Quick column replacement structure of chromatographic column thermostat

Abstract

This utility model discloses a rapid column changing structure for a chromatography column oven, relating to the field of chromatography column technology. It solves the problem that the connection between the chromatography column and the injector / detector relies on traditional bolt structures, requiring tools to tighten or loosen them one turn at a time, which is cumbersome, time-consuming, and restricts work efficiency. The rapid column changing structure for the chromatography column oven includes: a box body; a rectangular groove structure on the front side of the box body; a set of connecting pipes fixedly connected to both sides of the inner wall of the rectangular groove on the front side of the box body; a screw fixedly connected to the inner end of the connecting pipes; a circular plate-shaped outer plate fixedly connected to the outer end of the screw; a set of cylindrical second slide rods slidably disposed in each of the two sets of circular through grooves on the outer plate; and a circular sealing block fixedly disposed on the inner end of the two sets of second slide rods. This process requires no tool assistance, greatly improving the replacement efficiency, and is especially suitable for high-frequency column changing scenarios.

Description

Technical Field

[0001] This invention belongs to the field of chromatography column technology, and more specifically, relates to a rapid column changing structure for a chromatography column constant temperature oven. Background Technology

[0002] In the field of chromatographic analysis, the chromatographic column is the core component for sample separation. Its performance stability directly determines the accuracy and repeatability of the analytical results. To avoid the impact of environmental temperature fluctuations on the separation efficiency of the chromatographic column (such as retention time drift and peak broadening), the chromatographic column needs to be placed in a constant temperature chamber for a long time to maintain a stable separation environment through precise temperature control.

[0003] Current column replacement structures still have the following shortcomings:

[0004] The tubing connections between the chromatographic column and the injector and detector rely on traditional bolt structures, which require tightening or loosening with tools one turn at a time. This operation is cumbersome and time-consuming, especially in batch sample analysis or emergency experiments, which severely restricts work efficiency and has certain limitations. Utility Model Content

[0005] To address the aforementioned technical problems, this utility model provides a rapid column replacement structure for a chromatographic column constant temperature oven. This solves the problem mentioned in the background art, where the tubing connection between the chromatographic column and the injector / detector relies on a traditional bolt structure, requiring tools to tighten or loosen it turn by turn. This operation is cumbersome and time-consuming, especially in batch sample analysis or emergency experiments, severely restricting work efficiency.

[0006] The purpose and effectiveness of the rapid column changing structure of the chromatographic column constant temperature oven of this utility model are achieved by the following specific technical means:

[0007] A rapid column changing structure for a chromatography column oven includes: a chamber; a rectangular groove structure on the front side of the chamber; a set of connecting pipes fixedly connected to the left and right sides of the inner wall of the rectangular groove on the front side of the chamber; a screw fixedly connected to the inner end of the connecting pipe, and threaded grooves on the left and right sides of the outer wall of the screw, while the upper and lower sides of the outer wall of the screw are smooth; a circular plate structure outer plate fixedly installed at the outer end of the screw, and two sets of through circular slots on one side of the outer plate; a set of cylindrical second slide rods slidably installed in each of the two sets of circular slots on the outer plate, and springs sleeved on the outer side of the second slide rods; and annular sealing blocks fixedly installed at the inner ends of the two sets of second slide rods.

[0008] Furthermore, a rectangular plate cover is rotatably connected to the front side of the box; a rectangular plate fixing plate is fixedly installed inside the rectangular groove on the front side of the box, and a set of through circular slots is opened on both sides of the top of the fixing plate; a set of cylindrical first slide rods is slidably installed in the circular slots on both sides of the top of the fixing plate, and a spring is sleeved on the outside of the first slide rods; a rectangular plate pressure plate is fixedly installed at the bottom of the two sets of first slide rods, and a silicone protective layer is pasted on the bottom of the pressure plate.

[0009] Furthermore, a set of U-shaped plate structures are fixedly installed on both sides of the rectangular groove on the front side of the box.

[0010] Furthermore, a cylindrical chromatographic column is provided on the inner top of both sets of placement plates; a set of mounting nuts is fixedly provided at both ends of the chromatographic column, a through circular groove structure is provided on one side of the mounting nut, and a set of arc-shaped groove structure is provided on both the left and right sides of the inner wall of the mounting nut, and a threaded groove structure is provided on both the upper and lower sides of the inner wall of the mounting nut.

[0011] Furthermore, a connector is fixedly provided on the inner end of the screw.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] During installation, the screw can be directly inserted into the preset depth through the arc-shaped groove on the inner wall of the mounting nut, and rotated 90° to complete the thread engagement and fixation, without the need to tighten it turn by turn; during disassembly, rotating 90° in the opposite direction will disengage the thread, and it can be pulled out through the arc-shaped groove. This process does not require the assistance of tools, which greatly improves the replacement efficiency and is especially suitable for high-frequency column replacement scenarios.

