Protein purification system with drawing pocket type cabinet body structure

Abstract

The utility model relates to the technical field of separation and purification systems, in particular to a protein purification system with a drawing pocket type cabinet body structure, which comprises a main frame, the main frame is internally divided into a detection module, a valve module and a pump module in sequence from top to bottom, and a drawing pocket for mounting the valve module is arranged on the main frame. The main frame and the drawing pocket are jointly provided with a sliding assembly, the sliding assembly is used for achieving stable sliding of the drawing pocket, and the main frame and the drawing pocket are further jointly provided with a limiting assembly used for limiting the sliding range of the drawing pocket. According to the method and the device, the convenience of operation in the troubleshooting process of the protein purification system can be improved, so that the troubleshooting efficiency of the protein purification system can be improved.

Description

Technical Field

[0001] This application relates to the field of separation and purification system technology, and in particular to a protein purification system with a drawer-type cabinet structure. Background Technology

[0002] A protein purification instrument is a device specifically designed to separate and purify specific proteins from biological samples. The protein purification process involves a series of complex steps, such as cell disruption, centrifugation, precipitation, and chromatographic separation, to extract the target protein from other impurities. Protein purification instruments play a crucial role in life science research; for example, they can help study the function, structure, and interactions of proteins, or be used in the production of antibodies, vaccines, and other biopharmaceuticals. Furthermore, protein purification instruments are frequently used in the biopharmaceutical field for the production of recombinant protein drugs from microbial or mammalian cells.

[0003] Existing protein purification instruments are usually integrated structures. When a system failure occurs during use, each valve needs to be removed from the system one by one for troubleshooting and repair. If the removed valve is not the problem, the next valve needs to be removed for troubleshooting until the valve with the problem is found. This makes the maintenance process cumbersome and complicated, resulting in low maintenance efficiency. Utility Model Content

[0004] To improve the ease of operation during troubleshooting of protein purification systems and thus increase the efficiency of troubleshooting, this application provides a protein purification system with a drawer-type cabinet structure.

[0005] This application provides a protein purification system with a drawer-type cabinet structure, employing the following technical solution:

[0006] A protein purification system with a drawer-type cabinet structure includes a main frame, which is divided into a detection module, a valve module, and a pump module from top to bottom. The main frame is provided with a drawer for mounting the valve module. The main frame and the drawer are jointly provided with a sliding component for smooth sliding of the drawer. The main frame and the drawer are also jointly provided with a limiting component for limiting the sliding range of the drawer.

[0007] By employing the above technical solutions, the sliding assembly facilitates the smooth extraction of the suction bag from the main frame, thereby enabling the complete extraction of the valve module. This allows for centralized inspection and maintenance of the valve module, improving the ease of operation and efficiency of troubleshooting the protein purification system. The limiting assembly restricts the sliding range of the suction bag, preventing the valve module from falling off during complete extraction from the main frame, thus enhancing the effectiveness of centralized inspection and maintenance of the valve module.

[0008] In one specific implementation, the sliding assembly includes a slide rail and a guide seat. The slide rail is horizontally disposed on the opposite side walls of the drawer, and the guide seat is fixedly disposed on the opposite inner walls of the main frame, with the slide rail and the guide seat slidably engaged.

[0009] By adopting the above technical solution, the sliding of the slide rail on the guide seat helps to drive the drawer to slide smoothly, which helps maintenance personnel to smoothly pull the drawer out from the main frame. This also helps to pull the valve module out from the main frame as a whole, which facilitates centralized troubleshooting and maintenance of the valve module. This improves the convenience of operation during the troubleshooting of the protein purification system and increases the efficiency of troubleshooting the protein purification system.

[0010] In one specific implementation scheme, a sliding abutment block is provided on the inner wall of the guide seat, and a sliding abutment groove is provided on the outer wall of the slide rail, with the sliding abutment block slidably abutting within the sliding abutment groove.

[0011] By adopting the above technical solution, the sliding abutment block helps to slide within the sliding abutment groove, thereby improving the smoothness of the slide rail sliding on the guide seat, and further improving the stability of pulling the drawer and valve module out of the main frame.

[0012] In one specific implementation, the sliding abutment block is provided with a snap-fit ​​limiting strip, the groove wall of the sliding abutment groove is provided with a snap-fit ​​limiting groove, and the snap-fit ​​limiting strip is movably snap-fitted into the snap-fit ​​limiting groove.

[0013] By adopting the above technical solution, when the sliding abutment block slides in the sliding abutment groove, the locking limit strip helps to lock and place it in the locking limit groove, thereby helping to improve the stability of the sliding abutment block during the sliding process in the sliding abutment groove, further improving the smoothness of the slide rail sliding on the guide seat, and further improving the stability of pulling the drawer and valve module out of the main frame as a whole.

