Reaction device

Abstract

The utility model discloses a reaction device. The reaction device comprises a reaction kettle, a circulating pipe and a Venturi pipe, the reaction kettle comprises a feed port and a discharge port; the Venturi tube comprises an inlet section, a contraction section, a throat tube section and a diffusion section which are coaxially connected in sequence; the ratio of the length of the throat tube section to the total length of the Venturi tube is 1: 3-1: 12; the inlet section is provided with an air inlet, and the air inlet is communicated with the external environment; the feed port and the discharge port are respectively communicated with the circulating pipe; and the venturi tube is communicated with the circulating tube. According to the reaction device disclosed by the utility model, the gas-liquid mixing efficiency and the enzyme catalytic reaction efficiency are remarkably improved under the condition of no external power.

Description

Technical Field

[0001] This utility model relates to the field of chemical production technology, and in particular to a reaction apparatus. Background Technology

[0002] Enzyme-catalyzed reactions are characterized by rapid catalytic rates, high specificity, mild conditions, and environmental friendliness, aligning with the principles of green and sustainable development. Many existing enzyme-catalyzed reactions are oxidation reactions, typically requiring the introduction of air into the reaction solution to sustain the reaction. For example, the enzyme-catalyzed preparation of calciferiol, also known as 25-hydroxyvitamin D3, is the primary form of vitamin D in the human body. It can be converted into the active form of vitamin D, calcitriol, participating in calcium and phosphorus regulation, inducing cell proliferation and differentiation, and maintaining cardiovascular health, thus possessing significant medical value in the treatment of clinical diseases.

[0003] Traditional methods of introducing gas often involve mechanical stirring, blower aeration, or external air pump supply, which suffer from high energy consumption, complex equipment, and uneven gas dispersion. In recent years, gas-liquid mixing devices based on the Venturi effect have gradually attracted attention due to their advantages such as simple structure and no need for external power. Although reactors with Venturi structures have been reported in existing technologies, they are not suitable for enzyme-catalyzed reactions and it is difficult to achieve the ideal conversion rate. Utility Model Content

[0004] To address the aforementioned technical problems, this invention provides a reaction apparatus. This apparatus significantly improves the mixing efficiency of air or oxygen with liquid materials without external power, thereby enhancing the substrate conversion rate and product purity of enzyme-catalyzed reactions. It is particularly suitable for preparing enzyme-catalyzed reaction systems such as calcidiol, which are sensitive to oxygen transfer efficiency.

[0005] The present invention provides a reaction apparatus, which includes a reaction vessel, a circulation pipe and a venturi tube;

[0006] The reactor includes an inlet and an outlet;

[0007] The Venturi tube includes an inlet section, a constriction section, a throat section, and a diffuser section connected coaxially in sequence; the ratio of the length of the throat section to the total length of the Venturi tube is 1:3 to 1:12; the inlet section is provided with an air inlet, which is connected to the external environment;

[0008] The feed inlet and the discharge outlet are respectively connected to the circulation pipe; the venturi tube is connected to the circulation pipe.

[0009] This invention simplifies the structure of enzyme catalytic reaction devices by applying a Venturi tube to enzyme catalytic reactions. It achieves sufficient and uniform contact between air or oxygen and liquid materials, further optimizing the structural parameters of the Venturi tube. The ratio of the throat section length to the total Venturi tube length is 1:3-1:12. When the liquid material flows through the throat section, the flow velocity is high and the shear force is strong. The longer throat section length allows for a longer period of efficient contact between the liquid material and air, enabling more uniform and thorough mixing of air and liquid material, thus significantly improving the conversion rate in enzyme catalytic reactions. As those skilled in the art will understand, the liquid material mentioned is generally understood to be the liquid material participating in the enzyme catalytic reaction.

[0010] In another preferred embodiment, the ratio of the length of the throat segment to the total length of the Venturi tube is 1:4 to 1:6. This further optimizes the length of the throat segment in the Venturi tube, increasing the efficient contact time between gas and liquid, promoting more thorough mixing of air and liquid materials, and improving the conversion rate of the enzyme-catalyzed reaction. In a specific embodiment, the ratio of the length of the throat segment to the total length of the Venturi tube is 1:4.6.

