Biochemical reaction device

Abstract

A biochemical reaction device comprises a bearing frame and at least one biochemical reaction unit arranged on the bearing frame. The biochemical reaction unit comprises a driving assembly arranged on the bearing frame, a storage assembly arranged on the driving assembly, a pipetting assembly arranged on the bearing frame and above the storage assembly, and a biochemical reaction assembly in communication with the pipetting assembly. The storage assembly is used to detachably mount a fluid storage structure storing fluid. The driving assembly can drive the storage assembly to move the fluid storage structure in a vertical direction, so that the pipetting assembly extends into or exits a hole position of the fluid storage structure, and a fluid loading process is completed. The biochemical reaction device can realize automatic loading of reagents and samples, improve loading efficiency and loading success rate, and is particularly suitable for loading of gene sequencing samples.

Description

Technical Field

[0001] This application relates to the field of biochemistry, and more particularly to a biochemical reaction apparatus. Background Technology

[0002] In fields such as biology, chemistry, or medicine, such as gene sequencing, steps such as library construction, sample preparation, sample loading, and sequencing are usually required. These steps all involve loading the biochemical samples and reagents used into the sequencing chip.

[0003] However, most existing pipetting methods require manual operation, which is cumbersome and time-consuming, and the success rate of fluid loading is low. Whether loading is successful largely depends on the operator's skill level. Utility Model Content

[0004] In view of this, in order to solve at least one of the above defects, it is necessary to propose a biochemical reaction device.

[0005] This application provides a biochemical reaction apparatus, including: at least one biochemical reaction unit, the biochemical reaction unit including: a support frame, a driving component disposed on the support frame, a storage component disposed on the driving component, a pipetting component mounted on the support frame and located above the storage component, and a biochemical reaction component communicating with the pipetting component, wherein the storage component is configured to detachably install a fluid storage structure, the fluid storage structure being used to store fluid required for the biochemical reaction, the driving component being able to drive the storage component to move the fluid storage structure in a vertical direction, so that the pipetting component extends into or exits the orifice of the fluid storage structure.

[0006] In some possible embodiments, the driving component may also drive the storage component, thereby moving the fluid storage structure along a first direction perpendicular to the vertical direction, so that the pipetting component is positioned above different orifices of the fluid storage structure.

[0007] In some possible embodiments, the drive assembly includes: a first drive mechanism disposed on the support frame and a second drive mechanism disposed on the first drive mechanism, the storage assembly being disposed on the second drive mechanism, the first drive mechanism being capable of driving the storage assembly and the fluid storage structure to move along the vertical direction, and the second drive mechanism being capable of driving the storage assembly and the fluid storage structure to move along the first direction.

[0008] In some possible embodiments, the second driving mechanism includes: a slide rail disposed on the first driving mechanism, a slider disposed on the slide rail, a mounting plate disposed on the slider, a driving member disposed on the first driving mechanism, a transmission member disposed on the output shaft of the driving member, and a sliding guide plate disposed between the transmission member and the mounting plate. The slide rail and the transmission member both extend along the first direction. The slider is connected to the transmission member. The driving member can drive the transmission member to rotate, thereby causing the mounting plate to slide relative to the sliding guide plate along the first direction.

[0009] In some possible embodiments, the pipetting assembly includes a plurality of pipettes arranged side by side along a second direction, the second direction being perpendicular to the vertical direction and the first direction.

[0010] In some possible embodiments, the storage component includes a first storage location and a second storage location, the first storage location being for removable mounting of the fluid storage structure for storing reagents, and the second storage location being for removable mounting of the fluid storage structure for storing samples.

[0011] In some possible embodiments, the biochemical reaction device further includes a first detection component and a second detection component, wherein the first detection component is used to detect whether the fluid storage structure in the first storage position is installed in place, and the second detection component is used to detect whether the fluid storage structure in the second storage position is installed in place.

