High-efficiency medical intermediate purification device
By combining synchronous stirring and pre-filtration mechanisms, the problems of insufficient stirring and lack of pre-filtration in existing pharmaceutical intermediate purification devices are solved, achieving thorough mixing of the solution and removal of impurities, thereby improving purification efficiency and equipment lifespan.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- CHENGDU KESHENGYUAN PHARM CO LTD
- Filing Date
- 2025-03-27
- Publication Date
- 2026-04-17
AI Technical Summary
Existing pharmaceutical intermediate purification devices have shortcomings in terms of stirring. The stirring structure is simple and cannot achieve thorough mixing. Furthermore, they lack an effective pre-filtration mechanism, making it difficult to remove impurities, which affects the purification effect and equipment lifespan.
The system employs a synchronous stirring mechanism and a pre-filtration mechanism. The synchronous stirring motor drives the synchronous pulley and stirring shaft to rotate synchronously via a transmission belt, achieving up-and-down circulation and thorough mixing of the solution. The pre-filtration mechanism uses a centrifugal motor to drive a centrifugal drum to rotate at high speed, using centrifugal force to separate larger particle impurities. Combined with a slow-flow filtration mechanism, it performs dual filtration to prevent clogging.
It improves the mixing efficiency of pharmaceutical intermediate solutions and purification reagents, promotes impurity reactions, extends equipment lifespan, and ensures the normal operation of the purification process.
Smart Images
Figure CN224127118U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of pharmaceutical preparation technology, and in particular to a high-efficiency pharmaceutical intermediate purification device. Background Technology
[0002] Pharmaceutical intermediates are a key concept in the pharmaceutical manufacturing process, referring to intermediate compounds formed during the synthesis of a drug but not yet becoming the final formulation. These intermediates typically undergo a series of chemical reactions, purification, and processing steps to ultimately transform into the final drug product. Purification is a crucial step in the production of pharmaceutical intermediates, as its effectiveness directly impacts the quality and performance of subsequent pharmaceutical products. With the continuous development of the pharmaceutical industry, the purity requirements for pharmaceutical intermediates are increasing, and traditional purification equipment is gradually becoming insufficient to meet current production demands.
[0003] However, existing pharmaceutical intermediate purification devices have significant shortcomings in terms of stirring. Many devices employ simple stirring structures, typically using only a single stirring method, which fails to achieve thorough mixing of the pharmaceutical intermediate solution. This makes it difficult for some impurities to fully contact and react with the purification reagents, thus affecting the purification effect. Furthermore, the lack of an effective pre-filtration mechanism means that the pharmaceutical intermediate solution often contains some larger particulate impurities before entering the purification device. Without pre-filtration, these impurities may clog subsequent purification equipment or pipelines, affecting the normal operation of the purification process. Moreover, directly introducing unfiltered solutions into the purification device increases the processing burden and reduces the lifespan of the purification unit. Utility Model Content
[0004] In view of the above problems, this application provides a high-efficiency pharmaceutical intermediate purification device to address the significant shortcomings of existing pharmaceutical intermediate purification devices in terms of stirring. Many devices employ simple stirring structures, typically using only a single stirring method, which fails to achieve thorough mixing of the pharmaceutical intermediate solution. This makes it difficult for some impurities to fully contact and react with the purification reagents, thus affecting the purification effect. Furthermore, the lack of an effective pre-filtration mechanism means that the pharmaceutical intermediate solution often contains some larger particulate impurities before entering the purification device. Without pre-filtration, these impurities may clog subsequent purification equipment or pipelines, affecting the normal operation of the purification process. Moreover, directly introducing unfiltered solutions into the purification device increases the processing burden on the purification unit.
[0005] This application provides a high-efficiency pharmaceutical intermediate purification device. The device includes a purification unit, a stirred tank fixedly mounted on its upper surface, a mixing cylinder positioned above the surface of the stirred tank, a pre-filtration mechanism fixedly connected to one end of the mixing cylinder, and a synchronous stirring mechanism located inside the stirred tank and mixing cylinder. A filter flow retarder is fixedly connected above the surface of the stirred tank.
[0006] In some embodiments, the pre-filtration mechanism includes a material conveying chamber fixedly connected to one end of the mixing cylinder, a material discharge hopper fixedly installed on the upper surface of the material conveying chamber, and a filter box fixedly installed on the top surface of the material discharge hopper.
[0007] In some embodiments, a feed plate is fixedly installed on the upper surface of the filter box, and a centrifugal motor is fixedly installed on the front side surface of the filter box. A centrifugal filter assembly is fixedly installed at the output end of the centrifugal motor, and the centrifugal filter assembly is located inside the filter box.
