Sulfonamide sodium synthesis reaction kettle

Abstract

The utility model relates to a sulfonamide sodium synthesis reaction kettle which comprises a kettle body, the sealing head is formed at the lower end of the kettle body, and a bottom valve is mounted at the bottom of the sealing head; the jacket is formed on the outer wall of the kettle body and extends to the sealing head; the jacket is provided with a liquid inlet positioned at the lower part and a liquid outlet positioned at the upper part; the plurality of supporting lugs are fixed on the outer wall of the clamping sleeve; the reaction kettle cover plate is mounted at the top of the kettle body, and a motor bracket is mounted on the reaction kettle cover plate; the stirrer is rotatably mounted in the kettle body and extends to the motor bracket; and the motor is mounted on the motor bracket and is connected with the stirrer. The stirrer with a specific structure is adopted, so that the stirring cross rod is matched with the stirring half frame, the concentrated material can be crushed into powder under the driving of the motor, and the material is continuously dried to reach the required moisture in the kettle.

Description

Technical Field

[0001] This utility model belongs to the field of chemical equipment and relates to a reaction vessel, specifically a sodium sulfamethoxam synthesis reaction vessel. Background Technology

[0002] Sodium sulfamethamide, also known as sodium p-aminobenzenesulfonamide, with the molecular formula C6H8N2O2SNa, is an organic compound with medicinal value. It is commonly used in the pharmaceutical industry and is a major raw material for the synthesis of sulfonamide drugs. Sodium sulfamethamide has antibacterial effects against Staphylococcus aureus, Streptococcus pneumoniae, Neisseria meningitidis, and Escherichia coli.

[0003] Chinese utility model patent application number 202020766202.8 discloses a high-quality sodium sulfanilamide salt preparation device, belonging to the medical field. The device includes a base, with support plates bolted to both ends of the top of the base. A limiting groove is welded to the inner side of the support plate, and rubber shock-absorbing blocks are installed within the limiting groove. The bottom of each rubber shock-absorbing block is installed within the limiting groove via a shock-absorbing spring and screws. A reaction cylinder is bolted between the rubber shock-absorbing blocks. A ceramic inner liner is installed inside the reaction cylinder, and an anti-stick layer is provided on the inner surface of the ceramic inner liner. Quartz heating tubes are installed at both ends of the bottom of the reaction cylinder via grooves and screws. An output port is located at the bottom of the reaction cylinder, and a feeding funnel is welded to the periphery of the output port. A sealing cover is installed inside the feeding funnel, and a PP sealing gasket is placed between the sealing cover and the output port. An electric hydraulic cylinder is mounted on one end of the output port via a mounting base, and a concave feeding inclined plate is provided at the bottom of the sealing cover. However, the product obtained from this high-quality sodium sulfamethoxam preparation equipment is prone to clumping, requiring additional crushing equipment in the subsequent process, which is costly. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a sodium sulfamethoxam synthesis reactor.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is: a sodium sulfamethoxam synthesis reactor, comprising:

[0006] The vessel body;

[0007] A head is formed at the lower end of the vessel body, and a bottom valve is installed at its bottom;

[0008] A jacket is formed on the outer wall of the vessel body and extends to the end cap; the jacket has a liquid inlet at the lower part and a liquid outlet at the upper part;

[0009] Multiple support ears, the multiple support ears being fixed to the outer wall of the jacket;

[0010] A reactor cover plate is installed on the top of the reactor body, and a motor bracket is mounted on it;

[0011] A stirrer, which is rotatably mounted inside the vessel and extends to the motor bracket;

[0012] An electric motor, which is mounted on the motor bracket and connected to the stirrer, is used to drive the stirrer to rotate;

[0013] The stirrer includes a stirring shaft rotatably mounted inside the vessel and extending to the motor bracket, a motor coupling mounted on the upper end of the stirring shaft, two sets of stirring half-frames mounted on the stirring shaft and symmetrical about its axis, and multiple stirring crossbars mounted on the stirring shaft and perpendicular to it; the two sets of stirring half-frames form an accommodating space, and the multiple stirring crossbars are arranged vertically at intervals within the accommodating space; each stirring half-frame has a side working plate.