[0012] In some possible embodiments, the first detection component includes: a first detector disposed at one end of the driving component and a first sensing element disposed at the first storage location; the second detection component includes: a second detector disposed at one end of the driving component and a second sensing element disposed at the second storage location.

[0013] In some possible embodiments, the biochemical reaction apparatus includes a plurality of biochemical reaction units arranged side by side on the support frame, and the plurality of biochemical reaction units are independently controlled.

[0014] In some possible embodiments, the biochemical reaction assembly includes a stage and a temperature control structure disposed on the stage. The stage includes a mounting groove for detachably mounting a biochemical reaction substrate. The temperature control structure extends through the mounting groove and can contact the substrate.

[0015] In the biochemical reaction apparatus provided in this application embodiment, each biochemical reaction unit integrates a driving component, a storage component, a pipetting component, and a biochemical reaction component. No special debugging is required between these components, facilitating assembly and maintenance. The coordinated operation of these components enables automatic fluid loading, resulting in simple and efficient fluid loading. This effectively avoids inconsistencies caused by manual pipetting, improving loading success rate and the accuracy of the biochemical reaction. Furthermore, the driving component can move along a first direction, enabling pipetting operations at multiple orifices on the fluid storage structure. A smaller number of pipettes are needed for fully automated loading of various reagents, saving a significant number of pipette needles and further simplifying the structural complexity and piping design of the biochemical reaction apparatus. Additionally, the YZ motion platform formed by the driving component only needs to move in two directions, resulting in a simple structure, saving driving space, and contributing to a reduction in the size of the biochemical reaction apparatus. Attached Figure Description

[0016] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings used in the embodiments of this application will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a modular architecture diagram of a biochemical reaction device provided in an embodiment of this application.

[0018] Figure 2 This is a schematic diagram of the structure of a biochemical reaction device provided in an embodiment of this application.

[0019] Figure 3 for Figure 2 A schematic diagram of the drive mechanism.

[0020] Figure 4 for Figure 3 Exploded view of the drive mechanism.

[0021] Figure 5 for Figure 2 A schematic diagram of the structure of the storage component.

[0022] Figure 6 for Figure 5 A schematic diagram of a fluid storage structure mounted on a storage component.

[0023] Figure 7 for Figure 2 A schematic diagram of the structure of the biochemical reaction components and the carrier without installation.

[0024] Explanation of main component symbols

[0025]

[0026] The following detailed description, in conjunction with the accompanying drawings, will further illustrate this application. Detailed Implementation

[0027] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments.

[0028] It should be noted that when a component is described as "fixed to" or "mounted to" another component, it can be directly on the other component or may be interspersed with an intermediate component. When a component is described as "set to" another component, it can be directly set on the other component or may be interspersed with an intermediate component. The term "and / or" as used herein includes all and any combination of one or more of the associated listed items.

[0029] Please see Figure 1 and Figure 2 As shown, this application provides a biochemical reaction apparatus 100, which can be used for the reaction process of biochemical substances in the fields of biology, chemistry, or medicine. For example, it can be used to load gene sequencing samples onto sequencing slides. The biochemical reaction apparatus 100 includes at least one biochemical reaction unit 10. The biochemical reaction unit 10 includes: a support frame 1, a driving component 2 disposed on the support frame 1, a storage component 3 disposed on the driving component 2, a pipetting component 4 disposed on the support frame 1 and above the storage component 3, and a biochemical reaction component 5 communicating with the pipetting component 4.

