Dual channel multi-parameter electrochemical test strip

Abstract

The utility model provides a kind of double-channel multi-index electrochemical test strip, including first detection channel, second detection channel, first electrode group, second electrode group and conducting wire;Each electrode of the first electrode group is at least one part in first detection channel, each electrode of the second electrode group is at least one part in second detection channel;The first end and the second end of the conducting wire are respectively in the first detection channel and second detection channel, at least one electrode of the first electrode group can form current loop with at least one electrode of the second electrode group by the conducting wire.The setting of conducting wire makes that in addition to the current loop that can be formed between each electrode of first electrode group, second electrode group, electrode of first electrode group can also form current loop with electrode of second electrode group by conducting wire, which is conducive to the reuse of electrode, thereby reducing the number of electrode use.

Description

Technical Field

[0001] This utility model relates to the field of electrochemical test strip technology, and in particular to a dual-channel, multi-index electrochemical test strip. Background Technology

[0002] In the field of point-of-care testing, electrochemical test strips are commonly used to detect indicators such as blood glucose, uric acid, hemoglobin, and cholesterol in the blood. To improve the detection efficiency of electrochemical test strips, multifunctional electrochemical test strips have been introduced on the market, which can detect multiple indicators simultaneously.

[0003] For example, Chinese utility model publication CN218629626U discloses a multifunctional electrochemical test strip for blood glucose and uric acid with hematocrit correction function, comprising, from bottom to top, a PET substrate layer, a conductive layer, an insulating oil layer, a reagent layer, and a cover layer; wherein, the PET substrate layer is used to support the test strip; the conductive layer is provided with a detection electrode assembly; the insulating oil layer covers the portion above the pins of the detection electrode assembly, and the insulating oil layer is provided with a first reaction channel for blood glucose detection and a second reaction channel for uric acid detection, the first reaction channel and the second reaction channel exposing part of the electrodes on the detection electrode assembly; the reagent layer is disposed in the first reaction channel. The electrochemical test strip is configured in two reaction channels: the first reaction channel and the second reaction channel; the covering layer includes double-sided adhesive and a hydrophilic membrane, and the covering layer has exposed areas that expose the first reaction channel and the second reaction channel; the detection electrode group includes, in sequence: a hematocrit test working electrode, a hematocrit test counter electrode, a blood glucose test working electrode, a blood glucose test counter electrode, a turn-on electrode, a uric acid test counter electrode, and a uric acid test working electrode; the first reaction channel exposes the hematocrit test working electrode, the hematocrit test counter electrode, the blood glucose test working electrode, and the blood glucose test counter electrode; the second reaction channel exposes the uric acid test counter electrode and the uric acid test working electrode. In this configuration, a current loop cannot be formed between the electrodes in the first reaction channel and the electrodes in the second reaction channel, which is not conducive to reducing the number of electrodes used.

[0004] Therefore, existing technologies still need to be improved and developed. Utility Model Content

[0005] The purpose of this invention is to address the shortcomings and deficiencies of existing technologies by providing a dual-channel, multi-index electrochemical test strip.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0007] This utility model provides a dual-channel multi-index electrochemical test strip, including a first detection channel, a second detection channel, a first electrode group, a second electrode group, and conductive wires;

[0008] Each electrode in the first electrode group has at least a portion located within the first detection channel, and each electrode in the second electrode group has at least a portion located within the second detection channel;

[0009] The first end and the second end of the conductive wire are located in the first detection channel and the second detection channel, respectively. At least one electrode of the first electrode group can form a current loop with at least one electrode of the second electrode group through the conductive wire.

[0010] With the above structural design, in addition to the current loops that can be formed between the electrodes of the first electrode group and the second electrode group, the electrodes of the first electrode group can also form a current loop with the electrodes of the second electrode group through conductive wires. This facilitates the reuse of electrodes and reduces the number of electrodes used.

[0011] According to the above scheme, the first electrode group includes a first working electrode, and the second electrode group includes a common reference electrode; the first working electrode forms a current loop with the common reference electrode through the conductive line.

[0012] The first working electrode forms a current loop with the common reference electrode through the conductive wire, which is used to detect the first detection index signal.

[0013] According to the above scheme, the first electrode group further includes a common working electrode, and the first working electrode and the common working electrode form a current loop; the second electrode group further includes a second working electrode, and the second working electrode and the common reference electrode form a current loop.

[0014] The second working electrode and the shared reference electrode form a current loop for detecting a second detection index signal. The first working electrode and the shared working electrode form a current loop for detecting the HCT signal, the background signal, and the third detection index signal.