[0011] In another preferred embodiment, the length ratio of the inlet section, the constriction section, the throat section, and the diffuser section is 3-5:3-5:1-6:5-10. In a specific embodiment, the length ratio of the inlet section, the constriction section, the throat section, and the diffuser section is 4:4:5:10. In another preferred embodiment, the total length of the venturi tube is 18cm-25cm.

[0012] In another preferred embodiment, the length of the inlet segment is 3cm-5cm, for example, 4cm.

[0013] In another preferred embodiment, the length of the contraction segment is 3cm-5cm, for example, 4cm.

[0014] In another preferred embodiment, the length of the larynx segment is 1cm-6cm, for example 2cm or 5cm.

[0015] In another preferred embodiment, the length of the diffusion segment is 5cm-10cm, for example, 10cm.

[0016] In this invention, the diameter of the inlet section can be a conventional design in the art and does not require special restrictions. The diameter of the inlet section can be 35mm-45mm, for example, 40mm. In this invention, the diameter refers to the nominal diameter. The shape of the inlet section is conventional in the art and is usually cylindrical.

[0017] In this invention, the shape of the contraction section can be conventional in the art, usually a tapered tube. The diameter of the connection between the contraction section and the inlet section is the same as that of the inlet section, and the diameter of the connection between the contraction section and the throat section is the same as that of the throat section.

[0018] In this invention, the diameter of the throat segment can be 20mm-30mm, for example, 25mm. The shape of the throat segment is conventional in the art, usually cylindrical.

[0019] In this invention, the diameter of the widest part of the diffuser section can be 45mm-55mm, for example, 50mm. The shape of the diffuser section is usually a tapered tube, and the diameter at the connection between the diffuser section and the throat section is the same as that of the throat section. Specifically, the diameter of the widest part of the diffuser section is the diameter at the port furthest from the throat section.

[0020] In this invention, the external environment refers to the external environment relative to the circulation pipe and the reactor, typically referring to external air or oxygen. In another preferred embodiment, the air inlet is provided with an air inlet pipe, and the air inlet pipe is provided with an air inlet regulating valve, which can adjust the amount of air entering the Venturi tube at any time according to the pressure inside the reactor, so as to maximize the efficiency of enzyme catalytic reaction.

[0021] As those skilled in the art will know, the Venturi tube of this invention has an inlet and an outlet, the inlet being an end opening in the inlet section away from the constriction section, and the outlet being an end opening in the diffuser section away from the throat section.

[0022] In this invention, those skilled in the art will recognize from the described reaction apparatus that the Venturi tube is entirely or partially positioned along the path of the circulation pipe. Positioning it along the path of the circulation pipe means that the Venturi tube entirely or partially replaces the original location of the circulation pipe. Specifically, when the entire Venturi tube is positioned along the path of the circulation pipe, it is preferably located near the feed inlet or directly connected to the feed inlet via its outlet. When the Venturi tube is partially positioned along the path of the circulation pipe, along the direction from the outlet to the inlet (i.e., inlet at the top, outlet at the bottom), the portion preferably includes at least the portion containing the air inlet and above, with the inlet of the Venturi tube connected to the circulation pipe. The remaining portion passes through the feed inlet into the reactor and connects to the point where it intersects with the feed inlet.

[0023] Compared to placing the Venturi tube in other locations (such as near the outlet), the location specified in this invention not only ensures that the temperature of the Venturi tube is almost identical to that of the reactor, allowing for a more complete reaction to begin within the Venturi tube, but also allows air drawn in through the Venturi tube to quickly enter the reactor. The reactor has a suitable temperature and a stirring impeller, enabling any incomplete reactions within the reactor to occur fully and rapidly. Here, "near" has the conventional understanding in the art, meaning that the Venturi tube is placed as close as possible to the inlet, based on actual conditions.