[0014] The cross-section of the side working plate has two first line segments and two second line segments connected at their ends and forming an acute angle, as well as a convex arc segment connecting the corresponding first line segments and second line segments.

[0015] Ideally, the centerline of the inlet is vertically oriented, and the angle formed between its outer wall and the jacket is an obtuse angle.

[0016] Furthermore, the included angle between the outer wall of the liquid inlet and the jacket is 100~105°.

[0017] Ideally, the reactor cover, the reactor body, the jacket, the stirrer, and the end cap are all made of Q235F material.

[0018] Ideally, the outer surface of the reactor cover is equipped with a plurality of handles, each handle comprising two support rods erected on the outer surface of the reactor cover and spaced apart, and a handle crossbar formed on the top of the two support rods.

[0019] Ideally, the reactor cover is mounted on the reactor body via multiple sets of connecting structures at its edge.

[0020] Furthermore, the inner and outer surfaces of the top of the vessel body are formed with concave steps. Each set of the connection structure includes a support plate supported on the top of the vessel body, a connecting seat disposed on both sides of the support plate and cooperating with the step, a connecting bolt fixed at one end on the support plate and passing through the connecting seat, and a connecting nut detachably installed on the connecting bolt to abut against the connecting seat. The connecting seat located on the inner side is integrally formed at the edge of the reactor cover plate.

[0021] Due to the application of the above technical solutions, this utility model has the following advantages compared with the prior art: The sodium sulfamethoxam synthesis reactor of this utility model can be circulated with steam, condensate, or chilled brine in the jacket to adapt to the material characteristics and reaction conditions; moreover, the use of a stirrer with a specific structure allows the stirring crossbar and stirring half frame to cooperate, which can crush the concentrated (steam circulated in the jacket) material into powder under the drive of the motor, and continue to dry the material to reach the required moisture content (moisture content ≤0.3%) in the reactor, ensuring that the dried material is smoothly released. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of the sodium sulfamethoxam synthesis reactor of this utility model;

[0023] Figure 2 This is a top view of the sodium sulfamethoxam synthesis reactor of this utility model;

[0024] Figure 3 for Figure 1 Enlarged cross-sectional view at point I;

[0025] Figure 4 for Figure 1 Enlarged cross-sectional view at point II;

[0026] Figure 5 for Figure 1 Enlarged view of a section at point III;

[0027] Figure 6 for Figure 2 Enlarged side view of section IV. Detailed Implementation

[0028] The present invention will be further described below with reference to the embodiments shown in the accompanying drawings.

[0029] like Figure 1 and Figure 2 The sodium sulfamethoxam synthesis reactor shown mainly includes a motor 1, a reactor cover plate 2, a support lug 3, a reactor body 4, a jacket 5, a stirrer 6, and a head 7.

[0030] The reactor body 4 is a cylindrical structure open at both ends. A head 7 is formed (usually integrally molded or welded, the same below) at the lower end of the reactor body 4, and a bottom valve 8 is installed at its bottom. This bottom valve 8 is preferably a specially designed bottom valve with a nominal diameter of 250mm to ensure smooth discharge of the dried material. A reactor cover 2 is installed on top of the reactor body 4, and a motor bracket 21 is mounted on it. Specifically, the reactor cover 2 is detachably installed on top of the reactor body 4 (unlike the structure in this application, conventional reactors usually also have an upper head). By abandoning the upper head and innovatively using a stainless steel reactor cover (i.e., reactor cover 2), it can remain sealed during the reaction stage and open during the concentration stage to ensure normal evaporation of water vapor.

[0031] A jacket 5 is formed on the outer wall of the vessel body 4 and extends to the end cap 7, such that the jacket 5 has a liquid inlet 51 at the bottom and a liquid outlet 52 at the top. The axis of the liquid inlet 51 is vertically arranged, and the axis of the liquid outlet 52 is horizontally arranged. Steam, condensate, and chilled brine can be passed through the jacket 5 to adapt to the material characteristics and reaction conditions. In this embodiment, the axis of the liquid inlet 51 is vertically arranged, and the angle formed between its outer wall and the jacket 5 is an obtuse angle. Figure 5 As shown, the included angle between the outer wall of the liquid inlet 51 and the jacket 5 is preferably 100~105°, and more preferably 102°.

