A distributor for preparing a chromatographic column

Abstract

The utility model belongs to the technical field of liquid chromatography, specifically is a kind of preparative chromatographic column with distributor, the front of distributor main body is respectively equipped with main distribution flow passage and multistage distribution flow passage group, main distribution flow passage is located in the middle part of distributor main body, and the both ends of main distribution flow passage are respectively communicated with multistage distribution flow passage group;Multistage distribution flow passage group includes sequentially connected multistage distribution flow passage, vertically bent connection between each adjacent grade distribution flow passage in multistage distribution flow passage group, vertically bent connection between main distribution flow passage and one grade distribution flow passage in multistage distribution flow passage group;The back of distributor main body is equipped with channel, and one end of distribution flow passage of last level in multistage distribution flow passage group is communicated with upper grade distribution flow passage, and the other end of distribution flow passage of last level in multistage distribution flow passage group is communicated with channel.The utility model has solved the problem that the distributor for preparing chromatographic column in prior art is not enough uniform to distribute fluid.

Description

Technical Field

[0001] This invention belongs to the field of liquid chromatography technology, specifically a distributor for preparing chromatographic columns. Background Technology

[0002] In preparative liquid chromatography columns, the relatively large column diameter leads to uneven distribution of the mobile phase. As the column diameter increases, more mobile phase flows through the center inlet, resulting in less flow at the edges and more uneven distribution in the middle. To address this issue, a distributor is typically used in preparative columns to ensure the mobile phase passes through the column uniformly.

[0003] A column distributor is a device used to distribute samples and injection solvents, playing a crucial role in chromatographic analysis. The column distributor ensures that the high-pressure mobile phase does not concentrate at a single point on the column bed, while simultaneously dispersing the sample brought in by the mobile phase across the column head for uniform separation, thus forming symmetrical chromatographic peaks.

[0004] However, existing distributor technology only focuses on ensuring that the distance from each distribution channel to each distribution orifice is equal, while ignoring the turbulence and other situations that occur at the corners of the flow channels. This results in huge differences between the flow directions at different angles during distribution, thus making the distribution uneven. Utility Model Content

[0005] In order to solve the problem of uneven fluid distribution in existing preparative chromatographic column distributors, the purpose of this invention is to provide a preparative chromatographic column distributor.

[0006] The objective of this utility model is achieved through the following technical solution:

[0007] This invention relates to a structure for preparing a distributor for a chromatographic column, comprising a distributor body. The front of the distributor body has a main distribution channel and a multi-stage distribution channel group. The main distribution channel is located in the middle of the distributor body, and both ends of the main distribution channel are connected to the multi-stage distribution channel group. The multi-stage distribution channel group includes sequentially connected multi-stage distribution channels, with each adjacent stage of the multi-stage distribution channel group connected by a vertical bend. The main distribution channel is connected to a first-stage distribution channel in the multi-stage distribution channel group by a vertical bend. The back of the distributor body has a channel. One end of the last stage distribution channel in the multi-stage distribution channel group is connected to the previous stage distribution channel, and the other end of the last stage distribution channel in the multi-stage distribution channel group is connected to the channel.

[0008] Another structure of the distributor for preparing a chromatographic column according to this invention includes a distributor body. The front of the distributor body has a main distribution channel and a multi-stage distribution channel group. The main distribution channel is located in the middle of the distributor body, and both ends of the main distribution channel are connected to the multi-stage distribution channel group. The multi-stage distribution channel group includes sequentially connected multi-stage distribution channels. Except for the last distribution channel of a stage, adjacent distribution channels of other stages in the multi-stage distribution channel group are connected by vertical bends. One end of the last distribution channel of a stage is vertically connected to the previous stage distribution channel. The main distribution channel is vertically bend-connected to the first-stage distribution channel in the multi-stage distribution channel group. A channel is provided on the back of the distributor body. One end of the last distribution channel of the multi-stage distribution channel group is connected to the previous stage distribution channel, and the other end of the last distribution channel of the multi-stage distribution channel group is connected to the channel.