[0024] In another preferred embodiment, when the entire Venturi tube is positioned along the path of the circulation pipe, the feed inlet preferably has a pipe extending downwards into the reactor; during the reaction, the pipe is positioned above the liquid surface of the material. When the Venturi tube is close to the feed inlet, the pipe can be an extension of the circulation pipe. In another preferred embodiment, when the Venturi tube is partially positioned along the path of the circulation pipe, the outlet of the Venturi tube is positioned above the liquid material in the reactor. If the pipe or the outlet of the Venturi tube extends below the liquid surface of the material, it will reduce the amount of air or oxygen drawn into the Venturi tube, thereby affecting the conversion rate of the enzyme-catalyzed reaction.

[0025] In this invention, those skilled in the art will know from the described reaction apparatus that the inlet of the Venturi tube is connected to the circulation tube. To achieve the Venturi effect, i.e., to make the throat section a negative pressure zone, preferably, the diameter of the connection point between the circulation tube and the inlet of the Venturi tube is the same as or substantially the same as the diameter of the inlet section.

[0026] In another preferred embodiment, the feed inlet is located at the top of the reactor; the discharge outlet is located at the bottom of the reactor. Those skilled in the art will understand that, for more efficient reaction or to facilitate the complete discharge of liquid materials after the reaction, the discharge outlet is located at the exact center of the bottom of the reactor.

[0027] In another preferred embodiment, the upper part of the reactor has an exhaust port. When the entire Venturi tube is arranged along the path of the circulation pipe, the horizontal plane of the exhaust port is preferably higher than the horizontal plane of the pipe near the liquid material end; when the Venturi tube is partially arranged along the path of the circulation pipe, the horizontal plane of the exhaust port is preferably higher than the horizontal plane of the Venturi tube outlet. In this invention, the "upper part" refers to the area above the liquid material added to the reactor, excluding the liquid surface. In another preferred embodiment, the exhaust port is connected to an exhaust pipe, and the exhaust pipe is equipped with a valve.

[0028] As those skilled in the art will know, in order to circulate the liquid material within the circulation pipe and the reaction vessel, a circulation pump is required. The circulation pump is located on the circulation pipe outside the reaction vessel. In another preferred embodiment, a filter screen is also provided inside the circulation pipe, located upstream of the circulation pump, for filtering mechanical impurities in the circulation pipe.

[0029] In another preferred embodiment, the circulation tube is further provided with at least one branch tube, which is connected to the circulation tube and is used to discharge materials after the enzyme catalytic reaction is completed.

[0030] In another preferred embodiment, the reaction apparatus further includes a pressure gauge connected to the circulation tube for detecting the pressure within the circulation tube.

[0031] In another preferred embodiment, at least one temperature control chamber is disposed at different locations on the outer wall of the reactor.

[0032] In another preferred embodiment, the reaction apparatus is further provided with a sight glass, which is disposed on the wall of the circulation pipe for real-time observation of the material condition inside the circulation pipe.

[0033] As those skilled in the art will know, in order to improve the conversion rate of the enzyme-catalyzed reaction, the reactor is also equipped with a stirring paddle.

[0034] The beneficial effects of this invention are as follows: the reaction device of this invention can significantly improve the gas-liquid mixing efficiency without external power, and it is simple to operate, highly practical, and suitable for industrial production. For aerobic enzyme catalytic reaction systems, this reaction device can promptly replenish oxygen (or air) and rapidly and uniformly mix oxygen with liquid materials, thereby improving substrate conversion, reducing by-product formation, and increasing product purity. Attached Figure Description

[0035] Figure 1 This is a schematic diagram of the reaction apparatus of Embodiment 1 of this utility model.

[0036] Figure 2 This is a schematic diagram of the Venturi tube structure in Example 1.