[0015] According to the above scheme, the second electrode group also includes a third working electrode, which forms a current loop with the common reference electrode.

[0016] The third working electrode and the shared reference electrode form a current loop for detecting the fourth detection index signal.

[0017] Understandably, the first, second, third, and fourth test indicators can be set according to actual needs, such as choosing four from blood glucose, uric acid, lactic acid, total cholesterol, various lipoproteins (HDL, LDL, etc.), triglycerides, and hemoglobin.

[0018] According to the above scheme, it also includes a sample inlet, which is connected to the first detection channel and the second detection channel respectively.

[0019] With the above structural design, blood samples can flow into both the first and second detection channels simultaneously after entering through the inlet.

[0020] According to the above scheme, the first end of the conductive wire is located at the end of the first detection channel away from the sample inlet, and the second end of the conductive wire is located at the end of the second detection channel away from the sample inlet.

[0021] With the above structural arrangement, the first working electrode forms a current loop with the common reference electrode through the conductive wire. Besides detecting the first detection index signal, it can also be used to detect the full absorption judgment signal. Only when the blood sample substantially covers the first and second detection channels can it touch the first and second ends of the conductive wire and trigger the instrument to begin detection. This effectively avoids the impact of insufficient sample absorption on the detection results, thereby improving detection accuracy.

[0022] According to the above scheme, a code information electrode is also included. By setting the code information electrode, the electrochemical test strip has code information, enabling the detection instrument to automatically adjust the code.

[0023] It is understood that the code information electrode is existing technology, for example, Chinese utility model patent with publication number CN206710366U can be referenced.

[0024] According to the above scheme, it also includes a substrate, on which an electrode layer is printed, and on which the first electrode group, the second electrode group, conductive lines and code information electrodes are formed.

[0025] According to the above scheme, the electrode layer is covered with an insulating layer, and the insulating layer has a notch; the insulating layer is covered with a double-sided adhesive layer, and the double-sided adhesive layer has an opening corresponding to the notch; the double-sided adhesive layer and the substrate form an interconnected sample inlet, a first detection channel and a second detection channel.

[0026] The notch on the insulating layer corresponds to the opening on the double-sided adhesive layer, thereby assembling the double-sided adhesive layer onto the insulating layer to form the interconnected sample inlet, first detection channel, and second detection channel.

[0027] According to the above scheme, a hydrophilic film is covered on the double-sided adhesive layer, and the hydrophilic film is located above the opening.

[0028] The aspiration of blood samples is achieved through the hydrophilicity of the hydrophilic membrane covering the double-sided adhesive layer and the capillary action of the first and second detection channels. By incorporating the hydrophilic membrane, the diffusion rate of the blood sample within the first and second detection channels can be increased, thereby improving detection efficiency.

[0029] The beneficial effects of this utility model are as follows:

[0030] This invention provides that the first and second ends of the conductive wire are located in the first and second detection channels, respectively. This allows the electrodes of the first and second electrode groups to form current loops with each other through the conductive wire, in addition to the electrodes of the first and second electrode groups forming current loops. This facilitates electrode reuse and reduces the number of electrodes required. Attached Figure Description

[0031] Fig. 1 This is a schematic diagram of the structure of this utility model with the substrate omitted;

[0032] Fig. 2 This is an exploded structural diagram of the present invention;

[0033] Fig. 3 This is a schematic diagram of the structure of the electrode layer described in this utility model.

[0034] In the diagram: 1. Sample inlet; 11. First detection channel; 12. Second detection channel; 2. Substrate; 3. Electrode layer; 31. First electrode group; 311. First working electrode; 312. Common working electrode; 32. Second electrode group; 321. Second working electrode; 322. Third working electrode; 323. Common reference electrode; 33. Conductive wire; 34. Code information electrode; 4. Insulating layer; 41. Notch; 5. Double-sided adhesive layer; 51. Opening; 6. Hydrophilic membrane. Detailed Implementation

[0035] The technical solution of this utility model will be described below with reference to the accompanying drawings and embodiments.

[0036] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings. However, the present invention can be implemented in many different ways as defined and covered by the claims.

[0037] To facilitate understanding of the technical solution, in this embodiment, the first detection indicator is limited to uric acid, the second detection indicator is blood glucose, the third detection indicator is hemoglobin, and the fourth detection indicator is total cholesterol. Of course, in other embodiments, those skilled in the art can select according to actual needs.