[0009] Another structure of the distributor for preparing a chromatographic column according to this utility model includes a distributor body. A liquid injection hole is provided at the center of the distributor body. Multiple main distribution channels are equidistantly arranged around the periphery of the liquid injection hole in a circumferential direction. One end of each main distribution channel is connected to the liquid injection hole, and the other end of each main distribution channel is connected to a multi-stage distribution channel group. The multi-stage distribution channel group includes sequentially connected multi-stage distribution channels. Adjacent stages of the multi-stage distribution channel group are connected by vertical bends. The other end of each main distribution channel is connected by a vertical bend to a first-stage distribution channel in the multi-stage distribution channel group. A channel is provided on the back of the distributor body. One end of the last distribution channel in the multi-stage distribution channel group is connected to the previous stage distribution channel, and the other end of the last distribution channel in the multi-stage distribution channel group is connected to the channel.

[0010] Another structure of the distributor for preparing a chromatographic column according to this utility model includes a distributor body. A liquid injection hole is provided at the center of the distributor body. Multiple main distribution channels are equidistantly arranged around the periphery of the liquid injection hole in a circumferential direction. One end of each main distribution channel is connected to the liquid injection hole, and the other end of each main distribution channel is connected to a multi-stage distribution channel group. The multi-stage distribution channel group includes sequentially connected multi-stage distribution channels. Except for the last distribution channel of a stage, adjacent distribution channels of other stages in the multi-stage distribution channel group are connected by vertical bends. One end of the last distribution channel of a stage is vertically connected to the next higher-level distribution channel, and the other end of each main distribution channel is vertically bendable to a first-level distribution channel in the multi-stage distribution channel group. A channel is provided on the back of the distributor body. One end of the last distribution channel of the multi-stage distribution channel group is connected to the next higher-level distribution channel, and the other end of the last distribution channel of the multi-stage distribution channel group is connected to the channel.

[0011] Wherein: the vertical bend connection is a rounded transition connection.

[0012] The channels are arranged in multiple rows and columns, with equal spacing between adjacent channels.

[0013] The back of the distributor body is provided with multiple independent grooves. The bottom of each groove has a channel. The axial center line of each channel coincides with the center point of the groove. Each channel penetrates the distributor body and is connected to the other end of the groove and the last level of the multi-level distribution channel group.

[0014] The groove is a regular polygon or a circle.

[0015] The main body of the distributor is a centrally symmetrical shape.

[0016] The multi-level distribution channel group includes a first-level distribution channel, a second-level distribution channel, a third-level distribution channel, and a fourth-level distribution channel that are connected in sequence. One end of the first-level distribution channel is connected to the main distribution channel, the other end of the first-level distribution channel is connected to the second-level distribution channel, one end of the fourth-level distribution channel is connected to the third-level distribution channel, and the other end of the fourth-level distribution channel is connected to the channel.

[0017] The advantages and positive effects of this utility model are as follows:

[0018] 1. This utility model guides and distributes liquid by setting a main distribution channel on the main body of the distributor and a multi-level distribution channel group connected to the main distribution channel, so that the liquid flows evenly to various positions on the main body of the distributor, and flows out of the main body of the distributor at multiple points through the hole connected to one end of the channel at the end of the multi-level distribution channel group.

[0019] 2. The connection between the main distribution channel and the multi-level distribution channel group, as well as the connection between adjacent distribution channels in the multi-level channel group, are all designed to be perpendicular. This ensures that the distribution angle between each channel is consistent and that all channels flow at right angles. Even if turbulence exists, the consistent distribution angle at each channel connection ensures that the flow conditions at each channel connection are the same, resulting in a more uniform distribution of liquid through each channel. Attached Figure Description

[0020] Figure 1 This is a three-dimensional structural diagram of a main distribution channel of this utility model;

[0021] Figure 2 This is a front view of the structure of this utility model;

