Nitrogen-filled device for nalmefene mesylate for injection

Abstract

The utility model discloses a nitrogen filling device for nafamostat mesylate for injection, including the cabinet body and setting in the cabinet body downside for the foot stand of mobile, the rear upper side four corners of cabinet body are provided with slide rod respectively, the upper side of slide rod is provided with nitrogen filling tank, the front lower side of nitrogen filling tank is provided with the air pump box, the front lower side of air pump box is provided with nitrogen filling pipe, the downside bottom of nitrogen filling pipe is provided with the sealing plug, the front upper side of cabinet body is provided with the placing tray, the upper side inside of placing tray is provided with a plurality of placing mouth with equidistance annular array, this novel mainly helps chuck, spring, trigger ball's mechanical linkage, and the whole process of " putting in - clamping - loosening - taking out " of the penicillin bottle does not need manual intervention. The chuck area opens automatically when placing, which is convenient for feeding. After rotating, it is automatically clamped to ensure process stability. After processing, it is automatically loosened to facilitate unloading, which greatly improves the production line turnover efficiency.

Description

Technical Field

[0001] This utility model belongs to the technical field of nitrogen filling devices for medicine bottles, specifically relating to a nitrogen filling device for injectable naphthostat mesylate. Background Technology

[0002] The nitrogen filling device for naphthostat mesylate for injection is a device used to fill the vial with nitrogen to replace the air during the vial sealing process.

[0003] Its core function is based on the potential stability characteristics of nafamostat mesylate—these drugs may be sensitive to oxygen and easily degraded, have reduced potency, or produce impurities due to oxidation. The nitrogen filling device injects high-purity nitrogen into the bottle to be sealed, expels oxygen and air from the bottle, and then, in conjunction with subsequent sealing (such as capping), forms an inert gas protective environment, thereby extending the shelf life of the drug and ensuring the stability of drug quality.

[0004] In existing nitrogen-filling devices, the placement trays mostly use manual placement of vials or simple mechanical positioning, which is prone to causing the vials to shift due to operational errors or equipment vibration. During vacuuming, this shift can lead to incomplete sealing, insufficient vacuum, and high residual oxygen levels after nitrogen filling, affecting drug stability. Utility Model Content

[0005] The purpose of this invention is to provide a nitrogen-filling device for nafamostat mesylate for injection, to solve the problems in the background art where the placement tray is mostly used for manual placement of vials or simple mechanical limiting, which is prone to vial displacement due to operational errors and equipment vibration. During vacuuming, displacement will result in poor sealing, insufficient vacuum, high residual oxygen content after nitrogen filling, and affect drug stability.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a nitrogen filling device for injectable naphthostat mesylate, comprising a cabinet and feet disposed on the lower side of the cabinet for movement;

[0007] The cabinet is equipped with sliding rods at the four corners of the upper rear side, a nitrogen filling box is installed on the upper side of the sliding rods, an air pump box is installed on the lower front side of the nitrogen filling box, a nitrogen filling pipe is installed on the lower front side of the air pump box, and a sealing plug is installed at the bottom of the lower side of the nitrogen filling pipe.

[0008] A placement tray is movably provided on the upper front side of the cabinet, and multiple placement openings are equidistantly arranged in a circular array on the upper side of the placement tray.

[0009] The nitrogen filling box and the air pump box are respectively connected to an external power source for power supply. The cabinet is equipped with a nitrogen storage tank, and the nitrogen storage tank is connected to the nitrogen filling box.

[0010] A chuck is provided on the lower right side of the placement tray, and clamps are provided at both ends of the inner side of the placement opening. A rubber pad is provided at the top of the clamps, a fixing block is provided in the middle of the lower side of the clamps, and a trigger block is provided below the fixing block.

[0011] A stop ball is provided between the two trigger blocks, a fixing rod is provided on the lower side of the stop ball, a fixing seat is provided at the bottom inner side of the placement port and the connection of the fixing rod, a trigger ball is provided at the lower end of the fixing rod, and a spring is sleeved and connected at the gap between the upper side of the trigger ball and the bottom of the fixing seat.

