a peptide synthesis vessel that can intercept impurities without dead angles. Background Technology

[0002] In the industrial production of peptide synthesis, the reaction vessel is the core equipment, and the performance of its filtration components directly affects the purity and yield of peptide products. Peptide synthesis reactions have extremely high requirements for the purity of raw materials, and even small impurities may lead to an increase in reaction by-products, which seriously affects product quality.

[0003] Existing reactors only have simple filters at the feed inlet, which have limited filtration accuracy and are not effective at intercepting tiny impurities. Furthermore, impurities tend to accumulate on the filter surface, causing the filtration efficiency to drop rapidly, making it difficult to meet the requirements for high-quality peptide synthesis.

[0004] An existing patent (publication number: CN221999841U) discloses a safe filtering reactor for peptide synthesis. By setting a filtering structure, the filter box is placed inside a ring, so that the filter box fits against the surface of the ring. Pushing the arc plate causes the ring to move closer to the feed pipe. As the ring moves, it moves the filter box until the filter box moves into the feed pipe. The peptide raw material added in the feed pipe will fall into the filter box, thereby filtering the raw material.

[0005] Existing patents offer solutions to the aforementioned problems, but their flow guidance effect is unsatisfactory. In actual use, due to the lack of a reasonable flow guidance design, uneven flow rates are prone to occur when materials enter the filter box. In some areas, the flow rate is too fast, resulting in impurities not being fully filtered, while in other areas, the flow rate is too slow, causing raw materials to accumulate and clog, forming a large number of filtration dead zones. This makes it impossible to completely intercept impurities, making it difficult for the purity of subsequent products to meet standards. At the same time, frequent clogging problems significantly increase the frequency and cost of equipment maintenance, seriously affecting the production efficiency and product quality of peptide synthesis, and reducing the practicality of the device.

[0006] To address this, a filtration component for a peptide synthesis reactor that can intercept impurities without dead angles is proposed. Utility Model Content

[0007] The purpose of this invention is to provide a filter assembly for a peptide synthesis reactor that can intercept impurities without dead angles. This addresses the problem that existing filter assemblies often suffer from poor flow guidance. In actual use, due to the lack of a reasonable flow guidance design, uneven flow rates can easily occur when materials enter the filter box. In some areas, the flow rate is too fast, resulting in insufficient filtration of impurities, while in other areas, the flow rate is too slow, causing raw materials to accumulate and clog, forming numerous dead angles that cannot comprehensively intercept impurities. This makes it difficult to meet the purity standards of subsequent products. At the same time, frequent clogging significantly increases the frequency and cost of equipment maintenance, seriously affecting the production efficiency and product quality of peptide synthesis, and reducing the practicality of the device.

[0008] To achieve the above objectives, this utility model provides the following technical solution: a filtration assembly for a polypeptide synthesis reactor with no dead-angle impurity interception, comprising an inner cylinder, a screening assembly fixedly connected inside the inner cylinder, and an inner upper end cap and an inner lower end cap movably connected to the top and bottom of the inner cylinder, respectively. The screening assembly includes a fixed ring, a fixed groove is provided at the top of the fixed ring, and the fixed ring is fixedly connected to the top of the inner cylinder. A flow guiding assembly is fixedly connected inside the inner upper end cap, and an electric discharge valve is fixedly connected to the bottom of the inner lower end cap.

[0009] The flow guiding assembly includes a storage cylinder, a discharge plate is fixedly connected to the bottom of the storage cylinder, and a feed pipe is fixedly connected to the top left side of the storage cylinder. A baffle plate is rotatably connected to the bottom of the inner wall of the discharge plate, and the surface of the discharge plate contacts the inner wall of the inner upper end cap. A connecting rod is fixedly connected to the top of the baffle plate, and a rotating motor is fixedly connected to the other end of the connecting rod extending to the top of the storage cylinder.

[0010] Preferably, positioning plates are fixedly connected to both sides of the inner wall of the fixing groove, and a buckle block is rotatably connected to the top of the positioning plate. A mesh basket is movably connected to the bottom of the surface of the positioning plate, and a connecting ring is movably connected to the top of the surface of the positioning plate. A filter bag is fixedly connected inside the connecting ring.

[0011] Preferably, both sides of the top of the basket and the connecting ring are provided with positioning holes for use with positioning plates, and the surface of the positioning plate is in contact with the inner wall of the positioning hole.

[0012] Preferably, flanges are provided between the inner cylinder, the inner upper end cap, and the inner lower end cap, and a sieve plate is movably connected inside the bottom flange. Bolts are threaded to both sides inside the top and bottom flanges, and rubber sealing rings are fixedly connected between the flanges.

[0013] Preferably, a scraper is fixedly connected to the surface of the connecting rod, and the surface of the scraper is in contact with the inner wall of the storage cylinder.