[0022] Figure 3 for Figure 2 Enlarged view of section A in the image;

[0023] Figure 4 This is a rear view of the structure of this utility model;

[0024] Figure 5 This is a three-dimensional structural diagram of the multiple main distribution channels of this utility model;

[0025] Wherein: 10 is the main body of the distributor, 20 is the main distribution channel, 30 is the multi-stage distribution channel group, 31 is the first-stage distribution channel, 32 is the second-stage distribution channel, 33 is the third-stage distribution channel, 34 is the fourth-stage distribution channel, 40 is the channel, 50 is the groove, and 60 is the injection hole. Detailed Implementation

[0026] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. Several embodiments of this utility model are shown in the drawings. However, this utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that the disclosure of this utility model will be more thorough and complete.

[0027] It should be noted that when a component is said to be "fixed to" another component, it can be directly on the other component or there may be an intervening component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there may be an intervening component. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0029] Example 1

[0030] like Figures 1-4As shown, the dispenser in this embodiment includes a dispenser body 10. The front of the dispenser body 10 has a main distributing channel 20 and a multi-level distributing channel group 30. The main distributing channel 20 is located in the middle of the dispenser body 10, and both ends of the main distributing channel 20 are connected to the multi-level distributing channel group 30. The multi-level distributing channel group 30 includes sequentially connected multi-level distributing channels. Except for the last distributing channel, adjacent distributing channels in the multi-level distributing channel group 30 are connected by vertical bends. One end of the last distributing channel is vertically connected to the previous level distributing channel. The main distributing channel 20 is vertically bend-connected to the first-level distributing channel in the multi-level distributing channel group 30. A channel 40 is provided on the back of the dispenser body 10. One end of the last distributing channel in the multi-level distributing channel group 30 is connected to the previous level distributing channel, and the other end of the last distributing channel in the multi-level distributing channel group 30 is connected to the channel 40.

[0031] Understandably, the liquid is guided and distributed by the main distribution channel 20 and the multi-stage distribution channel group 30 connected to the main distribution channel 20 on the distributor body 10, allowing the liquid to flow to various positions on the distributor body 10. The liquid then flows out at multiple points on the distributor body 10 through the orifice 40 connected to the other end of the last distribution channel in the multi-stage distribution channel group 30. The connection between the main distribution channel 20 and the multi-stage distribution channel group 30 is a vertical bend. The two ends of the distribution channels in the multi-stage channel group are connected to the upper and lower level channels respectively. This vertical connection design ensures that the distribution angles between each level of distribution channel are consistent, all flowing at right angles. Even in the presence of turbulence, the consistent distribution angles at the connection points of each level of distribution channel result in identical flow conditions at those points, leading to more uniform liquid distribution. Furthermore, in this embodiment, by reducing the flow rate and roughness within the flow channel, turbulence within the distribution channel can be avoided, thereby ensuring that the connection points of each level of distribution channel are laminar flows with consistent distribution angles; consequently, the liquid distribution within the distribution channel becomes more uniform and controllable. Therefore, this invention solves the problem of insufficiently uniform fluid distribution in existing preparative chromatography column distributors.

[0032] Specifically, the vertical bends are connected by a rounded transition. By setting a rounded transition at the connection of the distribution channels, there is a bend between the distribution channels, which allows the liquid to flow in a laminar flow manner within the distribution channels, making the liquid flow more controllable. Furthermore, the right-angle connection between the distribution channels allows the liquid to flow and be distributed in a preset direction within the distribution channels, thus ensuring that the liquid is simultaneously and evenly distributed to each channel 40 in a set laminar flow manner.

