Modular multi-layer solid phase extraction purification column for environmental detection

Abstract

The utility model discloses modular multilayer solid -phase extraction purification column for environmental detection belongs to environmental detection technical field, and includes: the upper layer cylinder, the middle layer cylinder and the lower layer cylinder, the inner surface of upper layer cylinder, middle layer cylinder and lower layer cylinder all is provided with the buckle mechanism for limiting the sieve plate, through the cooperation of above -mentioned each device, in the utility model, through setting multilayer cylinder, each cylinder is connected through screw thread, has realized the modular installation of extraction column to realize the multiple mechanism collaborative purification, and single time passes the column and can satisfy the pretreatment demand of complex matrix sample, has improved the processing efficiency of extraction column, and adopts screw thread connection, has reduced the connection difficulty between each cylinder, is convenient for the assembly of extraction column, makes extraction column can support free combination adsorbent order or replace specific layer, has improved the versatility of extraction column, has reduced the cost of single use simultaneously.

Description

Technical Field

[0001] This utility model belongs to the field of environmental testing technology, and in particular relates to a modular multilayer solid phase extraction purification column for environmental testing. Background Technology

[0002] Solid phase extraction purification columns are sample pretreatment devices made of silica gel or polymers as a matrix. They achieve the separation and purification of target substances through selective adsorption and elution. Their structure typically includes a polypropylene or glass column, adsorbent packing material, and supporting sieves.

[0003] A search revealed Chinese Patent Publication No. CN209451373U, which discloses a solid-phase extraction column. The column includes a main body, a first liquid guide tube at the top, a protruding tube at the bottom, a first cavity on one side of the protruding tube containing a heating plate, and a second cavity on the side of the protruding tube away from the first cavity containing a cooling plate. An adsorption layer is also present inside the protruding tube. This invention uses the adsorption layer to adsorb the extractant from the extraction liquid, thus shortening the extraction time. Heating or cooling the adsorbed extractant on the adsorption layer using the heating or cooling plate separates extractants with different melting points from the adsorption layer, accelerating the extraction process and increasing the extraction rate. Furthermore, the adsorption layer prevents the extractant from mixing with the solvent during extraction, resulting in higher extraction purity.

[0004] Regarding the aforementioned technologies, the inventors have discovered the following drawbacks: Traditional solid-phase extraction columns are mostly single-adsorption layer structures, and a single adsorbent is difficult to deal with multiple interfering substances in complex matrix samples. Multiple extraction columns often need to be connected in series, which is cumbersome and time-consuming. Furthermore, special extraction columns need to be purchased for different detection items, resulting in high laboratory consumable costs and complex inventory management. At the same time, during the purification process of the extraction column, the sample flow rate needs to be controlled by an external vacuum pump or nitrogen blower, which requires a large investment in equipment and is prone to flow rate instability due to packing compaction.

[0005] Therefore, this invention provides a modular multilayer solid-phase extraction purification column for environmental testing to solve the above problems. Utility Model Content

[0006] (a) Technical problems to be solved

[0007] This invention provides a modular multilayer solid-phase extraction purification column for environmental testing, aiming to solve the problems mentioned in the background art.

[0008] (II) Technical Solution

[0009] To achieve the above objectives, this utility model provides the following technical solution:

[0010] A modular multilayer solid-phase extraction purification column for environmental testing includes an upper column, a middle column, and a lower column. The outer surfaces of the upper, middle, and lower columns are all threaded, and the inner surfaces of the upper, middle, and lower columns are all threaded grooves. The threads are located at the lower ends of the upper, middle, and lower columns, and the threaded grooves are located at the upper ends of the upper, middle, and lower columns. The threads and threaded grooves are mutually compatible. The upper, middle, and lower columns are sequentially connected by threads. The inner surfaces of the upper, middle, and lower columns are all equipped with a locking mechanism for limiting the position of the sieve plate.

[0011] The buckling mechanism includes grooves, and the inner surfaces of the upper, middle and lower columns are all provided with grooves at equal intervals.

[0012] As a further description of the above technical solution:

[0013] A support spring is fixedly installed on the inner wall of the groove, and a movable plate is fixedly installed on one end of the support spring. The outer surface of the movable plate is in contact with and slidably connected to the inner wall of the groove.

