Needleless microfluidic injection device
The laser-driven needleless microfluidic injection device, through the cooperation of an elastic membrane and a connecting plate, solves the stability problem of spring-driven injection devices, achieves uniformity and safety of injection dosage, and reduces needle prick pain and infection risk.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- CHENGDU QIPU BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-07-04
- Publication Date
- 2026-06-30
AI Technical Summary
Among existing needle-free injection devices, spring-driven ones have poor stability, resulting in significant differences in injection dosage, and pose risks of needle prick pain and infection.
A laser generator is used to generate laser energy that acts on a pressurized liquid. Through the cooperation of the first and second elastic membranes and the connecting plate, a stable micro-jet injection is formed, avoiding spring drive and ensuring the uniformity and stability of the injected liquid.
This achieves stability and consistency in injection dosage, reduces needle prick pain and infection risk, and improves injection safety and efficiency.
Smart Images
Figure CN224421645U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of needle-free injection technology, and more specifically, to a needle-free microjet injection device. Background Technology
[0002] Current medical aesthetic treatments generally include phototherapy and injection. Injection treatments typically use needles to inject fillers into the skin. However, using needles for injections can cause many adverse reactions, such as needle prick pain, needle prick infection, and in some cases, fainting.
[0003] Needle-free injection technology is gradually becoming a new development trend. Needle-free injection devices utilize an external power source to generate a reaction, applying force to the liquid medication, thus creating a high-speed jet of the injection solution within the syringe, ultimately penetrating the skin and releasing its effects. Common types of needle-free injectors include spring-driven and electro-driven types. However, spring-driven injectors primarily use springs for operation, and the stability of springs is relatively poor, easily leading to significant variations in the dosage. Utility Model Content
[0004] This application provides a needle-free microfluidic injection device with good stability, which can improve the problem of large differences in injection dosage.
[0005] The embodiments of this application are implemented as follows:
[0006] This application provides a needle-free microfluidic injection device, which includes:
[0007] The main body has a pressure generating chamber and a liquid storage chamber arranged sequentially along its height. The pressure generating chamber is used to hold a pressurized liquid, and the liquid storage chamber is used to hold an injection solution. The bottom end of the pressure generating chamber is provided with a first elastic membrane to seal the bottom end of the pressure generating chamber, and the top end of the liquid storage chamber is provided with a second elastic membrane to seal the top end of the liquid storage chamber. The surfaces of the first elastic membrane and the second elastic membrane that are close to each other are connected by a connecting plate.
[0008] A laser generator, wherein the laser generator is used to generate laser light to react with a pressurized liquid to produce energy; and
[0009] Multiple nozzles are mounted at the bottom of the main body, and the interior of each nozzle communicates with the liquid storage chamber. The nozzles are used to spray the injection liquid from the liquid storage chamber.
[0010] In one possible implementation, the first elastic membrane and the second elastic membrane are silicone rubber membranes, fluororubber membranes, or polyurethane membranes.
[0011] In one possible implementation, the connecting plate is a circular plate, and the center line of the connecting plate coincides with the center lines of the first elastic membrane and the second elastic membrane.
[0012] In one possible implementation, the upper and lower surfaces of the connecting plate are joined by an arc surface.
[0013] In one possible implementation, the inner wall of the main body is provided with a first mounting groove and a second mounting groove, both of which are arranged circumferentially around the main body. The edge of the first elastic membrane is fixed in the first mounting groove by a first elastic adhesive layer, and the edge of the second elastic membrane is fixed in the second mounting groove by a second elastic adhesive layer.
[0014] In one possible implementation, the wall of the first mounting groove has a first arc-shaped transition surface, which is connected to the inner wall of the main body. A portion of the first elastic adhesive layer covers the first arc-shaped transition surface and is arc-shaped. The first elastic membrane can stretch along the surface of the first elastic adhesive layer on the first arc-shaped transition surface. The wall of the second mounting groove has a second arc-shaped transition surface, which is connected to the inner wall of the main body. A portion of the first elastic adhesive layer covers the first arc-shaped transition surface and is arc-shaped. The first elastic membrane can stretch along the surface of the first elastic adhesive layer on the first arc-shaped transition surface.
[0015] In one possible implementation, the first elastic adhesive layer and the second elastic adhesive layer are silicone sealant layers or fluororubber adhesive layers.
[0016] In one possible implementation, a distributor is provided at the lower end of the liquid storage chamber. The distributor has multiple diversion channels, which are distributed around the center line of the liquid storage chamber. The ports of the diversion channels near the second elastic membrane can all be projected onto the lower surface of the connecting plate. The nozzle is installed in the diversion channel.
