A reagent pre-treatment tube facilitating rapid centrifugation

Abstract

The utility model belongs to reagent pretreatment pipe technical field, specifically speaking, it is a reagent pretreatment pipe convenient to quick centrifugal, including reagent pipe, still include: cross bar, fixed mounting in reagent pipe, and the both sides of cross bar still have gap with reagent pipe inner wall, the inside of cross bar is provided with the sliding slot of the sliding bar sliding, the inner wall of sliding slot is fixedly installed with the gasket that is in line with sliding bar, through the structure of design, make the anticoagulant can be mixed with blood gently fast, let anticoagulant and blood contact fully to prevent blood clotting, and the structure of the application design need not to traditional mixing adopt multiple times to overturn mode, thereby need not to rely on operator's " subjective control ", effectively avoided because the upper blood still not contact anticoagulant, lead to the phenomenon of partial blood coagulation to appear.

Description

Technical Field

[0001] This utility model relates to the field of reagent pretreatment tube technology, specifically a reagent pretreatment tube that is easy to centrifuge quickly. Background Technology

[0002] Reagent pretreatment tubes are specialized containers used for the pretreatment of biological samples (such as blood, saliva, and tissue fluid) or chemical reagents. They are typically sealed plastic or glass tubes. Many key steps in reagent pretreatment tubes (such as separation, impurity removal, and concentration) utilize centrifuges, which achieve rapid separation of substances of different densities by using the centrifugal force generated by high-speed rotation.

[0003] When blood is loaded into the reagent pretreatment tube, the coagulation mechanism (platelet aggregation + coagulation factor activation) will be activated immediately after the blood leaves the blood vessel. Within 10 to 15 minutes, it will coagulate into a mixture of "blood clots + serum". In order to prevent coagulation, a specific agent (such as an anticoagulant) is pre-loaded into the reagent pretreatment tube to keep the blood in a "homogeneous liquid state" before centrifugation, laying the foundation for "clear stratification" in subsequent centrifugation.

[0004] To ensure thorough mixing of the anticoagulant and blood, the reagent pretreatment tube is manually inverted multiple times. The effectiveness of this manual inversion relies entirely on the operator's subjective control. Since the anticoagulant is usually pre-filled at the bottom of the tube, insufficient inversions (e.g., only 5 times) or gentle pressure can result in the anticoagulant at the bottom mixing only with the lower layer of blood, while the upper layer remains uncontaminated, leading to localized blood coagulation (small blood clots or flocculent material).

[0005] Therefore, a reagent pretreatment tube that facilitates rapid centrifugation is proposed to address the above problems. Utility Model Content

[0006] In order to overcome the shortcomings of the prior art and solve at least one of the technical problems mentioned in the background art, this utility model proposes a reagent pretreatment tube that is easy to centrifuge quickly.

[0007] The technical solution adopted by this utility model to solve its technical problem is as follows: The reagent pretreatment tube of this utility model that is convenient for rapid centrifugation includes a reagent tube and further includes: a crossbar, which is fixedly installed inside the reagent tube, and there are still gaps between the two sides of the crossbar and the inner wall of the reagent tube. The crossbar has a sliding groove for sliding of a slide bar, and a gasket that fits against the slide bar is fixedly installed on the inner wall of the sliding groove; a tray, which is fixedly installed at the bottom of the slide bar and at the bottom of the reagent tube. The top of the tray has several through holes.

[0008] Furthermore, two symmetrically arranged sealing gaskets are fixedly installed in the groove of the slide rod, and the slide rod passes through the sealing gaskets and slides in a sealed manner.

[0009] Furthermore, several "U"-shaped fixing blocks are fixedly installed on the top of the tray, and several through holes are opened on both sides of the fixing blocks.

[0010] Furthermore, the top of the slide bar is fixedly equipped with guide blocks with arc-shaped sides.

[0011] Furthermore, the top of the guide block is provided with a rectangular groove for the slider to slide, one side of the slider is threaded with a bolt made of plastic material, and one side of the slide rod is provided with a threaded hole that matches the bolt.

[0012] Furthermore, a limiting post is fixedly installed on one side of the slider, and a limiting groove is opened on one side of the guide block, which is connected to the inside of the rectangular groove and is adapted to the limiting post.

[0013] Furthermore, the surface of the guide block is provided with several inclined guide holes that communicate with the interior of the rectangular groove.