[0033] By way of example, and not limitation, in this embodiment, the multi-level distribution channel group 30 includes a first-level distribution channel 31, a second-level distribution channel 32, a third-level distribution channel 33, and a fourth-level distribution channel 34 connected in sequence. One end of the first-level distribution channel 31 is connected to the main distribution channel 20, and the other end of the first-level distribution channel 31 is connected to the second-level distribution channel 32. One end of the fourth-level distribution channel 34 is connected to the third-level distribution channel 33, and the other end of the fourth-level distribution channel 34 is connected to the orifice 40. In specific implementation, in the multi-level distribution channel group 30, each level of distribution channel is connected by a vertical bend in sequence. The highest-level distribution channel, i.e., the first-level distribution channel 31, is connected by a vertical bend in one end to the main distribution channel 20, and the last level of distribution channel is connected to the orifice 40. In this embodiment, the fourth-level channel is connected to the orifice 40. Furthermore, it should be noted that, in specific implementation, the number of levels of distribution channels in the multi-level distribution channel group 30 is adaptively adjusted according to the size of the distributor body 10; the larger the size of the distributor body 10, the more distribution channels and levels there are in the multi-level distribution channel group 30.

[0034] Specifically, the channels 40 are evenly distributed on the distributor body 10. In practice, by reasonably controlling the bending direction between each distribution channel, the channels 40 are evenly distributed on the distributor body 10. This ensures that the liquid can flow evenly from each area of ​​the distributor body 10 through the distribution channels, and that the liquid flows through the same path length into different channels 40, thereby achieving uniform distribution of the liquid on the distributor body 10.

[0035] Additionally, the distributor body 10 has a main distribution channel 20 on its front side and multiple channels 40 on its back side. In this embodiment, the channels 40 are arranged in multiple rows and columns, with equal spacing between adjacent channels 40. Multiple independent grooves 50 are formed on the back side of the distributor body 10. Each groove 50 has a channel 40 at its bottom, and the axial centerline of each channel 40 coincides with the center point of the groove 50. Each channel 40 penetrates the distributor body 10 and connects to the other end of the groove 50 and the last distribution channel in the multi-stage distribution channel group 30. In actual use, after the liquid is distributed into the channels 40 through the distribution channels, it flows out of the channels 40 and is evenly distributed within the grooves 50, thus achieving a finer secondary distribution and ultimately realizing efficient, uniform, and fine distribution of the mobile phase.

[0036] Specifically, multiple grooves 50 are independently and evenly distributed on the dispenser body 10, and the grooves 50 are polygonal or circular. By setting multiple independently and evenly distributed grooves 50, the back surface of the dispenser body 10 is evenly covered by the grooves 50, so that the liquid flows from the channel 40 into the grooves 50 and is evenly distributed on the surface of the dispenser body 10. Preferably, the grooves 50 are regular polygons. Compared with circles and non-regular polygons, the grooves 50 are easier to distribute and arrange, and can occupy more area on the surface of the dispenser body 10, thereby improving the uniform distribution effect of the grooves 50.

[0037] By way of example, and not limitation, in this embodiment, the distributor body 10 is circular. The distributor body 10 can be circular or other centrally symmetrical shapes. To ensure that the liquid flows along the same path to each channel 40, thereby achieving uniform liquid distribution, the distributor needs to be centrally symmetrical. For ease of manufacturing, a regular shape is used. A circular shape is chosen because the vertical bending connection of the flow channels ensures a uniform distribution of the channels 40, resulting in an arc-shaped outer contour after the convergence of the channels, thus ensuring the utilization efficiency of the distributor body 10. Therefore, a circular distributor body 10 is preferred.

[0038] Example 2

[0039] The difference between this embodiment and Embodiment 1 is that in this embodiment, adjacent distribution channels in the multi-level distribution channel group 30 are connected by vertical bends, and the main distribution channel 20 is connected to the first-level distribution channel in the multi-level distribution channel group 30 by vertical bends. Everything else is the same as in Embodiment 1.