[0012] Preferably, connecting rods are provided at the upper two ends and the connection points of the trigger blocks on both sides of the ball, and the connecting rods are connected to the trigger blocks by a snap-fit ​​connection method.

[0013] Preferably, the fixing rod passes through the fixing seat and can move up and down within the fixing seat. The trigger ball and the stop ball are connected to the fixing rod by threaded connection.

[0014] Preferably, the rubber pad is connected to the clamping plate by bolts, and the clamping plate has an L-shaped structure.

[0015] Preferably, the clamping plate, the fixing block, and the triggering block are connected by welding. The clamping plate can be driven by the starting block and the fixing block to move downward around the ball, while the upper area moves towards the center.

[0016] Preferably, the upper areas at both ends of the chuck are arc-shaped, and the chuck is connected to the cabinet by bolts. When the ball near the placement opening is pressed against the upper surface of the chuck, it compresses the spring and moves upward.

[0017] Preferably, a control panel is provided on the front side of the nitrogen filling box, a display screen is provided on the upper side of the control panel, and switch buttons are provided on the left and right sides of the upper side of the cabinet.

[0018] Compared with the prior art, the present invention provides a nitrogen filling device for injectable naphthostat mesylate, which has the following beneficial effects:

[0019] 1. Utilizing the mechanical linkage of the chuck, spring, and trigger ball, the entire process of "insertion-clamping-releasing-removal" of vials requires no manual intervention. The chuck area automatically opens during placement to facilitate loading, automatically clamps after rotation to ensure process stability, and automatically releases after processing to facilitate unloading, significantly improving production line efficiency.

[0020] 2. With flexible contact of rubber pads and L-shaped clamp structure, it can be compatible with different sizes of vials (such as 10-30mm diameter) without changing the clamps, reducing changeover downtime and adapting to multi-variety small-batch production scenarios.

[0021] 3. The rubber pad prevents the metal clamp from directly contacting the vial, eliminating the risk of scratching and crushing; the flexible contact can also adapt to the slight deformation of the vial (such as the slight expansion of the vial opening after filling), ensuring the integrity of the naphthostat mesylate for injection container and avoiding drug contamination and leakage.

[0022] In addition, the clamping plate ensures that the vial is accurately positioned during vacuuming and nitrogen filling, and fits more tightly with the sealing plug 6, reducing leakage caused by vial misalignment and improving the drug's antioxidant stability. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the nitrogen filling device in this utility model.

[0024] Figure 2 This is a schematic diagram showing the upper view of the plate in this utility model.

[0025] Figure 3 This is a schematic diagram of the structure of the plate in this utility model from the bottom view.

[0026] Figure 4 This is a schematic diagram of the structure of a single placement opening forming a cylindrical body in this utility model.

[0027] Figure 5 In this utility model Figure 4 A schematic diagram of the cross-section.

[0028] Figure 6 This is a schematic diagram of the structure of the inner side of the bottom of the placement opening in this utility model.

[0029] Figure 7 In this utility model Figure 5 A structural diagram from a side view.

[0030] In the diagram: 1. Cabinet; 2. Foot; 3. Slide rod; 4. Air pump box; 5. Nitrogen filling pipe; 6. Sealing plug; 7. Control panel; 8. Display screen; 9. Nitrogen filling box; 10. Switch button; 11. Placement tray; 12. Placement port; 13. Chuck; 14. Trigger ball; 15. Spring; 16. Clamping plate; 17. Rubber pad; 18. Trigger block; 19. Fixing block; 20. Abutment ball; 21. Fixing rod; 22. Fixing base; 23. Connecting rod. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] This utility model provides, for example Figure 1-7 The nitrogen filling device for injectable naphthostat mesylate shown includes a cabinet 1 and feet 2 disposed on the lower side of the cabinet 1 for movement.

[0033] Among them, there are slide rods 3 at the four corners of the upper rear side of the cabinet 1, a nitrogen filling box 9 is installed on the upper side of the slide rods 3, an air pump box 4 is installed on the lower front side of the nitrogen filling box 9, a nitrogen filling pipe 5 is installed on the lower front side of the air pump box 4, and a sealing plug 6 is installed at the bottom of the lower side of the nitrogen filling pipe 5.

