Mixed reaction equipment

Abstract

The utility model relates to the technical field of hybrid reaction equipment, in particular to hybrid reaction equipment which comprises a shell and a main frame, a door plate is mounted on the shell and connected with the shell through a damper, the main frame is arranged in the shell, a reaction module support is arranged on the main frame, and the reaction module support is connected with the door plate through a damper. A reaction module is mounted on the reaction module bracket, a micro-fluidic chip is arranged on the reaction module, an ultrasonic device mounting groove and a refrigerating and heating device mounting groove are formed in the rear part of the reaction module, and a sample injection injector is driven by a sample injection driving device controlled by three driving motors to inject fluid into the micro-fluidic chip. The transverse movement driver is used for switching the path of the reacted fluid, and the sample injection syringe is directly connected with the micro-fluidic chip without a pipeline, so that the mixed reaction of various fluids is quickly realized. In the mixing reaction process, the equipment can control multiple functions such as heating, refrigerating, ultrasonic and photoreaction on the fluid.

Description

Technical Field

[0001] This utility model relates to the field of mixing reaction equipment technology, specifically a mixing reaction equipment. Background Technology

[0002] Currently, common mixing reaction equipment often employs simple devices such as stirred tanks, fermenters, thin-film hydration systems, and syringe pumps, which have poor precision and make it difficult to control the quality of the mixing reaction. Traditional gas pump microfluidic systems are also used, which involve cumbersome piping connections and pressure adjustments, resulting in significant sample waste. Furthermore, microfluidic systems with similar structures often only have two sample inlet channels, which cannot meet the requirements for mixing three or more fluids. Their functionality is also relatively limited, lacking the ability to be expanded and installed, making them unsuitable for fluid mixing reactions with diverse needs.

[0003] 1. Simple devices such as stirring tanks, fermentation tanks, thin-film hydration, and injection pumps are used, which have poor precision and make it difficult to control the quality of the mixed reaction.

[0004] 2. Traditional air pump microfluidic systems are very cumbersome in terms of connecting pipes and pressure regulation, resulting in a large amount of sample waste.

[0005] 3. Microfluidic systems with similar structures only have two injection channels, which cannot meet the requirements for mixing reactions of three or more fluids.

[0006] 4. Microfluidic systems with similar structures have relatively simple functions, lacking additional expansion capabilities such as cooling and power supply interfaces, making them unsuitable for fluid mixing reactions with diverse requirements.

[0007] 5. Microfluidic systems with similar structures lack grounding terminals, posing a significant safety hazard.

[0008] Therefore, in view of the above-mentioned technical characteristics, this patent provides a new technical solution. Utility Model Content

[0009] The purpose of this section is to outline some aspects of the embodiments of this utility model and to briefly introduce some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be used to limit the scope of this utility model.

[0010] In view of the problems existing in the existing mixing reaction equipment, this utility model is proposed.

[0011] Therefore, the purpose of this invention is to provide a mixing reaction device that uses a sample injection drive controlled by three drive motors to drive the injection syringe to inject fluid into a microfluidic chip. A transverse actuator switches the fluid path after the reaction. There is no tubing between the injection syringe and the microfluidic chip, enabling rapid mixing of various fluids. During the mixing reaction, the device can control the fluid through various functions such as heating, cooling, ultrasonication, and photoreaction.

[0012] To solve the above-mentioned technical problems, according to one aspect of the present invention, the present invention provides the following technical solution:

[0013] A mixing reaction apparatus comprising a housing and a main frame;

[0014] A door panel is installed on the outer shell, and the door panel is connected to the outer shell through a damper. A main frame is set inside the outer shell, and a reaction module bracket is set on the main frame. A reaction module is installed on the reaction module bracket, and a microfluidic chip is set on the reaction module. An ultrasonic device mounting slot and a cooling / heating device mounting slot are set at the rear of the reaction module. A cooling module is installed at the middle of the rear of the reaction module, and a heat dissipation fan is installed on the cooling module. A transverse actuator is installed on the side wall of the reaction module. A sample injection drive device is installed below the reaction module. A sample injection syringe is set between the sample injection drive device and the reaction module. A waste liquid tube and a sample receiving tube are installed at the front of the reaction module.