[0014] The advantages of this utility model are: 1. In this invention, a specific reagent is pre-placed in the reagent tube before use. When blood is introduced into the reagent tube, it is guided into the tube by the arc-shaped surface of the guide block, thereby accelerating the blood flow into the reagent tube and reducing blood residue on the crossbar. After the required blood enters the reagent tube, the sliding rod in the sliding groove moves the rod, along with the tray and several fixed blocks, up and down. The through holes on the tray facilitate the flow and mixing of anticoagulant or blood. Since the fixed blocks are initially submerged in anticoagulant, they carry some anticoagulant upwards as they move, thus mixing with the blood at the upper end of the reagent tube. Through the designed structure, the anticoagulant can quickly and gently mix with the blood, allowing the anticoagulant to fully contact the blood to prevent clotting. Furthermore, the structure designed in this application does not require the multiple inversions of traditional mixing methods, thus eliminating reliance on the operator's "subjective control" and effectively preventing localized blood coagulation due to the upper layer of blood not yet contacting the anticoagulant. Meanwhile, this design, by mixing the anticoagulant with the blood, can effectively prevent blood clots from hindering centrifugation and ensure that blood components are evenly separated according to density, thereby improving centrifugation efficiency.

[0015] 2. In this invention, when using the sliding rod, the slider inside the rectangular groove slides, allowing the slider to temporarily engage and fix the limiting post within the limiting groove, thus not affecting the up-and-down sliding of the sliding rod. When the reagent tube enters the centrifuge for operation, sliding the slider causes the bolt to enter the threaded hole of the sliding rod and tighten, preventing the sliding rod from shifting during subsequent centrifugation operations. When the liquid enters the reagent tube, some liquid will enter the rectangular groove, which can be discharged through the inclined guide hole, allowing it to flow back to the bottom of the reagent tube. Furthermore, the structure designed in this application is entirely made of lightweight plastic. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a three-dimensional structural diagram of the reagent tube in this utility model; Figure 2 This is a cross-sectional view of the reagent tube in this utility model; Figure 3 This is a schematic diagram of the structure of the fixing block in this utility model; Figure 4 This is a structural schematic diagram of the crossbar in this utility model; Figure 5 This is a schematic diagram of the structure of the guide block in this utility model; Figure 6 This is a schematic diagram of the slide groove in this utility model.

[0018] In the diagram: 1. Reagent tube; 2. Crossbar; 3. Slide groove; 4. Slide rod; 5. Gasket; 6. Tray; 7. Through hole; 8. Sealing gasket; 9. Fixing block; 10. Round hole; 11. Flow guide block; 12. Rectangular groove; 13. Slider; 14. Bolt; 15. Threaded hole; 16. Limiting groove; 17. Limiting post; 18. Flow guide hole. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present utility model.

[0020] Please see Figure 1-6 As shown, a reagent pretreatment tube for rapid centrifugation includes a reagent tube 1 and a crossbar 2, which is fixedly installed inside the reagent tube 1, with gaps between the two sides of the crossbar 2 and the inner wall of the reagent tube 1. The crossbar 2 has a groove 3 for sliding a slide bar 4, and a gasket 5 that fits against the slide bar 4 is fixedly installed on the inner wall of the groove 3. A tray 6 is fixedly installed at the bottom of the slide bar 4 and at the bottom of the reagent tube 1. The top of the tray 6 has several through holes 7.

[0021] Specifically, two symmetrically arranged sealing gaskets 8 are fixedly installed inside the groove 3 of the slide rod 4, and the slide rod 4 passes through the sealing gaskets 8 and slides in a sealed manner. Several "U"-shaped fixing blocks 9 are fixedly installed on the top of the tray 6, and several through-holes 10 are opened on both sides of the fixing blocks 9. The top of the slide rod 4 is fixedly installed with arc-shaped guide blocks 11 on both sides.

[0022] During operation, a specific agent (such as an anticoagulant) is pre-placed in reagent tube 1 before use. When blood is introduced into reagent tube 1, it is guided into the interior of reagent tube 1 by the arc-shaped surface of the guide block 11, thereby accelerating the flow of blood into reagent tube 1 and reducing blood residue on the crossbar 2. After the required blood enters reagent tube 1, the slide bar 4 in the sliding groove 3 moves the slide bar 4, along with the tray 6 and several fixing blocks 9, up and down. The through holes 7 on the tray 6 facilitate the flow and mixing of anticoagulant or blood. Since the fixing blocks 9 are initially submerged in anticoagulant, they carry some anticoagulant upwards during upward movement, thus mixing with the blood at the upper end of reagent tube 1.

[0023] It is important to note that the installation of the gasket 5 increases friction to prevent the slide bar 4 from sliding too quickly when moving the tray 6 and the fixing block 9 due to low friction, which could damage the sample structure due to "mechanical impact" and lead to distorted subsequent test results. The sealing gasket 8 is designed to prevent anticoagulant and blood from entering the slide groove 3.

[0024] The structure designed above allows the anticoagulant to mix rapidly and gently with the blood, ensuring sufficient contact between the anticoagulant and the blood to prevent clotting. Furthermore, this design eliminates the need for multiple inversions required in traditional mixing methods, thus avoiding reliance on operator "subjective control" and effectively preventing localized blood coagulation due to the upper layer of blood not yet contacting the anticoagulant. Simultaneously, this design, by mixing the anticoagulant with the blood, effectively prevents blood clots from hindering centrifugation and ensures that blood components are evenly separated according to density, thereby improving centrifugation efficiency.