[0030] The storage component 3 is configured to detachably mount the fluid storage structure 20. The fluid storage structure 20 stores the fluid required for biochemical reactions. This fluid can be, for example, a biological sample (such as a nucleic acid sample, human blood sample, tissue sample, or saliva sample), an adapter, reagents used in biochemical analysis, or a mixture of biological samples, reagents, and sample carriers (such as magnetic beads), but is not limited to these. The drive component 2 drives the storage component 3, thereby moving the fluid storage structure 20 located on the storage component 3 along the vertical direction Z, so that the pipetting component 4 extends into or exits the orifice 201 of the fluid storage structure 20. Furthermore, the fluid storage structure 20 may include at least one row of orifices 201 arranged along a first direction Y perpendicular to the vertical direction Z. The drive component 2 can also drive the storage component 3, thereby moving the fluid storage structure 20 along the first direction Y, so that the pipetting component 4 can be positioned above different orifices 201 of the fluid storage structure 20, enabling the pipetting component 4 to switch between different orifices 201 of the fluid storage structure 20. The biochemical reaction assembly 5 is used to hold the slide 30 for biochemical reactions. The slide 30 holds the sample to be tested and the corresponding reagents; for example, the slide 30 can be a gene sequencing slide. The pipetting assembly 4, after extending into the well 201 of the fluid storage structure 20, can aspirate the fluid from the well 201 and load the fluid into the slide 30 on the biochemical reaction assembly 5. Once the pipetting assembly 4 loads the fluid from the fluid storage structure 20 into the slide 30 on the biochemical reaction assembly 5, the biochemical reaction assembly 5 can perform a biochemical reaction on the fluid (including the sample to be tested and reagents) within the slide 30.

[0031] Please see Figure 3 and Figure 4 As shown, refer to the following: Figure 2The driving component 2 includes a first driving mechanism 21 mounted on the support frame 1 and a second driving mechanism 22 mounted on the first driving mechanism 21. The storage component 3 is mounted on the second driving mechanism 22. The first driving mechanism 21 can drive the storage component 3 and the fluid storage structure 20 located on the storage component 3 to move in the vertical direction Z, and the second driving mechanism 22 can drive the storage component 3 and the fluid storage structure 20 located on the storage component 3 to move in the first direction Y. The cooperation of the first driving mechanism 21 and the second driving mechanism 22 constitutes the YZ motion platform, which can realize the lifting and lowering and front-back position adjustment of the fluid storage structure 20 located on the storage component 3. This allows the stationary pipetting component 4 to extend into different holes 201 of the fluid storage structure 20 to complete the automatic loading of fluid in different holes 201, which can improve loading efficiency and loading success rate. Moreover, the structure of the above YZ motion platform is simple, and the pipetting component 4 does not require a complex driving mechanism for driving, which effectively simplifies the structural complexity of the biochemical reaction device 100 and reduces the volume of the biochemical reaction device 100.

[0032] like Figure 2 and Figure 3 As shown, the first drive mechanism 21 includes a first mounting plate 211, a first drive member 212, multiple guide shafts 213, and a connecting plate 214. The support frame 1 includes a bracket 11 and a support plate 12 located on the bracket 11. The first mounting plate 211 is located above the support plate 12, and the connecting plate 214 is located below the support plate 12. The guide shafts 213 movably pass through the support plate 12, with one end connected to the first mounting plate 211 and the other end connected to the connecting plate 214. The output shaft of the first drive member 212 is connected to the first mounting plate 211 and extends vertically in the Z direction. The second drive mechanism 22 is mounted on the first mounting plate 211. Driven by the first drive member 212, the first mounting plate 211 can move up and down relative to the support plate 12, thereby driving the second drive mechanism 22 and the storage component 3 located thereon to move up and down, thus realizing the up and down movement of the fluid storage structure 20. The length direction of the first mounting plate 211 is the first direction Y, and the second drive mechanism 22 can move along the first direction Y on the first mounting plate 211.