[0014] As a further description of the above technical solution:

[0015] The movable plate has locking blocks fixedly installed at equal intervals on its side wall. The locking blocks are right-angled triangular blocks with the right-angled face facing down.

[0016] As a further description of the above technical solution:

[0017] Support blocks are fixedly installed at equal intervals on the inner surfaces of the upper, middle and lower columns. A lower nylon sieve plate is placed on the upper surface of the support block. Adsorbent is filled above the lower nylon sieve plate. An upper nylon sieve plate is placed above the adsorbent. The upper surface of the upper nylon sieve plate is in contact with the lower surface of the block.

[0018] As a further description of the above technical solution:

[0019] The upper end of the upper column is threaded with an anti-backflow cap in the threaded groove, and the upper surface of the anti-backflow cap is equipped with a Luer connector.

[0020] As a further description of the above technical solution:

[0021] A flow limiting valve is threadedly installed at the lower end of the lower column, and the flow limiting valve is an integrated rotary flow limiting valve.

[0022] As a further description of the above technical solution:

[0023] The upper, middle, and lower columns, as well as the lower surface of the anti-backflow cap, are all fixedly equipped with sealing rings. The sealing rings are used to seal the connection points of each layer and are made of silicone.

[0024] (III) Beneficial Effects

[0025] In summary, due to the adoption of the above technical solution, the beneficial effects of this utility model are:

[0026] 1. In this utility model, by setting up multiple columns and connecting them with threads, the modular installation of the extraction column is realized, thereby achieving multi-mechanism synergistic purification. A single column pass can meet the pretreatment requirements of complex matrix samples, improving the processing efficiency of the extraction column. Furthermore, the use of threaded connections reduces the connection difficulty between the columns, making it easier to assemble the extraction column. This allows the extraction column to support free combination of adsorbent sequence or replacement of specific layers, improving the versatility of the extraction column and reducing the cost per use.

[0027] 2. In this utility model, by setting an integrated rotary flow limiting valve, the extraction column has a built-in flow limiting valve, and at the same time, the extraction column does not need to be connected to an external vacuum pump or nitrogen blower, reducing the use of external instruments, thereby simplifying the operation process of the extraction column, improving the ease of use of the extraction column, and also making the extraction column suitable for on-site rapid detection and small laboratory scenarios.

[0028] 3. In this utility model, by setting a snap-fit ​​mechanism, an upper nylon sieve plate and a lower nylon sieve plate, and setting nylon sieve plates between each column, the leakage of packing material can be effectively prevented, ensuring the stability of the extraction column in use. At the same time, with the cooperation of the snap-fit ​​mechanism, the upper nylon sieve plate squeezes the adsorbent, improving the compactness of the adsorbent in the column, thereby ensuring that the extraction time in each column is relatively stable and improving the extraction effect of the extraction column. Attached Figure Description

[0029] Figure 1 A three-dimensional structural diagram of a modular multilayer solid-phase extraction purification column for environmental monitoring.

[0030] Figure 2 This is a schematic diagram of the exploded structure of a modular multilayer solid-phase extraction purification column for environmental monitoring.

[0031] Figure 3 A schematic cross-sectional view of the upper column in a modular multilayer solid-phase extraction purification column for environmental monitoring.

[0032] Figure 4 Modular multilayer solid-phase extraction purification column for environmental monitoring Figure 3 A magnified structural diagram of point A in the middle.

[0033] Figure 5A schematic diagram of the exploded structure of the upper column in a modular multilayer solid-phase extraction purification column for environmental monitoring.