[0014] In one specific implementation, the limiting component includes a limiting baffle and a limiting device. The limiting baffle is disposed on opposite sides of the outer wall of the drawer and is used to abut against the main frame. The limiting device is disposed at the end of the slide rail away from the limiting baffle and is used to abut against the guide seat.

[0015] By adopting the above technical solution, when the drawer is pulled out from inside the main frame, the limiter helps to abut against the guide seat, thereby limiting the range of the drawer's withdrawal and preventing it from being completely pulled out of the main frame. This helps prevent the drawer and valve module from falling off, improving the centralized inspection and maintenance efficiency of the entire valve module. When the drawer is pushed into the main frame, the limit baffle helps to abut against the main frame, thereby helping to position the drawer inside the main frame and improving the accuracy of the overall position of the valve module inside the main frame.

[0016] In one specific implementation scheme, the main frame is made of magnetic material, and a magnet is provided on the side of the limiting baffle facing the main frame.

[0017] By adopting the above technical solution, the magnetic sheet helps to attract the main frame made of magnetic material, thereby helping to ensure the stability of the relative position between the limiting baffle and the main frame, and further helping to improve the stability of the position after the drawer is inserted into the main frame, thus improving the overall stability of the valve module's placement position inside the main frame.

[0018] In one specific implementation, a buffer pad is provided on the side of the limiting baffle facing the main frame. The buffer pad is located on the circumferential periphery of the magnet piece, and the thickness of the buffer pad is greater than the thickness of the magnet piece.

[0019] By adopting the above technical solution, when the drawer is pushed into the main frame, the buffer pad helps to cushion the movement, thereby reducing the vibration generated when the limit baffle comes into contact with the main frame, and thus helping to protect the valve module installed inside the drawer.

[0020] In one specific implementation, the drawer is provided with a plurality of mounting brackets for installing valve modules at intervals, and the mounting brackets are provided with through holes for wiring to pass through.

[0021] By adopting the above technical solution, the use of several mounting brackets facilitates the orderly installation of valve modules inside the drawer, thereby improving the convenience of centralized troubleshooting and maintenance of valve modules, and ultimately enhancing the effectiveness of centralized troubleshooting and maintenance. The perforations facilitate the passage of wiring on the valve modules, further improving the ease of installation on the mounting brackets.

[0022] In summary, this application includes at least one of the following beneficial technical effects:

[0023] 1. This application, through the setting of the drawer and sliding component, the sliding component helps to drive the drawer to move smoothly, thereby facilitating maintenance personnel to smoothly pull the drawer out from inside the main frame, and helping to bring the entire valve module out from inside the main frame through the drawer, which in turn facilitates centralized troubleshooting and maintenance of the entire valve module, improves the convenience of operation during the fault repair process of the protein purification system, and improves the fault repair efficiency of the protein purification system.

[0024] 2. By setting a limiting component, this application helps to limit the range of movement of the drawer relative to the main frame, thereby preventing the valve module from falling off due to the drawer being completely pulled out from inside the main frame, and thus helping to improve the centralized inspection and maintenance effect of the valve module. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the overall structure of an embodiment of this application.

[0026] Figure 2 It is a schematic diagram illustrating the specific structure of the sliding component and the limiting component.

[0027] Figure 3 This is a schematic diagram illustrating the specific connection method between the slide rail and the guide seat.

[0028] Figure 4 yes Figure 3 Enlarged view of point A in the middle.

[0029] Explanation of reference numerals in the attached drawings: 1. Main frame; 2. Drawer pocket; 3. Sliding assembly; 31. Slide rail; 32. Guide seat; 4. Limiting assembly; 41. Limiting baffle; 42. Limiter; 5. Sliding abutment block; 6. Sliding abutment groove; 7. Snap-fit ​​limiting strip; 8. Snap-fit ​​limiting groove; 9. Magnet piece; 10. Buffer pad; 11. Mounting bracket; 12. Perforation. Detailed Implementation

[0030] The present application will be further described in detail below with reference to the accompanying drawings.

[0031] This application discloses a protein purification system with a drawer-type cabinet structure, referring to... Figure 1The system includes a main frame 1, which is divided into three layers from top to bottom: the upper layer for installing detection modules, the middle layer for installing valve modules, and the lower layer for installing pump modules. A drawer 2 is movably installed in the middle layer of the main frame 1. Two mounting brackets 11 are vertically spaced on the inner wall of the drawer 2. Valve modules are installed in an orderly manner on the mounting brackets 11. Through holes 12 are provided on the side walls of the mounting brackets 11 for wiring to pass through.

