Multi-stage filtering device for producing biomedical intermediates

Abstract

The utility model relates to the technical field of medicine production, and discloses a multi-stage filtering device for biological medicine intermediate production, which comprises a collecting bin, a sieving bin fixedly mounted at the top of the collecting bin, a movable door movably mounted outside the collecting bin, a feeding hopper fixedly arranged outside the sieving bin, and a double-sieving mechanism arranged on the inner side of the sieving bin, according to the double-screening mechanism, raw materials are subjected to primary screening through the bucket-shaped screen under the action of rotation and vibration of the transmission rod, when the bucket-shaped screen falls down, the raw materials can be subjected to secondary screening, the screening fineness degree is further improved, through the anti-blocking screening mechanism, the screening efficiency is improved, and the screening quality is improved. And after the raw materials falling into the screening net B after secondary screening are stacked, the raw materials are pushed by the anti-blocking scraper blade and conveyed by the spiral blade rod and are sent back to the inner side of the bucket-shaped screening net again for secondary screening, so that the product quality is guaranteed, and the raw materials are prevented from being stacked and blocked at key parts.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production technology, specifically a multi-stage filtration device for the production of biopharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates play a crucial role in drug research and development and production. They are key intermediate products in drug synthesis, derived from active pharmaceutical ingredients or natural products through a series of organic synthetic reactions to gradually synthesize drugs with therapeutic activity. By rationally designing and optimizing the synthetic routes of pharmaceutical intermediates, the production efficiency and quality of drugs can be effectively improved. Filtration is one of the key steps in the production of pharmaceutical intermediates.

[0003] According to CN222092731U, a filtration device for processing pharmaceutical intermediates, the turntable and swing plate can drive the baffle to move back and forth, thereby achieving indirect feeding of raw materials in the feeding funnel and avoiding excessive feeding at one time, which would affect the filtration effect. In addition, a fixed rod can be used to drive the moving frame and filter plate to move back and forth to filter the raw materials, which can save energy. The reset spring and the striking ball can contact the striking ball when the moving frame moves left and right, thereby generating vibration when the moving frame is in contact, preventing the raw materials from clogging the filter plate during filtration and affecting the filtration effect.

[0004] While the above-mentioned scheme allows for single-raw material screening, the structural design is too simple, involving only single left-right screening and lacking the capability for repeated left-right screening of raw materials. This makes it difficult to control the size of raw material screening, resulting in unreliable pharmaceutical products. Therefore, a multi-stage filtration device for the production of biopharmaceutical intermediates is needed to solve this problem. Utility Model Content

[0005] The purpose of this invention is to provide a multi-stage filtration device for the production of biopharmaceutical intermediates, so as to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a multi-stage filtration device for the production of biopharmaceutical intermediates, comprising a collection chamber, a screening chamber fixedly installed on the top of the collection chamber, a movable door movably installed on the outside of the collection chamber, a feed hopper fixedly installed on the outside of the screening chamber, a double screening mechanism provided on the inside of the screening chamber, and an anti-clogging screening mechanism provided on the inside of the collection chamber.

[0007] The dual screening mechanism includes a power unit and a screening unit. The power unit is located outside the screening chamber, and the screening unit is located inside the screening chamber.

[0008] Preferably, the power assembly includes a motor A, which is fixedly installed outside the screening chamber. A transmission wheel is fixedly installed on the output shaft of the motor A. A transmission rod is rotatably installed outside the screening chamber. A belt A is driven between the transmission rod and the transmission wheel. An extrusion rod A is rotatably installed at the bottom of the screening chamber. A belt B is driven between the extrusion rod A and the transmission wheel.

[0009] Preferably, the screening component includes a movable block, which is slidably installed inside the screening chamber. A spring is fixedly installed between the movable block and the inside of the screening chamber. A transmission rod extends through the movable block to one end of the screening chamber where a centrifugal block is fixedly installed. A bucket-shaped screen is fixedly installed on the side of the movable block near the centrifugal block. A feed inlet is provided on the outside of the screening chamber. A screen A is slidably installed at the bottom of the screening chamber. An extrusion rod B is fixedly installed on the outside of the screen A.

[0010] Preferably, the number of springs is four sets, and they are symmetrically distributed on both sides inside the screening chamber.

