Diluting device for citicoline sodium injection

Abstract

The utility model discloses a dilution device for citicoline sodium injection, which comprises a support frame, a station plate is fixed on the top surface of the support frame, two groups of dilution buckets are arranged at the working position of the station plate, the dilution buckets and the station plate are obliquely arranged from top to bottom, mixing parts are arranged on the inner wall of the dilution buckets in a circumferential array, and the mixing parts are arranged on the inner wall of the dilution buckets. An arc-shaped filtering plate is arranged at the bottom of the diluting barrel, a discharging head is connected to the surface of the diluting barrel, a sampling pipe is connected to the back face of the diluting barrel, an extending base is welded to the back face of the supporting frame, and a PH detecting pen is connected to the top end of the extending base. According to the citicoline sodium injection diluting device, the efficiency, safety and precision of citicoline sodium injection diluting are remarkably improved, liquid medicine is efficiently mixed in an inclined state, splashing is avoided, double barrels of liquid medicine can be synchronously filtered through accurate butt joint of the arc-shaped filter plate and the discharging head, the process switching time is shortened, and the whole process automation of sampling, calibration and detection is achieved through the integrated PH detection design.

Description

Technical Field

[0001] This utility model relates to the field of injection dilution technology, specifically a dilution device for sodium citicoline injection. Background Technology

[0002] The equipment for preparing cytidine diphosphate choline sodium injection mainly functions to mix and dilute high-concentration cytidine diphosphate choline sodium raw material with water for injection or other solvents in a specific ratio to finally obtain a sterile injection solution that meets the requirements for clinical use.

[0003] In the prior art, a dilution device for cytidine diphosphate choline sodium injection disclosed in patent publication number "CN220633889U" is provided. The device has inlet pipes at both ends of the dilution tank, a fixing rod inside the tank, a fixing frame on the side of the fixing rod, a scraper on the side of the fixing frame, and an electromagnetic valve on the bottom of the tank. This dilution device uses a geared motor to drive a rotating rod inside the tank, causing the fixing rods and scrapers at both ends to rotate simultaneously. This mixes the cytidine diphosphate choline sodium injection with purified water inside the tank. The scraper prevents the cytidine diphosphate choline sodium injection from adhering to the inner wall of the tank. A water pump on the top of the tank re-pours water into the tank for cleaning, and the scraper effectively cleans the solution, thus improving the quality of the cytidine diphosphate choline sodium injection.

[0004] However, existing technologies still have significant shortcomings. Traditional dilution devices typically use single-bucket dilution and vertical axis stirring, which cannot process multiple batches of drug solution simultaneously, resulting in low production efficiency. After dilution, additional filtration equipment is required to filter and recover the liquid, making the operation process cumbersome. Furthermore, after dilution, it is not possible to promptly test the pH value of the injection solution and add the necessary adjusters. Utility Model Content

[0005] The purpose of this invention is to provide a dilution device for cytidine diphosphate choline sodium injection to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a dilution device for sodium citicoline injection, comprising a support frame, a workstation plate fixed to the top surface of the support frame, a dilution tank installed at the working position of the workstation plate, and two sets of dilution tanks, both the dilution tanks and the workstation plate being installed at an angle from top to bottom, a mixing element arranged in a circular array on the inner wall of the dilution tank, an arc-shaped filter plate provided at the bottom of the dilution tank, a discharge head connected to the surface of the dilution tank, a sampling tube connected to the back of the dilution tank, an extension base welded to the back of the support frame, a pH test pen connected to the top of the extension base, and a control panel fixed to the side of the workstation plate by screws.

[0007] As can be seen, the above technical solution significantly improves the efficiency, safety, and accuracy of dilution of cytidine diphosphate choline sodium injection through its dual-barrel rotating and tilting structure and integrated pH detection and filtration structure. The independent motor drive for both barrels, combined with the inner wall mixing component, achieves efficient mixing of the drug solution while tilting, avoiding splashing and ensuring uniform concentration. The precise alignment of the arc-shaped filter plate and the discharge head allows for simultaneous filtration of the drug solution from both barrels, reducing process changeover time. The integrated pH detection design automates the entire process of sampling, calibration, and testing.