[0037] Reference numerals: 100, Reaction apparatus; 1, Reactor; 11, Inlet; 12, Outlet; 13, Exhaust port; 14, First temperature control valve; 15, Second temperature control valve; 16, Stirring paddle; 2, Circulation pipe; 21, Filter screen; 22, Fourth valve; 23, Fifth valve; 24, Third valve; 25, Sight glass; 26, Pressure gauge; 3, Venturi tube; 4, Inlet pipe; 41, Flow meter; 42, Inlet regulating valve; 5, Second branch pipe; 51, Second valve; 6, First branch pipe; 61, First valve; 7, Exhaust pipe; 71, Sixth valve; 8, Circulation pump; 31, Inlet section; 32, Contraction section; 33, Throat section; 34, Diffusion section. Detailed Implementation

[0038] To make the objectives, technical solutions, and advantages of this utility model clearer, the various embodiments of this utility model will be described in detail below with reference to the accompanying drawings. However, those skilled in the art will understand that many technical details have been provided in the various embodiments of this utility model to facilitate a better understanding of this application. However, the technical solutions claimed in the claims of this application can be implemented even without these technical details and with various variations and modifications based on the following embodiments.

[0039] Unless the context requires otherwise, throughout the specification and claims, the word “comprising” and its variations, such as “including” and “having”, shall be understood to have an open, inclusive meaning, that is, to be interpreted as “including, but not limited to”.

[0040] The embodiments of this utility model will be described in detail below with reference to the accompanying drawings to provide a clearer understanding of the purpose, features, and advantages of this utility model. It should be understood that the embodiments shown in the drawings are not intended to limit the scope of this utility model, but are merely illustrative of the essential spirit of the technical solution of this utility model.

[0041] Throughout this specification, references to "an embodiment" or "an embodiment" indicate that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Therefore, the appearance of "in an embodiment" or "an embodiment" in various places throughout the specification does not necessarily refer to the same embodiment. Furthermore, a particular feature, structure, or characteristic may be combined in any manner in one or more embodiments.

[0042] The singular forms “a” and “the” used in this specification and the appended claims include plural references unless otherwise expressly stated herein. It should be noted that the term “or” is generally used to mean “and / or” unless otherwise expressly stated herein.

[0043] In the following description, in order to clearly demonstrate the structure and working method of this utility model, a number of directional terms will be used. However, terms such as "front", "back", "left", "right", "outside", "inside", "outward", "inward", "up", and "down" should be understood as convenient terms and not as limiting terms.

[0044] Example 1

[0045] like Figure 1 and Figure 2 As shown, this embodiment provides a reaction apparatus 100, which includes a reaction vessel 1, a circulation pipe 2, and a venturi tube 3. The reaction vessel 1 is provided with an inlet 11, an outlet 12, and an exhaust port 13. The inlet 11 and the outlet 12 are respectively connected to the circulation pipe 2. A circulation pump 8 is also provided on the circulation pipe 2 outside the reaction vessel 1, thereby realizing the circulation of liquid materials in the reaction vessel 1. The venturi tube 3 is arranged entirely on the path of the circulation pipe 2. The venturi tube 3 includes an inlet section 31 (4cm in length and 40mm in diameter), a contraction section 32 (4cm in length and 40mm in diameter at its widest point), a throat section 33 (5cm in length and 25mm in diameter), and a diffuser section 34 (10cm in length and 50mm in diameter at its widest point), which are connected coaxially in sequence.

[0046] The feed inlet 11 and exhaust outlet 13 are located on the upper sides of the reactor 1, respectively, while the discharge outlet 12 is located at the center of the bottom of the reactor 1. An exhaust pipe 7 is connected to the exhaust outlet 13 to discharge gas from the reactor 1. A sixth valve 71 is installed on the exhaust pipe 7 to control the exhaust and maintain atmospheric pressure within the reactor 1. The reactor 1 is also equipped with a stirring paddle 16 for agitating the materials within it.

[0047] The venturi tube 3 has an inlet and an outlet. Its inlet is the end opening of the inlet section 31 away from the contraction section 32, and its outlet is the end opening of the diffuser section 34 away from the throat section 33. The inlet of the venturi tube 3 is connected to and communicates with the circulation pipe 2, and the outlet of the venturi tube 3 is connected to and communicates with the feed inlet 11.