[0014] Preferably, the top of the inner upper end cap is provided with a mounting hole for use with the storage cylinder, and the surface of the storage cylinder is in contact with the inner wall of the mounting hole.

[0015] Preferably, a jacketed cylinder is fixedly connected to the surface of the inner cylinder, and a jacketed end cap is fixedly connected to the surface of the inner lower end cap.

[0016] Preferably, the bottom of the jacket end cap is fixedly connected to a fixing bracket.

[0017] Compared with the prior art, the beneficial effects of this utility model are:

[0018] 1. By setting up a screening component, this application can perform multi-stage filtration of materials to ensure the purity of the materials. It also facilitates the disassembly of the screening component, making it easier to clean impurities and maintain the screening component, thus improving the ease of use of the device.

[0019] 2. By setting up a flow guiding component, this application can accurately guide the material, promote the uniform distribution of the material on the screening component, reduce the generation of dead corners in filtration, and also adjust the material feeding speed, ensuring the filtration effect of the screening component and improving the practicality of the device. Attached Figure Description

[0020] Figure 1 This is an overall structural diagram of the filter assembly of the polypeptide synthesis reactor with no dead-angle impurity interception according to this utility model.

[0021] Figure 2 This is a front view of the filter assembly of the polypeptide synthesis reactor with no dead angle impurity interception according to this utility model;

[0022] Figure 3 This is a schematic diagram showing the connection between the inner cylinder, the upper inner end cap, and the lower inner end cap of this utility model.

[0023] Figure 4 This is a schematic diagram of the flow guiding component of this utility model;

[0024] Figure 5 This is a schematic diagram of the structure of the screening component of this utility model.

[0025] In the diagram, 1. Inner cylinder; 2. Screening assembly; 201. Fixing ring; 202. Fixing groove; 203. Positioning plate; 204. Buckle block; 205. Wire mesh basket; 206. Connecting ring; 207. Filter bag; 3. Inner upper end cap; 4. Inner lower end cap; 5. Flow guiding assembly; 501. Storage cylinder; 502. Discharge plate; 503. Feed pipe; 504. Baffle plate; 505. Connecting rod; 506. Rotary motor; 6. Electric discharge valve; 7. Positioning hole; 8. Flange; 9. Screen plate; 10. Bolt; 11. Rubber sealing ring; 12. Scraper; 13. Mounting hole; 14. Jacketed cylinder; 15. Jacketed end cap; 16. Fixing bracket. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] Please see Figure 1-5 The present invention provides the following technical solution:

[0028] A filtration assembly for a polypeptide synthesis reactor with no dead-angle impurity interception includes an inner cylinder 1. A screening assembly 2 is fixedly connected inside the inner cylinder 1. An inner upper end cap 3 and an inner lower end cap 4 are movably connected to the top and bottom of the inner cylinder 1, respectively. The screening assembly 2 includes a fixed ring 201. A fixed groove 202 is provided on the top of the fixed ring 201. The fixed ring 201 is fixedly connected to the top inside the inner cylinder 1. A flow guiding assembly 5 is fixedly connected inside the inner upper end cap 3. An electric discharge valve 6 is fixedly connected to the bottom of the inner lower end cap 4.

[0029] The flow guiding assembly 5 includes a storage cylinder 501, a discharge plate 502 fixedly connected to the bottom of the storage cylinder 501, and a feed pipe 503 fixedly connected to the top of the left side of the storage cylinder 501. A baffle plate 504 is rotatably connected to the bottom of the inner wall of the discharge plate 502, and the surface of the discharge plate 502 contacts the inner wall of the inner upper end cap 3. A connecting rod 505 is fixedly connected to the top of the baffle plate 504, and a rotating motor 506 is fixedly connected to the other end of the connecting rod 505 extending to the top of the storage cylinder 501.

[0030] In this embodiment: the feed pipe 503 allows the material to flow smoothly into the discharge plate 502 through the feed pipe 503 and the storage cylinder 501, and finally be evenly discharged into the screening component 2 through the discharge plate 502, reducing the generation of dead corners in the filter and improving the material filtration effect. Furthermore, the rotating motor 506 drives the connecting rod 505 to rotate, causing the baffle plate 504 to rotate inside the discharge plate 502. This not only scrapes off the material adhering to the discharge plate 502, ensuring its unobstructed flow, but also allows for precise control of the feed opening size, thus adjusting the material feeding speed. This ensures the filtration effect of the material and improves the ease of use of the flow guiding component 5. Then, the cooperation between the filter bag 207 and the mesh basket 205 allows the material to flow through the filter bag 207 and the mesh basket 205 in sequence, enabling multi-stage filtration of the material and ensuring its purity. At the same time, under the action of the latching block 204, the filter bag 207 and the mesh basket 205 can be quickly unlocked or locked, allowing them to move smoothly under the constraint of the positioning rod. This facilitates the cleaning of impurities and the maintenance of the screening component 2, ensuring the normal use of the screening component 2 and improving its ease of use.