[0014] The sealing block, the second slide rod, and the spring form an elastic sealing assembly: when the screw engages with the mounting nut, the mounting nut squeezes the sealing block, and the spring stores force to generate a continuous reaction force, so that the sealing block always fits tightly against the end face of the mounting nut, forming a ring-shaped dynamic seal. Compared with traditional threaded seals, this reduces leakage and is not affected by thread wear caused by frequent disassembly.

[0015] The pressure plate, the first slide rod, and the spring form an elastic fixing assembly. The silicone protective layer directly contacts the column body. The spring force adapts to different diameter chromatographic columns, which avoids column shaking caused by loose fixing and prevents mechanical damage caused by excessive tightness. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall axial view structure of this utility model.

[0017] Figure 2 This is a schematic diagram of the overall front view structure of this utility model.

[0018] Figure 3 This is a schematic diagram of the disassembled structure of the chromatographic column and screw of this utility model.

[0019] Figure 4 This is a schematic diagram of the disassembled structure of the screw and outer plate of this utility model.

[0020] Figure 5 This is a cross-sectional view of the mounting nut of this utility model.

[0021] In the diagram, the correspondence between component names and drawing numbers is as follows:

[0022] 1. Housing; 101. Cover plate; 102. Fixing plate; 103. First slide bar; 104. Pressure plate; 105. Placement plate; 106. Chromatographic column; 107. Mounting nut; 108. Connecting pipeline; 109. Screw; 110. Connector; 111. Outer plate; 112. Second slide bar; 113. Sealing block. Detailed Implementation

[0023] The embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples.

[0024] Example 1: As shown in the attached document Figure 1 To be continued Figure 5 As shown:

[0025] This utility model provides a rapid column changing structure for a chromatographic column constant temperature oven, comprising: a box body 1; a rectangular groove structure is provided on the front side of the box body 1; a set of connecting pipes 108 are fixedly connected to both the left and right sides of the inner wall of the rectangular groove on the front side of the box body 1, the connecting pipes 108 are used to realize fluid communication between the chromatographic column 106 and the external injector and detector; a screw 109 is fixedly connected to the inner end of the connecting pipe 108, and the screw 109 has threaded groove structures on both the left and right sides of its outer wall, and the upper and lower sides of the outer wall of the screw 109 are smooth; the screw 109... An outer plate 111 with a circular plate structure is fixedly installed on the outer end of the screw 109, and two sets of through circular groove structures are opened on one side of the outer plate 111; a set of cylindrical second slide rods 112 are slidably installed in each of the two sets of circular grooves of the outer plate 111, and a spring is sleeved on the outer side of the second slide rod 112, which provides elastic force for the second slide rod 112; a ring-shaped sealing block 113 is fixedly installed on the inner end of the two sets of second slide rods 112, which is used to enhance the sealing of the connection between the screw 109 and the mounting nut 107 and prevent leakage.

[0026] Among them, a cylindrical chromatographic column 106 is provided on the inner side of the top of the two sets of placement plates 105; a set of mounting nuts 107 are fixedly provided at both ends of the chromatographic column 106; a through circular groove structure is opened on one side of the mounting nut 107, and a set of arc-shaped groove structure is opened on both the left and right sides of the inner wall of the mounting nut 107; a threaded groove structure is opened on both the upper and lower sides of the inner wall of the mounting nut 107; the mounting nut 107 cooperates with the screw 109 to realize the connection between the chromatographic column 106 and the connecting pipeline 108.

[0027] The screw 109 has a connector 110 fixedly installed on its inner end. The connector 110 is used to precisely connect with the port of the chromatographic column 106 to ensure smooth flow of fluid.

[0028] The specific usage and function of this embodiment are as follows:

[0029] Ensure the constant temperature chamber 1 is powered off or in standby mode, the internal temperature has dropped to room temperature, and there is no high pressure residue in the connecting pipe 108. Then, flip the front cover 101 of chamber 1 upwards to expose the internal rectangular groove and the old chromatographic column 106. Ensure sufficient operating space. Rotate the two sets of screws 109 on both sides sequentially, rotating the threaded grooves on both sides of the screws 109 into the arc-shaped grooves on both sides of the inner wall of the mounting nut 107, thus disengaging the screws 109 from the mounting nut 107. At this point, the screws 109 and connector 110 can be directly pulled out from the inside of the chromatographic column 106 and the mounting nut 107. This disconnects the fluid passage between the old chromatographic column 106 and the connecting pipe 108. Then, the ends... The screw 109 is aligned with the arc-shaped grooves on both sides of the inner wall of the mounting nut 107 and inserted. After being inserted to a suitable depth, the screw 109 is rotated directly, so that the threaded grooves on both sides of the screw 109 engage with the threaded grooves on both sides of the inner wall of the mounting nut 107, thereby quickly connecting the two without the need for the traditional method of tightening bolts one turn at a time. It can be directly inserted to a suitable depth and then rotated to complete the fixation, which greatly improves the speed of connecting the chromatographic column 106 and the connecting pipeline 108. Under the reaction force of the spring on the outer side of the second slide rod 112, the sealing block 113 tightly fits against the end face of the mounting nut 107 to form an annular seal, preventing the mobile phase from leaking from the gap and improving the sealing performance.