[0008] In some embodiments, the synchronous stirring mechanism includes a connecting seat fixedly connected to one end surface of the stirring tank, a stirring motor fixedly mounted on the upper surface of the connecting seat, a synchronous wheel fixedly connected to the output end of the stirring motor, a stirring shaft fixedly connected to the inner wall surface of the synchronous wheel, the stirring shaft being located inside the stirring tank, and a stirring blade fixedly mounted on the outer surface of the stirring shaft.
[0009] In some embodiments, a transmission belt is sleeved on the outer surface of the first synchronous pulley, and a second synchronous pulley is movably mounted on the inner surface of the transmission belt. The second synchronous pulley is located on one end surface of the mixing cylinder, and a second stirring shaft is fixedly connected to the inner wall of the second synchronous pulley. A second stirring blade is fixedly mounted on the outer surface of the second stirring shaft, and flow holes are opened on the surfaces of both the first and second stirring blades.
[0010] In some embodiments, the filtration and flow control mechanism includes a filter fixedly connected above the surface of the mixing tank, a feed pipe fixedly connected to the top surface of the filter, and the top end of the feed pipe fixedly connected to the lower surface of the mixing cylinder.
[0011] In some embodiments, a filter plate one and a filter plate two are fixedly installed inside the feed pipe. The filter plate one and the filter plate two are located at the top and bottom of the inner cavity of the feed pipe, respectively. An elastic seat is fixedly connected to the inner wall surface of the feed pipe, and flow-slowing flaps are movably connected to both sides of the elastic seat.
[0012] The above scheme employs a synchronous stirring mechanism. The stirring motor drives synchronous pulleys one and two to rotate synchronously via a transmission belt. This causes stirring shaft one and stirring shaft two to drive stirring blades one and two respectively, synchronously stirring the solution in the stirring tank and mixing cylinder. Stirring blade one is spiral-shaped, enabling the solution to circulate vertically; stirring blade two is blade-shaped, ensuring thorough stirring of the solution in the mixing cylinder. This combination ensures consistent stirring in different areas, allowing the pharmaceutical intermediate solution to mix thoroughly with the purification reagents, promoting the reaction between impurities and reagents, and improving purification effect and efficiency. The pre-filtration mechanism uses a centrifugal motor to drive a high-speed centrifugal drum, using centrifugal force to separate larger particles of impurities from the solution. The inclined design of the feed hopper facilitates solution flow, and the feed hopper and feed plate guide the solution evenly into the filter box. Pre-filtration prevents larger particles of impurities from clogging subsequent purification equipment or pipelines, reducing the processing burden on the purification unit, extending its service life, and ensuring the normal operation of the purification process.
[0013] The above description is merely an overview of the technical solutions of the embodiments of this application. In order to better understand the technical means of the embodiments of this application and to implement them in accordance with the contents of the specification, and to make the above and other objects, features and advantages of the embodiments of this application more obvious and understandable, specific implementation methods of this application are described below. Attached Figure Description
[0014] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0015] Figure 1 This is a three-dimensional schematic diagram of the purification apparatus in some embodiments of this application.
[0016] Figure 2 For this application Figure 1 Enlarged diagram of point A in the diagram.
[0017] Figure 3 This is a three-dimensional schematic diagram of the synchronous stirring mechanism in some embodiments of this application.
[0018] Figure 4 This is a three-dimensional cross-sectional schematic diagram of the feed pipe in some embodiments of this application.
[0019] Explanation of reference numerals in the attached figures:
[0020] 1. Purification equipment; 2. Mixing tank; 3. Mixing cylinder; 4. Pre-filtration mechanism; 41. Material sliding chamber; 42. Discharge hopper; 43. Filter box; 44. Discharge plate; 45. Centrifugal motor; 5. Synchronous stirring mechanism; 51. Connecting seat; 52. Stirring motor; 53. Synchronous pulley one; 531. Stirring shaft one; 532. Stirring blade one; 54. Drive belt; 55. Synchronous pulley two; 551. Stirring shaft two; 552. Stirring blade two; 6. Filter flow control mechanism; 61. Filter; 62. Feed pipe; 63. Filter plate one; 64. Filter plate two; 65. Elastic seat; 66. Flow control flap. Detailed Implementation
[0021] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0022] The terms "comprising" and "having," and any variations thereof, in the specification, claims, and drawings of this application are intended to cover without excluding other terms. The words "a" or "an" do not exclude the presence of multiples. Unless otherwise stated, "multiple" means two or more (including two), and similarly, "multiple sets" means two or more (including two sets).
[0023] The directional terms appearing in the following description refer to the directions shown in the figures and are not intended to limit the specific structure of this application. For example, in the description of this application, terms such as "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "inner," "outer," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the figures. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.
