Animal sneezing stress urination dynamic detection device and system

Abstract

The utility model provides an animal sneezing stress urination dynamic detection device and system.The animal sneezing stress urination dynamic detection device comprises a binding assembly, filter paper and a camera shooting and recording assembly, the binding assembly is used for fixing and limiting an experimental mouse, the filter paper is laid at the bottom of the binding assembly and used for collecting urine spots of the experimental mouse, and the camera shooting and recording assembly is arranged on the binding assembly; the camera shooting and recording assembly is arranged on one side of the binding assembly and used for recording the experimental reaction of the experimental mouse. The whole process of sneezing and urine leakage of the laboratory mouse can be dynamically recorded in real time, the occurrence time of urine leakage and the process of capturing urine spots received by the filter paper are accurately recorded, the operation process is simple and rapid, the precision, efficiency and reliability of sneezing stress urination detection are remarkably improved, and the application prospect is wide. And more accurate and efficient technical support is provided for related biomedical research.

Description

Technical Field

[0001] This application relates to the field of experimental equipment technology, and more specifically, to a device and system for dynamic detection of urination in animals under sneezing stress. Background Technology

[0002] The sneeze-induced urination (SIU) test is an experimental method used to assess bladder function and the effectiveness of stress urinary incontinence models in animals. This test is based on the urination response of animals (primarily mice or rats) to a specific stimulus (such as a sneeze). By observing and analyzing these responses, the test assesses the mice's bladder control and urinary incontinence status. It is one of the important indicators for evaluating bladder function and the effectiveness of stress urinary incontinence models in mice.

[0003] Currently, the detection of sneezing-induced urination relies heavily on manual observation and operation. Therefore, traditional detection devices can only statically observe or manually record the urination behavior of experimental animals, and cannot dynamically and in real time capture the complete process of sneezing and urination leakage and its occurrence time. This leads to limitations and subjectivity in the interpretation of experimental results, and has at least the following drawbacks: 1. The detection process is cumbersome and easily affected by human factors; 2. It is impossible to record the amount and time of urination in real time and accurately; 3. It is difficult to achieve batch testing and is inefficient.

[0004] Therefore, existing technologies need to be improved. Utility Model Content

[0005] The purpose of this application is to provide a device and system for dynamic detection of sneezing stress and urination in animals, aiming to solve the technical problem of how to achieve real-time dynamic recording and capture of the process of sneezing and urination leakage in experimental animals in the prior art.

[0006] To achieve the above objectives, the technical solution adopted in this application is as follows:

[0007] In a first aspect, this application provides a device for dynamically detecting urination in animals during sneezing stress, comprising:

[0008] A restraint assembly for securing and restricting laboratory mice;

[0009] Filter paper, which is laid at the bottom of the restraint assembly, is used to collect urine stains from the laboratory mice;

[0010] A video recording component is disposed on one side of the restraint component and is used to record the experimental response of the experimental mouse.

[0011] In one embodiment, the restraint assembly includes:

[0012] Countertop support frame;

[0013] A restraint platform is provided on the table support frame, and a suspended space is provided between the restraint platform and the table support frame;

[0014] Several Velcro straps are provided, which are detachably connected to the restraint table and are used to fix and restrict the experimental mouse on the restraint table.

[0015] In one embodiment, the restraint platform includes:

[0016] A column structure is mounted on the table support frame. The column structure has a first vertical side, a second vertical side, a third vertical side, and a fourth vertical side. The first vertical side, the second vertical side, the third vertical side, and the fourth vertical side are all used to fix and restrain the experimental mouse.

[0017] In one embodiment, the length of the column structure is 25cm-35cm, the width of the column structure is 25cm-35cm, and the height of the column structure is 25cm-35cm.

[0018] In one embodiment, the tabletop support frame includes:

[0019] A base chassis, wherein the filter paper is laid inside the base chassis;

[0020] A support column is provided, which is connected to the base chassis and the restraint platform. The size of the support column is smaller than that of the restraint platform, so as to form the suspended space between the support column and the restraint platform.

[0021] In one embodiment, the height of the support column is 5-10cm.

[0022] In one embodiment, the base chassis has a length of 30-50cm and a width of 50-60cm.

[0023] In one embodiment, the video recording component includes:

[0024] A fixing bracket, which is movably disposed on one side of the restraint assembly;

[0025] A camera, movably mounted on the fixed bracket, is used to record the experimental response of the laboratory mouse.