[0038] like Figs. 1-3As shown, the dual-channel multi-index electrochemical test strip of this utility model includes a first detection channel 11, a second detection channel 12, a first electrode group 31, a second electrode group 32, and a conductive wire 33; at least a portion of each electrode of the first electrode group 31 is located within the first detection channel 11, and at least a portion of each electrode of the second electrode group 32 is located within the second detection channel 12; the first end and the second end of the conductive wire 33 are respectively located within the first detection channel 11 and the second detection channel 12, and at least one electrode of the first electrode group 31 can form a current loop with at least one electrode of the second electrode group 32 through the conductive wire 33.

[0039] With the above structural arrangement, in addition to the current loops that can be formed between the electrodes of the first electrode group 31 and the second electrode group 32, the electrodes of the first electrode group 31 can also form a current loop with the electrodes of the second electrode group 32 through the conductive wire 33, which is beneficial for electrode reuse and thus reduces the number of electrodes used.

[0040] Furthermore, the first electrode group 31 includes a first working electrode 311 and a common working electrode 312, and the second electrode group 32 includes a second working electrode 321, a third working electrode 322 and a common reference electrode 323; the first working electrode 311 forms a current loop with the common reference electrode 323 through the conductive line 33, the first working electrode 311 forms a current loop with the common working electrode 312, the second working electrode 321 forms a current loop with the common reference electrode 323, and the third working electrode 322 forms a current loop with the common reference electrode 323.

[0041] The first working electrode 311 forms a current loop with the common reference electrode 323 via the conductive wire 33 for detecting uric acid signals. The first working electrode 311 and the common working electrode 312 form a current loop for detecting HCT signals, background signals, and hemoglobin signals. The second working electrode 321 and the common reference electrode 323 form a current loop for detecting blood glucose signals. The third working electrode 322 and the common reference electrode 323 form a current loop for detecting total cholesterol signals.

[0042] Furthermore, it also includes a sample inlet 1, which is connected to the first detection channel 11 and the second detection channel 12 respectively.

[0043] With the above structural design, the blood sample enters from the inlet 1 and simultaneously flows into the first detection channel 11 and the second detection channel 12.

[0044] Furthermore, the first end of the conductive wire 33 is located at the end of the first detection channel 11 furthest from the sample inlet 1, and the second end of the conductive wire 33 is located at the end of the second detection channel 12 furthest from the sample inlet 1. In practice, the first and second ends of the conductive wire 33 can span any position between the first detection channel 11 and the second detection channel 12; for example, the first and second ends of the conductive wire 33 can be located near the sample inlet 1, far from the sample inlet 1, or anywhere between these two positions. Preferably, the first and second ends of the conductive wire 33 are located at the furthest point from the sample inlet 1, i.e., at the innermost bottom of the two detection channels. This is more conducive to the corresponding electrodes forming a current loop with specific detection function through the blood sample and the conductive wire 33 after the blood sample enters the two detection channels.

[0045] With the above structural arrangement, the first working electrode 311 forms a current loop with the common reference electrode 323 through the conductive wire 33. Besides detecting the first detection index signal, it can also be used to detect the full absorption judgment signal. Only when the blood sample substantially covers the first detection channel 11 and the second detection channel 12 can it touch the first and second ends of the conductive wire 33 and trigger the instrument to start detection. This effectively avoids the impact of insufficient sample absorption on the detection results, thereby improving detection accuracy.

[0046] Furthermore, it also includes a code information electrode 34. By setting the code information electrode 34, the electrochemical test strip is endowed with code information, enabling the detection instrument to automatically adjust the code.

[0047] Furthermore, it also includes a substrate 2, on which an electrode layer 3 is printed, and on which the first electrode group 31, the second electrode group 32, the conductive line 33 and the code information electrode 34 are formed.

[0048] Furthermore, the electrode layer 3 is covered with an insulating layer 4, and the insulating layer 4 has a notch 41; the insulating layer 4 is covered with a double-sided adhesive layer 5, and the double-sided adhesive layer 5 has an opening 51 corresponding to the notch 41; the double-sided adhesive layer 5 and the substrate 2 form the sample inlet 1, the first detection channel 11 and the second detection channel 12 that are interconnected.

[0049] The notch 41 on the insulating layer 4 corresponds to the opening 51 on the double-sided adhesive layer 5, thereby assembling the double-sided adhesive layer 5 onto the insulating layer 4 to form the interconnected sample inlet 1, the first detection channel 11, and the second detection channel 12.