[0040] Example 3

[0041] The difference between this embodiment and Embodiment 1 is that, as Figure 5 As shown, in this embodiment, an injection hole 60 is provided at the center of the distributor body 10. Multiple (four in this embodiment) main distribution channels 20 are equidistantly arranged around the injection hole 60 along the circumferential direction. One end of each main distribution channel 20 is connected to the injection hole 60, and the other end of each main distribution channel 20 is connected to a multi-stage distribution channel group 30. In practical implementation, when the distributor body 10 is large, multiple main distribution channels 20 are usually required instead of a single main distribution channel 20. Therefore, by providing an injection hole 60 at the center of the distributor body 10, the main distribution channels 20 are evenly distributed outside the injection hole 60, and the length direction of the main distribution channels 20 is perpendicular to the axis of the injection hole 60. This allows the liquid to first flow evenly through the injection hole 60 to each main distribution channel 20, and then the main distribution channels 20 and the multi-stage distribution channel group 30 evenly distribute the liquid into each channel 40. The rest is the same as in Embodiment 1.

[0042] Example 4

[0043] The difference between this embodiment and Embodiment 3 is that in this embodiment, the adjacent distribution channels in the multi-level distribution channel group 30 are connected by vertical bends, and the main distribution channel 20 is connected to the first-level distribution channel in the multi-level distribution channel group 30 by vertical bends. Everything else is the same as in Embodiment 3.

[0044] In summary, the preparative chromatographic column distributor in the above embodiments of this utility model guides and distributes the liquid through a main distribution channel 20 disposed on the distributor body 10 and a multi-stage distribution channel group 30 connected to the main distribution channel 20. This allows the liquid to flow to various positions on the distributor body 10 and exits at multiple points on the distributor body 10 through orifices 40 connected to one end of the last stage of the multi-stage distribution channel group 30. The connection between the main distribution channel 20 and the multi-stage distribution channel group 30 is a vertical bend. The two ends of the distribution channels in the multi-stage channel group are connected to the upper and lower stage channels respectively. This vertical connection design ensures that the distribution angles between each distribution channel are consistent, all flowing at right angles. Even in the presence of turbulence, the consistent distribution angles at the connection points of each stage ensure uniform flow conditions at the connection points, resulting in more uniform liquid distribution through each stage of the distribution channels. Furthermore, in practical implementation, the roughness within the flow channel can be reduced by lowering the flow rate, thus preventing turbulence within the distribution channel. This ensures that the connection points of each distribution channel are connected at a consistent laminar flow angle, resulting in more uniform and controllable liquid distribution within the distribution channel. Therefore, this invention solves the problem of insufficient fluid distribution in existing preparative chromatography column distributors.

[0045] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0046] The embodiments described above are merely illustrative of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A distributor for preparing a chromatographic column, characterized in that: The device includes a distributor body (10), on the front of which are respectively provided a main distribution channel (20) and a multi-level distribution channel group (30). The main distribution channel (20) is located in the middle of the distributor body (10), and both ends of the main distribution channel (20) are respectively connected to the multi-level distribution channel group (30). The multi-level distribution channel group (30) includes sequentially connected multi-level distribution channels. Each adjacent level distribution channel in the multi-level distribution channel group (30) is connected by a vertical bend. The main distribution channel (20) is connected to the first-level distribution channel in the multi-level distribution channel group (30) by a vertical bend. The back of the distributor body (10) is provided with a channel (40). One end of the last level distribution channel in the multi-level distribution channel group (30) is connected to the previous level distribution channel, and the other end of the last level distribution channel in the multi-level distribution channel group (30) is connected to the channel (40).

2. A distributor for preparing a chromatographic column, characterized in that: The device includes a distributor body (10), on the front of which are respectively provided a main distribution channel (20) and a multi-level distribution channel group (30). The main distribution channel (20) is located in the middle of the distributor body (10), and both ends of the main distribution channel (20) are connected to the multi-level distribution channel group (30). The multi-level distribution channel group (30) includes sequentially connected multi-level distribution channels. Except for the distribution channel at the end of the level, the adjacent distribution channels of the other levels in the multi-level distribution channel group (30) are connected to each other. The main distribution channel (20) and the first-level distribution channel in the multi-level distribution channel group (30) are connected by a vertical bend. The back of the distributor body (10) is provided with a channel (40). One end of the last-level distribution channel in the multi-level distribution channel group (30) is connected to the first-level distribution channel in the multi-level distribution channel group (30), and the other end of the last-level distribution channel in the multi-level distribution channel group (30) is connected to the channel (40).