[0026] In one embodiment, the fixing bracket includes:

[0027] A first fixing seat is used for fixed connection with the base chassis of the restraint assembly.

[0028] A first support rod, the first support rod being connected to the first fixed base;

[0029] A sliding seat, which is sleeved on the first support rod and slidably connected to the first support rod, and the camera is provided on the sliding seat;

[0030] An adjusting screw is connected to the sliding seat and the first support rod, and the adjusting screw is used to limit the movement of the sliding seat on the first support rod.

[0031] Secondly, this application provides a dynamic detection system for urination in animals in response to sneezing stress, wherein the system includes:

[0032] The dynamic detection device for animal sneezing stress urination as described in the above embodiments;

[0033] The controller is electrically connected to the camera recording component;

[0034] A display device, which is electrically connected to the controller;

[0035] A cloud server is connected to the controller.

[0036] The beneficial effects of the animal sneezing stress urination dynamic detection device and system provided in this application are at least as follows:

[0037] This application discloses a dynamic detection device and system for sneezing stress urination in animals. The device includes a restraint component, filter paper, and a recording camera. The restraint component is used to fix and restrict the experimental mouse. The filter paper is placed at the bottom of the restraint component and is used to collect urine stains from the mouse. The recording camera is located on one side of the restraint component and is used to record the experimental response of the mouse. This application can record the entire process of sneezing and urination leakage in experimental mice in real time and dynamically, accurately recording the time of urine leakage and the process of capturing urine stains on the filter paper. The operation is simple and quick, significantly improving the accuracy, efficiency, and reliability of sneezing stress urination detection, and providing more accurate and efficient technical support for related biomedical research. Attached Figure Description

[0038] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0039] Figure 1 This is a schematic diagram of the structure of the animal sneezing stress urination dynamic detection device provided in the embodiments of this application;

[0040] Figure 2 This is a schematic diagram of the structure of the base plate provided in the embodiments of this application;

[0041] Figure 3 This is a schematic diagram of the structure of the camera recording component provided in the embodiments of this application;

[0042] Figure 4 This is a schematic diagram of a specific embodiment of the animal sneezing stress urination dynamic detection device provided in this application.

[0043] The following are the labeling elements in the figure:

[0044] 100. Restraint assembly; 200. Filter paper; 300. Camera recording assembly; 400. Controller; 500. Display device; 600. Cloud server; 110. Tabletop support frame; 120. Restraint table; 130. Velcro; 111. Base chassis; 112. Support column; 310. Fixing bracket; 320. Camera; 311. First fixing seat; 312. First support rod; 313. Sliding seat; 314. Adjusting screw. Detailed Implementation

[0045] To make the technical problems, technical solutions, and beneficial effects to be solved by this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and are not intended to limit the scope of this application.

[0046] It should be noted that when a component is referred to as "fixed to" or "set on" another component, it may be directly or indirectly located on that other component. When a component is referred to as "connected to" another component, it may be directly or indirectly connected to that other component. The terms "upper," "lower," "left," "right," "front," "rear," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate orientations or positions based on the accompanying drawings, and are for ease of description only, and should not be construed as limiting the technical solution. The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features. "A plurality" means two or more, unless otherwise explicitly defined.

[0047] Please see Figure 1This embodiment provides a dynamic detection device for animal sneezing stress urination, wherein the animal sneezing stress urination dynamic detection device includes: a restraint component 100, a filter paper 200, and a camera recording component 300. The restraint component 100 is used to fix and restrict the experimental mouse. The filter paper 200 is laid at the bottom of the restraint component 100 and is used to collect the urine stains of the experimental mouse. The camera recording component 300 is disposed on one side of the restraint component 100 and is used to record the experimental response of the experimental mouse.

[0048] In existing technologies, traditional detection devices for sneezing stress urination tests can only statically observe or manually record the urination behavior of experimental animals. They cannot dynamically and in real-time capture the complete process of sneezing and urinary leakage, as well as the timing of its occurrence. This leads to limitations and subjectivity in the interpretation of experimental results. Furthermore, traditional detection processes typically require manual operation and can only be performed on a single mouse at a time. This not only increases the burden on operators but also limits the scale of experiments, making large-scale batch testing difficult.