[0033] like Figures 2 to 4As shown, the second drive mechanism 22 includes: a slide rail 221 disposed on the first drive mechanism 21, a slider 222 disposed on the slide rail 221, a mounting plate (here named the second mounting plate 223) disposed on the slider 222, a second drive member 224 disposed on the first drive mechanism 21 (specifically the first mounting plate 211), a transmission member 225 disposed on the output end of the second drive member 224, and a sliding guide plate 226 disposed between the transmission member 225 and the second mounting plate 223. The slide rail 221, the conveyor 225, and the sliding guide plate 226 all extend along the first direction Y. The slider 222 is connected to the conveyor 225, and the second mounting plate 223 is fixed to the slider 222. Driven by the conveyor 225, the second mounting plate 223 can slide relative to the sliding guide plate 226 along the first direction Y, thereby driving the storage component 3 and the fluid storage structure 20 located on the second mounting plate 223 to move along the first direction Y, so that different holes 201 in the same row of the fluid storage structure 20 are located directly below the pipetting component 4, thereby realizing the switching of different holes 201. By adding the sliding guide plate 226, the stability of the storage component 3 and the fluid storage structure 20 during the sliding process can be improved. In some embodiments, the conveyor 225 can be a transmission belt.

[0034] Please refer to it again. Figure 1 and Figure 2 As shown, the pipetting assembly 4 includes a pipette 41, a tubing structure 42 connected to the pipette 41, and a power source 43. The tubing structure 42 enables fluid connection between the pipette 41, the power source 43, and the biochemical reaction assembly 5. When the second drive mechanism 22 moves the storage assembly 3 along the first direction Y, thereby moving the corresponding orifice 201 of the fluid storage structure 20 directly below the pipette 41, the first drive mechanism 21 will drive the storage assembly 3 and the fluid storage structure 20 to rise, causing the pipette 41 to extend into the corresponding orifice 201. After the pipette 41 extends into the orifice 201, the power source 43 is activated. Through the power source 43, the tubing structure 42, and the pipette 41, the fluid in the orifice 201 can be drawn and loaded into the biochemical reaction assembly 5, completing the automatic loading process.

[0035] In some embodiments, the pipetting assembly 4 includes a plurality of pipetting needles 41 arranged side by side along a second direction X, wherein the second direction X is perpendicular to the vertical direction Z and the first direction Y, that is, the first direction Y, the second direction X, and the vertical direction Z approximately constitute a three-dimensional coordinate system. When multiple rows of orifices 201 are provided on the fluid storage structure 20, the pipetting assembly 4 includes a plurality of pipetting needles 41 arranged side by side, each pipetting needle 41 being used to transfer fluid within the same row of orifices 201, thus enabling automatic loading of more fluid and further improving loading efficiency.

[0036] In some embodiments, the piping structure 42 may include piping and a reversing element for selecting the direction of fluid flow, such as a solenoid valve, a rotary valve, etc.

[0037] In some embodiments, the power source 43 may include various types of power sources for driving fluid movement, such as syringe pumps, plunger pumps, diaphragm pumps, gear pumps, and peristaltic pumps.

[0038] In some embodiments, the carrier 1 is provided with a support frame 13, which is mounted above the drive assembly 2 and the storage assembly 3, and the pipette 41 is disposed through the support frame 13.

[0039] Please see Figure 5 and Figure 6 As shown, refer to the following: Figure 2 As shown, the storage component 3 includes a first storage position 31 and a second storage position 32. The first storage position 31 is used for the detachable installation of a fluid storage structure 20 for storing reagents (defined as the first fluid storage structure 20a), and the second storage position 32 is used for the detachable installation of a fluid storage structure 20 for storing samples (defined as the second fluid storage structure 20b).

[0040] like Figure 2 , Figure 5 and Figure 6 As shown, the first storage position 31 can be a groove-shaped structure, and the first fluid storage structure 20a is detachably installed within the groove-shaped structure. Specifically, the first fluid storage structure 20a integrates multiple rows of wells 201, each row of wells 201 may include one or more wells 201, and each well 201 can hold a reagent required for a biochemical reaction. This allows multiple pipettes 41 to correspondingly aspirate the reagents stored in each row of wells 201. For example, in the field of gene sequencing, the first fluid storage structure 20a can be a reagent plate capable of storing various reagents required for loading gene sequencing samples.