3. A distributor for preparing a chromatographic column, characterized in that: The device includes a distributor body (10), with an injection hole (60) at its center. Multiple main distribution channels (20) are equidistantly arranged around the injection hole (60) along a circumferential direction. One end of each main distribution channel (20) is connected to the injection hole (60), and the other end of each main distribution channel (20) is connected to a multi-stage distribution channel group (30). The multi-stage distribution channel group (30) includes sequentially connected multi-stage distribution channels. Each adjacent level of the distribution channel in the group (30) is connected by a vertical bend. The other end of the main distribution channel (20) is connected by a vertical bend to the first-level distribution channel in the multi-level distribution channel group (30). The back of the distributor body (10) is provided with a channel (40). One end of the last level distribution channel in the multi-level distribution channel group (30) is connected to the next level distribution channel. The other end of the last level distribution channel in the multi-level distribution channel group (30) is connected to the channel (40).

4. A distributor for preparing a chromatographic column, characterized in that: The device includes a distributor body (10), with an injection hole (60) at its center. Multiple main distribution channels (20) are equidistantly arranged around the injection hole (60) along a circumferential direction. One end of each main distribution channel (20) is connected to the injection hole (60), and the other end of each main distribution channel (20) is connected to a multi-level distribution channel group (30). The multi-level distribution channel group (30) includes sequentially connected multi-level distribution channels. Except for the last distribution channel, the remaining channels in the multi-level distribution channel group (30) are... The adjacent distribution channels are connected by a vertical bend. One end of the distribution channel at the end of the level is connected vertically to the distribution channel at the next higher level. The other end of the main distribution channel (20) is connected vertically to the first-level distribution channel in the multi-level distribution channel group (30). The back of the distributor body (10) is provided with a channel (40). One end of the distribution channel at the end of the level in the multi-level distribution channel group (30) is connected to the distribution channel at the next higher level. The other end of the distribution channel at the end of the level in the multi-level distribution channel group (30) is connected to the channel (40).

5. The preparative chromatographic column distributor according to any one of claims 1 to 4, characterized in that: The vertical bend connection is a rounded transition connection.

6. The preparative chromatographic column distributor according to any one of claims 1 to 4, characterized in that: The channel (40) has multiple rows and columns, and the spacing between two adjacent channels (40) is equal.

7. The preparative chromatographic column distributor according to any one of claims 1 to 4, characterized in that: The back of the distributor body (10) is provided with a plurality of independent grooves (50), and the bottom of each groove (50) has a channel (40). The axial center line of each channel (40) coincides with the center point of the groove (50). Each channel (40) penetrates the distributor body (10) and is connected to the other end of the groove (50) and the last level of the multi-level distribution channel group (30).

8. The preparative chromatographic column distributor according to claim 7, characterized in that: The groove (50) is a regular polygon or a circle.

9. The preparative chromatographic column distributor according to any one of claims 1 to 4, characterized in that: The main body (10) of the distributor is a centrally symmetrical figure.

10. The preparative chromatographic column distributor according to any one of claims 1 to 4, characterized in that: The multi-level distribution channel group (30) includes a first-level distribution channel (31), a second-level distribution channel (32), a third-level distribution channel (33), and a fourth-level distribution channel (34) connected in sequence. One end of the first-level distribution channel (31) is connected to the main distribution channel (20), and the other end of the first-level distribution channel (31) is connected to the second-level distribution channel (32). One end of the fourth-level distribution channel (34) is connected to the third-level distribution channel (33), and the other end of the fourth-level distribution channel (34) is connected to the channel (40).

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