[0030] Example 2: Based on Example 1, as shown in the appendix Figure 1 To be continued Figure 5 As shown:

[0031] The front of the chamber 1 is rotatably connected to a rectangular plate cover 101, which can seal the rectangular groove after the chromatographic column 106 is installed, ensuring the temperature stability inside the constant temperature chamber. A rectangular plate fixing plate 102 is fixedly installed inside the rectangular groove on the front of the chamber 1, and a set of through circular slots is opened on both sides of the top of the fixing plate 102. A set of cylindrical first slide rods 103 are slidably installed in the circular slots on both sides of the top of the fixing plate 102, and springs are sleeved on the outside of the first slide rods 103. A rectangular plate pressure plate 104 is fixedly installed at the bottom of the two sets of first slide rods 103, and a silicone protective layer is pasted on the bottom of the pressure plate 104. The pressure plate 104 can press and fix the chromatographic column 106 under the action of the spring, and the silicone protective layer can prevent the pressure plate 104 from damaging the chromatographic column 106.

[0032] Among them, a set of U-shaped plate structure placement plates 105 are fixedly installed on both sides of the rectangular groove on the front side of the box body 1. The placement plates 105 are used to support the chromatographic column 106 and provide stable support for the chromatographic column 106.

[0033] The specific usage and function of this embodiment are as follows:

[0034] In this invention, the first slide bar 103 on both sides of the top of the fixing plate 102 is held with both hands and pulled vertically upward to compress the spring on the outside of the first slide bar 103, so that the pressure plate 104 rises synchronously with the first slide bar 103 until the silicone protective layer at the bottom of the pressure plate 104 is completely detached from the column body of the old chromatographic column 106. The old chromatographic column 106 is held with both hands and taken out upward along the U-shaped groove of the placement plate 105. Then the new column is placed into the placement plate 105. The hands holding the first slide bar 103 are slowly released. Under the action of the elastic restoring force of the spring, the first slide bar 103 drives the pressure plate 104 to move vertically downward until the silicone protective layer at the bottom of the pressure plate 104 is tightly attached to the column body of the new chromatographic column 106. The elasticity of the silicone protective layer can adapt to chromatographic columns 106 of different diameters, ensuring a firm fixation while avoiding squeezing and damaging the column body.

Claims

1. A rapid column changing structure for a chromatographic column oven, characterized in that, include: Box body (1); a rectangular groove structure is provided on the front side of the box body (1); a set of connecting pipes (108) are fixedly connected to the left and right sides of the inner wall of the rectangular groove on the front side of the box body (1); a screw (109) is fixedly connected to the inner end of the connecting pipe (108), and a threaded groove structure is provided on the left and right sides of the outer wall of the screw (109), and the upper and lower sides of the outer wall of the screw (109) are smooth; a circular plate structure outer plate (111) is fixedly provided on the outer end of the screw (109), and two sets of through circular slot structures are provided on one side of the outer plate (111); a set of cylindrical second slide rods (112) are slidably provided in the two sets of circular slots of the outer plate (111), and a spring is sleeved on the outer side of the second slide rods (112); a circular sealing block (113) is fixedly provided on the inner end of the two sets of second slide rods (112).

2. The rapid column changing structure of the chromatographic column oven as described in claim 1, characterized in that: The front side of the box (1) is rotatably connected to a cover plate (101) with a rectangular plate structure; a fixing plate (102) with a rectangular plate structure is fixedly installed inside the rectangular groove on the front side of the box (1), and a set of through circular slot structures are opened on both sides of the top of the fixing plate (102).

3. The rapid column changing structure of the chromatographic column oven as described in claim 2, characterized in that: A set of cylindrical first slide rods (103) are slidably arranged in the circular through grooves on both sides of the top of the fixed plate (102), and springs are sleeved on the outer side of the first slide rods (103); rectangular plate pressure plates (104) are fixedly arranged at the bottom of the two sets of first slide rods (103), and silicone protective layer is pasted on the bottom of the pressure plates (104).

4. The rapid column changing structure of the chromatographic column oven as described in claim 1, characterized in that: A set of U-shaped plate structure placement plates (105) are fixedly installed on both sides of the rectangular groove on the front side of the box (1).

5. The rapid column changing structure of the chromatographic column oven as described in claim 4, characterized in that: The two sets of placement plates (105) are provided with cylindrical chromatographic columns (106) on the inner side of their tops.

6. The rapid column changing structure of the chromatographic column oven as described in claim 5, characterized in that: Both ends of the chromatographic column (106) are fixedly provided with a set of mounting nuts (107). One side of the mounting nut (107) is provided with a through circular groove structure, and both the left and right sides of the inner wall of the mounting nut (107) are provided with a set of arc-shaped groove structures. Both the upper and lower sides of the inner wall of the mounting nut (107) are provided with threaded groove structures.

7. The rapid column changing structure of the chromatographic column oven as described in claim 1, characterized in that: A connector (110) is fixedly provided on the inner end of the screw (109).

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