[0034] A placement tray 11 is movably installed on the upper front side of the cabinet 1. Multiple placement ports 12 are equidistantly arranged in a circular array on the upper side of the placement tray 11. In addition, the nitrogen filling box 9 and the air pump box 4 are respectively connected to an external power supply for power supply. A nitrogen storage tank is installed inside the cabinet 1, and the installed nitrogen storage tank is connected to the nitrogen filling box 9.

[0035] A chuck 13 is provided on the lower right side of the placement plate 11. Clamping plates 16 are provided at both ends of the inner side of the placement opening 12. A rubber pad 17 is provided at the top of the clamping plate 16. A fixing block 19 is provided in the middle of the lower side of the clamping plate 16. A trigger block 18 is provided below the fixing block 19. A ball stop 20 is provided in the middle of the two trigger blocks 18. A fixing rod 21 is provided below the ball stop 20. A fixing seat 22 is provided at the connection between the bottom inner side of the placement opening 12 and the fixing rod 21. A trigger ball 14 is provided at the lower end of the fixing rod 21. A spring 15 is sleeved and connected between the upper side of the trigger ball 14 and the bottom gap of the fixing seat 22.

[0036] A control panel 7 is installed on the front side of the nitrogen filling box 9, and a display screen 8 is installed on the upper side of the control panel 7. Switch buttons 10 are installed on the left and right sides of the upper side of the cabinet 1.

[0037] In this embodiment, the nitrogen filling device for injectable naphthostat mesylate of the present invention mainly consists of a cabinet 1, feet 2, a slide bar 3, an air pump box 4, a nitrogen filling pipe 5, a sealing plug 6, a control panel 7, a display screen 8, a nitrogen filling box 9, a switch button 10, and a placement tray 11. The cabinet 1 serves as the supporting foundation and contains a nitrogen storage tank to store nitrogen gas and provide a gas source for the nitrogen filling operation; the feet 2 enable the movement of the device; the slide bar 3 connects and supports the nitrogen filling box 9, ensuring the stability of the nitrogen filling box 9; the air pump box 4 includes a vacuum pump, a nitrogen filling pipe 5, and a sealing plug 6, which work together to complete the vacuuming and nitrogen filling operations; the control panel 7, the display screen 8, and the switch button 10 constitute the operation and display system, facilitating users to set parameters, view the operating status, and start and stop the equipment.

[0038] When using the device, the user can manually place the vial containing naphthostat mesylate for injection into the placement opening 12 of the placement tray 11, ensuring that the vial is approximately centered in the placement opening 12. If there is no innovative structural assistance, manual fixation or other simple limiting devices on the equipment are required to prevent the vial from shifting during subsequent operations.

[0039] At this time, the air pump box 4 is connected to the internal vacuum pump, and the area where the vials are placed is evacuated through the nitrogen filling tube 5. When the air pump box 4 is working, it uses its internal air circuit design to create negative pressure in the nitrogen filling tube 5, extracting air from the vials and reducing the gas pressure inside the vials to prepare for nitrogen filling. The vacuum pressure, duration and other parameters are precisely controlled by the control panel 7 according to the set values, and the display screen 8 shows the changes in vacuum level in real time during the process.

[0040] After the vacuum reaches the preset requirements, the nitrogen filling chamber 9 begins operation. It connects to the nitrogen storage tank inside cabinet 1, delivering nitrogen gas through the filling pipe 5 to the space containing the vials. The sealing plug 6 on the lower side of the filling pipe 5 fits into the vial neck, providing a seal and ensuring that the injected nitrogen gas is effectively retained inside the vial, replacing residual air and increasing the nitrogen concentration. The filling pressure, flow rate, and duration are also controlled by the control panel 7, and the display screen 8 simultaneously displays the relevant filling parameters.

