A rapid weighing device for use in conjunction with liquid chromatography

Abstract

A kind of matched liquid chromatography determination fast weighing device belongs to sample pretreatment equipment field.It includes bottom table, auxiliary electronic balance and high-precision electronic balance, balance is fixed on bottom table and is respectively equipped with transparent cover, multiple batches of sample plates are placed in the transparent cover of auxiliary balance, sample bottle is placed in the transparent cover of high-precision balance, storage box is arranged on the back of auxiliary balance to store sampling dropper.The device realizes rapid, accurate and no spillage weighing of sample by double-balance division, batch processing of multiple batches of sample plates, spillage prevention design of sampling dropper and environment control of transparent cover, greatly improves the detection efficiency of large batch of samples, and is convenient to operate and low in cost.

Description

Technical Field

[0001] This utility model relates to the field of sample pretreatment equipment, and in particular to a rapid weighing device for liquid chromatography determination. Background Technology

[0002] Liquid chromatography (LC) is widely used in the chemical, pharmaceutical, and food industries for determining the content of major components in powder and granular samples due to its high separation efficiency and accurate detection. In this detection process, sample pretreatment is a crucial step, and the weighing operation, as the core step of pretreatment, directly determines the overall detection cycle and the reliability of the results based on its efficiency and accuracy.

[0003] The currently common weighing method in the industry involves analysts using a weighing spoon to gradually transfer powdered and granular samples into a volumetric flask placed on an electronic balance. This requires multiple small transfers of sample until the target mass of approximately 0.1g is achieved. This method has several inherent drawbacks: 1. The mouth of the volumetric flask is relatively narrow, and when using a weighing spoon to transfer the sample, the sample is very easy to spill, which not only wastes the sample, but may also contaminate the experimental environment. 2. In order to control the weighing accuracy, it is necessary to repeatedly add or remove samples using the weighing spoon. Weighing a single batch of samples takes a long time and is cumbersome. 3. Repeated manual operations are prone to human error, leading to weighing deviations and affecting the accuracy of subsequent test results; 4. With the expansion of industrial production scale, factories need to process hundreds of sample batches every day. The traditional single-batch weighing mode is inefficient, and the weighing process has become the core bottleneck restricting the improvement of the overall testing process efficiency, which cannot meet the actual needs of rapid testing of large batches of samples. Utility Model Content

[0004] Based on the problems mentioned in the background technology, there is an urgent need for a dedicated device that can solve sample spillage, improve weighing efficiency, and ensure weighing accuracy, so as to meet the large-scale pretreatment needs of powder and granular samples in liquid chromatography.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows: A rapid weighing device for liquid chromatography determination includes a base, an auxiliary electronic balance, and a high-precision electronic balance, which are fixedly mounted on the base. The auxiliary electronic balance is equipped with a first transparent cover, inside which multiple batches of sample plates are placed. The high-precision electronic balance is equipped with a second transparent cover, inside which a sampling bottle is placed.

[0006] In the preferred embodiment, both the auxiliary electronic balance and the high-precision electronic balance are vertically positioned at their four bottom corners, and positioning holes are provided on the base platform corresponding to the positioning supports. The auxiliary electronic balance and the high-precision electronic balance are positioned and installed by inserting the positioning supports into the positioning holes.

[0007] In the preferred embodiment, both the auxiliary electronic balance and the high-precision electronic balance are equipped with weighing plates on their upper surfaces, and a magnetic suction plate is provided at the axial center of the weighing plates; the bottom surfaces of the multi-batch sample plates and sampling bottles are equipped with metal plates, and positioning is achieved through the magnetic attraction between the metal plates and the magnetic suction plate.

[0008] In the preferred embodiment, both the auxiliary electronic balance and the high-precision electronic balance have insertion slots on their upper surfaces, which are arranged around the outside of the weighing plate; the bottoms of the first transparent cover and the second transparent cover are inserted into the corresponding insertion slots.

[0009] In a preferred embodiment, the top of the first transparent cover is provided with a cover plate, and the lower end face of the cover plate is provided with a magnetic strip corresponding to the top end face of the first transparent cover; the cover plate is provided with first sampling ports at equal intervals, and the lower end face of the cover plate is provided with a guide tube vertically, the guide tube corresponding to and connected to the first sampling ports.

[0010] In the preferred embodiment, sample slots are equidistantly provided on the upper surface of multiple batches of sample plates, and the positions of the sample slots correspond directly to the lower end ports of the guide cylinder.