[0008] Preferably, there are two sets of workstation plates, and each workstation plate is located near the beginning and end of the dilution tank. The arc-shaped filter plate is located between the two workstation plates and is fixed at both ends to the workstation plates.

[0009] As can be seen, in the above technical solution, the workstation plate can be used to install dilution tanks or arc-shaped filter plates. The two sides of the arc-shaped filter plate are inclined towards the center, which can help the liquid concentrate at the position of the filter holes and wait for filtration.

[0010] Preferably, a mixing motor is connected to the center of the back of the dilution tank, and a fixing bracket is fixed to the surface of the mixing motor, and the fixing bracket is fixed to the work station plate at the end position.

[0011] As can be seen, in the above technical solutions, the mixing motors can be controlled independently, and the speed can be adjusted differently to adapt to the dilution requirements of liquids with different viscosities, avoiding batch-to-batch interference caused by traditional single-tank series connection.

[0012] Preferably, the top of the dilution tank is provided with an addition tube, and the liquid outlet end of the addition tube is located inside the dilution tank. A connector is sleeved on the surface of the addition tube, and the connector is fixed to the top surface of the first end station plate.

[0013] As can be seen, in the above technical solution, the number of pipes and connectors can be increased or decreased according to the needs, mainly for adding the required liquid.

[0014] Preferably, a turntable is fixed at the rotation position of the extended base, and containers are arranged in a circular array on the top surface of the turntable, with the positions of the containers corresponding to the positions of the sampling tube and the pH test pen.

[0015] As can be seen, in the above technical solution, equipping the turntable with a motor to make it rotate allows multiple containers to pass through the pH test pen and sampling tube in sequence.

[0016] Preferably, a limiting post is fixed to the top surface of the extended base, and a lifting plate is slidably connected inside the limiting post, and the pH test pen is connected to the lifting plate.

[0017] As can be seen, in the above technical solution, the lifting plate can slide within the limiting column, thereby driving the pH testing pen to move up and down.

[0018] Preferably, a lead screw is installed inside the limiting post, and a lifting plate is sleeved on the surface of the lead screw, and the lifting plate is threadedly connected to the surface of the lead screw.

[0019] As can be seen, in the above technical solution, a motor is added to the lead screw inside the limiting column, so that the lifting plate can move up and down along the inner wall of the limiting column and the surface of the lead screw as the lead screw rotates.

[0020] Compared with the prior art, the beneficial effects of this utility model are:

[0021] 1. The dual-barrel structure allows for the independent dilution of two batches of drug solution simultaneously. The inclined design, ranging from 15° to 30°, allows the drug solution to naturally concentrate at the lower end under gravity. Combined with the inner wall mixing components, this enhances the vortex mixing effect, ensuring that sodium citicoline is fully dissolved and at a uniform concentration. It also avoids droplet splashing caused by high-speed stirring. Furthermore, the inclined layout reduces the overall height of the equipment, facilitating installation and maintenance in clean rooms and greatly improving the working efficiency of the device.

[0022] 2. The arc-shaped filter plate is installed between the two workstation plates. Its radius of curvature matches the discharge head of the dilution tank. The position of the discharge head below the dilution tank is adjusted. When the discharge valve is opened, the liquid in the two dilution tanks flows into the arc-shaped filter plate at the same time. The liquid is filtered through the arc-shaped filter plate. Due to the arc design of the arc-shaped filter plate, it can ensure that the liquid flows towards the center and avoids filtration leakage.

[0023] 3. The sampling tube on the back of the tilted barrel extracts the drug solution using the principle of gravity flow. The sample container is precisely positioned under the pH test pen by a turntable. The lifting mechanism and the rotation of the turntable achieve fully automatic immersion testing, eliminating human error, greatly improving work efficiency, and realizing the automation of the device. The required additives are added according to the pH value to ensure that the drug solution is always within the optimal acid-base range, thus improving the quality of dilution. Attached Figure Description

[0024] Figure 1 This is a perspective view of the present utility model;

[0025] Figure 2 for Figure 1 Enlarged view of point A;

[0026] Figure 3 This is a schematic diagram of the overall structure of this utility model;

[0027] Figure 4 This is a side view of the present invention;

[0028] Figure 5This is an isometric view of the present invention;

[0029] Figure 6 This is a top view of the present invention.