[0015] In a preferred embodiment of the mixing reaction device described in this utility model, an indicator light and a power switch are provided at the front of the outer shell, and foot pads are provided at the bottom of the outer shell, with the foot pads distributed at the four corners of the bottom of the outer shell.

[0016] In a preferred embodiment of the mixing reaction device described in this utility model, heat dissipation vents are provided at the bottom and rear of the outer casing, and a data interface, an extended power interface and a main power interface are also provided at the rear of the outer casing.

[0017] In a preferred embodiment of the mixing reaction device described in this utility model, a power converter and an integrated circuit board are provided in the inner cavity at the rear of the outer shell.

[0018] As a preferred embodiment of the mixing reaction device described in this utility model, sample placement racks are provided on both sides of the outer shell, and sample placement racks are provided with sample receiving tubes of different types, injection syringes and injection adapters.

[0019] As a preferred embodiment of the mixing reaction device described in this utility model, the reaction module is designed with a cavity that can accommodate heating wires, coils, heating rods, heating plates, and a cooler.

[0020] As a preferred embodiment of the mixing reaction device described in this utility model, the bottom of the reaction module is provided with three circular holes, which can be used to load the sample injection adapter. Multiple dispersed magnetic blocks are designed around the circular holes, and a magnetic suction device is designed on the sample injection adapter to realize the magnetic loading and rotation unloading of the sample injection adapter.

[0021] As a preferred embodiment of the mixing reaction device described in this utility model, the transverse drive comprises a transverse main slider, a main slider adjustment screw, a sample receiving slide, a sample receiving slide fixing component, a spring, a guide blocking block, and a transverse push rod and a transverse push motor on one side of the reaction module.

[0022] As a preferred embodiment of the mixing reaction device described in this utility model, the reaction module is designed with handles on both sides, which can be used for manual operation when the reaction module is flipped or reset, effectively avoiding burns or frostbite.

[0023] In a preferred embodiment of the mixing reaction device described in this utility model, the sample injection drive device includes a drive motor, a moving stage, a pushing stage, a guide rod, and a displacement sensor. The output end of the drive motor is connected to the moving stage, and a pushing stage is installed on the moving stage. The pushing stage is connected to the piston end of the sample injection syringe, and the moving stage is slidably connected to the guide rod.

[0024] Compared with existing technologies, the advantages of this invention are as follows: A sample injection drive device controlled by three drive motors drives the injection syringe to inject fluid into the microfluidic chip. A transverse actuator switches the fluid path after the reaction. There is no tubing between the injection syringe and the microfluidic chip, enabling rapid mixing of various fluids. During the mixing reaction, the device can control the fluid through various functions such as heating, cooling, ultrasonication, and photoreaction. Attached Figure Description

[0025] To more clearly illustrate the technical solutions of the embodiments of this utility model, the present utility model will be described in detail below with reference to the accompanying drawings and detailed embodiments. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Among them:

[0026] Figure 1 This is a schematic diagram of the structure of this utility model;

[0027] Figure 2 This is a three-dimensional structural diagram of the present invention;

[0028] Figure 3 This is a schematic diagram of the three-dimensional structure of the main frame of this utility model;

[0029] Figure 4 This is a schematic diagram of the rear view structure of this utility model;

[0030] Figure 5 This is a schematic diagram showing the location of the integrated circuit board of this utility model;

[0031] Figure 6 This is a schematic diagram showing the location of the refrigeration module of this utility model;

[0032] Figure 7 This is a cross-sectional view of the reaction module of this utility model;

[0033] Figure 8 This is a three-dimensional structural diagram of the sample introduction adapter of this utility model.