[0048] Liquid material in reactor 1 flows out from outlet 12, passes through circulation pipe 2, enters venturi tube 3 via inlet section 31, and finally exits from diffuser section 34. Venturi tube 3 then directly enters reactor 1 via inlet 11. Inlet 11 has a pipe extending downwards into reactor 1. This pipe is located above the liquid surface (excluding the surface) and below the level of exhaust port 13. Inserting this pipe below the liquid surface reduces the amount of air entering venturi tube 3 and reactor 1. Inlet section 31 also has an air inlet connected to an air inlet pipe 4. Air inlet pipe 4 is equipped with an air inlet regulating valve 42 and a flow meter 41, which are electrically connected. The regulating valve 42 and flow meter 41 can adjust the amount of air entering venturi tube 3 according to the pressure inside reactor 1, maximizing the efficiency of the enzyme catalytic reaction.

[0049] A filter screen 21 is installed inside the circulation pipe 2, located upstream of the circulation pump 8. The filter screen 21 is used to filter mechanical impurities in the circulation pipe 2 to prevent mechanical impurities from damaging the circulation pump 8. A first branch pipe 6 is provided on the circulation pipe 2, and a first valve 61 is installed on the first branch pipe 6 for discharging the material in the reactor 1 at the end of the reaction. A second branch pipe 5 is formed between the downstream of the first branch pipe 6 and the upstream of the circulation pump 8, and a second valve 51 is installed on the second branch pipe 5 for discharging the material and waste liquid in the circulation pipe 2 at the end of the reaction.

[0050] The reaction apparatus 100 is also provided with a third valve 24, which is located on the circulation pipe 2 between the outlet 12 and the first branch pipe 6; a fourth valve 22, which is located on the circulation pipe 2 between the first branch pipe 6 and the second branch pipe 5; and a fifth valve 23, which is located on the circulation pipe 2 between the second branch pipe 5 and the circulation pump 8.

[0051] The reaction apparatus 100 is also equipped with a sight glass 25, which is installed on the wall of the circulation pipe 2 for real-time observation of the material status in the circulation pipe 2. The reaction apparatus 100 is also equipped with a pressure gauge 26, which is connected to the circulation pipe 2 for detecting the pressure inside the circulation pipe 2. The outer wall of the reaction vessel 1 is also equipped with a first temperature control chamber 14 and a second temperature control valve 15 for heating or cooling the reaction vessel 1 to adapt to different reaction requirements.

[0052] The working process of preparing calcidiol using this reaction apparatus via enzyme catalysis is as follows:

[0053] Add 5 kg of vitamin D3 and 10 kg of methyl-β-cyclodextrin to reactor 1, then add 100 L of crude oxidase solution, 1 L of crude isopropanol dehydrogenase solution, 20 kg of isopropanol, and 100 g of sodium NAD salt. Turn on the agitator 16 in reactor 1 to mix the materials evenly and obtain a liquid material. Turn on the first temperature control 14 and the second temperature control 15 to maintain the temperature of reactor 1 at 25°C. Open the sixth valve 71 to ensure that the reactor 1 is kept at atmospheric pressure after air is added. Turn on the circulation pump 8, the third valve 24, the fourth valve 22, the fifth valve 23, and the air intake regulating valve 42 to circulate the liquid material in the circulation pipe 2. When the liquid material passes through the throat section 33, a negative pressure zone is formed, and air is drawn in through the air intake pipe 4. The liquid material mixed with air immediately begins to react and returns to reactor 1 through the circulation pipe 2.

[0054] The reaction was carried out with stirring for 12 hours. Then, the circulation pump 8 was turned off, the fourth valve 22 was closed, and the first valve 61 was opened to drain all liquid material from reactor 1. After draining the liquid material from reactor 1, the fourth valve 22 and the second valve 51 were opened to drain the liquid material from circulation pipe 2. After the liquid material was collected, the reaction apparatus 100 was cleaned and the waste liquid was discharged. HPLC analysis using the area normalization method showed that the substrate conversion rate was 94.6%, and the product purity reached 95%.