[0030] In the diagram: 1. Support frame; 2. Workstation plate; 3. Arc-shaped filter plate; 4. Dilution tank; 5. Mixing component; 6. Discharge head; 7. Control panel; 8. Connector; 9. Addition tube; 10. Extension base; 11. Turntable; 12. Container; 13. Sampling tube; 14. Limiting post; 15. Lead screw; 16. Lifting plate; 17. pH test pen; 18. Mixing motor; 19. Fixed bracket. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Please see Figure 1-6 This utility model provides a technical solution:

[0033] Example 1: A dilution device for sodium citicoline injection: including a support frame 1, a work station plate 2 fixed on the top surface of the support frame 1, a dilution tank 4 installed at the working position of the work station plate 2, and two sets of dilution tanks 4, both the dilution tanks 4 and the work station plate 2 are installed at an angle from top to bottom, and a mixing element 5 is arranged in a circular array on the inner wall of the dilution tank 4. The dilution device mainly uses the dilution tank 4 to rotate inside the work station plate 2. The work station plate 2 is located near the first and second ends of the dilution tank 4, with two sets in total. The mixing element 5 is a stirring element that can rotate with the dilution tank 4. The double-tank structure allows the work station plate 2 and the dilution tank 4 to be installed at an angle. The double-tank structure can simultaneously dilute two batches of drug solution independently. The angle design is usually between 15° and 30°, so that the drug solution naturally concentrates at the lower end under the action of gravity, avoiding droplet splashing caused by high-speed stirring, and greatly improving the dilution efficiency. It also facilitates the cleaning and maintenance of the inside of the dilution tank 4 by the staff.

[0034] After adding the injection solution, a measured amount of water for injection is added for dilution. This is the most commonly used diluent, providing a high-purity, pyrogen-free water environment to ensure drug dissolution. It is suitable for diluting most cytidine diphosphate choline sodium injection solutions. The final concentration must meet the standard. The control panel 7 is fixed to the side of the workstation plate 2 with screws. A mixing motor 18 is connected to the center of the back of the dilution tank 4. A fixing bracket 19 is fixed to the surface of the mixing motor 18, and the fixing bracket 19 is fixed to the workstation plate 2 at the end position. It is worth noting that each dilution tank 4 is equipped with a dedicated mixing motor 18, which can adjust the speed individually to adapt to the dilution requirements of drug solutions with different viscosities, avoiding batch interference caused by traditional single tank series connection. The mixing motor 18 is directly fixed to the workstation plate 2 at the end position through the fixing bracket 19, which serves to install and support the mixing motor 18.

[0035] The bottom of the dilution tank 4 is equipped with an arc-shaped filter plate 3, and the surface of the dilution tank 4 is connected to a discharge head 6. There are two sets of station plates 2, and the station plates 2 are located near the first and last ends of the dilution tank 4. The arc-shaped filter plate 3 is located between the two station plates 2, and its two ends are fixed to the station plates 2. The arc-shaped filter plate 3 is directly connected and fixed to the two station plates 2. The discharge head 6 on the surface of the dilution tank 4 includes a solenoid valve. During the dilution process, the dilution tank 4 rotates together with the discharge head 6. The gap between the arc-shaped filter plate 3 and the dilution tank 4 will not affect its rotation, ensuring that the discharge head 6 can pass through. Finally, after the dilution is completed, the position of the discharge head 6 is adjusted and the valve is opened so that the diluted liquid can fall directly into the receiving surface of the arc-shaped filter plate 3. Due to the arc design, the liquid can flow along the arc surface to the center position and filter the injection liquid through the filter holes. Simply take out the recovery box and place it under the filter holes of the arc-shaped filter plate 3 to wait for recovery.