[0041] like Figure 2 , Figure 5 and Figure 6 As shown, along the first direction Y, the second storage position 32 is located at one end of the first storage position 31. In some embodiments, the second storage position 32 can be a mounting hole, and the second fluid storage structure 20b can be a sample tube detachably disposed in the mounting hole. Thus, when the driving component 2 drives the storage component 3 to move along the first direction Y, the pipetting component 4 can first aspirate the sample in the sample tube within the second storage position 32. Specifically, the reagents in the first fluid storage structure 20a are arranged sequentially along the first direction Y according to the loading order. In addition, the sample is usually loaded first, so the second storage position 32 is located at the front end of the first storage position 31. Here, "front end" means that according to the forward direction of the driving component 2, the second storage position 32 is located in front of the first storage position 31.

[0042] In some embodiments, the storage component 3 further includes a plurality of clearance positions 33 arranged side-by-side with the second storage position 32 along the second direction X. Since the first fluid storage structure 20a includes multiple rows of apertures 201, and the first fluid storage structure 20a has only one aperture 201, when a sample needs to be drawn from the first fluid storage structure 20a, the pipetting component 4 moves to the first storage position 31. At this time, driven by the driving component 2, the storage component 3 rises, one pipette 41 extends into the first fluid storage structure 20a, and several other pipettes 41 extend into the corresponding clearance positions 33. The clearance positions 33 prevent damage to pipettes 41 that are not needed for pipetting.

[0043] Please refer to it again. Figure 2 As shown, the biochemical reaction apparatus 100 also includes a first detection component 6 and a second detection component 7. The first detection component 6 is used to detect whether the first fluid storage structure 20a (i.e., reagent plate) in the first storage position 31 is properly installed; the first detection component 6 can be a positioning sensor. The second detection component 7 is used to detect whether the second fluid storage structure 20b (i.e., sample tube) in the second storage position 32 is properly installed; the second detection component 7 can also be a positioning sensor.

[0044] like Figure 2 and Figure 5 As shown, the first detection component 6 includes: a first detector 61 disposed on the support frame 1 and located at one end of the drive component 2, and a first sensing element 62 disposed in the first storage position 31. Specifically, the first sensing element 62 is disposed at the bottom of the first storage position 31 and extends into the first storage position 31. When the first fluid storage structure 20a is placed into the first storage position 31, the first sensing element 62 will be triggered, and at this time the first detector 61 will sense that the first fluid storage structure 20a is installed in the first storage position 31.

[0045] like Figure 2 and Figure 5 As shown, the second detection component 7 includes: a second detector 71 disposed on the support frame 1 and located at one end of the drive component 2, and a second sensing element 72 disposed in the second storage position 32. Specifically, the second sensing element 72 is disposed at the bottom of the second storage position 32 and extends into the second storage position 32. When the second fluid storage structure 20b is placed into the second storage position 32, the second sensing element 72 will be triggered. At this time, the second detector 71 will sense that the second fluid storage structure 20b is installed in the second storage position 32.

[0046] Please see Figure 2 and Figure 7As shown, the biochemical reaction assembly 5 includes a stage 51 and a temperature control structure 52 disposed on the stage 51. The stage 51 includes a mounting groove 53 for detachably mounting a biochemical reaction substrate 30. The temperature control structure 52 passes through the mounting groove 53 and can contact the substrate 30. In some embodiments, the biochemical reaction assembly 5 can be disposed on a support frame 13, and a pipette 41 is located at the front end of the biochemical reaction assembly 5 to facilitate fluid connection between the pipette 41 and the biochemical reaction assembly 5, thereby loading fluid onto the substrate 30.