[0032] Reference Figure 2 and Figure 3 Two sets of sliding components 3 are provided on both the main frame 1 and the drawer 2, and the two sets of sliding components 3 are symmetrically distributed on both sides of the drawer 2. Each set of sliding components 3 includes a slide rail 31 and multiple guide seats 32. The slide rail 31 is horizontally fixedly installed on the side wall of the drawer 2, and the multiple guide seats 32 are fixedly installed at intervals along the horizontal direction on the inner wall of the main frame 1, and the slide rail 31 and the multiple guide seats 32 are slidably engaged.

[0033] Reference Figure 2 and Figure 3 When the protein purification system malfunctions, maintenance personnel can pull out the drawer 2, causing the slide rail 31 to slide on multiple guide seats 32. This allows the drawer 2 to slide smoothly out of the main frame 1, thereby causing the valve module to move smoothly out of the main frame 1. This facilitates centralized troubleshooting and maintenance of the valve module that has been removed from the main frame 1, thus improving the convenience of operation during the troubleshooting of the protein purification system and increasing the efficiency of troubleshooting.

[0034] Reference Figure 3 and Figure 4 Each guide seat 32 has an integrally formed sliding abutment block 5 on its inner wall, and a sliding abutment groove 6 is formed on the outer wall of the slide rail 31, with the sliding abutment block 5 slidingly abutting against the inside of the sliding abutment groove 6. A locking limit strip 7 is integrally formed on the sliding abutment block 5, and a locking limit groove 8 is formed on the groove wall of the sliding abutment groove 6, with the locking limit strip 7 slidingly locking against the inside of the locking limit groove 8.

[0035] Reference Figure 3 and Figure 4 When the slide rail 31 slides on the multiple guide seats 32, the sliding abutment block 5 slides against the groove wall of the sliding abutment groove 6, which helps to improve the smoothness of the slide rail 31 sliding above the multiple guide seats 32, thereby helping to improve the stability of the drawer 2 and valve module sliding out of the main frame 1. At the same time, the locking limit strip 7 slides into the locking limit groove 8, which helps to limit the position of the sliding abutment block 5 in the sliding abutment groove 6, thereby helping to improve the stability of the sliding abutment block 5 sliding in the sliding abutment groove 6, further improving the smoothness of the slide rail 31 sliding above the multiple guide seats 32, and further improving the stability of the drawer 2 and valve module sliding out of the main frame 1.

[0036] Reference Figure 2 and Figure 3 The main frame 1 and the drawer 2 are also equipped with two sets of limiting components 4, which are symmetrically distributed on both sides of the drawer 2. Each set of limiting components 4 includes a limiting baffle 41 and a limiter 42. The limiting baffle 41 is integrally formed on the opposite sides of the outer wall of the drawer 2. A magnet 9 and a buffer pad 10 are fixedly installed on the side of the limiting baffle 41 facing the main frame 1. In this embodiment, the main frame 1 is made of magnetic material, the buffer pad 10 is located on the circumferential periphery of the magnet 9, and the thickness of the buffer pad 10 is greater than the thickness of the magnet 9. The limiter 42 is fixedly installed on the end of the slide rail 31 away from the limiting baffle 41.

[0037] Reference Figure 2 and Figure 3 When maintenance personnel pull the drawer 2 out of the main frame 1, the slide rail 31 slides on the guide seat 32. When the limiter 42 abuts against the guide seat 32, the slide rail 31 stops sliding on the guide seat 32, thus preventing the drawer 2 from being pulled out further. This helps to limit the range of the drawer 2 being pulled out, thereby preventing maintenance personnel from completely pulling the drawer 2 out of the main frame 1 and causing the drawer 2 and valve module to fall off. This, in turn, helps to improve the centralized inspection and maintenance effect of the valve module as a whole.

[0038] Reference Figure 2 and Figure 3 After the maintenance personnel have completed the inspection and maintenance of the valve module, they push the drawer 2 into the main frame 1. The position of the drawer 2 inside the main frame 1 is determined by the contact between the limiting baffle 41 and the main frame 1, which helps to improve the accuracy of the valve module's position inside the main frame 1.

[0039] Reference Figure 2 and Figure 3 When the limiting baffle 41 abuts against the main frame 1, the buffer pad 10 acts as a buffer, helping to reduce the vibration generated when the limiting baffle 41 abuts against the main frame 1, thereby helping to protect the valve module installed inside the drawer 2. At the same time, the magnet 9 attracts the main frame 1, keeping the position between the limiting baffle 41 and the main frame 1 relatively stable, which helps to improve the stability of the position of the drawer 2 after it is pushed into the main frame 1, thereby helping to improve the stability of the valve module's placement position inside the main frame 1.