[0034] In the diagram: 100 Housing, 101 Indicator Light, 102 Power Switch, 103 Feet, 104 Heat Dissipation Vent, 105 Data Interface, 106 Extended Power Interface, 107 Main Power Interface, 108 Power Converter, 109 Integrated Circuit Board, 110 Door Panel, 120 Sample Placement Rack, 130 Main Frame, 131 Reaction Module Support, 140 Reaction Module, 141 Microfluidic Chip, 142 Ultrasonic Device Mounting Slot, 143 Cooling / Heating Device Mounting Slot, 144 Cooling Module, 145 Cooling Fan, 146 Handle, 147 Transverse Driver, 150 Sample Injection Drive Device, 151 Drive Motor, 152 Moving Stage, 153 Push Stage, 154 Guide Rod, 155 Displacement Sensor, 160 Injector, 170 Waste Liquid Tube, 180 Sample Connector, 190 Injection Adapter. Detailed Implementation

[0035] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings.

[0036] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art can make similar extensions without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0037] Secondly, this utility model is described in detail with reference to the schematic diagrams. When describing the embodiments of this utility model, for ease of explanation, the cross-sectional views showing the device structure may be partially enlarged, not according to the usual scale. Furthermore, the schematic diagrams are merely examples and should not limit the scope of protection of this utility model. In addition, in actual manufacturing, the three-dimensional spatial dimensions of length, width, and depth should be included.

[0038] To make the objectives, technical solutions, and advantages of this utility model clearer, the embodiments of this utility model will be described in further detail below with reference to the accompanying drawings.

[0039] This utility model provides the following technical solution: a mixing reaction device, in use, uses a sample injection device controlled by three drive motors to drive the injection syringe to inject fluid into a microfluidic chip. A transverse actuator switches the fluid path after the reaction. There is no tubing between the injection syringe and the microfluidic chip, enabling rapid mixing of various fluids. During the mixing reaction, the device can control the fluid through various functions such as heating, cooling, ultrasonication, and photoreaction.

[0040] Figures 1-8 The diagram shown is a structural schematic of a first embodiment of a mixing reaction device according to this utility model. Please refer to [link / reference]. Figures 1-8 The mixing reaction device of this embodiment includes a main body comprising a shell 100 and a main frame 130.

[0041] A door panel 110 is installed on the outer shell 100. The door panel 110 is connected to the outer shell 100 through a damper. A main frame 130 is provided inside the outer shell 100. A reaction module bracket 131 is provided on the main frame 130. A reaction module 140 is installed on the reaction module bracket 131. A microfluidic chip 141 is provided on the reaction module 140. An ultrasonic device mounting slot 142 and a cooling / heating device mounting slot 143 are provided at the rear of the reaction module 140. A cooling module 144 is installed at the middle of the rear of the reaction module 140. A cooling fan 145 is installed on the cooling module 144. A transverse drive 147 is installed on the side wall of the reaction module 140. A sample injection drive 150 is installed below the reaction module 140. A sample injection syringe 160 is provided between the sample injection drive 150 and the reaction module 140. The sample injection syringe 160 is magnetically connected to the bottom of the reaction module 140. A waste liquid tube 170 and a sample receiving tube 180 are installed at the front of the reaction module 140.

[0042] The front of the housing 100 is equipped with an indicator light 101 and a power switch 102. Foot pads 103 are located at the four corners of the bottom of the housing 100. Ventilation vents 104 are provided at both the bottom and rear of the housing 100. A data interface 105, an extended power interface 106, and a main power interface 107 are also located at the rear of the housing 100. A power converter 108 and an integrated circuit board 109 are located within the rear cavity of the housing 100. Sample racks 120 are located on both sides of the housing 100, and different types of sample tubes 180, injection syringes 160, and injection adapters 190 are placed on the sample racks 120.