[0047] Please refer to it again. Figure 1 and Figure 2 As shown, the biochemical reaction device 100 may include multiple biochemical reaction units 10, which can be independently controlled, enabling independent operation of multiple motion / fluid systems, and achieving multi-channel fluid loading and biochemical reaction. The multiple carrier plates 30 do not interfere with each other, improving the efficiency of the biochemical reaction. Furthermore, the assembly of the multiple biochemical reaction units 10 is simple, and the number of biochemical reaction units 10 can be flexibly increased or decreased according to actual needs.

[0048] In some embodiments, a plurality of biochemical reaction units 10 are arranged side by side.

[0049] The biochemical reaction device 100 is equipped with RFID code 8. By scanning and identifying RFID code 8, the fluid loading and biochemical reaction process can be carried out automatically.

[0050] The biochemical reaction apparatus 100 also includes a control component (not shown), which can control the coordinated operation of the drive component 2, the pipetting component 4 and the biochemical reaction component 5 to complete the fluid loading and biochemical reaction process.

[0051] Specifically, the biochemical reaction device 100 can be used for loading gene sequencing samples. For example, it can be a gene sequencing sample loading device. The following uses gene sequencing sample loading as an example to further illustrate the process of loading reagents and samples using the biochemical reaction device 100.

[0052] The slide 30 is installed into the mounting slot 53 of the stage 51. The slide 30 is mechanically positioned and / or adhered to the stage 51 by negative pressure adsorption. The negative pressure is used to determine whether the slide 30 is in place. The first fluid storage structure 20a (i.e., reagent plate) and the second fluid storage structure 20b (i.e., sample tube) are respectively installed into the first storage position 31 and the second storage position 32 of the storage component 3. After the reagent plate is placed in the first storage position 31, the first detection component 6 determines whether the reagent plate is in place; after the sample tube is placed in the second storage position 32, the second detection component 7 determines whether the sample tube is in place.

[0053] After the first fluid storage structure 20a, the second fluid storage structure 20b, and the slide 30 are installed in place, sample and reagent loading can be performed without manual intervention. The drive assembly 2 (i.e., the YZ motion platform) provides forward and backward movement, allowing the pipette 41 to switch the corresponding well position. The YZ motion platform also provides lifting and lowering movement, allowing the pipette 41 to extend into the corresponding well position. Once inserted, hydraulic power is provided by the power source 43 (such as a syringe pump) and tubing structure 42 of the pipetting assembly 4, enabling the switching and extraction of reagents within the reagent plate and the loading of DNB samples. When the YZ motion platform moves forward and backward to the corresponding position, the pipette 41 can extract the reagent from the corresponding position, satisfying the required reagent extraction sequence.

[0054] After the sample and reagents are loaded, the stage 51 is equipped with a temperature control structure 52 (with TEC) to raise and lower the temperature, thereby controlling the temperature of the reagents in the slide 30 to complete the sequencing reaction.

[0055] The biochemical reaction apparatus 100 provided in this application embodiment has the following beneficial effects:

[0056] (1) In the biochemical reaction device 100, each biochemical reaction unit 10 integrates a driving component 2, a storage component 3, a pipetting component 4 and a biochemical reaction component 5. No special debugging is required between the parts, which is convenient for assembly and maintenance. Automatic loading of fluid can be achieved through the cooperation of the parts. The fluid loading operation is simple and the loading efficiency is high. It can effectively avoid the consistency error caused by manual pipetting and improve the loading success rate and the accuracy of biochemical reaction.

[0057] (2) The drive assembly 2 can move along the first direction Y, enabling pipetting operations at multiple orifices 201 on the fluid storage structure 20. A smaller number of pipettes 41 can be used to achieve fully automated loading of various reagents, saving a significant number of pipettes and further simplifying the structural complexity and piping design of the biochemical reaction device 100. The YZ motion platform formed by the drive assembly 2 only needs to move in two directions, resulting in a simple structure, saving drive space, and helping to reduce the volume of the biochemical reaction device 100.