[0017] In one possible implementation, the inner wall of the diversion channel has a ceramic layer.
[0018] In one possible implementation, the outer wall of the main body is also connected to a fluid replenishment connector, which communicates with the reservoir. The fluid replenishment connector is used to install and fix a syringe for replenishing the reservoir with injection fluid. The fluid replenishment connector is provided with an anti-backflow valve, which is configured to allow liquid to flow from the syringe to the reservoir while preventing liquid from flowing from the reservoir to the syringe.
[0019] The embodiments of this application have at least the following beneficial effects:
[0020] The needle-free microjet device of this application isolates the pressure generation chamber and the liquid storage chamber through a first elastic membrane and a second elastic membrane. A laser generator emits strong laser energy that acts on the pressurized liquid in the sealed pressure generation chamber, causing the pressurized liquid to generate bubbles. The shock waves generated by the expansion and collapse of these bubbles act on the first elastic membrane, causing the first and second elastic membranes to deform and rapidly extend towards the liquid storage chamber, pushing the injection liquid in the liquid storage chamber towards the nozzle. The liquid is then injected through the nozzle in a microjet manner with high speed. Since the surfaces of the first and second elastic membranes are connected by a connecting plate, the extension of the first and second elastic membranes towards the liquid storage chamber causes the connecting plate to move towards the liquid storage chamber as well. The surface of the connecting plate is flat, resulting in relatively uniform pressure on the liquid storage chamber corresponding to the position of the connecting plate. Furthermore, the absence of spring drive ensures good stability, which in turn helps to ensure a more consistent ejection speed and injection dosage from the nozzle, thus improving the problem of large differences in injection dosage. Attached Figure Description
[0021] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.
[0022] Figure 1 This is a schematic diagram of the structure of the needle-free microfluidic injection device according to an embodiment of this application;
[0023] Figure 2 for Figure 1 Enlarged view of region A in the middle;
[0024] Figure 3 This is a schematic diagram of the needle-free microfluidic injection device according to an embodiment of this application in another state;
[0025] Figure 4 This is a schematic diagram of the distribution of the diversion channels according to an embodiment of this application.
[0026] Icons: 10-Needle-free micro-jet injection device; 11-Main body; 111-Pressure generating chamber; 112-Liquid storage chamber; 113-First mounting groove; 1131-First arc-shaped transition surface; 114-Second mounting groove; 1141-Second arc-shaped transition surface; 12-Laser generator; 13-Nozzle; 141-First elastic membrane; 142-Second elastic membrane; 143-Connecting plate; 1431-Arc surface; 151-First elastic adhesive layer; 152-Second elastic adhesive layer; 16-Dispenser; 161-Dispensing channel; 17-Replenishment connector; 172-Anti-backflow valve. Detailed Implementation
[0027] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0028] Therefore, the following detailed description of the embodiments of this application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments of the application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.
[0029] In the description of this application, it should be noted that the terms "upper," "lower," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. In addition, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.
[0030] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances. Example
[0031] This embodiment provides a needle-free microfluidic injection device 10. Please refer to... Figures 1-3 It includes a main body 11, a laser generator 12 and a nozzle 13.
[0032] The main body 11 includes a pressure generating chamber 111 and a liquid storage chamber 112 arranged sequentially along its height. The pressure generating chamber 111 holds a pressurized liquid, and a first elastic membrane 141 is provided at the bottom of the pressure generating chamber 111 to seal the bottom. A laser generator 12 generates laser light to react with the pressurized liquid and generate energy. The laser generator 12 emits strong laser energy that acts on the pressurized liquid inside the sealed pressure generating chamber 111, causing the pressurized liquid to generate bubbles. The shock waves generated by the expansion and collapse of these bubbles act on the first elastic membrane 141. For example, the pressurized liquid can be ordinary water, such as distilled water or pure water.
[0033] The reservoir 112 is used to hold the injection solution, which can be selected according to actual needs. For example, the injection solution can be a collagen implant, an implant containing collagen and biodegradable polymer microspheres (such as PLLA microspheres, PCL microspheres), etc. This needle-free microfluidic injection device 10 can be used on the face, abdominal skin, or skin on the arms and legs. A second elastic membrane 142 is provided at the upper end of the reservoir 112 to seal the upper end of the reservoir 112. The surfaces of the first elastic membrane 141 and the second elastic membrane 142 that are close to each other are connected by a connecting plate 143, that is, the connecting plate 143 is connected and fixed to the lower surface of the first elastic membrane 141 and the upper surface of the second elastic membrane 142.