[0043] The sample rack 120 holds various types of injection syringes 160, including 1mL, 2.5mL, 3mL, 5mL, 10mL, 20mL, and 30mL syringes. By changing the inner diameter, it can accommodate injection syringes 160 and sample tubes.

[0044] The reaction module 140 is connected to the main frame 130 via a bracket. The connection point is designed with a damping device and a wear-resistant bushing. Both the bracket and the reaction module 140 have screw holes for securing the damping device with fasteners. Different dampers can be replaced to meet various requirements for increasing or decreasing damping force. The wear-resistant bushing is made of a material with high wear resistance and low thermal conductivity, effectively preventing friction during the rotation of the damping device and providing thermal isolation between the reaction module 140 and the bracket.

[0045] The reaction module 140 is equipped with a cooling module 144 and a heat dissipation fan 145 at the rear, which are used for cooling control of the reaction module 140 and cooling of devices such as the sample adapter 190, sampler, fluid, microfluidic chip 141, microfluidic chip 141 clamp, mixing reaction converter, mixing reactor, sample tube clamp, and sample tube installed in the reaction module 140.

[0046] The top is designed with two screw holes as expansion interfaces, which can be used to fix microfluidic chip 141, microfluidic chip 141 fixture, mixing reaction converter, mixing reactor and other devices with two screws or other fasteners; it can fix and install various devices such as refrigeration device, heating device, ultrasonic device, photoreaction device and so on.

[0047] The reaction module 140 has a cavity designed to accommodate temperature control devices such as heating wires, coils, heating rods, heating plates, and coolers, for temperature control of the reaction module 140 and related devices mounted on it, including the sample adapter 190, injector, fluid, microfluidic chip 141, microfluidic chip 141 clamp, mixing reactor, sample tube clamp, and sample tube. A temperature sensor can be installed to detect the temperature of the reaction module 140. A gyroscope can be installed to detect the angle and attitude of the reaction module 140. Sensors such as NFC tag readers can be installed to track the loading frequency and usage records of the sample adapter 190, microfluidic chip 141, microfluidic chip 141 clamp, mixing reactor, and other components mounted on the reaction module 140. It is also possible to incorporate other devices such as ultrasonic generators to apply ultrasound to the injection syringe 160, injection drive device 150, microfluidic chip 141, microfluidic chip 141 clamp, mixing reaction converter, mixing reactor, sample tube clamp, sample tube, and other devices mounted on the reaction module 140, thereby enhancing the intensity of the fluid mixing reaction.

[0048] The front of the reaction module 140 is designed with a slot to accommodate devices such as the microfluidic chip 141, the microfluidic chip 141 fixture, the mixing reaction converter, the mixing reactor, and the limiter, for mixing reaction, fluid conversion, and fixing of the microfluidic chip 141, the microfluidic chip 141 fixture, the mixing reaction converter, the mixing reactor, and the limiter.

[0049] The bottom of the reaction module 140 has three circular holes for loading the sample adapter 190. Multiple dispersed magnetic blocks are designed around the circular holes, and a corresponding magnetic device is designed on the sample adapter 190 to realize the magnetic loading and rotational unloading of the sample adapter 190. A U-shaped opening is designed on the front to facilitate the disassembly of the sample injector 160 and to check whether the sample injector 160 is installed.

[0050] The reaction module 140 has a slot for housing the transverse actuator 147, which consists of a transverse main slider, a main slider adjustment screw, a sample receiving slide, a sample receiving slide fixing component, a spring, and a guide block, all built into the reaction module 140. It also includes a transverse push rod and a transverse push motor on one side of the reaction module 140. The transverse switching device can be designed to move from left to right or from right to left. The sample receiving slide can be replaced with various styles as needed. The sample tube clamps can also be repositioned according to changes in the direction of the transverse switching device.

