Multi-stage ultrafiltration purification equipment for glutathione catalytic liquid

Abstract

The utility model discloses glutathione catalytic liquid multistage ultrafiltration purification equipment, and relates to the technical field of ultrafiltration purification, the glutathione catalytic liquid multistage ultrafiltration purification equipment comprises a liquid storage box, a purification box and a microbial limit detector, the inner side of the purification box is fixedly connected with two groups of vertically arranged partition plates, the outer parts of the partition plates are provided with filter screens, and a purification mechanism is installed between the two groups of partition plates; a polyether sulfone ultrafiltration membrane layer is arranged outside the first mounting plate, and a sterilization-grade terminal filter membrane is arranged outside the second mounting plate; the microbial limit detector is fixedly connected to the inner side of the purification box, and a backflow mechanism is mounted in the purification box. The device realizes step-by-step interception of impurities through functional stacking of a polypropylene fiber layer, a glass fiber layer and an activated carbon layer, combines molecular sieve separation and absolute interception of a polyethersulfone ultrafiltration membrane and a terminal degerming membrane, introduces a liquid level sensor to be linked with a material conveying pump to realize dynamic circulating purification, ensures high recovery rate of glutathione, and meanwhile, reduces the production cost of glutathione. And the sterile and integrated efficient treatment of the catalytic liquid is achieved.

Description

A multi-stage ultrafiltration purification device for glutathione catalyst solution Technical Field

[0001] This utility model relates to the field of ultrafiltration purification technology, and more specifically, to a multi-stage ultrafiltration purification device for glutathione catalyst solution. Background Technology

[0002] Glutathione, as an important bioactive substance, has wide applications in pharmaceuticals, food, and cosmetics. In the production process of its catalytic solution, the effective removal of impurities directly affects the purity and safety of the final product. Traditional purification processes typically employ a step-by-step approach, including pre-filtration, adsorption, and ultrafiltration. This discrete operational mode is not only inefficient but also prone to secondary contamination during the transitions between processes.

[0003] While existing technologies attempt to improve purification efficiency by modifying filter materials or optimizing individual processes, they still have significant limitations. Conventional filter materials struggle to handle impurities of different particle sizes simultaneously, activated carbon adsorption processes are often accompanied by non-selective loss of target products, and step-by-step processing lacks sufficient process control precision, failing to meet the dual standards of aseptic production and high recovery rates required by modern biopharmaceuticals. In particular, when processing catalytic solutions containing microorganisms, existing equipment often struggles to achieve stable and reliable sterilization effects. Therefore, to address the aforementioned technical problems, a multi-stage ultrafiltration purification device for glutathione catalytic solutions is proposed. Summary of the Invention

[0004] The purpose of this invention is to provide a multi-stage ultrafiltration purification device for glutathione catalytic liquid. It achieves step-by-step interception of impurities through the functional stacking of polypropylene fiber layer, glass fiber layer and activated carbon layer. It combines molecular sieving and absolute retention of polyethersulfone ultrafiltration membrane and terminal sterilization membrane, and introduces a liquid level sensor to link the feed pump to achieve dynamic circulation purification. While ensuring a high recovery rate of glutathione, it achieves sterilization of catalytic liquid and integrated high-efficiency treatment.

[0005] This utility model is achieved through the following technical solution:

[0006] A multi-stage ultrafiltration purification device for glutathione catalyst solution includes:

[0007] A liquid storage tank, with a first feed pump fixedly connected inside, and a first feed pipe fixedly connected to the outside of the first feed pump;

[0008] A purification box is placed on one side of a storage tank. The end of the first feed pipe passes through the outside of the storage tank and the top of the purification box, and is positioned at the top of the inner side of the purification box. Two sets of vertically arranged partitions are fixedly connected to the inner side of the purification box. A filter screen is provided on the outside of the partitions. A purification mechanism is installed between the two sets of partitions. A first mounting plate is fixedly connected to the inner side of the purification box and is located below the two sets of partitions. A polyethersulfone ultrafiltration membrane layer is provided on the outside of the first mounting plate. A second mounting plate is fixedly connected to the inner side of the purification box and is located below the first mounting plate. A sterilization-grade terminal filter membrane is provided on the outside of the second mounting plate.