[0049] In this embodiment, the restraint assembly 100 is used for quick and harmless fixation of the laboratory mouse, the filter paper 200 is used to collect urine stains from the laboratory mouse, and the video recording assembly 300 is used to dynamically record the urination process of the laboratory mouse in real time. The filter paper 200 is laid at the bottom of the restraint assembly 100. For example, by fixing the laboratory mouse to the restraint assembly 100, the filter paper 200 can effectively collect urine stains. The video recording assembly 300 is located on one side of the restraint assembly 100, and its shooting angle and shooting range can cover the entire body of the laboratory mouse. The video recording assembly 300 can be connected to a computer or a dedicated monitor for real-time viewing and recording.

[0050] Procedure for using the animal sneezing stress urination dynamic monitoring device:

[0051] 1. Secure the experimental mouse to the restraint assembly 100;

[0052] 2. Start the video recording component 300;

[0053] 3. The experimental mice were given a sneezing stimulus and the results were observed and recorded on video.

[0054] 4. Collect 200 filter papers and analyze the urine stain data;

[0055] 5. Finally, clean the apparatus and prepare for the next round of experiments.

[0056] Therefore, this embodiment uses restraint component 100 and camera recording component 300 to record the entire process of sneezing and urinary leakage of experimental mice in real time and dynamically, and accurately records the time of urinary leakage and the process of capturing urine stains on filter paper 200. The operation process is simple and quick, which significantly improves the accuracy, efficiency and reliability of sneezing stress urination detection, and provides more accurate and efficient technical support for related biomedical research.

[0057] Specifically, please refer to Figure 1 The restraint assembly 100 includes: a table support frame 110, a restraint table 120, and several Velcro straps 130. The restraint table 120 is disposed on the table support frame 110, and there is a suspended space between the restraint table 120 and the table support frame 110. The Velcro straps 130 are detachably connected to the restraint table 120 and are used to fix and restrict the experimental mouse on the restraint table 120.

[0058] In this embodiment, the combination of the restraint platform 120 and the Velcro 130 effectively secures the experimental mouse to the restraint platform 120. The platform support frame 110 stably supports the restraint platform 120. The suspended design between the platform support frame 110 and the restraint platform 120 effectively isolates the restraint platform 120 from direct contact with the collection area below. This greatly optimizes the collection efficiency of urine stains, avoids interference from the edge of the filter paper 200 on the urine flow direction, and ensures the accuracy and reliability of experimental data. The use of Velcro 130 ensures the stability of the experimental mouse during the experiment while avoiding unnecessary pressure or injury, reflecting the humanistic care and scientific rigor in the design of this device.

[0059] Specifically, please refer to Figure 1 The restraint table 120 includes a column structure, which is mounted on the table support frame 110. The column structure has a first vertical side, a second vertical side, a third vertical side, and a fourth vertical side, all of which are used to fix and restrain the experimental mouse.

[0060] In this embodiment, the restraint table 120 adopts a column structure design. This allows the experimental mouse to be fixedly restrained to the side of the restraint table 120, changing the existing practice of placing the experimental mouse horizontally. This avoids the difficulty in accurately capturing and measuring urine stains formed after sneezing, which affects the accuracy and repeatability of the results. The column structure keeps the experimental mouse in a vertical position, allowing the camera recording component 300 to capture the process of the filter paper 200 collecting the urine stains. For example, the restraint table 120 can be a cuboid or cube column, which not only ensures that the experimental mouse can be easily installed on all four sides but also greatly improves experimental efficiency, allowing simultaneous observation and recording of the reactions of multiple experimental mice, providing valuable parallel data support for scientific research. For example, the column structure has a first vertical side, a second vertical side, a third vertical side, and a fourth vertical side, all of which are used to fix and restrain the experimental mouse. Essentially, each side of the restraint table 120 is equipped with an experimental position for the Velcro 130, facilitating flexible adjustment of the fixing position according to experimental needs and meeting the requirements of different experimental scenarios.

[0061] Specifically, please refer to Figure 1 and Figure 2 The table support frame 110 includes a base chassis 111 and a support column 112. Filter paper 200 is laid inside the base chassis 111. The support column 112 is connected to the base chassis 111 and the restraint platform 120. The size of the support column 112 is smaller than that of the restraint platform 120, so as to achieve a suspended space between the support column 112 and the restraint platform 120.

[0062] In this embodiment, a support column 112 is provided inside the base chassis 111, and a restraint platform 120 is provided on the support column 112. The base chassis 111 can provide a stable and flat support for the restraint platform 120, and the size of the support column 112 is smaller than that of the restraint platform 120. This effectively isolates the restraint platform 120 from direct contact with the collection area below, greatly optimizes the collection efficiency of urine stains, avoids interference of the filter paper 200 edge on the urine flow direction, and ensures the accuracy and reliability of experimental data.