[0034] The laser generator 12 emits strong laser energy, which acts on the pressurized liquid in the sealed pressure generating chamber 111, causing the pressurized liquid to generate bubbles. The shock wave generated by the expansion and collapse of the bubbles acts on the first elastic membrane 141. The first elastic membrane 141, together with the second elastic membrane 142, deforms and extends rapidly to one side of the liquid storage chamber 112, pushing the injection liquid in the liquid storage chamber 112 toward the nozzle 13. The liquid is then injected through the nozzle 13 in a micro-jet manner, accompanied by high speed.
[0035] Since the surfaces of the first elastic membrane 141 and the second elastic membrane 142 that are close to each other are connected by the connecting plate 143, when the first elastic membrane 141 and the second elastic membrane 142 extend toward the liquid storage chamber 112, they will drive the connecting plate 143 to move toward the liquid storage chamber 112 together. Since the surface of the connecting plate 143 is flat, the pressure on the liquid storage chamber 112 corresponding to the position of the connecting plate 143 is relatively consistent, and there is no spring drive, so the stability is good. This is conducive to the consistent speed of the injection from the nozzle 13 and the consistent injection dosage, which can improve the problem of large differences in injection dosage.
[0036] Optionally, a fluid replenishment connector 17 is also connected to the outer wall of the main body 11. The fluid replenishment connector 17 communicates with the reservoir 112 and is used to mount and fix a syringe (not shown) for replenishing the reservoir 112 with injection fluid. Optionally, the fluid replenishment connector 17 is inclined relative to the main body 11, and the angle between the central axis of the fluid replenishment connector 17 and the central axis of the main body 11 is 30° to 60°, for example, any one or any two of 30°, 35°, 40°, 45°, 50°, 55°, and 60°. The fluid replenishment connector 17 is provided with an anti-backflow valve 172, which is configured to allow liquid to flow from the syringe to the reservoir 112 while preventing liquid from flowing from the reservoir 112 to the syringe side. Due to the anti-backflow valve 172, the injection solution in the syringe can be smoothly pushed into the reservoir 112 to replenish the injection solution in the reservoir 112, and the injection solution in the reservoir 112 is prevented from flowing back to the syringe side, which can better ensure the stability of the injection sprayed by the nozzle 13.
[0037] The anti-backflow valve 172 can be of various shapes, as long as it can achieve the anti-backflow function. For example, the anti-backflow valve 172 is formed of elastic rubber, and has a slit in the central area through which the supplementary injection solution flows. The slit is normally closed. When the supplementary injection solution is pushed from the syringe into the reservoir 112, the slit opens, allowing the supplementary injection solution to enter the reservoir 112. When the syringe stops pushing the injection solution into the reservoir 112, the slit closes due to the elastic restoring force of the anti-backflow valve 172, preventing the injection solution from flowing back from the reservoir 112.
[0038] In some embodiments, the first elastic membrane 141 and the second elastic membrane 142 are silicone rubber membranes, fluororubber membranes, or polyurethane membranes. These elastic membranes have a low elastic modulus, and can deform under slight pressure, which can reduce stress concentration and further facilitate uniform pressure transmission.
[0039] For example, the connecting plate 143 is a circular plate, and the center line of the connecting plate 143 coincides with the center lines of the first elastic membrane 141 and the second elastic membrane 142. When the laser generator 12 emits strong laser energy to act on the pressurized liquid in the pressure generating chamber 111, causing the pressurized liquid to generate bubbles, the shock waves generated by the expansion and collapse of the bubbles will act on the first elastic membrane 141. The connecting plate 143 will always move towards one side of the liquid storage chamber 112 with the deformation of the first elastic membrane 141, which can make the pressure transmission in the central area more uniform.
[0040] For example, the upper and lower surfaces of the connecting plate 143 are connected by an arc surface 1431. When the connecting plate 143, together with the first elastic membrane 141 and the second elastic membrane 142, moves toward one side of the liquid storage chamber 112, the connecting plate 143 will exert a certain amount of tension on the first elastic membrane 141 and the second elastic membrane 142. Since the upper and lower surfaces of the connecting plate 143 are connected by the arc surface 1431, the first elastic membrane 141 and the second elastic membrane 142 are less likely to be cut by the side edge of the connecting plate 143, which can improve their service life.