[0031] Specifically, such as Figure 5 As shown, positioning plates 203 are fixedly connected to both sides of the inner wall of the fixing groove 202, and a buckle block 204 is rotatably connected to the top of the positioning plate 203. A mesh basket 205 is movably connected to the bottom of the surface of the positioning plate 203, and a connecting ring 206 is movably connected to the top of the surface of the positioning plate 203. A filter bag 207 is fixedly connected inside the connecting ring 206.

[0032] Specifically, such as Figure 5 As shown, both sides of the top of the basket 205 and the connecting ring 206 are provided with positioning holes 7 for use with the positioning plate 203, and the surface of the positioning plate 203 is in contact with the inner wall of the positioning hole 7.

[0033] Specifically, such as Figure 3 As shown, flanges 8 are provided between the inner cylinder 1, the inner upper end cap 3 and the inner lower end cap 4, and a screen plate 9 is movably connected inside the bottom flange 8. Bolts 10 are threadedly connected to both sides inside the top and bottom flanges 8, and a rubber sealing ring 11 is fixedly connected between the flanges 8.

[0034] In this embodiment: the positioning plate 203 and the positioning hole 7 work together to allow the mesh basket 205 and the connecting ring 206 to move smoothly under the restriction of the positioning plate 203, enabling precise installation and disassembly of the mesh basket 205 and the filter bag 207. This facilitates the cleaning and maintenance of the screening component 2, ensures the filtration effect of the screening component 2, and allows for secondary filtration of materials under the action of the screen plate 9, ensuring the purity of the materials and improving the ease of use of the screening component 2. Then, the bolts 10 and the flange 8 work together to facilitate the opening of the inner cylinder 1, enabling the maintenance and cleaning of the screen plate 9 and the screening component 2. This also allows the inner cylinder 1, the inner upper end cap 3, and the inner lower end cap 4 to be tightly connected. At the same time, the rubber sealing ring 11 can fill the gaps between the inner cylinder 1, the inner upper end cap 3, and the inner lower end cap 4, forming an efficient sealing environment, preventing material leakage, ensuring normal material processing, and improving the ease of use of the device.

[0035] Specifically, such as Figure 4 As shown, a scraper 12 is fixedly connected to the surface of the connecting rod 505, and the surface of the scraper 12 is in contact with the inner wall of the storage cylinder 501.

[0036] Specifically, such as Figure 3 As shown, the top of the inner upper end cap 3 is provided with a mounting hole 13 for use with the storage cylinder 501, and the surface of the storage cylinder 501 is in contact with the inner wall of the mounting hole 13.

[0037] In this embodiment: by using the storage cylinder 501 in conjunction with the mounting hole 13, the surface of the storage cylinder 501 comes into contact with the inner wall of the mounting hole 13, which allows the storage cylinder 501 to be tightly connected to the inner upper end cap 3, enabling the material to flow smoothly into the inner cylinder 1 for subsequent processing. At the same time, under the action of the scraper 12, the connecting rod 505 drives the scraper 12 to rotate at the inner wall of the storage cylinder 501, which can scrape off the material attached to the inner wall of the storage cylinder 501, avoiding material accumulation and blockage of the storage cylinder 501, ensuring normal material feeding, and improving the ease of use of the flow guiding component 5.

[0038] Specifically, such as Figure 1 , Figure 2 , Figure 3 As shown, a jacketed cylinder 14 is fixedly connected to the surface of the inner cylinder 1, and a jacketed end cap 15 is fixedly connected to the surface of the inner lower end cap 4.

[0039] Specifically, such as Figure 1 , Figure 2 As shown, a fixed bracket 16 is fixedly connected to the bottom of the jacket end cap 15.

[0040] In this embodiment, the fixed bracket 16 can firmly fix the device to the ground, effectively reducing equipment vibration and ensuring stable material processing. At the same time, the jacket cylinder 14 and the jacket end cap 15 can form a highly efficient double-layer circulating temperature control system, which can accurately regulate the temperature inside the equipment, thereby providing a suitable temperature for material processing and ensuring that the material is always in the optimal reaction temperature range. This guarantees the quality and efficiency of product processing and improves the practicality of the device.