[0032] There are multiple supporting ears 3, such as in this embodiment... Figure 2 As shown, there are two supporting ears 3 arranged opposite each other. Multiple supporting ears 3 are fixed to the outer wall of the jacket 5, used to cooperate with other conventional support structures to fix or support the reactor. The stirrer 6 is rotatably mounted inside the reactor body 4 and extends to the motor bracket 21. The rotatability can be achieved using existing conventional methods (as long as the stirrer 6 can rotate around its own axis), such as embedding a bearing in the reactor cover plate 2, allowing the stirrer 6 to be connected to the inner ring of the bearing by interference fit or pin connection. The motor 1 is mounted on the motor bracket 21 and connected to the stirrer 6 to drive its rotation.

[0033] In this embodiment, the stirrer 6 includes a stirring shaft 61 (rotatable in the same way as above) rotatably mounted inside the vessel body 4 and extending to the motor bracket 21, a motor coupling 64 mounted on the upper end of the stirring shaft 61, two sets of stirring half-frames 63 mounted on the stirring shaft 61 and symmetrical about its axis, and multiple stirring crossbars 62 mounted on the stirring shaft 61 and perpendicular to it (e.g., multiple sleeves are mounted on the stirring shaft 61 using screws or other fasteners, and the stirring half-crossbars are integrally formed on the circumferential surface of the sleeves and are on the same straight line to form a complete stirring crossbar 62; in this embodiment, there are three stirring crossbars 62). The two sets of stirring half-frames 63 form an accommodating space, and the multiple stirring crossbars 62 are spaced vertically within this accommodating space. At this time, the stirring half-frame 63 has a side working plate 631 and two adapter plates integrally connected to both ends of the side working plate 631 and connected to the stirring shaft 61 (the two adapter plates have different structures; the upper one is entirely straight, and the lower one is entirely arc-shaped). Figure 4 As shown, the cross section of the working plate 631 has two first line segments 6311 and two second line segments 6312 connected at their ends and forming an acute angle (i.e., the included angle between the two first line segments 6311 is the same as the included angle between the two second line segments 6312), and a convex arc segment 6313 connecting the corresponding first line segments 6311 and second line segments 6312.

[0034] A specially designed agitator 6, in conjunction with motor 1, can pulverize the material into powder after concentration. Further drying will bring the material to the required moisture content (≤0.3%) within the reactor. The bottom valve 8 differs from traditional bottom valves, using a specially designed valve with a nominal diameter of 250mm to ensure smooth discharge of the dried material. Therefore, the above-mentioned sodium sulfamethoxam synthesis reactor is a dedicated multi-functional integrated reactor for sodium sulfamethoxam, combining reaction, concentration, pulverization, and drying functions into one unit, offering rich functionality and significantly reducing equipment costs. The reactor cover 2, reactor body 4, jacket 5, agitator 6, and end cap 7 are all independently made of Q235F. Figure 6 As shown, the outer surface of the reactor cover plate 2 is equipped with a plurality of handles 22 (four in a regular arrangement in this embodiment). Each handle 22 includes two support rods 221 that are erected on the outer surface of the reactor cover plate 2 and spaced apart, and a handle crossbar 222 formed on the top of the two support rods 221.

[0035] In this embodiment, as Figure 3 As shown, the reactor cover 2 is installed (detachably installed) on the reactor body 4 through multiple sets of connecting structures at its edge. Specifically, the inner and outer surfaces of the top of the reactor body 4 (i.e., the inner and outer walls at the top of the reactor body 4) are independently formed with concave steps 41. Each set of connecting structures includes a support plate 231 supported on the top of the reactor body 4 (preferably, the top of the reactor body 4 is also supported by a support plate that is close to the support plate 231 to improve the supporting force; it is only supported and not fixed), connecting seats 233 provided on both sides of the support plate 231 and cooperating with the steps 41 (i.e., there are two connecting seats 233, which are correspondingly matched with the two steps 41), connecting bolts 232 fixed at one end to the support plate 231 and passing through the connecting seats 233 (there are two connecting bolts 232, which extend backward and pass through the corresponding connecting seats 233), and connecting nuts 234 detachably installed on the connecting bolts 232 to abut against the connecting seats 233. It should be noted that: one connecting seat 233 (the inner one of the two connecting seats 233) is integrally formed at the edge of the reactor cover plate 2 (i.e., integrally connected with the reactor cover plate 2). In this way, the clamping force of the two connecting seats 233 on the reactor body 4 can be adjusted by adjusting the tightness of the connecting bolts 232, so as to realize the detachable installation of the reactor cover plate 2.

