Granulation equipment for granule production

Abstract

This utility model relates to the field of granule production and discloses a granulation equipment for granule production, including a mixing tank. The mixing tank is fixed to the top surface of a granulation box, and a sealing cover is detachably provided on the top surface of the mixing tank. A first drive motor is fixed to the top surface of the sealing cover, and the output shaft of the first drive motor passes through the sealing cover and is fixed with a spiral stirring rod. Several material boxes are respectively connected to and fixed with discharge pipes connected to the sealing cover. In this utility model, the coordinated use of the mixing tank, sealing cover, first drive motor, spiral stirring rod, U-shaped frame, stirring inclined rod, first elastic scraper, and second elastic scraper facilitates multi-directional and multi-form mixing and scraping, avoids the occurrence of mixing dead zones, achieves efficient and uniform mixing of various powdered agents in the mixing tank, improves the uniformity of mixing of various powdered agents, and ensures the stable quality of granules produced subsequently.

Description

Technical Field

[0001] This utility model relates to the technical field of granule production, specifically to a granulation equipment for granule production. Background Technology

[0002] Granules are a solid dosage form obtained by mixing the active pharmaceutical ingredient with carriers, binders, dispersants, wetting agents, stabilizers, and other adjuvants and then granulating the mixture. During granule production, a stirring device is typically used to mix the powdered drug, and then the mixture is granulated into granules using a granulation chamber.

[0003] Chinese Patent Announcement CN222325092U discloses a granulation device for producing solid granules. Its key technical features include: a granulation box, with a mixing chamber and a hydraulic cylinder fixedly installed on its top; several discharge pipes fixedly installed on the top of the mixing chamber; valves rotatably installed inside the discharge pipes; a loading box fixedly installed at the top of the discharge pipes; and graduation lines on one side of the loading box; a rotating rod rotatably installed at the bottom of the mixing chamber's inner cavity; several stirring rods fixedly installed around the rotating rod; and a scraper fixedly installed on the rotating rod at the bottom of the mixing chamber's inner cavity; and a granulation chamber located within the granulation box.

[0004] In the above scheme, the powdered agent in the loading box is transported to the mixing tank, and then the powdered agent in the mixing tank is stirred and mixed by the rotating rod, stirring plate and dual-shaft motor. This has the following disadvantages: when the equipment is in use, the stirring structure and method are simple, there are mixing dead corners, which leads to a reduction in the uniformity of mixing of various powdered agents. Utility Model Content

[0005] The purpose of this invention is to provide a granulation equipment for granule production, in order to solve the problem that the equipment has a single stirring structure and method, resulting in mixing dead zones and reduced uniformity of various powdered drugs.

[0006] To achieve the above-mentioned utility model objectives, the present utility model adopts the following technical solution: a granulation equipment for granule production, comprising a mixing box, the mixing box being fixed to the top surface of a granulation box, a sealing cover being detachably provided on the top surface of the mixing box, a first drive motor being fixed to the top surface of the sealing cover, the output shaft of the first drive motor passing through the sealing cover and fixed to a spiral stirring rod, a U-shaped frame being fixed to the bottom end of the spiral stirring rod, stirring plates being fixed to the front and rear sides of the inner wall of the U-shaped frame, two stirring inclined rods being fixed to the front and rear sides of the inner wall of the U-shaped frame, a first elastic scraper being fixed to the front and rear sides of the outer wall of the U-shaped frame, a second elastic scraper being fixed to the bottom surface of the U-shaped frame, a plurality of material boxes being provided above the sealing cover, each of the plurality of material boxes having a feed inlet on its top surface, a discharge pipe being fixedly connected between the plurality of material boxes and the sealing cover, and a first valve being provided on each of the plurality of discharge pipes.

[0007] Preferably, a connecting pipe is fixedly connected between the mixing tank and the granulation tank. An insertion hole is provided on the front side of the granulation tank, and a pull-out plate is slidably arranged inside the insertion hole. An extrusion plate is movably arranged inside the granulation tank. A hydraulic cylinder is fixed on the top surface of the granulation tank. One end of the extension rod of the hydraulic cylinder passes through the granulation tank and is fixedly connected to the top surface of the extrusion plate. Two crushing rollers are rotatably arranged inside the granulation tank. A second drive motor is fixed on the right side of the outer wall of the granulation tank. The output shafts of the two second drive motors pass through the granulation tank and are fixedly connected to the right ends of the two crushing rollers respectively. A collection box is slidably arranged on the front side of the granulation tank.