[0034] Legend:

[0035] 1. Upper column; 2. Middle column; 3. Lower column; 4. Anti-backflow cap; 5. Flow limiting valve; 6. Support block; 7. Lower nylon screen plate; 8. Buckling mechanism; 801. Groove; 802. Support spring; 803. Movable plate; 804. Locking block; 9. Upper nylon screen plate; 10. Sealing ring. Detailed Implementation

[0036] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0037] In specific implementation, such as Figures 1-5 As shown, this utility model provides a technical solution: a modular multilayer solid-phase extraction purification column for environmental testing, comprising an upper column 1, a middle column 2, and a lower column 3. The outer surfaces of the upper column 1, middle column 2, and lower column 3 are all provided with threads, and the inner surfaces of the upper column 1, middle column 2, and lower column 3 are all provided with threaded grooves. The threads are located at the lower ends of the upper column 1, middle column 2, and lower column 3, and the threaded grooves are located at the lower ends of the upper column 1, middle column 2, and lower column 3. The upper ends of the middle column 2 and the lower column 3 have threads and thread grooves that are compatible with each other. The upper column 1, the middle column 2 and the lower column 3 are connected sequentially by threads. The inner surfaces of the upper column 1, the middle column 2 and the lower column 3 are all provided with a snap-fit ​​mechanism 8 for limiting the screen plate. The snap-fit ​​mechanism 8 includes a groove 801, and the inner surfaces of the upper column 1, the middle column 2 and the lower column 3 are all provided with grooves 801 at equal intervals.

[0038] A support spring 802 is fixedly installed on the inner wall of the groove 801. A movable plate 803 is fixedly installed on one end of the support spring 802. The outer surface of the movable plate 803 is in contact with and slidably connected to the inner wall of the groove 801.

[0039] The movable plate 803 has a locking block 804 fixedly installed at equal intervals on its side wall. The locking block 804 is a right-angled triangular block with the right-angled face facing down.

[0040] Support blocks 6 are fixedly installed at equal intervals on the inner surfaces of the upper column 1, the middle column 2 and the lower column 3. A lower nylon sieve plate 7 is placed on the upper surface of the support block 6. Adsorbent is filled above the lower nylon sieve plate 7. An upper nylon sieve plate 9 is placed above the adsorbent. The upper surface of the upper nylon sieve plate 9 is in contact with the lower surface of the card block 804.

[0041] Specifically, through the cooperation between the above structures, during the loading process of the upper nylon sieve plate 9 and the lower nylon sieve plate 7 into the column, the upper nylon sieve plate 9 and the lower nylon sieve plate 7 will first squeeze the locking block 804. At this time, the locking block 804 drives the movable plate 803 to retract into the groove 801. After the upper nylon sieve plate 9 has finished squeezing the adsorbent, the upper nylon sieve plate 9 is located between the two locking blocks 804. At this time, the movable plate 803 supports the spring 802. Under the action of the force, it will move outward from the groove 801, thereby driving the locking block 804 to move synchronously. Under the action of the right angle surface of the locking block 804, the upper nylon screen plate 9 is limited, so that the upper nylon screen plate 9 is fixed in the column. When the upper nylon screen plate 9 and the lower nylon screen plate 7 are to be disassembled, the locking block 804 is pressed into the groove 801, so that the outermost end of the locking block 804 is flush with the inner surface of the column, and the upper nylon screen plate 9 and the lower nylon screen plate 7 can be removed.

[0042] An anti-backflow cap 4 is installed in the threaded groove at the upper end of the upper column 1, and a Luer connector is provided on the upper surface of the anti-backflow cap 4.

[0043] A flow limiting valve 5 is threadedly installed at the lower end of the lower column 3. The flow limiting valve 5 is an integrated rotary flow limiting valve 5.

[0044] A sealing ring 10 is fixedly installed on the lower surface of the upper column 1, the middle column 2, the lower column 3 and the anti-backflow cap 4. The sealing ring 10 is used to seal the connection of each layer and is made of silicone.

[0045] Specifically, through the cooperation of the above structures, the anti-backflow cap 4, upper column 1, middle column 2, lower column 3 and flow limiting valve 5 are connected by threads. At the same time, the sealing ring 10 improves the sealing of the connection to prevent leakage or contamination of the target substance. After the extraction column is used, the components are disassembled by rotating them, and then the upper nylon sieve plate 9, lower nylon sieve plate 7 and valve body are recycled. The remaining components are discarded to their respective recycling points.