[0051] Handles 146 are designed on both sides of the reaction module 140 for manual operation when flipping or resetting the reaction module 140, effectively avoiding burns or frostbite. The sample injection drive device 150 includes a drive motor 151, a moving stage 152, a push stage 153, a guide rod 154, and a displacement sensor 155. The output end of the drive motor 151 is connected to the moving stage 152. The push stage 153 is mounted on the moving stage 152. The push stage 153 drives the piston end of the sample injection syringe 160 to move. The moving stage 152 is slidably connected to the guide rod 154.

[0052] Although the present invention has been described above with reference to embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the features in the embodiments disclosed in this invention can be combined with each other in any way. The lack of an exhaustive description of these combinations in this specification is merely for the sake of brevity and resource conservation. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A mixing reaction apparatus, characterized in that: Includes an outer shell (100) and a main frame (130); A door panel (110) is installed on the outer shell (100), and the door panel (110) is connected to the outer shell (100) through a damper. A main frame (130) is provided inside the outer shell (100), and a reaction module bracket (131) is provided on the main frame (130). A reaction module (140) is installed on the reaction module bracket (131), and a microfluidic chip (141) is provided on the reaction module (140). An ultrasonic device mounting slot (142) and a cooling / heating device mounting slot (143) are provided at the rear of the reaction module (140). 43) A cooling module (144) is installed at the middle of the rear of the reaction module (140). A cooling fan (145) is installed on the cooling module (144). A transverse drive (147) is installed on the side wall of the reaction module (140). An injection drive device (150) is installed below the reaction module (140). An injection syringe (160) is provided between the injection drive device (150) and the reaction module (140). A waste liquid tube (170) and a sample receiving tube (180) are installed at the front of the reaction module (140).

2. The mixing reaction apparatus according to claim 1, characterized in that: The front of the housing (100) is provided with an indicator light (101) and a power switch (102), and the bottom of the housing (100) is provided with foot pads (103), which are distributed at the four corners of the bottom of the housing (100).

3. The mixing reaction apparatus according to claim 1, characterized in that: The bottom and rear of the housing (100) are provided with heat dissipation vents (104), and the rear of the housing (100) is also provided with a data interface (105), an expansion power interface (106) and a main power interface (107).

4. The mixing reaction apparatus according to claim 1, characterized in that: The inner cavity at the rear of the housing (100) is provided with a power converter (108) and an integrated circuit board (109).

5. The mixing reaction apparatus according to claim 1, characterized in that: Sample racks (120) are provided on both sides of the outer shell (100), and sample racks (120) are provided with sample tubes (180), injection syringes (160) and injection adapters (190) of different types.

6. The mixing reaction apparatus according to claim 1, characterized in that: The reaction module (140) is designed with a cavity that can hold heating wires, coils, heating rods, heating plates and a cooler.

7. The mixing reaction apparatus according to claim 1, characterized in that: The reaction module (140) has three circular holes at the bottom, which can be used to load the sample adapter (190). Multiple dispersed magnetic blocks are designed around the circular holes, and a magnetic suction device is designed on the sample adapter (190) to realize the magnetic loading and rotation unloading of the sample adapter (190).

8. A mixing reaction apparatus according to claim 1, characterized in that: The transverse drive (147) consists of a transverse main slider, a main slider adjustment screw, a sample receiving slide, a sample receiving slide fixing component, a spring, a guide blocking block, and a transverse push rod and a transverse push motor on one side of the reaction module (140).

9. A mixing reaction apparatus according to claim 1, characterized in that: The reaction module (140) is equipped with handles (146) on both sides, which can be used for manual operation when the reaction module (140) is flipped or reset, effectively avoiding burns or frostbite.

10. A mixing reaction apparatus according to claim 1, characterized in that: The sample injection drive device (150) includes a drive motor (151), a moving stage (152), a push stage (153), a guide rod (154), and a displacement sensor (155). The output end of the drive motor (151) is connected to the moving stage (152). The push stage (153) is mounted on the moving stage (152). The push stage (153) is connected to the piston end of the sample injection syringe (160). The moving stage (152) is slidably connected to the guide rod (154).

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