[0011] In a preferred embodiment, a second sampling port is provided at the top of the second transparent cover, and the position of the second sampling port corresponds to the top port of the sampling bottle; a flip cover is hinged at the second sampling port.

[0012] In the preferred embodiment, the back of the auxiliary electronic balance is equipped with a storage box, and a sampling dropper is inserted inside the storage box.

[0013] In the preferred embodiment, the upper surface of the storage box has a storage hole, and the outer wall of the sampling dropper has a convex ring. The sampling dropper is locked into the storage hole by the convex ring to achieve a limiting position.

[0014] In the preferred embodiment, the sampling dropper is made of a transparent material, and its wall is engraved with graduation strips.

[0015] A rapid weighing device for determination by liquid chromatography, which has the following beneficial effects during use: 1. This utility model can avoid spillage through a dual structure: the special sampling dropper adopts a 45° angled design, which can be smoothly inserted into the mouth of the sampling bottle; the guide tube inside the first transparent cover is precisely aligned with the sample slot of the multi-batch sample plate, and the sample is directly transferred to the sampling bottle along the guide tube. The dual structure together avoids spillage, and there is no exposure operation throughout the process, which reduces sample waste and avoids sample contamination by environmental dust. 2. The multi-batch sample plate can accommodate multiple batches of samples at the same time, realizing "one-time tray placement and multiple retrievals"; the two balances work together to assist the electronic balance in initial weighing and control, and the high-precision electronic balance accurately weighs, eliminating the need for repeated sample addition and subtraction steps, greatly shortening the weighing time of a single batch, and can efficiently process hundreds of sample batches, breaking through the traditional efficiency bottleneck. 3. Dual precision control through structural positioning and accuracy grading: The balance is fixed by the support and positioning hole, and the sample container is positioned by magnetic attraction to avoid displacement and shaking; the auxiliary balance is used for initial weighing, and the high-precision balance is used for fine calibration. With the help of the sampling dropper scale strip for observation, human error is effectively reduced, and the weighing accuracy is stable at 0.1mg level, which meets the testing requirements; 4. The first transparent cover has a magnetic opening and closing mechanism for easy sample plate placement and cleaning; the second transparent cover has a flip-top cover for easy sampling bottle operation, and its transparent design facilitates observation; the storage box neatly stores sampling tools to prevent loss or contamination. Attached Figure Description

[0016] The present invention will be further described below with reference to the accompanying drawings and embodiments: Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the auxiliary electronic balance and the fixing structure of the high-precision electronic balance of this utility model; Figure 3 This is a cross-sectional view of the internal structure of the auxiliary electronic balance of this utility model; Figure 4 This is a bottom view of the top cover plate of the auxiliary electronic balance of this utility model; Figure 5 This is a schematic diagram of the sampling dropper and storage device of this utility model; Figure 6 This is a schematic diagram of the internal structure of the auxiliary electronic balance and the high-precision electronic balance of this utility model.

[0017] In the diagram: 1. Base platform; 2. Auxiliary electronic balance; 3. High-precision electronic balance; 4. First transparent cover; 5. Second transparent cover; 6. Positioning support; 7. Positioning hole; 8. Weighing plate; 9. Multi-batch sample plate; 10. Sample slot; 11. Cover plate; 12. First sampling port; 13. Storage box; 14. Guide tube; 15. Storage hole; 16. Sampling dropper; 17. Convex ring; 18. Scale strip; 19. Second sampling port; 20. Flip cover plate; 21. Magnetic suction plate; 22. Sampling bottle; 23. Insertion slot; 24. Magnetic suction strip. Detailed Implementation

[0018] like Figure 1 and Figure 6As shown, a rapid weighing device for liquid chromatography determination includes a base 1, an auxiliary electronic balance 2, and a high-precision electronic balance 3. The base 1 is made of 304 stainless steel, providing good load-bearing capacity and rust resistance. The auxiliary electronic balance 2 has a weighing accuracy of 1 mg, suitable for initial weighing of multiple batches of samples. The high-precision electronic balance 3 has a weighing accuracy of 0.1 mg, meeting the accuracy requirements of liquid chromatography detection. Both are fixedly mounted on the base 1 with appropriate spacing, facilitating simultaneous operation by the operator. The auxiliary electronic balance 2 is equipped with a first transparent cover 4, which isolates external airflow and dust, and contains multiple batches of sample plates 9. The high-precision electronic balance 3 is equipped with a second transparent cover 5, which contains sampling bottles 22 (stoppered volumetric flasks, suitable for subsequent ultrasonic dissolution of samples). The dual balances work together to achieve "initial weighing control + precise weighing," while the transparent covers ensure a stable weighing environment and avoid external interference.