[0040] The implementation principle of this application embodiment is as follows: When the protein purification system malfunctions, the maintenance personnel pull the drawer 2, causing the slide rail 31 to slide on multiple guide seats 32, thereby allowing the drawer 2 to slide smoothly out of the main frame 1, and then driving the valve module as a whole to move smoothly out of the main frame 1. This facilitates the maintenance personnel to conduct centralized troubleshooting and maintenance of the valve module that has been moved out of the main frame 1, thereby helping to improve the convenience of operation during the fault repair process of the protein purification system, and thus helping to improve the fault repair efficiency of the protein purification system.

[0041] When maintenance personnel pull out the drawer 2 from inside the main frame 1, the slide rail 31 slides on the guide seat 32. When the limiter 42 abuts against the guide seat 32, the slide rail 31 stops sliding on the guide seat 32, thus preventing the drawer 2 from being pulled out further. This helps to limit the range of the drawer 2 being pulled out, thereby preventing maintenance personnel from completely pulling out the drawer 2 from inside the main frame 1 and causing the drawer 2 and valve module to fall off. This, in turn, helps to improve the centralized inspection and maintenance effect of the valve module as a whole.

[0042] After maintenance personnel complete the inspection and maintenance of the valve module, they push the drawer 2 into the main frame 1. The position of the drawer 2 inside the main frame 1 is positioned by the contact between the limiting baffle 41 and the main frame 1, thus improving the accuracy of the valve module's placement within the main frame 1. When the limiting baffle 41 contacts the main frame 1, the buffer pad 10 acts as a buffer, helping to reduce the vibration generated when the limiting baffle 41 contacts the main frame 1, thereby protecting the valve module installed inside the drawer 2. At the same time, the magnet 9 attracts the main frame 1, keeping the position between the limiting baffle 41 and the main frame 1 relatively stable, which helps improve the stability of the drawer 2's position after it is pushed into the main frame 1, thus improving the stability of the valve module's placement within the main frame 1.

[0043] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A protein purification system with a pocketed cabinet structure, characterized by: The system includes a main frame (1), which is divided into a detection module, a valve module and a pump module from top to bottom. The main frame (1) is provided with a drawer (2) for installing the valve module. The main frame (1) and the drawer (2) are jointly provided with a sliding component (3), which is used to realize the smooth sliding of the drawer (2). The main frame (1) and the drawer (2) are also jointly provided with a limiting component (4) for limiting the sliding range of the drawer (2).

2. The protein purification system with a pocketed cabinet structure according to claim 1, characterized in that: The sliding assembly (3) includes a slide rail (31) and a guide seat (32). The slide rail (31) is horizontally arranged on the opposite side walls of the drawer (2), and the guide seat (32) is fixedly arranged on the opposite two inner walls of the main frame (1). The slide rail (31) and the guide seat (32) are slidably engaged.

3. The protein purification system with a pocketed cabinet structure according to claim 2, characterized in that: A sliding abutment block (5) is provided on the inner wall of the guide seat (32), and a sliding abutment groove (6) is provided on the outer wall of the slide rail (31), and the sliding abutment block (5) is slidably abutted in the sliding abutment groove (6).

4. The protein purification system with a pocketed cabinet structure according to claim 3, characterized in that: The sliding abutment block (5) is provided with a snap-fit ​​limiting strip (7), and the sliding abutment groove (6) is provided with a snap-fit ​​limiting groove (8) on the groove wall, and the snap-fit ​​limiting strip (7) is movably snap-fitted into the snap-fit ​​limiting groove (8).

5. The protein purification system with a pocketed cabinet structure according to claim 2, characterized in that: The limiting component (4) includes a limiting baffle (41) and a limiter (42). The limiting baffle (41) is disposed on opposite sides of the outer side wall of the drawer (2) and is used to abut against the main frame (1). The limiter (42) is disposed at one end of the slide rail (31) away from the limiting baffle (41) and is used to abut against the guide seat (32).

6. The protein purification system with a pocketed cabinet structure according to claim 5, characterized in that: The main frame (1) is made of magnetic material, and a magnet (9) is provided on the side of the limiting baffle (41) facing the main frame (1).

7. The protein purification system with a pocketed cabinet structure according to claim 6, characterized in that: The limiting baffle (41) is provided with a buffer pad (10) on the side facing the main frame (1). The buffer pad (10) is located on the circumferential periphery of the magnet (9), and the thickness of the buffer pad (10) is greater than the thickness of the magnet (9).

8. The protein purification system with a pocketed cabinet structure according to claim 1, characterized in that: The drawer (2) is provided with a number of mounting brackets (11) for installing valve modules, and the mounting brackets (11) are provided with through holes (12) for the wiring to pass through.

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