[0055] The size of the Venturi tube 3 in this embodiment allows for the intake of sufficient air from the outside. The throat section 33, being a negative pressure zone (with the highest flow rate), is the location where gas-liquid mixing is most efficient and enzyme catalysis occurs most rapidly. Its relatively long length extends the contact and mixing time between air and liquid materials, improving the problem of poor gas dispersion in liquid materials. Furthermore, placing the Venturi tube 3 near or directly connected to the inlet 11, compared to placing it in other locations (such as near the outlet 12), not only ensures that the temperature of the Venturi tube 3 is almost identical to that of the reactor, allowing for a more complete reaction to begin within the Venturi tube 3, but also enables the liquid material and air to quickly enter the reactor 1, ensuring that any unreacted liquid material can also fully react within the reactor.

[0056] Example 2

[0057] The only difference between this embodiment and Example 1 is the length of the throat segment in the venturi tube; in this embodiment, the throat segment is 2 cm long. All other structures are identical. The same enzymatic reaction for the preparation of calcidiol was performed, along with the same HPLC detection method, and the substrate conversion rate was measured to be 90.2%.

[0058] In another preferred embodiment, a venturi tube is disposed along the path of the circulation pipe, dividing the circulation pipe into two parts. Preferably, the venturi tube is located near the feed inlet. Preferably, the circulation pipe extends downward from the feed inlet into the reactor, and the horizontal plane of the circulation pipe near the liquid material end is below the horizontal plane of the exhaust port.

[0059] In another preferred embodiment, a venturi tube is disposed on the path of the circulation tube, and the outlet of the venturi tube is connected to the feed inlet, which preferably has a pipe extending downward into the reactor.

[0060] In another preferred embodiment, a portion of the Venturi tube is disposed along the path of the circulation pipe, in the direction from the outlet to the inlet of the Venturi tube (i.e., the inlet is above and the outlet is below). The portion includes at least the portion above the air inlet, and the inlet of the Venturi tube is connected to the circulation pipe. The remaining portion passes through the feed inlet into the reactor and is connected at the intersection with the feed inlet. The horizontal plane where the outlet of the Venturi tube is located is below the horizontal plane where the exhaust port is located.

[0061] During the reaction, the pipe extending downwards from the feed inlet into the reactor, or the Venturi tube outlet passing through the feed inlet, is located above the liquid surface of the liquid material, but not below it. If the pipe enters below the liquid surface, it will reduce the amount of air or oxygen drawn into the Venturi tube, thereby affecting the conversion rate of the enzyme-catalyzed reaction.

[0062] In one example, the ratio of the length of the throat segment to the total length of the venturi tube is 1:3 to 1:12.

[0063] Furthermore, the ratio of the length of the throat segment to the total length of the Venturi tube is 1:4 to 1:6. This further optimizes the length of the throat segment in the Venturi tube, improving the conversion rate of the enzyme-catalyzed reaction. In a specific embodiment, the ratio of the length of the constriction segment to the total length of the Venturi tube is 1:4.6.

[0064] In another preferred embodiment, the length ratio of the inlet section, the contraction section, the throat section, and the diffuser section is (3-5):(3-5):(1-6):(5-10). In a specific embodiment, the length ratio of the inlet section, the contraction section, the throat section, and the diffuser section is 4:4:5:10. Those skilled in the art will understand that the inlet section and the outlet are connected and communicated via a circulation pipe, and the diffuser section and the feed inlet are connected and communicated via a circulation pipe.

[0065] In another preferred embodiment, the total length of the venturi tube is 18cm-25cm.

[0066] In another preferred embodiment, the length of the inlet section is 3cm-5cm; the length of the constriction section is 3cm-5cm; the length of the throat section is 1cm-6cm; and the length of the diffuser section is 5cm-10cm.

[0067] In another preferred embodiment, the length of the inlet section is 4 cm, the length of the constriction section is 4 cm, the length of the throat section is 5 cm, and the length of the diffuser section is 10 cm.