[0041] Further, in one embodiment, the inner wall of the main body 11 is provided with a first mounting groove 113 and a second mounting groove 114, both of which are arranged circumferentially around the main body 11. The pressure generating chamber 111 and the liquid storage chamber 112 both have circular cross-sections. The edge of the first elastic membrane 141 is fixed to the first mounting groove 113 by a first elastic adhesive layer 151, and the edge of the second elastic membrane 142 is fixed to the second mounting groove 114 by a second elastic adhesive layer 152. Since both the first elastic adhesive layer 151 and the second elastic adhesive layer 152 are elastic and not rigid materials, stress concentration is less likely to occur during deformation of the first elastic membrane 141 and the second elastic membrane 142, preventing rupture of either the first elastic membrane 141 or the second elastic membrane 142. Optionally, the first elastic adhesive layer 151 and the second elastic adhesive layer 152 are silicone sealant layers or fluororubber adhesive layers.
[0042] The groove wall of the first mounting groove 113 has a first arc-shaped transition surface 1131, which connects smoothly with the inner wall of the main body 11. That is, the first arc-shaped transition surface 1131 smoothly transitions with the inner wall of the main body 11. A portion of the first elastic adhesive layer 151 covers the first arc-shaped transition surface 1131 and is arc-shaped, such as... Figure 1 and Figure 2 As shown, a portion of the first elastic adhesive layer 151 bonds and fixes the first elastic film 141 within the first mounting groove 113, while the other portion covers the first arc-shaped transition surface 1131. During bonding, a portion of one side surface of the first elastic adhesive layer 151 can be covered with release paper, and the section covered with release paper is used to be bonded to the first arc-shaped transition surface 1131. After the first elastic film 141 is bonded and fixed in the first mounting groove 113 and the first elastic adhesive layer 151 has cured, the release paper is removed.
[0043] The first elastic membrane 141 can stretch along the first elastic adhesive layer 151 on the surface of the first arc-shaped transition surface 1131. When the first elastic membrane 141 stretches and deforms towards one end of the liquid storage chamber 112, since the first elastic membrane 141 can stretch along the first elastic adhesive layer 151 on the surface of the first arc-shaped transition surface 1131, there will be no sharp surfaces causing stress concentration or cuts on the first elastic membrane 141.
[0044] Similarly, the wall of the second mounting groove 114 has a second arc-shaped transition surface 1141, which connects to the inner wall of the main body 11. The second arc-shaped transition surface 1141 smoothly transitions to the inner wall of the main body 11. Part of the second elastic adhesive layer 152 covers the second arc-shaped transition surface 1141 and is arc-shaped. The second elastic membrane 142 can stretch along the surface of the second arc-shaped transition surface 1141. When the second elastic membrane 142 stretches and deforms towards one end of the liquid storage chamber 112, since the second elastic membrane 142 can stretch along the surface of the second arc-shaped transition surface 1141, there will be no sharp surfaces causing stress concentration or cuts on the second elastic membrane 142.
[0045] Furthermore, in one embodiment, a distributor 16 is provided at the lower end of the liquid storage chamber 112. The distributor 16 has multiple diversion channels 161, which are distributed around the center line of the liquid storage chamber 112. That is, the diversion channels 161 are arranged around the center line, and the distance between the multiple diversion channels 161 and the center line is the same (e.g., ...). Figure 4 (As shown). The ports of the diversion channels 161 near the second elastic membrane 142 can all be projected onto the lower surface of the connecting plate 143. When the connecting plate 143, along with the first elastic membrane 141 and the second elastic membrane 142, moves towards the liquid storage chamber 112, the pressure transmission through the connecting plate 143 is more uniform. Consequently, the pressure applied to each diversion channel 161 is also more uniform. Each diversion channel 161 has a nozzle 13 installed at its lower port. When multiple nozzles 13 are provided, the dosage of the injection solution sprayed from each nozzle 13 is more likely to be consistent. Furthermore, during use, multiple nozzles 13 can simultaneously complete multi-point injection, improving injection efficiency. Additionally, exemplarily, the inner wall of the diversion channel 161 has a ceramic layer, such as a zirconia ceramic layer. This layer has good chemical stability and oxidation resistance, resulting in a long service life.