[0041] Once the nitrogen filling reaches the set parameters, the equipment automatically stops the nitrogen filling process, and the air pump box 4 and nitrogen filling box 9 cease operation. The operator manually removes the processed vials from the placement port 12. If the next batch needs to be processed, the above placement, vacuuming, and nitrogen filling steps are repeated. If the equipment is to be temporarily out of service, it can be turned off using the switch button 10 and will be ready for the next use.

[0042] Optionally, the device is electrically powered, with the nitrogen filling tank 9 and the air pump tank 4 connected to an external power source to obtain electrical energy. The control panel 7 serves as the control core, with a built-in control program (such as a PLC control module, which can be customized according to actual design). It receives user input commands via buttons, converts them into electrical signals to control the working status of the air pump tank 4 and the nitrogen filling tank 9, realizing the start and stop of the vacuuming and nitrogen filling processes, as well as parameter adjustment. The display screen 8, based on the data transmitted from the control module, intuitively presents parameters such as vacuum level, nitrogen filling pressure, and time in digital and graphical form, facilitating user monitoring.

[0043] Preferably, when the air pump box 4 is working, its internal air pump operates, creating a negative pressure environment in the gas path where the nitrogen filling tube 5 is located. Based on the principle of pressure difference, under the action of negative pressure, the air in the vial is drawn through the nitrogen filling tube 5 and discharged into the gas path where the air pump box 4 is located, gradually reducing the gas pressure inside the vial, achieving the purpose of vacuuming, and realizing the initial replacement of the air inside the vial.

[0044] Preferably, the nitrogen stored in the nitrogen storage tank is delivered to the vial through the nitrogen filling tube 5 under the control of the nitrogen filling box 9. Because the vacuuming process beforehand lowers the pressure inside the vial compared to the outside, the incoming nitrogen rapidly fills the space inside the vial under the pressure difference, replacing any residual air. The sealing plug 6 ensures a seal at the vial opening, reducing nitrogen leakage and allowing the nitrogen concentration inside the vial to gradually increase. This protects the injectable nafamostat mesylate from oxidation and other factors that could affect its efficacy.

[0045] like Figure 1-7 As shown, connecting rods 23 are respectively provided at the upper ends of the ball 20 and the connection points of the trigger blocks 18 on both sides. The connecting rods 23 are connected to the trigger blocks 18 by a snap-fit ​​connection. The fixing rod 21 passes through the fixing seat 22 and can move up and down within the fixing seat 22. The trigger ball 14 and the ball 20 are respectively connected to the fixing rod 21 by a threaded connection. The rubber pad 17 is connected to the clamping plate 16 by a bolt connection. The clamping plate 16 has an L-shaped structure. The clamping plate 16, the fixing block 19 and the trigger block 18 are respectively connected by welding. The clamping plate 16 can be driven by the starting block and the fixing block 19 to move downward around the ball 20 as the center. At the same time, the upper area completes the action of moving towards the middle. The upper areas of both ends of the chuck 13 are respectively set in an arc shape. The chuck 13 is connected to the cabinet 1 by a bolt connection. The trigger ball 14 near the placement port 12 is abutted by the upper surface of the chuck 13, and the compression spring 15 moves upward.

[0046] Preferably, when the equipment is not in operation, the spring 15 is in a naturally extended state, and the trigger ball 14 is supported by the elastic force of the spring 15 and is in a relatively lower position. The position of the abutment ball 20 is thus determined. Due to the structural connection between the trigger block 18, the fixing block 19, and the clamping plate 16, the area where the rubber pads 17 on the upper side of the two clamping plates 16 are located is in a clamping preparation state that moves towards the center. The chuck 13 is fixed to the cabinet 1 by bolts. Its position can be adjusted according to actual needs based on the rotation range of the placement plate 11, the layout of the placement port 12, etc., to ensure that the trigger ball 14 can effectively contact the upper surface of the chuck 13.

[0047] When a vial needs to be processed, align the vial with the placement opening 12 located above the chuck 13 (the area corresponding to the placement opening 12 is in the open state because the trigger ball 14 is pressed against the chuck 13, making it easier to insert the vial). Place the vial into the placement opening 12. At this time, because the trigger ball 14 corresponding to the placement opening 12 is pressed against the upper surface of the chuck 13, the compression spring 15 moves upward. The force is transmitted through the fixing rod 21, the abutment ball 20 moves upward, and the connecting rod 23 drives the trigger blocks 18 on both sides to move, thereby causing the upper area of ​​the clamp 16 to move outward, completing the opening effect and making it easier to insert the vial.