[0019] Preferred solutions include Figure 2 As shown, both the auxiliary electronic balance 2 and the high-precision electronic balance 3 have vertically positioned support pillars 6 at their four bottom corners, and corresponding positioning holes 7 are provided on the base 1. The auxiliary electronic balance 2 and the high-precision electronic balance 3 are positioned and installed by inserting the positioning support pillars 6 into the positioning holes 7. The precise fit between the support pillars and the holes fixes the position of the balance, preventing it from shifting due to collisions or vibrations during weighing, thus ensuring weighing accuracy. If necessary, anti-slip pads can be used to further improve stability.

[0020] Preferred solutions include Figure 6 As shown, both the auxiliary electronic balance 2 and the high-precision electronic balance 3 have a weighing plate 8 on their upper surfaces. The surface of the weighing plate 8 is flat, which can reduce weighing deviation. A magnetic suction plate 21 is provided at the axial position of the weighing plate 8, and metal plates are provided on the bottom surfaces of the multi-batch sample plate 9 and the sampling bottle 22. Through the magnetic attraction between the metal plate and the magnetic suction plate 21, the sample plate and the sampling bottle are quickly positioned, preventing the containers from shifting due to airflow or slight collisions during weighing, ensuring the stability of the container position during the weighing process, and avoiding reading errors.

[0021] Preferred solutions include Figure 3 and Figure 6 As shown, both the auxiliary electronic balance 2 and the high-precision electronic balance 3 have insertion slots 23 on their upper surfaces, which surround the weighing plate 8. The bottoms of the first transparent cover 4 and the second transparent cover 5 are inserted into the corresponding insertion slots 23. The bottom of the transparent cover is embedded in the insertion slot 23 to form a slight seal, further isolating the external airflow from interfering with the load-bearing area, while fixing the position of the transparent cover to prevent displacement and failure of protection.

[0022] Preferred solutions include Figure 3 and Figure 4As shown, a cover plate 11 is provided at the top of the first transparent cover 4, and a magnetic strip 24 is provided corresponding to the top of the cover plate 11 and the first transparent cover 4. First sampling ports 12 are equidistantly opened on the cover plate 11, and a guide tube 14 is vertically provided on the lower end face of the cover plate 11. The guide tube 14 corresponds to and communicates with the first sampling ports 12. The magnetic strip 24 facilitates the quick opening and closing of the cover plate 11, making it convenient to place the sample plate and maintaining a seal when closed. The guide tube 14 is precisely aligned with the sample tank 10, allowing the sample to fall directly into the sample tank or sampling bottle along the guide tube 14 during sampling, avoiding leakage during transfer and reducing contact between the sample and the outside environment.

[0023] Preferred solutions include Figure 3 As shown, sample slots 10 are equidistantly spaced on the upper surface of the multi-batch sample plate 9. The positions of the sample slots 10 correspond directly to the lower end ports of the guide cylinder 14, and the outer side of the sample slots 10 is marked with numbers. The multi-slot design can accommodate multiple batches of samples simultaneously, enabling multiple retrievals from a single tray placement, reducing the time spent frequently changing sample containers; the numbering facilitates the recording of sample batch information and avoids confusion; the alignment of the slots with the guide cylinder ensures accurate sampling and improves operational efficiency.

[0024] Preferred solutions include Figure 6 As shown, a second sampling port 19 is provided at the top of the second transparent cover 5, and the position of the second sampling port 19 corresponds to the top port of the sampling bottle 22; a flip cover 20 is hinged to the second sampling port 19. The flip cover 20 can be opened and closed flexibly. When sampling, it can be opened to facilitate the insertion of the dropper, and after sampling, it can be closed to isolate external interference; the sampling port is aligned with the sampling bottle to ensure that the dropper can be smoothly inserted into the bottle and to prevent the sample from spilling into the weighing area of ​​the balance.

[0025] Preferred solutions include Figure 3 and Figure 5 As shown, the auxiliary electronic balance 2 has a storage box 13 on its back, and a sampling dropper 16 is inserted into the storage box 13. The lower end of the sampling dropper 16 is cut to form a 45° angle. The storage box 13 can store sampling tools in an orderly manner to avoid loss or contamination of tools; the 45° angled design makes it easy for the dropper to be inserted into the narrow sample slot and the mouth of the sampling bottle, reducing sample sticking to the wall and ensuring accurate sampling. At the same time, disposable droppers can avoid cross-contamination.