[0058] (3) The slide 30 on the biochemical reaction assembly 5 is directly connected to the pipetting assembly 4. After loading reagents and samples, the biochemical reaction can be completed automatically, which improves the overall efficiency and automation of the biochemical reaction. In addition, the biochemical reaction device 100 can integrate multiple biochemical reaction units 10 to realize multi-channel fluid loading and independent operation of biochemical reactions, further improving the efficiency of biochemical reactions.

[0059] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit it. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the spirit and scope of the technical solutions of this application.

Claims

1. A biochemical reaction apparatus, characterized in that, The device includes at least one biochemical reaction unit, comprising: a support frame, a drive assembly disposed on the support frame, a storage assembly disposed on the drive assembly, a pipetting assembly mounted on the support frame and located above the storage assembly, and a biochemical reaction assembly communicating with the pipetting assembly. The storage assembly is configured to detachably mount a fluid storage structure for storing fluids required for the biochemical reaction. The drive assembly can drive the storage assembly, thereby moving the fluid storage structure vertically to allow the pipetting assembly to extend into or retract from the orifice of the fluid storage structure.

2. The biochemical reaction apparatus as described in claim 1, characterized in that, The driving component can also drive the storage component, thereby moving the fluid storage structure along a first direction perpendicular to the vertical direction, so that the pipetting component is positioned above different orifices of the fluid storage structure.

3. The biochemical reaction apparatus as described in claim 2, characterized in that, The driving assembly includes: a first driving mechanism disposed on the support frame and a second driving mechanism disposed on the first driving mechanism, the storage assembly being disposed on the second driving mechanism, the first driving mechanism being able to drive the storage assembly and the fluid storage structure to move along the vertical direction, and the second driving mechanism being able to drive the storage assembly and the fluid storage structure to move along the first direction.

4. The biochemical reaction apparatus as described in claim 3, characterized in that, The second driving mechanism includes: a slide rail disposed on the first driving mechanism, a slider disposed on the slide rail, a mounting plate disposed on the slider, a driving member disposed on the first driving mechanism, a transmission member disposed on the output shaft of the driving member, and a sliding guide plate disposed between the transmission member and the mounting plate. The slide rail and the transmission member both extend along the first direction. The slider is connected to the transmission member. The driving member can drive the transmission member to rotate, thereby causing the mounting plate to slide relative to the sliding guide plate along the first direction.

5. The biochemical reaction apparatus as described in claim 2, characterized in that, The pipetting assembly includes a plurality of pipetting needles arranged side by side along a second direction, which is perpendicular to the vertical direction and the first direction.

6. The biochemical reaction apparatus as described in claim 1, characterized in that, The storage component includes a first storage location and a second storage location, wherein the first storage location is used for removable installation of the fluid storage structure for storing reagents, and the second storage location is used for removable installation of the fluid storage structure for storing samples.

7. The biochemical reaction apparatus as described in claim 6, characterized in that, It also includes a first detection component and a second detection component. The first detection component is used to detect whether the fluid storage structure in the first storage position is installed in place, and the second detection component is used to detect whether the fluid storage structure in the second storage position is installed in place.

8. The biochemical reaction apparatus as described in claim 7, characterized in that, The first detection component includes: a first detector disposed at one end of the driving component and a first sensing element disposed at the first storage location; The second detection component includes: a second detector disposed at one end of the driving component and a second sensor disposed at the second storage location.

9. The biochemical reaction apparatus as described in claim 1, characterized in that, The biochemical reaction device includes multiple biochemical reaction units arranged side by side on the support frame, and the multiple biochemical reaction units are independently controlled.

10. The biochemical reaction apparatus as described in claim 1, characterized in that, The biochemical reaction assembly includes a stage and a temperature control structure disposed on the stage. The stage includes a mounting groove for detachably mounting a biochemical reaction substrate. The temperature control structure passes through the mounting groove and can contact the substrate.

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