[0048] Then, the relevant rotating mechanisms of the equipment are activated (such as the rotation drive of the placement tray 11, which can be achieved by the transmission structure on the upper side of the cabinet 1; here, the motor drives the placement tray 11 to rotate). The placement tray 11 begins to rotate, gradually rotating the placement port 12 containing the vial to the working position below the nitrogen filling tube 5. During the rotation, when the placement port 12 leaves the upper area of ​​the chuck 13, the trigger ball 14 is no longer resisted by the chuck 13. The spring 15 generates a downward restoring force due to its own elasticity, resisting the trigger ball 14, causing the fixing rod 21 to move downward. The resisting ball 20 then moves downward. Through the linkage of the connecting rod 23 and the trigger block 18, the area where the rubber pads 17 on the upper side of the two clamping plates 16 are located moves towards the center. Utilizing the flexible contact of the rubber pads 17 and the clamping force of the clamping plates 16, the vial is firmly fixed in the placement port 12, preventing the vial from shifting during subsequent vacuuming and nitrogen filling, and ensuring a precise seal between the sealing plug 6 and the vial opening.

[0049] When the placement tray 11 rotates to bring the placement port 12 to the lower side of the nitrogen filling tube 5 for vacuuming and nitrogen filling operations, the vial is clamped and fixed by the clamping plate 16, and the vial is in a stable position. During the process of vacuuming by the air pump box 4 through the nitrogen filling tube 5 and nitrogen filling by the nitrogen filling box 9 through the nitrogen filling tube 5, the vial will not be displaced due to airflow impact, equipment vibration, etc., ensuring that the negative pressure environment of vacuuming is stably established, and the nitrogen gas can be effectively injected into the vial, improving the effect and stability of vacuuming and nitrogen filling.

[0050] After nitrogen filling and vacuuming are completed, the placement tray 11 continues to rotate. When the placement port 12 rotates to the upper area of ​​the chuck 13 again, the trigger ball 14 is again pressed against the upper surface of the chuck 13, the compression spring 15 moves upward, and the force transmission process in step 2 is repeated. The abutment ball 20 moves upward, and the upper area of ​​the clamp 16 moves outward and opens. At this time, the operator can easily take out the processed vial from the placement port 12, completing one work cycle. If continuous processing is required, the placement tray 11 continues to rotate, and the subsequent placement ports 12 repeat the above process of "placement-rotation clamping-processing-rotation releasing and taking out".

[0051] Preferably, this patented innovative structure achieves linkage through the rigid connection and flexible cooperation of a series of mechanical components. The fixing rod 21 passes through the fixing seat 22 and can move up and down within the fixing seat 22, providing a path for the longitudinal transmission of force; the ball 20 and the fixing rod 21, the trigger block 18 and the ball 20, and the clamping plate 16 and the trigger block 18 are connected by welding, snap-fitting, etc., to construct a structure for the transverse and longitudinal conversion and transmission of force. When the trigger ball 14 is resisted by the chuck 13 or subjected to the spring restoring force, the force is transmitted sequentially through the fixing rod 21, the ball 20, the connecting rod 23, and the trigger block 18 to the clamping plate 16, realizing the conversion between opening and clamping actions in the upper area of ​​the clamping plate 16.

[0052] Preferably, the spring 15 plays a crucial role in the entire innovative structure, providing elastic reset and force buffering and control. When the trigger ball 14 is pressed against the chuck 13, the spring 15 is compressed, storing elastic potential energy; when the trigger ball 14 disengages from the chuck 13, the spring 15 releases its elastic potential energy, converting it into a force that moves the fixed rod 21 downwards, driving the clamping plate 16 to complete the clamping action. Through the elastic characteristics of the spring, automatic switching and reset of the action are achieved, eliminating the need for additional complex electrical control, simplifying the structure while improving the stability and reliability of the action.