[0008] Preferably, the top surface of the mixing tank is provided with a plurality of threaded grooves, and the top surface of the sealing cover is provided with a plurality of threaded holes, and bolts are threadedly connected to the plurality of threaded holes respectively, and the threaded ends of the plurality of bolts are respectively threadedly connected to the interior of the plurality of threaded grooves.

[0009] Preferably, the connecting pipe is provided with a second valve.

[0010] Preferably, the top surface of the granulation box has two limiting holes, and limiting posts are slidably inserted into the two limiting holes respectively. The bottom ends of the two limiting posts are fixedly connected to the top surface of the extrusion plate.

[0011] Preferably, a hopper is fixed to the top surface of each of the several material boxes, and the through holes of the several hoppers correspond to a several feeding holes.

[0012] Compared with existing technologies, a granulation equipment for granule production using the above-mentioned technical solution has the following beneficial effects:

[0013] 1. In use, the combined use of the mixing tank, sealing cover, first drive motor, spiral stirring rod, U-shaped frame, stirring slant bar, first elastic scraper, and second elastic scraper facilitates multi-directional and multi-form mixing and scraping, avoids the occurrence of mixing dead corners, achieves efficient and uniform mixing of various powdered agents in the mixing tank, improves the uniformity of mixing of various powdered agents, and ensures the stable quality of granules produced subsequently.

[0014] Second, during use, no liquid binder needs to be added during the entire granulation process, avoiding potential changes in drug composition due to drying in wet granulation. The use of threaded grooves, threaded holes, and bolts facilitates the disassembly and assembly of the sealing cap, making it easy for workers to clean the interior of the mixing tank.

[0015] Third, during use, staff can open the second valve as needed according to the production schedule, allowing the mixed agent to smoothly enter the granulation box through the connecting pipe for subsequent granulation operations. The use of the limiting hole and limiting post effectively limits the extrusion plate, ensuring it does not shift or shake during lifting and lowering, thus improving stability. The hopper makes it easier and more efficient for staff to add powdered agents to the loading box, reducing the possibility of agent spillage. Attached Figure Description

[0016] Figure 1 This is a three-dimensional schematic diagram of an embodiment.

[0017] Figure 2 This is a breakdown diagram of an embodiment.

[0018] Figure 3 This is a cross-sectional view of the mixing tank in an embodiment.

[0019] Figure 4 Examples Figure 2 Enlarged diagram of point A in the middle.

[0020] In the diagram: 1. Mixing tank; 2. Granulation tank; 3. Sealing cover; 4. First drive motor; 5. Spiral stirring rod; 6. U-shaped frame; 7. Stirring plate; 8. Stirring bar; 9. First elastic scraper; 10. Second elastic scraper; 11. Feeding box; 12. Discharge pipe; 13. First valve; 14. Connecting pipe; 15. Insertion hole; 16. Pull-out plate; 17. Extrusion plate; 18. Hydraulic cylinder; 19. Crushing roller; 20. Second drive motor; 21. Collection box; 22. Threaded groove; 23. Threaded hole; 24. Bolt; 25. Second valve; 26. Limiting hole; 27. Limiting post; 28. Hopper. Detailed Implementation

[0021] The preferred embodiments of this utility model will now be described in detail with reference to the accompanying drawings.

[0022] like Figures 1-4 As shown, a granulation device for granule production includes a mixing tank 1, which is fixed to the top surface of a granulation box 2. A sealing cover 3 is detachably provided on the top surface of the mixing tank 1. A first drive motor 4 is fixed to the top surface of the sealing cover 3. The output shaft of the first drive motor 4 passes through the sealing cover 3 and is fixed to a spiral stirring rod 5. A U-shaped frame 6 is fixed to the bottom end of the spiral stirring rod 5. A stirring plate 7 is fixed to the front and rear sides of the inner wall of the U-shaped frame 6. Two stirring inclined rods 8 are fixed to the front and rear sides of the inner wall of the U-shaped frame 6. A first elastic scraper 9 is fixed to the front and rear sides of the outer wall of the U-shaped frame 6. A second elastic scraper 10 is fixed to the bottom surface of the U-shaped frame 6. Several material boxes 11 are provided above the sealing cover 3. Each of the material boxes 11 has a feed inlet on its top surface. Each of the material boxes 11 is connected to the sealing cover 3 by a discharge pipe 12. Each of the discharge pipes 12 is provided with a first valve 13.