[0025] The top of the flow guide block 11 has a rectangular groove 12 for the slider 13 to slide. One side of the slider 13 is threaded with a bolt 14 made of plastic material, and one side of the slide rod 4 has a threaded hole 15 that matches the bolt 14. A limiting post 17 is fixedly installed on one side of the slider 13, and one side of the flow guide block 11 has a limiting groove 16 that communicates with the inside of the rectangular groove 12 and matches the limiting post 17. The surface of the flow guide block 11 has several inclined flow guide holes 18 that communicate with the inside of the rectangular groove 12.

[0026] During operation, when using slide bar 4, slide slider 13 within rectangular groove 12, allowing slider 13 to temporarily engage and fix the limiting post 17 into limiting groove 16, thus not affecting the up-and-down sliding of slide bar 4. When reagent tube 1 is inserted into the centrifuge for operation, slide slider 13, along with bolt 14, into threaded hole 15 of slide bar 4 and tighten it, preventing slide bar 4 from shifting due to subsequent centrifugation operations.

[0027] It should be noted that when the liquid enters the reagent tube 1, some liquid will enter the rectangular groove 12. At this time, it can be discharged through the inclined guide hole 18, and then flow back to the bottom of the reagent tube 1. In addition, the structure designed in this application is a lightweight plastic structure.

[0028] Working principle: Before using reagent tube 1, a specific reagent is pre-placed inside. When blood is introduced into reagent tube 1, it is guided into the interior of reagent tube 1 by the arc-shaped surface of the guide block 11, thereby accelerating the blood flow into reagent tube 1 and reducing blood residue on the crossbar 2. After the required blood enters reagent tube 1, the sliding rod 4 in the sliding groove 3 moves the rod 4, along with the tray 6 and several fixing blocks 9, up and down. The through holes 7 on the tray 6 facilitate the flow and mixing of anticoagulant or blood. Since the fixing blocks 9 are initially submerged in anticoagulant, they carry some anticoagulant with them as they move upward, thus mixing with the blood at the upper end of reagent tube 1.

[0029] When using slide bar 4, slide slider 13 in rectangular groove 12, allowing slider 13 to carry limit post 17 into limit groove 16 for temporary locking and fixation, thus not affecting the up and down sliding of slide bar 4. When reagent tube 1 is inserted into centrifuge for operation, slide slider 13, allowing slider 13 to carry bolt 14 into threaded hole 15 of slide bar 4 and tighten it, so that slide bar 4 will not be displaced due to subsequent centrifugation operations.

[0030] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0031] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.

Claims

1. A reagent pretreatment tube for rapid centrifugation, comprising a reagent tube (1), characterized in that: Also includes: A crossbar (2) is fixedly installed inside a reagent tube (1), and there is still a gap between the two sides of the crossbar (2) and the inner wall of the reagent tube (1). The crossbar (2) has a groove (3) for sliding rod (4) to slide inside. A gasket (5) that fits against the sliding rod (4) is fixedly installed on the inner wall of the groove (3). The tray (6) is fixedly installed at the bottom of the slide bar (4) and is located at the bottom of the reagent tube (1). The top of the tray (6) has several through holes (7) that penetrate through itself.

2. The reagent pretreatment tube for rapid centrifugation according to claim 1, characterized in that: Two symmetrically arranged sealing gaskets (8) are fixedly installed in the groove (3) of the slide rod (4), and the slide rod (4) passes through the sealing gaskets (8) and slides in a sealed manner.

3. The reagent pretreatment tube for rapid centrifugation according to claim 1, characterized in that: The top of the tray (6) is fixedly equipped with several "U"-shaped fixing blocks (9), and several circular holes (10) are opened on both sides of the fixing blocks (9).

4. The reagent pretreatment tube for rapid centrifugation according to claim 1, characterized in that: The top of the slide bar (4) is fixedly equipped with guide blocks (11) with arc-shaped sides.

5. A reagent pretreatment tube for rapid centrifugation according to claim 4, characterized in that: The top of the guide block (11) is provided with a rectangular groove (12) for the slider (13) to slide. One side of the slider (13) is threaded with a bolt (14) made of plastic material. One side of the slide rod (4) is provided with a threaded hole (15) that matches the bolt (14).

6. A reagent pretreatment tube for rapid centrifugation according to claim 5, characterized in that: One side of the slider (13) is fixedly installed with a limiting post (17), and one side of the guide block (11) is provided with a limiting groove (16) that is connected to the inside of the rectangular groove (12) and is adapted to the limiting post (17).

7. A reagent pretreatment tube for rapid centrifugation according to claim 6, characterized in that: The surface of the guide block (11) is provided with several inclined guide holes (18) that are connected to the interior of the rectangular groove (12).

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