Mechanical arm clamping jaw

Abstract

The utility model relates to the technical field of cell culture automation equipment, in particular to a mechanical arm clamping jaw which comprises a base of a mechanical arm and a clamping jaw body installed on the base, the clamping jaw body is used for clamping experimental equipment, the mechanical arm clamping jaw further comprises an air supply mechanism, the air supply mechanism is installed on the base, and the air outlet end of the air supply mechanism is aligned with the experimental equipment. The mechanical arm clamping jaw is provided with the air supply mechanism, the local low-oxygen environment of experimental equipment can be maintained, low-oxygen culture whole-process operation is achieved, and the mechanical arm clamping jaw is simple in structure and convenient to install and use.

Description

A robotic arm gripper Technical Field

[0001] This utility model relates to the field of automated cell culture equipment technology, specifically a robotic arm gripper. Background Technology

[0002] Hypoxic culture of mesenchymal stem cells (MSCs) can promote cell proliferation, enhance stem cell stemness and differentiation capacity, and improve the immunomodulatory function and cell survival rate of MSCs, making it a beneficial culture method for the medical application of MSCs. The hypoxic environment is mainly established by introducing 94% nitrogen, 1% oxygen, and 5% carbon dioxide into the incubator. Under this mixed gas condition, good hypoxic culture results for MSCs can be obtained.

[0003] Culture flasks are used to expand and passage adherent mesenchymal stem cells during the culturing process. During culture, the flasks need to be removed from the incubator for observation, medium addition, medium change, and passage. Currently, the entire process can be automated in a closed, clean space using robotic arms. However, when the culture flasks are removed from the incubator for these operations, the cells suddenly lose their hypoxic environment, significantly impacting their growth and reducing expansion efficiency and quality. Constructing a hypoxic environment within the expansion and passage area is costly, and maintaining positive pressure ventilation is necessary for observation, medium addition, medium change, and passage, making the creation of a hypoxic environment difficult to achieve. Summary of the Invention

[0004] To address the aforementioned problems, this invention provides a robotic gripper equipped with a gas delivery mechanism, capable of creating a localized hypoxic environment for culture flasks and other similar containers, thereby achieving hypoxic culture treatment of cells and ensuring their stable state. The technical solution adopted by this invention is as follows:

[0005] A robotic arm gripper includes a base for the robotic arm and grippers mounted on the base. The grippers are used to hold experimental equipment. The gripper also includes an air supply mechanism mounted on the base, with the air outlet of the air supply mechanism aligned with the experimental equipment.

[0006] The aforementioned robotic arm gripper includes an air delivery mechanism comprising an air delivery pipe and a gas dispersion disc. The air delivery pipe is mounted on a base, and the gas dispersion disc comprises a bottom cover and a top cover. The bottom cover is connected to the air delivery pipe, and the top cover has several through holes for air outlet and is detachably mounted on the bottom cover.

[0007] The aforementioned robotic arm gripper, the gas dispersion disk also includes a bubble stone disk and a filter membrane arranged sequentially between the bottom cover and the top cover.

[0008] The aforementioned robotic arm gripper uses a culture flask as the experimental equipment; the filter membrane is selected with a pore size of 0.2~0.3μm.

[0009] The beneficial effects of this utility model are as follows: the robotic arm gripper is equipped with an air supply mechanism, which can maintain a local low-oxygen environment for experimental equipment, realize the entire process of low-oxygen culture, and has a simple structure, making it easy to install and use. Attached Figure Description

[0010] Figure 1 is a structural schematic diagram of an embodiment of the present utility model;

[0011] Figure 2 is a schematic diagram of the structure of the gas dispersion disc in an embodiment of this utility model.

[0012] In the diagram: 1 is the gripper, 2 is the base, 3 is the gas delivery tube, 4 is the gas dispersion plate, 5 is the culture flask, 41 is the bottom cover, 42 is the bubble stone plate, 43 is the filter membrane, and 44 is the top cover. Detailed Implementation

[0013] The technical solution of this utility model will now be described in detail with reference to the accompanying drawings. The following embodiments are illustrative and intended to provide further explanation of this application. Unless otherwise specified, all technical terms, connection methods, installation methods, etc., used have the same meaning as commonly understood by those skilled in the art to which this application pertains. It should be noted that the terminology used is only for describing specific embodiments and is not intended to limit the scope of this application.

[0014] This embodiment describes a robotic arm gripper, comprising a base 2 for the robotic arm and grippers 1 mounted on the base 2. The grippers 1 are used to hold experimental equipment. A gas delivery mechanism is mounted on the base 2, with the gas outlet of the gas delivery mechanism aligned with the experimental equipment. The experimental equipment can be a 175cm standard culture flask 5, or other experimental equipment. The robotic arm and other components are commercially available standard products, and the gas delivery mechanism can be installed using bolts, magnets, or other methods.

[0015] Specifically, the gas delivery mechanism includes a gas delivery pipe 3 and a gas dispersion disk 4. The gas dispersion disk 4 includes a bottom cover 41, a bubble stone disk 42, a filter membrane 43, and a top cover 44. The bottom cover 41 is connected to the gas delivery pipe 3, which is connected to a gas cylinder (a conventional product, in this embodiment providing a mixed gas containing 94% nitrogen, 1% oxygen, and 5% carbon dioxide, connected to the gas delivery pipe 3 in a conventional manner), as shown in Figure 1. The gas delivery pipe 3 is installed on the base 2 in a conventional installation manner. The top cover 44 has several through holes for gas outlet and is detachably installed on the bottom cover 41, for example, the top cover 44 and the bottom cover 41 can be connected by threads. The bubble stone disk 42 and the filter membrane 43 are sequentially arranged between the bottom cover 41 and the top cover 44. The filter membrane 43 has a pore size of 0.2~0.3μm, preferably 0.22μm. The sterile low-oxygen gas sprayed by the gas dispersion plate 4 maintains a local low-oxygen environment around the culture bottle 5, ensuring the stability of the cells in the culture bottle during the operation of the robotic arm. The amount of gas sprayed does not need to be too large, which greatly saves costs and reduces the difficulty of operation.

[0016] The above are merely preferred embodiments of this application. It should be noted that those skilled in the art can make various changes or improvements without departing from the principles of this application, and these changes or improvements should also be considered within the scope of protection of this application.

Claims

1. A robotic arm gripper, comprising a base (2) of the robotic arm and grippers (1) mounted on the base (2), the grippers (1) being used to hold experimental equipment, characterized in that: It also includes a gas delivery mechanism, which is installed on the base (2) and the gas outlet of the gas delivery mechanism is aligned with the experimental equipment; the gas delivery mechanism includes a gas delivery pipe (3) and a gas dispersion disk (4), the gas delivery pipe (3) is installed on the base (2), the gas dispersion disk (4) includes a bottom cover (41) and a top cover (44), the bottom cover (41) is connected to the gas delivery pipe (3), and the top cover (44) is provided with several through holes for gas outlet and is detachably installed on the bottom cover (41).

2. The robotic arm gripper according to claim 1, characterized in that: The gas dispersion disk (4) also includes a bubble stone disk (42) and a filter membrane (43) arranged sequentially between the bottom cover (41) and the top cover (44).

3. The robotic arm gripper according to claim 2, characterized in that: The experimental equipment is a culture flask; the filter membrane (43) is selected with a pore size of 0.2~0.3μm.

Images