[0063] Specifically, please refer to Figure 3 The video recording component 300 includes a fixed bracket 310 and a camera 320. The fixed bracket 310 is movably disposed on one side of the restraint component 100, and the camera 320 is movably disposed on the fixed bracket 310. The camera 320 is used to record the experimental response of the experimental mouse.

[0064] In this embodiment, the camera 320 can be fixed to one side of the restraint assembly 100 by the fixing bracket 310. For example, the fixing bracket 310 can be fixed on the base chassis 111 to ensure that the shooting angle and range of the camera 320 cover the whole body of the experimental mouse, and can record the entire process of the mouse sneezing and urinary leakage in real time and dynamically, and accurately record the time of urinary leakage.

[0065] Specifically, please refer to Figure 3 The fixed bracket 310 includes: a first fixed seat 311, a first support rod 312, a sliding seat 313, and an adjusting screw 314. The first fixed seat 311 is used to be fixedly connected to the base chassis 111 of the restraint assembly 100. The first support rod 312 is connected to the first fixed seat 311. The sliding seat 313 is sleeved on the first support rod 312 and slidably connected to the first support rod 312. A camera 320 is provided on the sliding seat 313. The adjusting screw 314 is connected to the sliding seat 313 and the first support rod 312. The adjusting screw 314 is used to limit the movement of the sliding seat 313 on the first support rod 312.

[0066] In this embodiment, the mounting bracket 310 can be adjusted in height by adjusting the screw 314, thereby adjusting the height of the camera 320. This allows for easy coverage of the entire experimental mouse, providing comprehensive monitoring without blind spots. It also allows for flexible adjustment of the camera 320 to various angles, such as upward, downward, or side views, to achieve unique visual effects. By fine-tuning the bracket, the camera 320 can be accurately aimed at the experimental mouse to be filmed or monitored, ensuring that the mouse remains centered or in an ideal position within the frame, avoiding issues such as the mouse being out of frame.

[0067] Optionally, the length of the column structure is 25cm-35cm, the width of the column structure is 25cm-35cm, and the height of the column structure is 25cm-35cm.

[0068] Optionally, the height of the support column 112 is 5-10cm.

[0069] Optionally, the base chassis 111 has a length of 30-50cm and a width of 50-60cm.

[0070] The animal sneezing stress urination dynamic detection device provided in this embodiment is designed to efficiently and accurately evaluate the urination behavior of laboratory mice under sneezing stress response. Its overall layout is reasonable, which can optimize the experimental process and improve data collection efficiency.

[0071] Example 2:

[0072] Please see Figure 4This embodiment provides a dynamic detection system for animal sneezing stress urination, which includes: an animal sneezing stress urination dynamic detection device as described in the above embodiment, a controller 400, a display device 500, and a cloud server 600. The controller 400 is electrically connected to the camera recording component 300, the display device 500 is electrically connected to the controller 400, and the cloud server 600 is connected to the controller 400.

[0073] For example, the usage procedure can be as follows: 1. Disinfect the urethral opening of the experimental mouse with povidone-iodine. After emptying the rat's bladder with a catheter, slowly inject sterile saline into the bladder using a syringe until urine overflows from the urethral opening. Record the maximum bladder capacity. After emptying the bladder again, inject sterile saline at half the maximum bladder capacity. 2. Vertically fix the experimental mouse with Velcro 130. Activate the camera 320 via the controller 400 to record the experimental mouse in real time. 3. Induce the experimental mouse to sneeze using the physical action of hair. 4. After sneezing, leaked urine drips directly onto filter paper 200, forming a clearly visible urine stain. The camera 320 records the entire process, and the image processing software on the display device 500 analyzes parameters such as leakage time, volume, and morphology. 5. Researchers can view the experimental data on the display device 500 or connect to the cloud server 600 via a terminal device, such as a mobile app, to view the experimental data.

[0074] In this embodiment, the core of the animal sneezing stress urination dynamic detection device lies in the optimization of urine detection and collection. It mainly uses vertically fixed experimental mice and cameras for dynamic recording and capture to ensure that the urine of experimental animals can be accurately recorded. At the same time, the integrated design simplifies the experimental operation process and improves the versatility of the equipment and experimental efficiency.