[0024] In the description of this application, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linkage" should be interpreted broadly. For example, "connection" or "linkage" in mechanical structures can refer to a physical connection, such as a fixed connection, a detachable connection, or an integral connection. In addition to referring to a physical connection, "connection" or "linkage" in circuit structures can also refer to an electrical connection or a signal connection. For example, it can be a direct connection, i.e., a physical connection, or an indirect connection through at least one intermediate component, as long as the circuit is connected. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0025] To facilitate understanding of the technical solutions in the embodiments of this application, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings.
[0026] This application provides a high-efficiency pharmaceutical intermediate purification device. Figure 1 This is a three-dimensional schematic diagram of the purification apparatus in some embodiments of this application. Figure 2 For this application Figure 1 An enlarged diagram of point A in the image. (See image for example.) Figure 1 , Figure 2 As shown, the high-efficiency pharmaceutical intermediate purification device includes a purification device 1. A stirring tank 2 is fixedly installed on the upper surface of the purification device 1. A mixing cylinder 3 is arranged above the surface of the stirring tank 2. A pre-filtration mechanism 4 is fixedly connected to one end of the mixing cylinder 3. A synchronous stirring mechanism 5 is arranged inside the stirring tank 2 and the mixing cylinder 3. A filter slow-flow mechanism 6 is fixedly connected above the surface of the stirring tank 2. The pre-filtration mechanism 4 includes a material slide box 41 fixedly connected to one end of the mixing cylinder 3. A discharge hopper 42 is fixedly installed on the upper surface of the material slide box 41. A filter box 43 is fixedly installed on the top surface of the discharge hopper 42. A discharge plate 44 is fixedly installed on the upper surface of the filter box 43. A centrifugal motor 45 is fixedly installed on the front side surface of the filter box 43. A centrifugal filter assembly is fixedly installed at the output end of the centrifugal motor 45. The centrifugal filter assembly is located inside the filter box 43.
[0027] In the technical solution of this application embodiment, after the solution enters the filter box 43, the centrifugal motor 45 drives the centrifugal filter assembly to rotate at high speed. The centrifugal filter assembly includes a cylindrical centrifugal drum with uniformly distributed filter holes on its surface. When the centrifugal motor 45 drives the centrifugal drum to rotate at high speed, larger particles of impurities in the solution are thrown to the inner wall of the drum and adhere to it due to centrifugal force. The filtered solution then flows into the mixing drum 3 through the filter holes, achieving a pre-filtration function. The filtered solution then enters the sliding chamber 41 through the discharge hopper 42. The sliding chamber 41 is set as an inclined box structure and fixedly connected to one end of the mixing drum 3 to facilitate the smooth flow of the solution. 。
[0028] According to other embodiments of this application, such as Figure 3 As shown, the synchronous stirring mechanism 5 includes a connecting seat 51 fixedly connected to one end surface of the mixing tank 2. A stirring motor 52 is fixedly installed on the upper surface of the connecting seat 51. A synchronous pulley 53 is fixedly connected to the output end of the stirring motor 52. A stirring shaft 531 is fixedly connected to the inner wall surface of the synchronous pulley 53. The stirring shaft 531 is located inside the mixing tank 2, and a stirring blade 532 is fixedly installed on the outer surface of the stirring shaft 531. A transmission belt 54 is sleeved on the outer surface of the synchronous pulley 53. A synchronous pulley 55 is movably installed on the inner surface of the transmission belt 54. The synchronous pulley 55 is located on one end surface of the mixing cylinder 3, and a stirring shaft 551 is fixedly connected to the inner wall of the synchronous pulley 55. A stirring blade 552 is fixedly installed on the outer surface of the stirring shaft 551. Flow holes are opened on the surfaces of both the stirring blade 532 and the stirring blade 552.
[0029] In the technical solution of this embodiment, when the stirring motor 52 starts, it drives the synchronous wheel 53 to rotate, and the synchronous wheel 55 rotates synchronously through the transmission belt 54. This causes the stirring shaft 531 and the stirring shaft 551 to drive the stirring blades 532 and 552 to stir the solution in the stirring tank 2 and the mixing cylinder 3, respectively. Since the two rotate synchronously, the consistency of stirring of the solution in different areas can be ensured, and the stirring effect can be improved.
[0030] According to other embodiments of this application, such as Figure 4 As shown, the filtration and flow control mechanism 6 includes a filter 61 fixedly connected to the surface of the mixing tank 2. A feed pipe 62 is fixedly connected to the top surface of the filter 61. The top end of the feed pipe 62 is fixedly connected to the lower surface of the mixing cylinder 3. A filter plate 63 and a filter plate 64 are fixedly installed inside the feed pipe 62. The filter plate 63 and the filter plate 64 are located at the top and bottom of the inner cavity of the feed pipe 62, respectively. An elastic seat 65 is fixedly connected to the inner wall surface of the feed pipe 62. Flow control flaps 66 are movably connected to both sides of the elastic seat 65.