[0036] A sampling tube 13 is connected to the back of the dilution tank 4, and an extension base 10 is welded to the back of the support frame 1. A pH test pen 17 is connected to the top of the extension base 10. By adding a pH detection structure to the back of the dilution tank 4, sampling and testing can be carried out directly after dilution. The required additives are added according to the detected pH value to ensure that the drug solution is always in the optimal acid-base range, thereby improving the quality of dilution. When the pH exceeds the specified range, a pH adjuster such as sodium citrate is added to adjust the pH value of the drug solution. When the pH of the cytidine diphosphate choline sodium injection is lower than the specified range, an alkaline pH adjuster such as sodium bicarbonate needs to be added to raise the pH value to the standard range.

[0037] Example 2:

[0038] Based on Embodiment 1, a turntable 11 is fixed at the rotation position of the extension base 10. Containers 12 are arranged in a circular array on the top surface of the turntable 11, and the positions of the containers 12 correspond to the positions of the sampling tube 13 and the pH testing pen 17. It is worth noting that pH detection is achieved by raising and lowering the pH testing pen 17 in conjunction with rotating the turntable 11 to adjust the positions of the containers 12, thus completing automated detection. The pH of cytidine diphosphate choline sodium injection is typically 5.0-7.0, requiring the selection of a pH testing pen with a range covering this range, such as 0-14 or a narrow range of 4-8. The pH testing pen is based on the potentiometric method, detecting the hydrogen ion concentration in the solution through electrodes. The pH pen includes, but is not limited to, a glass electrode, a reference electrode, and a signal processor. Adding a motor to the turntable 11 allows it to rotate on the extension base 10 to adjust the positions of the multiple containers 12 above, thus allowing the containers to... Both 12 can pass through sampling tube 13 and pH test pen. There are at least three sets of containers 12. The bottom of container 12 can be made of metal sheet for magnetic attraction with the magnet at the installation position on the top of the turntable 11. One is used to store cleaning solution, one is used to store sample, and one is used to store buffer solution. First, open the valve of sampling tube 13 on the back of dilution tank 4 and extract the drug solution into the corresponding container 12 by gravity. Rotate the container 12 containing buffer solution to be directly below the pH test pen. Immerse the electrode into the buffer solution by raising and lowering the pH test pen. Calibrate until the reading is stable. Immerse the electrode in the drug solution and wait for the reading to stabilize. The sensitive membrane of the pH glass electrode, such as lithium glass, needs to be completely wetted in the buffer solution to form a stable potential difference. Adjust the position of the sample container 12 to the pH test pen for descent detection.

[0039] According to the test results, the required additives can be added. After the test is completed, the pH test pen is immersed in the cleaning solution for cleaning to avoid affecting the next test result. The cleaning solution needs to be manually replaced. The top surface of the extension base 10 is fixed with a limit post 14, and a lifting plate 16 is slidably connected inside the limit post 14. The pH test pen 17 is connected to the lifting plate 16. A lead screw 15 is installed inside the limit post 14, and the lifting plate 16 is sleeved on the surface of the lead screw 15. The lifting plate 16 is threadedly connected to the surface of the lead screw 15. A motor is added to the lead screw 15 inside the limit post 14 so that the lifting plate 16 can move up and down along the inner wall of the limit post 14 and the surface of the lead screw 15 as the lead screw 15 rotates. The control panel 7 mainly outputs PWM pulses according to the PLC preset program, such as the test mode, to drive the motor to move up and down to the target position. At the same time, it can receive the pH test value, which makes it convenient for the staff to directly operate the control panel 7 to complete the dilution process.

[0040] The top of the dilution tank 4 is equipped with an addition pipe 9, and the liquid outlet end of the addition pipe 9 is located inside the dilution tank 4. The surface of the addition pipe 9 is fitted with a connector 8, and the connector 8 is fixed to the top surface of the first end station plate 2. It should be noted that there are multiple addition pipes 9 that can be added or reduced as needed. The required liquid pipes are connected to the addition pipes 9 through pumps and flanges to inject the required liquid into the corresponding dilution tank 4. The addition pipe 9 is also equipped with a valve.