[0023] In operation, the operator first adds different powdered agents through the inlets at the top of several loading boxes 11. After the agents enter the loading boxes 11, the operator opens several first valves 13. At this time, the powdered agents in the loading boxes 11 smoothly enter the mixing tank 1 through several discharge pipes 12. Then, the first drive motor 4 is started. The output shaft of the first drive motor 4 drives the spiral stirring rod 5 to rotate at high speed. The rotation of the spiral stirring rod 5 applies a vertical mixing force to the various powdered agents, causing the agents to continuously tumble and mix in the vertical direction. At the same time, the spiral stirring rod 5 drives the U-shaped frame 6 to rotate, and the inner wall of the U-shaped frame 6... The front and rear fixed stirring plates 7 rotate in the same horizontal plane to stir the agent horizontally, further promoting the mixing of the agent. The stirring bar 8 provides stirring action at different angles, enhancing the deagglomeration effect of the powder and ensuring that the agent can be fully dispersed and mixed evenly. During the stirring process, the first elastic scraper 9 fixed to the front and rear sides of the outer wall of the U-shaped frame 6 and the second elastic scraper 10 fixed to the bottom surface also rotate. The first elastic scraper 9 adheres to the inner wall of the mixing box 1 and scrapes off the agent adhering to the inner wall in time to prevent agent residue. The second elastic scraper 10 scrapes the material on the bottom surface of the mixing box 1 to prevent the agent from accumulating at the bottom. The combined use of mixing tank 1, sealing cover 3, first drive motor 4, spiral stirring rod 5, U-shaped frame 6, stirring inclined rod 8, first elastic scraper 9, and second elastic scraper 10 facilitates multi-directional and multi-form mixing and scraping, avoids the occurrence of mixing dead zones, and achieves efficient and uniform mixing of various powdered agents in mixing tank 1. This improves the uniformity of mixing of various powdered agents and ensures the stable quality of granules produced subsequently.

[0024] like Figures 1-4As shown, a connecting pipe 14 is fixedly connected between the mixing tank 1 and the granulation tank 2. An insertion hole 15 is provided on the front side of the granulation tank 2. A pull plate 16 is slidably arranged inside the insertion hole 15. An extrusion plate 17 is movably arranged inside the granulation tank 2. A hydraulic cylinder 18 is fixed on the top surface of the granulation tank 2. One end of the telescopic rod of the hydraulic cylinder 18 passes through the granulation tank 2 and is fixedly connected to the top surface of the extrusion plate 17. Two crushing rollers 19 are rotatably arranged inside the granulation tank 2. The crushing rollers 19 are existing structures. For reference, please refer to the Chinese patent publication with announcement number CN222325092U. The crushing rollers 19 in this application document are the same as the crushing rollers in the referenced document. A second drive motor 20 is fixed on the right side of the outer wall of the granulation tank 2. The output shafts of the two second drive motors 20 pass through the granulation tank 2 respectively and are fixedly connected to the right ends of the two crushing rollers 19 respectively. A collection box 21 is slidably arranged on the front side of the granulation tank 2.

[0025] In use, after the powdered medicine inside the mixing tank 1 is mixed, it enters the granulation tank 2 through the connecting pipe 14 and falls onto the pull plate 16. Then, the hydraulic cylinder 18 is activated to move the extrusion plate 17 downward, which can extrude the powdered medicine on the pull plate 16 into a cake shape. Then, the pull plate 16 is pulled out, and the two second drive motors 20 are activated to make the two crushing rollers 19 rotate in opposite directions, crushing the cake-shaped medicine into granules. Finally, the granules fall into the collection box 21. The entire granulation process does not require the addition of liquid binder, avoiding the changes in drug composition that may be caused by drying in wet granulation.

[0026] like Figures 1-3 As shown, the top surface of the mixing tank 1 is provided with several threaded grooves 22, the top surface of the sealing cover 3 is provided with several threaded holes 23, and bolts 24 are threadedly connected to the several threaded holes 23 respectively. The threaded ends of the several bolts 24 are respectively threadedly connected to the inside of the several threaded grooves 22. A second valve 25 is provided on the connecting pipe 14.