[0041] Working Principle: When filtering polypeptide raw materials, the material first flows into the storage cylinder 501 through the feed pipe 503, and then is evenly conveyed to the screening component 2 by the discharge plate 502, reducing the generation of dead corners in the filtration. At the same time, the rotating motor 506 is started to drive the connecting rod 505 to rotate, which drives the baffle plate 504 to rotate inside the discharge plate 502. This not only scrapes off the material attached to the discharge plate 502, ensuring the unobstructed flow of the discharge plate 502, but also allows for precise control of the size of the feeding port, realizing the adjustment of the material feeding speed and ensuring the filtration effect of the material. In addition, the inner walls of the inner cylinder 1, the inner upper end 3, and the inner lower end 4 are coated with Hala paint and mirror-finished, which can reduce the corrosion of the tank by the material. This extends the service life of the equipment, allowing materials to flow sequentially through the filter bag 207, mesh basket 205, and sieve plate 9, enabling multi-stage filtration. After filtration, the electric discharge valve 6 is activated to smoothly discharge the material for subsequent processing. Once processing is complete, the bolt 10 is manually tightened to release the flange 8, opening the inner cylinder 1 to clean the sieve plate 9. Then, the locking block 204 is rotated to release the lock on the filter bag 207 and mesh basket 205, facilitating maintenance and cleaning. After cleaning, the parts are reset, and the locking block 204 is rotated to lock the filter bag 207 and mesh basket 205. Finally, the bolt 10 is tightened to ensure a tight connection of all components, preparing for the next operation.

[0042] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A filtration assembly for a polypeptide synthesis reactor with no dead-angle impurity interception, comprising an inner cylinder (1), characterized in that: The inner cylinder (1) is fixedly connected to a screening component (2), and the top and bottom of the inner cylinder (1) are movably connected to an upper inner head (3) and an lower inner head (4), respectively. The screening component (2) includes a fixed ring (201), the top of which is provided with a fixed groove (202), and the fixed ring (201) is fixedly connected to the top of the inner cylinder (1). The upper inner head (3) is fixedly connected to a flow guiding component (5), and the bottom of the lower inner head (4) is fixedly connected to an electric discharge valve (6). The flow guiding assembly (5) includes a storage cylinder (501), a discharge plate (502) is fixedly connected to the bottom of the storage cylinder (501), and a feed pipe (503) is fixedly connected to the top left side of the storage cylinder (501). A baffle plate (504) is rotatably connected to the bottom of the inner wall of the discharge plate (502), and the surface of the discharge plate (502) contacts the inner wall of the inner upper end cap (3). A connecting rod (505) is fixedly connected to the top of the baffle plate (504), and the other end of the connecting rod (505) extends to the top of the storage cylinder (501) and is fixedly connected to a rotating motor (506).

2. The peptide synthesis reactor filtration assembly with no dead-angle impurity interception according to claim 1, characterized in that: Positioning plates (203) are fixedly connected to both sides of the inner wall of the fixing groove (202), and a buckle block (204) is rotatably connected to the top of the positioning plate (203). A mesh basket (205) is movably connected to the bottom of the surface of the positioning plate (203), and a connecting ring (206) is movably connected to the top of the surface of the positioning plate (203). A filter bag (207) is fixedly connected inside the connecting ring (206).

3. The peptide synthesis reactor filtration assembly with no dead-angle impurity interception according to claim 2, characterized in that: The basket (205) and the connecting ring (206) are provided with positioning holes (7) on both sides of the top, which are used to cooperate with the positioning plate (203), and the surface of the positioning plate (203) is in contact with the inner wall of the positioning hole (7).

4. The peptide synthesis reactor filtration assembly with no dead-angle impurity interception according to claim 1, characterized in that: Flanges (8) are provided between the inner cylinder (1), the inner upper end cap (3) and the inner lower end cap (4), and a sieve plate (9) is movably connected inside the bottom flange (8). Bolts (10) are threadedly connected to both sides inside the top and bottom flanges (8), and a rubber sealing ring (11) is fixedly connected between the flanges (8).

5. The peptide synthesis reactor filtration assembly with no dead-angle impurity interception according to claim 1, characterized in that: A scraper (12) is fixedly connected to the surface of the connecting rod (505), and the surface of the scraper (12) is in contact with the inner wall of the storage cylinder (501).

6. The filtration assembly for a polypeptide synthesis reactor with no dead-angle impurity interception according to claim 1, characterized in that: The top of the inner upper end cap (3) is provided with a mounting hole (13) for use with the storage cylinder (501), and the surface of the storage cylinder (501) is in contact with the inner wall of the mounting hole (13).

7. The peptide synthesis reactor filtration assembly with no dead-angle impurity interception according to claim 1, characterized in that: The inner cylinder (1) is fixedly connected to the surface of the jacket cylinder (14), and the inner lower end cap (4) is fixedly connected to the surface of the jacket end cap (15).

8. The peptide synthesis reactor filtration assembly with no dead-angle impurity interception according to claim 7, characterized in that: The bottom of the jacket end cap (15) is fixedly connected to a fixed bracket (16).

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