[0041] Working principle: The dilution tank 4 has a double-tank structure and can rotate inside the workstation plate 2. Both tanks are driven by independent mixing motors 18 and are designed with an overall tilt. As the dilution tank 4 rotates, the mixing components 5 on the inner wall mix and dilute the injection solution, concentrating it at the lower end to prevent splashing during mixing. An arc-shaped filter plate 3 is added between the workstation plates 2. After dilution, the discharge head 6 valve opens, ensuring that the discharge head 6 of the dilution tank 4 corresponds to the receiving arc surface of the arc-shaped filter plate 3. This allows the injection solution in both tanks to be filtered simultaneously by the arc-shaped filter plate 3 for later recovery. A sampling tube 13 is added to the back interface of the dilution tank 4, integrating the pH detection structure with the dilution equipment. The composition involves opening the valve of the sampling tube 13 after dilution. Due to the tilt of the dilution tank 4, the injection solution can be extracted and discharged from the sampling tube 13 into the corresponding container 12. The position of multiple containers 12 above can be controlled by rotating the turntable 11. When performing pH value testing of the injection solution, the container 12 with buffer solution is rotated to the bottom of the pH test pen 17. The electrode is immersed in the buffer solution by raising and lowering the pH test pen 17. The calibration is performed until the reading is stable. Then, the sample container 12 is rotated and the position is adjusted. Similarly, the pH value of the diluted sample is tested using the pH test pen 17, and the required adjustment agent is added appropriately according to the test results.

[0042] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A dilution apparatus for sodium citicoline injection, characterized in that: The device includes a support frame (1), a work station plate (2) fixed on the top surface of the support frame (1), a dilution tank (4) installed at the working position of the work station plate (2), and there are two sets of dilution tanks (4). Both the dilution tanks (4) and the work station plate (2) are installed at an angle from top to bottom. The inner wall of the dilution tank (4) is circumferentially arrayed with mixing components (5). The bottom of the dilution tank (4) is provided with an arc-shaped filter plate (3). The surface of the dilution tank (4) is connected with a discharge head (6). The back of the dilution tank (4) is connected with a sampling tube (13). The back of the support frame (1) is welded with an extension base (10). The top of the extension base (10) is connected with a pH test pen (17). The side of the work station plate (2) is screwed with a control panel (7).

2. The dilution apparatus for sodium citicoline injection according to claim 1, characterized in that: There are two sets of workstation plates (2), and both workstation plates (2) are located at the beginning and end positions close to the dilution tank (4). The arc-shaped filter plate (3) is located between the two workstation plates (2), and both ends are fixed to the workstation plates (2).

3. The dilution apparatus for sodium citicoline injection according to claim 1, characterized in that: A mixing motor (18) is connected to the center of the back of the dilution tank (4). A fixing bracket (19) is fixed to the surface of the mixing motor (18), and the fixing bracket (19) is fixed to the work station plate (2) at the end position.

4. The dilution apparatus for sodium citicoline injection according to claim 1, characterized in that: The top of the dilution tank (4) is provided with an addition tube (9), and the liquid outlet end of the addition tube (9) is located inside the dilution tank (4). A connector (8) is sleeved on the surface of the addition tube (9), and the connector (8) is fixed to the top surface of the first end workstation plate (2).

5. The dilution apparatus for sodium citicoline injection according to claim 1, characterized in that: A turntable (11) is fixed at the rotation position of the extension base (10). Containers (12) are arranged in a circular array on the top surface of the turntable (11), and the positions of the containers (12) correspond to the positions of the sampling tube (13) and the pH test pen (17).

6. The dilution apparatus for sodium citicoline injection according to claim 1, characterized in that: The top surface of the extension base (10) is fixed with a limiting post (14), and a lifting plate (16) is slidably connected inside the limiting post (14), and the pH test pen (17) is connected to the lifting plate (16).

7. The dilution apparatus for sodium citicoline injection according to claim 6, characterized in that: The limiting post (14) is equipped with a lead screw (15), and the lifting plate (16) is sleeved on the surface of the lead screw (15), and the lifting plate (16) is threadedly connected to the surface of the lead screw (15).

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