[0046] In summary, the needleless microjet device of this application isolates the pressure generating chamber 111 and the liquid storage chamber 112 through the first elastic membrane 141 and the second elastic membrane 142. The laser generator 12 emits strong laser energy to act on the pressurized liquid in the sealed pressure generating chamber 111, causing the pressurized liquid to generate bubbles. The shock wave generated by the expansion and collapse of the bubbles acts on the first elastic membrane 141. The first elastic membrane 141 and the second elastic membrane 142 deform and extend rapidly to the side of the liquid storage chamber 112, pushing the injection liquid in the liquid storage chamber 112 toward the nozzle 13, and injecting it through the nozzle 13 in a microjet manner with high speed. Since the surfaces of the first elastic membrane 141 and the second elastic membrane 142 that are close to each other are connected by the connecting plate 143, when the first elastic membrane 141 and the second elastic membrane 142 extend toward the liquid storage chamber 112, they will drive the connecting plate 143 to move toward the liquid storage chamber 112 together. Since the surface of the connecting plate 143 is flat, the pressure on the liquid storage chamber 112 corresponding to the position of the connecting plate 143 is relatively consistent, and there is no spring drive, so the stability is good. This is conducive to the consistent speed of the injection from the nozzle 13 and the consistent injection dosage, which can improve the problem of large differences in injection dosage.
[0047] The above are merely preferred embodiments of this application and are not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.
Claims
1. A needleless microfluidic injection device, characterized by, It includes: The main body has a pressure generating chamber and a liquid storage chamber arranged sequentially along its height. The pressure generating chamber is used to hold a pressurized liquid, and the liquid storage chamber is used to hold an injection solution. The bottom end of the pressure generating chamber is provided with a first elastic membrane to seal the bottom end of the pressure generating chamber, and the top end of the liquid storage chamber is provided with a second elastic membrane to seal the top end of the liquid storage chamber. The surfaces of the first elastic membrane and the second elastic membrane that are close to each other are connected by a connecting plate. A laser generator, the laser generator being used to generate laser light to react with a pressurized liquid to produce energy; as well as Multiple nozzles are mounted at the bottom of the main body, and the interior of each nozzle communicates with the liquid storage chamber. The nozzles are used to spray the injection liquid from the liquid storage chamber.
2. The needle-free microfluidic injector of claim 1, wherein, The first elastic membrane and the second elastic membrane are silicone rubber membranes, fluororubber membranes, or polyurethane membranes.
3. The needle-free microfluidic injector of claim 1, wherein, The connecting plate is a circular plate, and the center line of the connecting plate coincides with the center lines of the first elastic membrane and the second elastic membrane.
4. The needle-free microfluidic injector of claim 3, wherein, The upper and lower surfaces of the connecting plate are connected by an arc surface.
5. The needle-free microfluidic injector of claim 1, wherein, The inner wall of the main body is provided with a first mounting groove and a second mounting groove. The first mounting groove and the second mounting groove are both arranged around the circumference of the main body. The edge of the first elastic membrane is fixed in the first mounting groove by a first elastic adhesive layer, and the edge of the second elastic membrane is fixed in the second mounting groove by a second elastic adhesive layer.
6. The needle-free microfluidic injector of claim 5, wherein, The first mounting groove has a first arc-shaped transition surface on its wall, which is connected to the inner wall of the main body. A portion of the first elastic adhesive layer covers the first arc-shaped transition surface and is arc-shaped. The first elastic membrane can stretch along the surface of the first elastic adhesive layer on the first arc-shaped transition surface. The second mounting groove has a second arc-shaped transition surface on its wall, which is connected to the inner wall of the main body. A portion of the first elastic adhesive layer covers the first arc-shaped transition surface and is arc-shaped. The first elastic membrane can stretch along the surface of the first elastic adhesive layer on the first arc-shaped transition surface.
7. The needle-free microfluidic injector of claim 5, wherein, The first elastic adhesive layer and the second elastic adhesive layer are silicone sealant layers or fluororubber adhesive layers.
8. The needle-free microfluidic injector of any one of claims 1-7, wherein, The lower end of the liquid storage chamber is provided with a distributor, which has multiple diversion channels. The multiple diversion channels are distributed around the center line of the liquid storage chamber, and the ports of the diversion channels near the second elastic membrane can be projected onto the lower surface of the connecting plate; the nozzle is installed in the diversion channel.
9. The needle-free microfluidic injection device according to claim 8, characterized in that, The inner wall of the diversion channel has a ceramic layer.
10. The needle-free microfluidic injection device according to any one of claims 1 to 7, characterized in that, The outer wall of the main body is also connected to a liquid replenishment connector, which communicates with the liquid storage chamber. The liquid replenishment connector is used to install and fix a syringe for replenishing injection fluid into the liquid storage chamber. The liquid replenishment connector is equipped with an anti-backflow valve, which is configured to allow liquid to flow from the syringe to the liquid storage chamber while preventing liquid from flowing from the liquid storage chamber to the syringe.