[0075] The animal sneezing stress urination dynamic detection device is easy to operate. The experimental mouse is fixed to the restraint table 120 with Velcro 130 and adjusted to a vertical position; the camera 320 and controller 400 are activated; the experimental mouse is given a sneezing stimulus and the video recording results are observed; the filter paper 200 is collected and the urine stain data is analyzed; finally, the device is cleaned and the next round of experiments is prepared.

[0076] The dynamic detection device for animal sneezing stress urination provided in this embodiment not only overcomes the limitations of manual urine detection and the fixed space of traditional devices, but also achieves accurate tracking and real-time recording of urine stains in experimental animals. It can provide stable and reliable experimental data support for the study of bladder function and the effectiveness of stress urinary incontinence models in mice.

[0077] In summary, this application provides a dynamic detection device and system for animal sneezing stress urination. The device includes a restraint component, filter paper, and a recording camera. The restraint component is used to fix and restrict the experimental mouse. The filter paper is placed at the bottom of the restraint component and is used to collect urine stains from the mouse. The recording camera is located on one side of the restraint component and is used to record the experimental response of the mouse. This application can record the entire process of sneezing and urination leakage in experimental mice in real time and dynamically, accurately recording the time of urination leakage and the process of capturing urine stains on the filter paper. The operation is simple and quick, significantly improving the accuracy, efficiency, and reliability of sneezing stress urination detection, and providing more accurate and efficient technical support for related biomedical research.

[0078] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A dynamic detection device for urination in response to sneezing stress in animals, characterized in that, include: A restraint assembly for securing and restricting laboratory mice; Filter paper, which is laid at the bottom of the restraint assembly, is used to collect urine stains from the laboratory mice; A video recording component is disposed on one side of the restraint component and is used to record the experimental response of the experimental mouse.

2. The animal sneezing stress urination dynamic detection device as described in claim 1, characterized in that, The restraint component includes: Countertop support frame; A restraint platform is provided on the table support frame, and a suspended space is provided between the restraint platform and the table support frame; Several Velcro straps are provided, which are detachably connected to the restraint table and are used to fix and restrict the experimental mouse on the restraint table.

3. The animal sneezing stress urination dynamic detection device as described in claim 2, characterized in that, The restraint platform includes: A column structure is mounted on the table support frame. The column structure has a first vertical side, a second vertical side, a third vertical side, and a fourth vertical side. The first vertical side, the second vertical side, the third vertical side, and the fourth vertical side are all used to fix and restrain the experimental mouse.

4. The animal sneezing stress urination dynamic detection device as described in claim 3, characterized in that, The length of the column structure is 25cm-35cm, the width of the column structure is 25cm-35cm, and the height of the column structure is 25cm-35cm.

5. The animal sneezing stress urination dynamic detection device as described in claim 2, characterized in that, The tabletop support frame includes: A base chassis, wherein the filter paper is laid inside the base chassis; A support column is provided, which is connected to the base chassis and the restraint platform. The size of the support column is smaller than that of the restraint platform, so as to form the suspended space between the support column and the restraint platform.

6. The animal sneezing stress urination dynamic detection device as described in claim 5, characterized in that, The height of the support column is 5-10cm.

7. The animal sneezing stress urination dynamic detection device as described in claim 5, characterized in that, The base chassis has a length of 30-50cm and a width of 50-60cm.

8. The animal sneezing stress urination dynamic detection device as described in claim 1, characterized in that, The video recording component includes: A fixing bracket, which is movably disposed on one side of the restraint assembly; A camera, movably mounted on the fixed bracket, is used to record the experimental response of the laboratory mouse.

9. The animal sneezing stress urination dynamic detection device as described in claim 8, characterized in that, The fixing bracket includes: A first fixing seat is used for fixed connection with the base chassis of the restraint assembly. A first support rod, the first support rod being connected to the first fixed base; A sliding seat, which is sleeved on the first support rod and slidably connected to the first support rod, and the camera is provided on the sliding seat; An adjusting screw is connected to the sliding seat and the first support rod, and the adjusting screw is used to limit the movement of the sliding seat on the first support rod.

10. A dynamic detection system for urination in response to sneezing stress in animals, characterized in that, include: The animal sneezing stress urination dynamic detection device as described in any one of claims 1-9; The controller is electrically connected to the camera recording component; A display device, which is electrically connected to the controller; A cloud server is connected to the controller.

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