[0046] Working principle: Lower nylon sieve plates 7 are installed inside the upper column 1, middle column 2, and lower column 3 respectively. At this time, the lower nylon sieve plates 7 are fixed inside the column under the support of the support block 6. Then, adsorbents with different functions are injected into the upper column 1, middle column 2, and lower column 3 respectively. Then, the upper nylon sieve plate 9 is pressed towards the lower nylon sieve plate 7. At this time, the upper nylon sieve plate 9 will squeeze the adsorbent, thereby increasing the density of the adsorbent. Under the action of the snap-fit ​​mechanism 8, the upper nylon sieve plate 9 is fixed. Then, the anti-backflow cap 4 is connected to the upper column 1 by threads, the upper column 1 is connected to the middle column 2 by threads, the middle column 2 is connected to the lower column 3 by threads, and the lower column 3 is connected to the flow limiting valve 5 by threads. The silicone sealing ring 10 will enhance the sealing of each connection.

[0047] Connect the output end of the syringe containing the target substance to the Luer connector on the anti-backflow cap 4, then open the flow limiting valve 5, and push the syringe by hand to push the target substance into the column. The target substance is extracted by the adsorbent in the upper column 1, middle column 2 and lower column 3, and then flows out through the outlet of the flow limiting valve 5. After the extraction column is used, disassemble it, recycle the upper nylon sieve plate 9, the lower nylon sieve plate 7 and the valve body, and discard the remaining structure.

[0048] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A modular multilayer solid-phase extraction purification column for environmental monitoring, characterized in that: include: The upper column (1), the middle column (2) and the lower column (3) are provided with threads on their outer surfaces and threaded grooves on their inner surfaces. The threads are located at the lower ends of the upper column (1), the middle column (2) and the lower column (3), and the threaded grooves are located at the upper ends of the upper column (1), the middle column (2) and the lower column (3). The threads and threaded grooves are compatible with each other. The upper column (1), the middle column (2) and the lower column (3) are connected in sequence by threads. The inner surfaces of the upper column (1), the middle column (2) and the lower column (3) are provided with a snap-fit ​​mechanism (8) for limiting the screen plate. The buckling mechanism (8) includes a groove (801), and the inner surfaces of the upper column (1), the middle column (2) and the lower column (3) are all provided with grooves (801) at equal intervals.

2. The modular multilayer solid-phase extraction purification column for environmental monitoring according to claim 1, characterized in that, A support spring (802) is fixedly installed on the inner wall of the groove (801), and a movable plate (803) is fixedly installed on one end of the support spring (802). The outer surface of the movable plate (803) is in contact with and slidably connected to the inner wall of the groove (801).

3. The modular multilayer solid-phase extraction purification column for environmental monitoring according to claim 2, characterized in that, The movable plate (803) has a locking block (804) fixedly installed at equal intervals on its side wall. The locking block (804) is a right-angled triangular block with the right-angled face facing down.

4. The modular multilayer solid-phase extraction purification column for environmental monitoring according to claim 1, characterized in that, Support blocks (6) are fixedly installed at equal intervals on the inner surfaces of the upper column (1), middle column (2) and lower column (3). A lower nylon sieve plate (7) is placed on the upper surface of the support block (6). Adsorbent is filled above the lower nylon sieve plate (7). An upper nylon sieve plate (9) is placed above the adsorbent. The upper surface of the upper nylon sieve plate (9) is in contact with the lower surface of the card block (804).

5. The modular multilayer solid-phase extraction purification column for environmental monitoring according to claim 1, characterized in that, The upper end of the upper column (1) is threaded with an anti-backflow cap (4) in the threaded groove, and the upper surface of the anti-backflow cap (4) is equipped with a Luer connector.

6. The modular multilayer solid-phase extraction purification column for environmental monitoring according to claim 1, characterized in that, A flow limiting valve (5) is threadedly installed at the lower end of the lower column (3), and the flow limiting valve (5) is an integrated rotary flow limiting valve (5).

7. The modular multilayer solid-phase extraction purification column for environmental monitoring according to claim 1, characterized in that, The upper column (1), middle column (2), lower column (3) and the lower surface of the anti-backflow cap (4) are all fixedly installed with sealing rings (10). The sealing rings (10) are used to seal the connection of each layer. The sealing rings (10) are made of silicone.

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