[0011] Preferably, the extrusion rod B is located on the inner side of the bottom of the screening chamber, and the groove of the extrusion rod B is engaged with the corresponding part of the extrusion rod A.

[0012] Preferably, the anti-clogging screening mechanism includes a motor B, which is fixedly installed outside the collection bin. A screen B is fixedly installed inside the collection bin. A conveying pipe is fixedly installed on the side of the collection bin away from the movable door, and the feed hopper is fixedly connected to the movable door. A threaded rod is fixedly installed at one end of the output shaft of the motor B extending to the inside of the collection bin. A limit rod is fixedly installed inside the collection bin. An anti-clogging scraper is installed on the external thread of the threaded rod. A motor C is fixedly installed at the top of the conveying pipe, and a spiral blade is fixedly installed at one end of the output shaft of the motor C extending to the inside of the conveying pipe.

[0013] Preferably, the anti-blocking scraper is located inside the collection chamber, and the anti-blocking scraper is slidably connected to the limiting rod.

[0014] Compared with the prior art, this utility model provides a multi-stage filtration device for the production of biopharmaceutical intermediates, which has the following beneficial effects:

[0015] 1. This multi-stage filtration device for the production of biopharmaceutical intermediates employs a dual screening mechanism. First, raw materials are initially screened through a bucket-shaped screen under the action of a rotating and vibrating transmission rod. This vibration screening method utilizes centrifugal force and the vibration-generated agitation to effectively separate raw materials of different particle sizes. Raw materials meeting the particle size requirements fall through the holes of the bucket-shaped screen. Screen A, driven by the meshing of extrusion rods A and B, circulates repeatedly within the screening chamber, performing a secondary screening of the raw materials falling from the bucket-shaped screen. This further enhances the fineness of the screening, maximizing the quality of raw materials entering subsequent processes and meeting the stringent requirements for high purity and high quality in biopharmaceutical intermediate production.

[0016] 2. This multi-stage filtration device for the production of biopharmaceutical intermediates uses an anti-clogging sieving mechanism. After the raw materials fall into the sieve B through the secondary screening, if they accumulate, they are pushed back to the inside of the bucket-shaped screen by the anti-clogging scraper and the spiral blade conveyor. The multiple-cycle screening mode helps to remove unqualified raw materials more thoroughly, ensure product quality, and prevent raw materials from accumulating and clogging in key parts. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the front structure of this utility model;

[0019] Figure 2 This is a schematic cross-sectional view of the present invention.

[0020] Figure 3 This is a schematic diagram of the power component structure of this utility model;

[0021] Figure 4 This is a schematic diagram of the screening component structure of this utility model;

[0022] Figure 5 This is a schematic diagram of part of the structure of this utility model;

[0023] Figure 6 This is a schematic diagram of the anti-clogging screening mechanism of this utility model.

[0024] In the diagram: 1. Collection bin; 2. Screening bin; 3. Movable door; 4. Feed hopper; 5. Double screening mechanism; 51. Power assembly; 511. Motor A; 512. Drive wheel; 513. Belt A; 514. Drive rod; 515. Belt B; 516. Extrusion rod A; 52. Screening assembly; 521. Movable block; 522. Spring; 523. Bucket screen; 524. Centrifugal block; 525. Feed inlet; 526. Screen A; 527. Extrusion rod B; 6. Anti-clogging screening mechanism; 61. Motor B; 62. Screen B; 63. Conveying pipe; 64. Threaded rod; 65. Limiting rod; 66. Anti-clogging scraper; 67. Motor C; 68. Spiral blade. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0027] Example 1:

[0028] Please see Figures 1-4 To control product quality, it is necessary to screen raw materials at multiple levels to meet product requirements. Therefore, this utility model provides a technical solution: a multi-stage filtration device for the production of biopharmaceutical intermediates, including a collection chamber 1, a screening chamber 2 fixedly installed on the top of the collection chamber 1, a movable door 3 movably installed on the outside of the collection chamber 1, a feed hopper 4 fixedly installed on the outside of the screening chamber 2, a double screening mechanism 5 installed on the inside of the screening chamber 2, and an anti-clogging screening mechanism 6 installed on the inside of the collection chamber 1.