[0031] In this embodiment, the filter 61 in the filtration and slow-flow mechanism 6 is a cylindrical metal container filled with filter media such as activated carbon and filter paper for further fine filtration of the solution. Filter plate 63 and filter plate 64 are fixedly installed inside the feed pipe 62 by bolts. Both filter plate 63 and filter plate 64 are porous plates with different pore sizes. Filter plate 63 has a larger pore size to filter larger particles, while filter plate 64 has a smaller pore size to filter smaller particles. They are located at the top and bottom of the inner cavity of the feed pipe 62, respectively, providing a dual filtration effect. When the solution flows through the feed pipe 62, the slow-flow flaps 66 undergo elastic deformation under the impact of the solution, hindering the flow and thus slowing the flow, allowing the solution sufficient residence time within the device for purification.
[0032] Those skilled in the art will understand that although some embodiments herein include certain features included in other embodiments but not others, combinations of features from different embodiments are intended to be within the scope of this application and form different embodiments. For example, in the claims, any of the claimed embodiments can be used in any combination.
[0033] The above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit it. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application.
Claims
1. A high-efficiency pharmaceutical intermediate purification device, characterized in that, The purification device (1) includes a stirring tank (2) fixedly installed on the upper surface of the purification device (1), a mixing cylinder (3) is provided above the surface of the stirring tank (2), a pre-filtration mechanism (4) is fixedly connected to one end surface of the mixing cylinder (3), and a synchronous stirring mechanism (5) is provided inside the stirring tank (2) and the mixing cylinder (3). A filter slow flow mechanism (6) is fixedly connected above the surface of the stirring tank (2).
2. The high efficiency pharmaceutical intermediate purification device of claim 1, wherein, The pre-filtration mechanism (4) includes a material hopper (41) fixedly connected to one end of the mixing cylinder (3). A material discharge hopper (42) is fixedly installed on the upper surface of the material hopper (41), and a filter box (43) is fixedly installed on the top surface of the material discharge hopper (42).
3. The high efficiency pharmaceutical intermediate purification device of claim 2, wherein, A feed plate (44) is fixedly installed on the upper surface of the filter box (43), and a centrifugal motor (45) is fixedly installed on the front side surface of the filter box (43). A centrifugal filter assembly is fixedly installed at the output end of the centrifugal motor (45), and the centrifugal filter assembly is located inside the filter box (43).
4. The high efficiency pharmaceutical intermediate purification device of claim 1, wherein, The synchronous stirring mechanism (5) includes a connecting seat (51) fixedly connected to one end surface of the stirring tank (2). A stirring motor (52) is fixedly installed on the upper surface of the connecting seat (51). A synchronous wheel (53) is fixedly connected to the output end of the stirring motor (52). A stirring shaft (531) is fixedly connected to the inner wall surface of the synchronous wheel (53). The stirring shaft (531) is located inside the stirring tank (2), and a stirring blade (532) is fixedly installed on the outer surface of the stirring shaft (531).
5. The high efficiency pharmaceutical intermediate purification device of claim 4, wherein, A transmission belt (54) is fitted on the outer surface of the first synchronous pulley (53). A second synchronous pulley (55) is movably installed on the inner surface of the transmission belt (54). The second synchronous pulley (55) is located on one end surface of the mixing cylinder (3). A stirring shaft (551) is fixedly connected to the inner wall of the second synchronous pulley (55). A stirring blade (552) is fixedly installed on the outer surface of the stirring shaft (551). Flow holes are opened on the surfaces of both the first stirring blade (532) and the second stirring blade (552).
6. The high efficiency pharmaceutical intermediate purification device of claim 1, wherein, The filtering and slowing mechanism (6) includes a filter (61) fixedly connected above the surface of the mixing tank (2), and a feed pipe (62) is fixedly connected to the top surface of the filter (61). The top end of the feed pipe (62) is fixedly connected to the bottom surface of the mixing cylinder (3).
7. The high efficiency pharmaceutical intermediate purification device of claim 6, wherein, The feed pipe (62) is fixedly installed with filter plate one (63) and filter plate two (64). Filter plate one (63) and filter plate two (64) are located at the top and bottom of the inner cavity of the feed pipe (62), respectively. An elastic seat (65) is fixedly connected to the inner wall surface of the feed pipe (62). Flow-slowing flaps (66) are movably connected to both sides of the elastic seat (65).