[0027] During use, the use of the threaded groove 22, threaded hole 23, and bolt 24 facilitates the disassembly and assembly of the sealing cover 3, thereby enabling workers to clean the interior of the mixing tank 1. The second valve 25 allows workers to control the flow of chemicals between the mixing tank 1 and the granulation tank 2. During the mixing of the powdered chemicals in the mixing tank 1, the second valve 25 is closed to prevent premature entry of chemicals into the granulation tank 2, ensuring uninterrupted mixing and thorough, uniform mixing. Once the chemicals in the mixing tank 1 are fully mixed, workers can open the second valve 25 as needed, according to the production schedule, allowing the mixed chemicals to smoothly enter the granulation tank 2 through the connecting pipe 14 for subsequent granulation operations.

[0028] like Figure 1 , Figure 2 and Figure 4As shown, the top surface of the granulation box 2 has two limiting holes 26, and the two limiting holes 26 are respectively slidably inserted with limiting posts 27. The bottom ends of the two limiting posts 27 are respectively fixedly connected to the top surface of the extrusion plate 17. The top surfaces of several material boxes 11 are respectively fixed with hoppers 28, and the through holes of several hoppers 28 correspond to several feeding holes.

[0029] During use, the combination of the limiting hole 26 and the limiting post 27 helps to limit the extrusion plate 17, ensuring that it will not deviate or shake during lifting and lowering, thus improving stability. The hopper 28 makes it easier and more efficient for workers to add powdered agents to the material box 11, reducing the possibility of agent spillage.

[0030] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A granulation device for producing granules, comprising a mixing tank (1) fixed to the top surface of a granulation box (2), characterized in that, The top surface of the mixing tank (1) is detachably equipped with a sealing cover (3). A first drive motor (4) is fixed to the top surface of the sealing cover (3). The output shaft of the first drive motor (4) passes through the sealing cover (3) and is fixed with a spiral stirring rod (5). A U-shaped frame (6) is fixed to the bottom end of the spiral stirring rod (5). Stirring plates (7) are fixed to the front and rear sides of the inner wall of the U-shaped frame (6). Two stirring slant rods are fixed to the front and rear sides of the inner wall of the U-shaped frame (6). 8) The front and rear sides of the outer wall of the U-shaped frame (6) are respectively fixed with a first elastic scraper (9), the bottom surface of the U-shaped frame (6) is fixed with a second elastic scraper (10), a plurality of loading boxes (11) are provided above the sealing cover (3), the top surface of the plurality of loading boxes (11) is provided with a feeding port, the plurality of loading boxes (11) and the sealing cover (3) are respectively connected and fixed with a discharge pipe (12), and a first valve (13) is provided on the plurality of discharge pipes (12).

2. The granulation equipment for granule production according to claim 1, characterized in that: A connecting pipe (14) is fixedly connected between the mixing tank (1) and the granulation tank (2). An insertion hole (15) is provided on the front side of the granulation tank (2). A pull plate (16) is slidably provided inside the insertion hole (15). An extrusion plate (17) is movably provided inside the granulation tank (2). A hydraulic cylinder (18) is fixed on the top surface of the granulation tank (2). One end of the telescopic rod of the hydraulic cylinder (18) passes through the granulation tank (2) and is fixedly connected to the top surface of the extrusion plate (17). Two crushing rollers (19) are rotatably provided inside the granulation tank (2). A second drive motor (20) is fixed on the right side of the outer wall of the granulation tank (2). The output shafts of the two second drive motors (20) pass through the granulation tank (2) respectively and are fixedly connected to the right end of the two crushing rollers (19) respectively. A collection box (21) is slidably provided on the front side of the granulation tank (2).

3. The granulation equipment for granule production according to claim 2, characterized in that: The top surface of the mixing tank (1) is provided with several threaded grooves (22), and the top surface of the sealing cover (3) is provided with several threaded holes (23). Bolts (24) are threadedly connected to the several threaded holes (23), and the threaded ends of the several bolts (24) are threadedly connected to the inside of the several threaded grooves (22).

4. The granulation equipment for granule production according to claim 3, characterized in that: A second valve (25) is provided on the connecting pipe (14).

5. The granulation equipment for granule production according to claim 2, characterized in that: The top surface of the granulation box (2) has two limiting holes (26), and the two limiting holes (26) are respectively slidably inserted with limiting posts (27), and the bottom ends of the two limiting posts (27) are respectively fixedly connected to the top surface of the extrusion plate (17).

6. The granulation equipment for granule production according to claim 5, characterized in that: A hopper (28) is fixed on the top surface of a plurality of the loading boxes (11), and the through holes of the plurality of hoppers (28) correspond to a plurality of feeding holes.

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