[0068] In this invention, the diameter of the inlet section can be 35mm-45mm, for example, 40mm. In this invention, the diameter refers to the nominal diameter.

[0069] In this invention, the diameter of the throat segment can be 20mm-30mm, for example, 25mm.

[0070] In this invention, the diameter of the widest part of the diffusion section can be 45-55mm, for example, 50mm.

[0071] When the reaction device of this invention is used for the reaction of oxygen (or air) and liquid, air is drawn in by the negative pressure generated when the liquid passes through the throat section 33, eliminating the need for an additional air pump. Compared with the traditional Venturi tube, this invention further improves the structure of the Venturi tube, increasing the length of the section with the highest gas-liquid mixing efficiency. This extends the mixing time of the gas and liquid materials without increasing frictional losses and thus reducing the effective pressure difference, resulting in more thorough mixing of the liquid and gas, effectively promoting the reaction, and shortening the total reaction time. Simultaneously, because the reaction time is short, the enzyme activity is more stable, improving the substrate conversion rate and product purity. As shown in Examples 1 and 2, Example 1 further optimized the length of the throat section, resulting in a higher conversion rate.

[0072] The preferred embodiments of the present invention have been described in detail above, but it should be understood that, if necessary, aspects of the embodiments can be modified to utilize aspects, features, and concepts from various patents, applications, and publications to provide other embodiments.

[0073] In light of the detailed description above, these and other changes can be made to the embodiments. Generally, the terminology used in the claims should not be considered limited to the specific embodiments disclosed in the specification and claims, but should be understood to include all possible embodiments together with the full scope of equivalents enjoyed by these claims.

[0074] Those skilled in the art will understand that the above embodiments are specific examples of implementing the present invention, and in practical applications, various changes can be made to them in form and detail without departing from the spirit and scope of the present invention.

Claims

1. A reaction apparatus, characterized in that, It includes a reaction vessel, circulation pipes, and a venturi tube; The reactor includes an inlet and an outlet; The Venturi tube includes an inlet section, a constriction section, a throat section, and a diffuser section connected coaxially in sequence; the ratio of the length of the throat section to the total length of the Venturi tube is 1:3 to 1:12; the inlet section is provided with an air inlet, which is connected to the external environment; The feed inlet and the discharge outlet are respectively connected to the circulation pipe; the venturi tube is connected to the circulation pipe.

2. The reaction apparatus according to claim 1, characterized in that, The ratio of the length of the throat segment to the total length of the venturi tube is 1:4 to 1:

6.

3. The reaction apparatus according to claim 2, characterized in that, The length ratio of the inlet section, the constriction section, the throat section, and the diffuser section is 3-5:3-5:1-6:5-10.

4. The reaction apparatus according to claim 3, characterized in that, The length ratio of the inlet section, the constriction section, the throat section, and the diffuser section is 4:4:5:

10.

5. The reaction apparatus according to claim 1, characterized in that, The total length of the Venturi tube is 18cm-25cm.

6. The reaction apparatus according to any one of claims 1-5, characterized in that, The venturi tube is disposed on the path of the circulation tube; the venturi tube is close to the feed inlet or directly connected to the feed inlet through the outlet of the venturi tube.

7. The reaction apparatus according to claim 6, characterized in that, The feed inlet is provided with a pipe extending downward into the reactor; the pipe is located above the liquid surface of the liquid material in the reactor.

8. The reaction apparatus according to any one of claims 1-5, characterized in that, The inlet of the venturi tube is connected to the circulation tube; The air inlet of the Venturi tube is located outside the reactor, while the portion of the Venturi tube below the air inlet passes through the feed inlet and enters the reactor, connecting with the feed inlet at the intersection.

9. The reaction apparatus according to claim 8, characterized in that, The outlet of the venturi tube is located above the liquid material inside the reactor.

10. The reaction apparatus according to claim 1, characterized in that, The upper part of the reactor has an exhaust port; The feed inlet is located at the top of the reactor; the discharge outlet is located at the bottom of the reactor.

Images