[0029] The dual screening mechanism 5 includes a power unit 51 and a screening unit 52. The power unit 51 is located outside the screening chamber 2, and the screening unit 52 is located inside the screening chamber 2.

[0030] Furthermore, the power assembly 51 includes a motor A511, which is fixedly installed outside the screening chamber 2. A transmission wheel 512 is fixedly installed on the output shaft of the motor A511. A transmission rod 514 is rotatably installed outside the screening chamber 2. A belt A513 is installed between the transmission rod 514 and the transmission wheel 512. A pressing rod A516 is rotatably installed at the bottom of the screening chamber 2. A belt B515 is installed between the pressing rod A516 and the transmission wheel 512 to facilitate the provision of power and generate a vibration screening effect.

[0031] Furthermore, the screening component 52 includes a movable block 521, which is slidably installed inside the screening chamber 2. A spring 522 is fixedly installed between the movable block 521 and the inside of the screening chamber 2. A transmission rod 514 extends through the movable block 521 to one end of the inside of the screening chamber 2, where a centrifugal block 524 is fixedly installed. A bucket-shaped screen 523 is fixedly installed on the side of the movable block 521 near the centrifugal block 524. A feed inlet 525 is opened on the outside of the screening chamber 2. A screen A526 is slidably installed at the bottom of the screening chamber 2. An extrusion rod B527 is fixedly installed on the outside of the screen A526, which facilitates double screening and ensures the quality of raw materials.

[0032] Furthermore, there are four sets of springs 522, which are symmetrically distributed on both sides inside the screening chamber 2 to facilitate vibration.

[0033] Furthermore, the extrusion rod B527 is located on the inner side of the bottom of the screening chamber 2, and the groove of the extrusion rod B527 is engaged with the corresponding part of the extrusion rod A516 for easy transmission.

[0034] Example 2:

[0035] Please see Figures 5-6 When the screened raw materials accumulate, they can be transferred and screened again to prevent blockage. In conjunction with Embodiment 1, the anti-blockage screening mechanism 6 includes a motor B61, which is fixedly installed outside the collection bin 1. A screen B62 is fixedly installed inside the collection bin 1. A conveying pipe 63 is fixedly installed on the side of the collection bin 1 away from the movable door 3, and the feed hopper 4 is fixedly connected to the movable door 3. A threaded rod 64 is fixedly installed at one end of the output shaft of the motor B61 extending to the inside of the collection bin 1. A limit rod 65 is fixedly installed inside the collection bin 1. An anti-blockage scraper 66 is installed on the external thread of the threaded rod 64. A motor C67 is fixedly installed at the top of the conveying pipe 63. A spiral blade 68 is fixedly installed at one end of the output shaft of the motor C67 extending to the inside of the conveying pipe 63. This facilitates the transfer of accumulated raw materials, prevents blockage, and achieves the function of re-screening.

[0036] Furthermore, the anti-blocking scraper 66 is located inside the collection chamber 1, and the anti-blocking scraper 66 is slidably connected to the limiting rod 65, which facilitates limiting the anti-blocking scraper 66 and achieving the effect of movement.

[0037] In actual operation, when this device is used, the raw materials to be filtered are first fed into the inner side of the bucket-shaped screen 523 inside the screening chamber 2 through the feed hopper 4. The motor A511 is turned on, causing the drive wheel 512 to rotate. Through the transmission of belts A513 and B515, the drive rod 514 and the extrusion rod A516 rotate. When the drive rod 514 rotates along the movable block 521, the centrifugal block 524 rotates, causing the drive rod 514 to vibrate up and down. The spring force of the spring 522 resets the rotation, achieving cyclic vibration. When the drive rod 514 vibrates, it drives the material inside the bucket-shaped screen 523 to rotate, thus better screening the raw materials through the vibration. The material is then transferred to the screening screen A526 through the holes on the outside of the bucket-shaped screen 523. When the extrusion rod A516 rotates, the material inside the extrusion rod A51... The groove 6 engages with the extrusion rod B527, causing the extrusion rod B527 to drive the screen A526 to move back and forth inside the screening chamber 2, achieving a secondary screening effect. When the raw material from the secondary screening falls into the screen B62, a large amount of raw material will accumulate on the top of the screen B62. At this time, by turning on the motor B61, the threaded rod 64 is rotated, causing the anti-blocking scraper 66 to move back and forth along the limit rod 65 on the top of the screen B62, pushing the excess raw material to the inside of the conveying pipe 63. Turning on the motor C67 causes the spiral blade 68 to rotate, rotating the accumulated material to the top of the conveying pipe 63, and then feeding it back into the inner side of the bucket screen 523 through the feed inlet 525 for a second screening, avoiding blockage by excessive raw material, and also achieving the effect of multiple screenings to ensure product quality.