[0036] By controlling the size of the sodium sulfamethoxam synthesis reactor, the reactor can produce 260 kg ± 10 kg of sodium sulfamethoxam per batch, with a production cycle of about 8 hours, thus meeting the material supply needs of downstream sulfamethoxam raw materials.

[0037] The above embodiments are only for illustrating the technical concept and features of this utility model, and are intended to enable those skilled in the art to understand the content of this utility model and implement it accordingly. They should not be construed as limiting the scope of protection of this utility model. All equivalent changes or modifications made in accordance with the spirit and essence of this utility model should be included within the scope of protection of this utility model.

Claims

1. A sodium sulfamethoxam synthesis reactor, comprising: The vessel body (4); End cap (7), the end cap (7) is formed at the lower end of the vessel body (4), and a bottom valve (8) is installed at its bottom; A jacket (5) is formed on the outer wall of the vessel body (4) and extends to the end cap (7); the jacket (5) has a liquid inlet (51) at the lower part and a liquid outlet (52) at the upper part. Multiple support ears (3) are fixed to the outer wall of the sleeve (5); The reactor cover plate (2) is installed on the top of the reactor body (4), and a motor bracket (21) is installed on it. A stirrer (6) is rotatably mounted inside the vessel body (4) and extends to the motor bracket (21); Motor (1), the motor (1) is mounted on the motor bracket (21) and connected to the stirrer (6) for driving it to rotate; The stirrer (6) includes a stirring shaft (61) rotatably mounted inside the vessel body (4) and extending to the motor bracket (21), a motor coupling (64) mounted on the upper end of the stirring shaft (61), two sets of stirring half-frames (63) mounted on the stirring shaft (61) and symmetrical about its axis, and multiple stirring crossbars (62) mounted on the stirring shaft (61) and perpendicular to it; the two sets of stirring half-frames (63) form an accommodating space, the multiple stirring crossbars (62) are arranged vertically at intervals and located within the accommodating space, and the stirring half-frames (63) have side working plates (631). The side working plate (631) is characterized in that: the cross section has two first line segments (6311) and two second line segments (6312) connected at the ends and forming an acute angle, and a convex arc segment (6313) connecting the corresponding first line segment (6311) and second line segment (6312).

2. The sodium sulfamethoxam synthesis reactor according to claim 1, characterized in that: The centerline of the inlet (51) is vertically arranged, and the angle formed between its outer wall and the jacket (5) is an obtuse angle.

3. The sodium sulfamethoxam synthesis reactor according to claim 2, characterized in that: The included angle between the outer wall of the liquid inlet (51) and the jacket (5) is 100~105°.

4. The sodium sulfamethoxam synthesis reactor according to claim 1, characterized in that: The reactor cover (2), the reactor body (4), the jacket (5), the stirrer (6), and the end cap (7) are all made of Q235F.

5. The sodium sulfamethoxam synthesis reactor according to claim 1, characterized in that: The outer surface of the reactor cover plate (2) is equipped with a plurality of handles (22), each handle (22) including two support rods (221) erected on the outer surface of the reactor cover plate (2) and spaced apart, and a handle crossbar (222) formed on the top of the two support rods (221).

6. The sodium sulfamethoxam synthesis reactor according to claim 1, characterized in that: The reactor cover plate (2) is installed on the reactor body (4) through multiple sets of connecting structures at the edge.

7. The sodium sulfamethoxam synthesis reactor according to claim 6, characterized in that: The inner and outer surfaces of the top of the vessel body (4) are formed with concave steps (41). Each set of the connection structure includes a support plate (231) supported on the top of the vessel body (4), a connecting seat (233) provided on both sides of the support plate (231) and cooperating with the step (41), a connecting bolt (232) fixed at one end on the support plate (231) and passing through the connecting seat (233), and a connecting nut (234) detachably installed on the connecting bolt (232) to abut against the connecting seat (233). The connecting seat (233) located on the inner side is integrally formed at the edge of the reactor cover plate (2).

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