[0009] A microbial limit tester is fixedly connected to the inside of the purification chamber and installed below the second mounting plate. The purification chamber is equipped with a reflux mechanism.

[0010] Preferably, an inlet pipe is fixedly connected to the upper side of the liquid storage tank.

[0011] Preferably, the purification mechanism includes a polypropylene fiber layer, a glass fiber layer, and an activated carbon layer, which are sequentially filled between the two sets of partitions from top to bottom.

[0012] Preferably, the reflux mechanism includes a second feed pump and a second feed pipe, wherein the second feed pump is fixedly connected to the inner bottom of the purification tank, and the second feed pipe is fixedly connected to the outside of the second feed pump.

[0013] Preferably, the end of the second conveying pipe passes through the inside of the purification box and the outside of the purification box in sequence and is placed at the top of the inside of the purification box.

[0014] Preferably, a liquid level sensor is fixedly connected to the inside of the purification box, and the liquid level sensor is located in the upper part of the two sets of partitions.

[0015] Preferably, the liquid level sensor is connected to both the first and second feed pumps via signal connections.

[0016] Preferably, the external part of the purification box is fixedly connected to a discharge pipe, and a piston is detachably connected to the end of the discharge pipe.

[0017] The technical solution of this utility model has at least the following beneficial effects:

[0018] This multi-stage ultrafiltration purification equipment for glutathione catalytic solution uses a polypropylene fiber layer to intercept large particulate impurities, a glass fiber layer to adsorb medium-sized pollutants in a gradient manner, and an activated carbon layer to precisely capture dissolved metal ions and pigments, forming a progressively fine filtration barrier. A polyethersulfone ultrafiltration membrane and a terminal sterilization membrane work together to screen bacteria and microorganisms. Combined with a microbial detector, the purification results are determined in real time. Abnormal liquids undergo closed-loop circulation for secondary treatment to ensure that the impurity rejection rate meets requirements. A level sensor, linked to a feed pump, dynamically adjusts the flow rate to prevent filter clogging and maintain a stable flow rate. The activated carbon layer, after low-adsorption modification, reduces ineffective glutathione loss, significantly improving the recovery rate. The entire process is completed continuously within a single device, eliminating the pollution risks of traditional step-by-step treatments, and ultimately achieving the industrial purification goal of high purity, sterility, and low energy consumption of the catalytic solution. Attached Figure Description

[0019] Figure 1 is a schematic diagram of the overall structure of this utility model;

[0020] Figure 2 is an enlarged view of A in Figure 1;

[0021] Figure 3 is an enlarged view of B in Figure 1;

[0022] Figure 4 is an enlarged view of C in Figure 1;

[0023] Icons: 1. Storage tank; 2. Inlet pipe; 3. First feed pump; 4. First feed pipe; 5. Purification tank; 6. Partition; 7. Filter screen; 8. Polypropylene fiber layer; 9. Glass fiber layer; 10. Activated carbon layer; 11. First mounting plate; 12. Polyethersulfone ultrafiltration membrane layer; 13. Second mounting plate; 14. Sterilization-grade terminal filter membrane; 15. Microbial limit detector; 16. Second feed pump; 17. Second feed pipe; 18. Liquid level sensor; 19. Discharge pipe. Detailed Implementation

[0024] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0025] Example:

[0026] Please refer to Figures 1-4. This application proposes a multi-stage ultrafiltration purification device for glutathione catalyst solution, comprising a storage tank 1, a purification tank 5, and a microbial limit detector 15. A first feed pump 3 is fixedly connected inside the storage tank 1, and a first feed pipe 4 is fixedly connected to the outside of the first feed pump 3. The purification tank 5 is placed on one side of the storage tank 1. The end of the first feed pipe 4 passes through the outside of the storage tank 1 and the top of the purification tank 5, and is positioned at the top inside the purification tank 5. Two sets of vertically arranged partitions 6 are fixedly connected to the inside of the purification tank 5. Filter screens 7 are provided on the outside of the partitions 6, and a filter screen 7 is installed between the two sets of partitions 6. The purification chamber 5 is equipped with a purification mechanism. A first mounting plate 11 is fixedly connected to the inside of the purification chamber 5 and is located below two sets of partitions 6. A polyethersulfone ultrafiltration membrane layer 12 is provided on the outside of the first mounting plate 11. A second mounting plate 13 is fixedly connected to the inside of the purification chamber 5 and is located below the first mounting plate 11. A sterilization-grade terminal filter membrane 14 is provided on the outside of the second mounting plate 13. A microbial limit detector 15 is fixedly connected to the inside of the purification chamber 5 and is installed below the second mounting plate 13. A reflux mechanism is installed inside the purification chamber 5.

[0027] A liquid inlet pipe 2 is fixedly connected to the upper side of the liquid storage tank 1. By setting the liquid inlet pipe 2, glutathione catalyst solution that needs to be purified by ultrafiltration can be added to the liquid storage tank 1.

[0028] The purification mechanism includes a polypropylene fiber layer 8, a glass fiber layer 9, and an activated carbon layer 10. The polypropylene fiber layer 8, glass fiber layer 9, and activated carbon layer 10 are filled between two sets of partitions 6 from top to bottom. Through the layered stacking design, it can intercept large particulate impurities, adsorb medium pollutants, and dissolved metal ions step by step.

[0029] The reflux mechanism includes a second feed pump 16 and a second feed pipe 17. The second feed pump 16 is fixedly connected to the bottom of the inner side of the purification tank 5, and the second feed pipe 17 is fixedly connected to the outside of the second feed pump 16. The liquid is driven by the second feed pump 16 to reflux through the second feed pipe 17, so as to realize the secondary purification and circulation of the liquid that does not meet the standard.

[0030] The end of the second feed pipe 17 passes through the inside and outside of the purification box 5 in sequence and is placed on the top of the inside of the purification box 5. The extension of the pipe to the top of the purification box 5 can ensure that the return liquid re-enters the filtration process.

[0031] A liquid level sensor 18 is fixedly connected to the inside of the purification box 5, and the liquid level sensor 18 is located on the upper part of the two sets of partitions 6. The liquid level sensor 18 monitors the liquid level height of the upper layer of the partition 6 in real time to prevent the filter layer from being overloaded or the liquid supply from being interrupted.

[0032] The liquid level sensor 18 is connected to both the first feed pump 3 and the second feed pump 16 via signal linkage. The start and stop of the feed pumps can be automatically adjusted through signal linkage to maintain the dynamic balance of the liquid level in the purification tank 5.

[0033] The purification chamber 5 is externally fixedly connected to a discharge pipe 19, and a piston is detachably connected to the end of the discharge pipe 19. The purified catalytic liquid is discharged through the discharge pipe 19. The piston design facilitates control of the discharge flow rate and prevents external contamination.