[0053] Preferably, a rubber pad 17 is provided on the upper side of the clamping plate 16. Utilizing the flexibility and elasticity of rubber, when clamping the vial, the rigid contact of the clamping plate 16 is avoided from causing damage to the vial (such as scratching the surface of the vial or crushing the vial neck). At the same time, the rubber pad 17 can increase the friction between the vial and the vial, improve the stability of the clamping, better adapt to the possible slight differences in the size of the vial, and ensure the consistency of the clamping effect.

[0054] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A nitrogen filling device for injectable naphthostat mesylate, comprising a cabinet (1) and a foot (2) disposed on the underside of the cabinet (1) for movement; The cabinet (1) has four sliding rods (3) at the upper rear corners, a nitrogen filling box (9) on the upper side of the sliding rods (3), an air pump box (4) on the lower front side of the nitrogen filling box (9), a nitrogen filling pipe (5) on the lower front side of the air pump box (4), and a sealing plug (6) on the bottom of the lower side of the nitrogen filling pipe (5). The cabinet (1) is movably provided with a placement tray (11) on the upper front side, and the upper side of the placement tray (11) has multiple placement openings (12) arranged in an equidistant circular array. The nitrogen filling box (9) and the air pump box (4) are respectively connected to an external power source for power supply. The cabinet (1) is equipped with a nitrogen storage tank, and the nitrogen storage tank is connected to the nitrogen filling box (9). Its features are: A chuck (13) is provided on the lower right side of the placement tray (11), and clamps (16) are provided at both ends of the inner side of the placement opening (12). A rubber pad (17) is provided at the top of the clamp (16), and a fixing block (19) is provided in the middle of the lower side of the clamp (16). A trigger block (18) is provided on the lower side of the fixing block (19). A stop ball (20) is provided between the two trigger blocks (18), a fixing rod (21) is provided on the lower side of the stop ball (20), a fixing seat (22) is provided at the connection between the bottom inner side of the placement port (12) and the fixing rod (21), a trigger ball (14) is provided at the lower end of the fixing rod (21), and a spring (15) is sleeved and connected at the gap between the upper side of the trigger ball (14) and the bottom of the fixing seat (22).

2. The nitrogen-filling device for naphthostat mesylate for injection according to claim 1, characterized in that: Connecting rods (23) are provided at the upper two ends and the connection points of the trigger blocks (18) on both sides of the ball (20), and the connecting rods (23) are connected to the trigger blocks (18) by a snap-fit ​​connection.

3. The nitrogen-filling device for naphthostat mesylate for injection according to claim 2, characterized in that: The fixing rod (21) passes through the fixing seat (22), and the fixing rod (21) can move up and down within the fixing seat (22). The trigger ball (14) and the abutment ball (20) are connected to the fixing rod (21) by threaded connection.

4. The nitrogen-filling device for naphthostat mesylate for injection according to claim 3, characterized in that: The rubber pad (17) is connected to the clamp plate (16) by bolts, and the clamp plate (16) has an L-shaped structure.

5. The nitrogen-filling device for naphthostat mesylate for injection according to claim 4, characterized in that: The clamping plate (16), the fixing block (19) and the triggering block (18) are connected by welding. The clamping plate (16) can be driven by the starting block and the fixing block (19) to move downward with the ball (20) as the center, while the upper area completes the action of moving towards the middle.

6. The nitrogen-filling device for naphthostat mesylate for injection according to claim 5, characterized in that: The upper areas of both ends of the chuck (13) are respectively arc-shaped, and the chuck (13) is connected to the cabinet (1) by bolt connection. The trigger ball (14) near the placement port (12) is pressed against the upper surface of the chuck (13), compressing the spring (15) to move upward.

7. The nitrogen-filling device for naphthostat mesylate for injection according to claim 1, characterized in that: The nitrogen filling box (9) is provided with a control panel (7) on the front side, and a display screen (8) is provided on the upper side of the control panel (7). Switch buttons (10) are provided on the left and right sides of the upper side of the cabinet (1).

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