[0050] Furthermore, the double-sided adhesive layer 5 is covered with a hydrophilic film 6, which is located above the opening 51.

[0051] The aspiration of the blood sample is achieved by utilizing the hydrophilicity of the hydrophilic membrane 6 covering the double-sided adhesive layer 5 and the capillary action of the first detection channel 11 and the second detection channel 12. By setting the hydrophilic membrane 6, the diffusion rate of the blood sample within the first detection channel 11 and the second detection channel 12 can be increased, thereby improving the detection efficiency.

[0052] In use, the dual-channel multi-index electrochemical test strip of this invention allows the detection instrument to automatically adjust the code information contained in the electrode 34. Then, a blood sample enters from the inlet 1 and simultaneously flows into the first detection channel 11 and the second detection channel 12. The blood sample touches the first end of the conductive wire 33 located in the first detection channel 11 and the second end of the conductive wire 33 located in the second detection channel 12. The first working electrode 311 forms a current loop with the common reference electrode 323 through the conductive wire 33, thereby triggering the instrument to start detection and detect the uric acid signal. The second working electrode 321 forms a current loop with the common reference electrode 323 to detect the blood glucose signal. The first working electrode 311 forms a current loop with the common working electrode 312 to detect the HCT signal, background signal, and hemoglobin signal. The third working electrode 322 forms a current loop with the common reference electrode 323 to detect the total cholesterol signal.

[0053] The above description is only a preferred embodiment of the present utility model. Therefore, all equivalent changes or modifications made to the structure, features and principles described in the claims of the present utility model patent application are included in the scope of the present utility model patent application.

Claims

1. A dual-channel, multi-index electrochemical test strip, characterized in that, It includes a first detection channel (11), a second detection channel (12), a first electrode group (31), a second electrode group (32), and a conductive wire (33); Each electrode of the first electrode group (31) has at least a portion located within the first detection channel (11), and each electrode of the second electrode group (32) has at least a portion located within the second detection channel (12). The first end and the second end of the conductive wire (33) are located in the first detection channel (11) and the second detection channel (12) respectively. At least one electrode of the first electrode group (31) can form a current loop with at least one electrode of the second electrode group (32) through the conductive wire (33).

2. The dual-channel multi-index electrochemical test strip according to claim 1, characterized in that, The first electrode group (31) includes a first working electrode (311), and the second electrode group (32) includes a common reference electrode (323); The first working electrode (311) forms a current loop with the common reference electrode (323) through the conductive line (33).

3. The dual-channel multi-index electrochemical test strip according to claim 2, characterized in that, The first electrode group (31) further includes a common working electrode (312), and the first working electrode (311) and the common working electrode (312) form a current loop; The second electrode group (32) further includes a second working electrode (321), which forms a current loop with the common reference electrode (323).

4. The dual-channel multi-index electrochemical test strip according to claim 3, characterized in that, The second electrode group (32) further includes a third working electrode (322), which forms a current loop with the common reference electrode (323).

5. The dual-channel multi-index electrochemical test strip according to claim 2, characterized in that, It also includes a sample inlet (1), which is connected to the first detection channel (11) and the second detection channel (12) respectively.

6. The dual-channel multi-index electrochemical test strip according to claim 5, characterized in that, The first end of the conductive wire (33) is located at the end of the first detection channel (11) away from the injection port (1), and the second end of the conductive wire (33) is located at the end of the second detection channel (12) away from the injection port (1).

7. The dual-channel multi-index electrochemical test strip according to claim 5, characterized in that, It also includes code information electrodes (34).

8. The dual-channel multi-index electrochemical test strip according to claim 7, characterized in that, It also includes a substrate (2) on which an electrode layer (3) is printed, and on which the first electrode group (31), the second electrode group (32), the conductive line (33) and the code information electrode (34) are formed.

9. The dual-channel multi-index electrochemical test strip according to claim 8, characterized in that, The electrode layer (3) is covered with an insulating layer (4), and the insulating layer (4) has a notch (41); The insulating layer (4) is covered with a double-sided adhesive layer (5), and the double-sided adhesive layer (5) has an opening (51) corresponding to the notch (41); The double-sided adhesive layer (5) and the substrate (2) form an interconnected sample inlet (1), a first detection channel (11), and a second detection channel (12).

10. The dual-channel multi-index electrochemical test strip according to claim 9, characterized in that, The double-sided adhesive layer (5) is covered with a hydrophilic film (6), which is located above the opening (51).

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