[0034] The working principle of the multi-stage ultrafiltration purification equipment for glutathione catalyst solution based on the embodiment is as follows: After the catalyst solution enters the storage tank 1 through the inlet pipe 2, it is driven by the first feed pump 3 inside and transported to the inlet at the top of the purification tank 5 through the first feed pipe 4. The liquid first enters the multi-layer filtration zone between two sets of vertical partitions 6. The filter screen 7 on the outside of the partition 6 initially guides the liquid, and then flows sequentially through the polypropylene fiber layer 8, glass fiber layer 9 and activated carbon layer 10 stacked from top to bottom. The polypropylene fiber layer 8 intercepts large particulate impurities, the glass fiber layer 9 removes medium-sized pollutants through gradient interception and electrostatic adsorption, and the activated carbon layer 10 adsorbs soluble impurities such as pigments and metal ions, forming a progressively refined pretreatment system. After the pretreatment is completed, the liquid flows downward to the polyethersulfone ultrafiltration membrane layer 12 of the first mounting plate 11, where bacteria, fungi and macromolecules are separated by molecular weight interception. The protein then enters the sterile terminal filter membrane 14 of the second mounting plate 13, where residual microorganisms are completely intercepted using an absolute pore size of 0.22μm. The purified liquid is monitored for microbial content in real time by a microbial limit detector 15. If the content meets the standard, it is discharged through the discharge pipe 19. If the detection is abnormal, the liquid is returned to the top of the purification tank 5 by the second feed pump 16 at the bottom through the second feed pipe 17 for secondary circulation treatment until it meets the sterility standard. The liquid level sensor 18 installed in the purification tank 5 monitors the liquid level on the upper layer of the partition 6 in real time and controls the start and stop of the first feed pump 3 and the second feed pump 16 through signal linkage to avoid the filter layer from being blocked due to excessive liquid level or the treatment efficiency being affected by insufficient liquid level. This equipment achieves deep purification and stable operation of the catalytic liquid while ensuring a high recovery rate of glutathione active ingredients through multi-stage physical interception, chemical adsorption and closed-loop feedback mechanism.

[0035] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A multi-stage ultrafiltration purification device for glutathione catalytic solution, characterized in that, include: A liquid storage tank (1) is fixedly connected to a first feed pump (3) inside, and a first feed pipe (4) is fixedly connected to the outside of the first feed pump (3); a purification tank (5) is placed on one side of the liquid storage tank (1), the end of the first feed pipe (4) passes through the outside of the liquid storage tank (1) and the top of the purification tank (5) and is placed on the top of the inner side of the purification tank (5), two sets of vertically arranged partitions (6) are fixedly connected to the inner side of the purification tank (5), a filter screen (7) is provided on the outside of the partitions (6), a purification mechanism is installed between the two sets of partitions (6), and a first mounting plate (1) is fixedly connected to the inner side of the purification tank (5). 1), and the first mounting plate (11) is located below the two sets of partitions (6), the first mounting plate (11) is provided with a polyethersulfone ultrafiltration membrane layer (12) on the outside, the second mounting plate (13) is fixedly connected to the inner side of the purification box (5), and the second mounting plate (13) is located below the first mounting plate (11), the second mounting plate (13) is provided with a sterilization-grade terminal filter membrane (14) on the outside; a microbial limit detector (15) is fixedly connected to the inner side of the purification box (5), and the microbial limit detector (15) is installed below the second mounting plate (13), and a reflux mechanism is installed inside the purification box (5).

2. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 1, characterized in that: The liquid storage tank (1) is fixedly connected to the upper side of the liquid inlet pipe (2).

3. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 1, characterized in that: The purification mechanism includes a polypropylene fiber layer (8), a glass fiber layer (9), and an activated carbon layer (10), which are filled between the two sets of partitions (6) from top to bottom.

4. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 1, characterized in that: The reflux mechanism includes a second feed pump (16) and a second feed pipe (17). The second feed pump (16) is fixedly connected to the bottom of the inner side of the purification box (5), and the second feed pipe (17) is fixedly connected to the outside of the second feed pump (16).

5. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 4, characterized in that: The end of the second conveying pipe (17) passes through the inside of the purification box (5) and the outside of the purification box (5) in sequence and is placed on the top of the inside of the purification box (5).

6. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 4, characterized in that: A liquid level sensor (18) is fixedly connected to the inside of the purification box (5), and the liquid level sensor (18) is located on the upper part of the two sets of partitions (6).

7. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 6, characterized in that: The liquid level sensor (18) is connected to both the first feed pump (3) and the second feed pump (16) via signal connections.

8. The multi-stage ultrafiltration purification device for glutathione catalytic solution according to claim 1, characterized in that: The external part of the purification box (5) is fixedly connected to a discharge pipe (19), and a piston is detachably connected to the end of the discharge pipe (19).

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