[0038] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

Claims

1. A multi-stage filtration device for the production of biopharmaceutical intermediates, comprising a collection chamber (1), characterized in that: The top of the collection bin (1) is fixedly installed with a screening bin (2), the outside of the collection bin (1) is movably installed with a movable door (3), the outside of the screening bin (2) is fixedly provided with a feed hopper (4), the inside of the screening bin (2) is provided with a double screening mechanism (5), and the inside of the collection bin (1) is provided with an anti-blocking screening mechanism (6). The dual screening mechanism (5) includes a power component (51) and a screening component (52). The power component (51) is located outside the screening chamber (2), and the screening component (52) is located inside the screening chamber (2).

2. The multi-stage filtration device for the production of biopharmaceutical intermediates according to claim 1, characterized in that: The power assembly (51) includes a motor A (511), which is fixedly installed outside the screening chamber (2). A transmission wheel (512) is fixedly installed on the output shaft of the motor A (511). A transmission rod (514) is rotatably installed outside the screening chamber (2). A belt A (513) is driven between the transmission rod (514) and the transmission wheel (512). An extrusion rod A (516) is rotatably installed at the bottom of the screening chamber (2). A belt B (515) is driven between the extrusion rod A (516) and the transmission wheel (512).

3. The multi-stage filtration device for the production of biopharmaceutical intermediates according to claim 2, characterized in that: The screening component (52) includes a movable block (521), which is slidably installed on the inner side of the screening chamber (2). A spring (522) is fixedly installed between the movable block (521) and the inner side of the screening chamber (2). A transmission rod (514) extends through the movable block (521) to one end of the inner side of the screening chamber (2) and is fixedly installed with a centrifugal block (524). A bucket-shaped screen (523) is fixedly installed on the side of the movable block (521) near the centrifugal block (524). A feed inlet (525) is opened on the outside of the screening chamber (2). A screen A (526) is slidably installed on the bottom of the screening chamber (2). An extrusion rod B (527) is fixedly installed on the outside of the screen A (526).

4. The multi-stage filtration device for the production of biopharmaceutical intermediates according to claim 3, characterized in that: The number of springs (522) is four sets, and they are symmetrically distributed on both sides inside the screening chamber (2).

5. A multi-stage filtration device for the production of biopharmaceutical intermediates according to claim 3, characterized in that: The extrusion rod B (527) is located on the inner side of the bottom of the screening chamber (2), and the groove of the extrusion rod B (527) is engaged with the corresponding part of the extrusion rod A (516).

6. A multi-stage filtration device for the production of biopharmaceutical intermediates according to claim 1, characterized in that: The anti-clogging screening mechanism (6) includes a motor B (61), which is fixedly installed outside the collection bin (1). A screen B (62) is fixedly installed inside the collection bin (1). A conveying pipe (63) is fixedly installed on the side of the collection bin (1) away from the movable door (3), and the feed hopper (4) is fixedly connected to the movable door (3). A threaded rod (64) is fixedly installed at one end of the output shaft of the motor B (61) extending to the inside of the collection bin (1). A limit rod (65) is fixedly installed inside the collection bin (1). An anti-clogging scraper (66) is installed on the external thread of the threaded rod (64). A motor C (67) is fixedly installed at the top of the conveying pipe (63). A spiral blade (68) is fixedly installed at one end of the output shaft of the motor C (67) extending to the inside of the conveying pipe (63).

7. A multi-stage filtration device for the production of biopharmaceutical intermediates according to claim 6, characterized in that: The anti-blocking scraper (66) is located inside the collection chamber (1), and the anti-blocking scraper (66) is slidably connected to the limiting rod (65).

Images