[0026] Preferred solutions include Figure 5 As shown, the upper surface of the storage box 13 has a storage hole 15, and the outer wall of the sampling dropper 16 has a protruding ring 17. The sampling dropper 16 is engaged in the storage hole 15 through the protruding ring 17. The engagement between the protruding ring 17 and the storage hole 15 can limit the position of the dropper, so that the lower end of the dropper is suspended in the air and does not contact the bottom of the storage box, thus avoiding contamination of the dropper; at the same time, it is convenient for operators to quickly take it out and improve the convenience of operation.

[0027] Preferred solutions include Figure 5As shown, the sampling dropper 16 is made of transparent material, and a scale strip 18 is engraved on its wall. The transparent material makes it easy to observe the amount of sample in the tube, and the scale strip 18 can help to make a preliminary judgment on the sample volume. Combined with the balance to weigh the mass, it forms a dual control of volume observation and mass weighing, which further improves the sampling accuracy and meets the stringent requirements of liquid chromatography detection for sample volume.

[0028] When using this device for liquid chromatography sample weighing, the specific operating procedure is as follows: 1) Load each batch of powder / granular samples into the corresponding sample slots 10 of the multi-batch sample plate 9, and record the correspondence between the sample and the slot numbers; 2) Place the sample plate 9 on the weighing plate 8 of the auxiliary electronic balance 2, and after magnetic positioning, operate the auxiliary electronic balance 2 to perform the tare operation, so that the balance display is zero (principle: after tare, the mass change of subsequent sampling can be directly read, and the single sampling quantity can be intuitively controlled); 3) Take a sampling bottle 22 and place it on the weighing plate 8 of the high-precision electronic balance 3, and after magnetic positioning, perform the "tare" operation in the same way; 4) Open the cover plate 11 at the top of the first transparent cover 4. Select the corresponding sample slot 10 according to the sample number, use the sampling dropper 16 in the storage box 13 to transfer the sample, extend it into the sample slot 10 along the first sampling port 12 and the guide tube 14, transfer the specified amount of sample, and then release the sample into the sampling bottle 22 through the second sampling port 19; 5) The high-precision electronic balance 3 displays the sample mass in real time. If the target value is reached, the sampling of this batch is completed. If it is not reached, the sampling steps are repeated; 6) After each sampling is completed, the auxiliary electronic balance 2 is operated to perform the tare operation on the sample plates 9 of multiple batches again so that the sampling mass can be accurately read in the next sampling; 7) The weighing of all batches of samples is completed in sequence according to the above steps, realizing efficient, accurate and leak-free operation throughout the process.

Claims

1. A rapid weighing device for liquid chromatography determination, comprising a base (1), an auxiliary electronic balance (2), and a high-precision electronic balance (3), characterized in that: An auxiliary electronic balance (2) and a high-precision electronic balance (3) are fixedly mounted on a base (1); the auxiliary electronic balance (2) is equipped with a first transparent cover (4), and multiple batches of sample plates (9) are placed inside the first transparent cover (4); the high-precision electronic balance (3) is equipped with a second transparent cover (5), and a sampling bottle (22) is placed inside the second transparent cover (5).

2. The rapid weighing device for determination by liquid chromatography according to claim 1, characterized in that: The bottom four corners of the auxiliary electronic balance (2) and the high-precision electronic balance (3) are provided with vertical positioning pillars (6), and the base (1) is provided with positioning holes (7) corresponding to the positioning pillars (6). The auxiliary electronic balance (2) and the high-precision electronic balance (3) are positioned and installed by inserting the positioning pillars (6) and the positioning holes (7).

3. The rapid weighing device for determination by liquid chromatography according to claim 1, characterized in that: The upper surfaces of the auxiliary electronic balance (2) and the high-precision electronic balance (3) are equipped with weighing plates (8), and the axial position of the weighing plates (8) is equipped with magnetic plates (21); the bottom surfaces of the multi-batch sample plates (9) and the sampling bottles (22) are equipped with metal plates, and the positioning is achieved by the magnetic attraction between the metal plates and the magnetic plates (21).

4. The rapid weighing device for determination by liquid chromatography according to claim 3, characterized in that: Both the auxiliary electronic balance (2) and the high-precision electronic balance (3) have insertion slots (23) on their upper surfaces, which are arranged around the outside of the weighing plate (8); the bottoms of the first transparent cover (4) and the second transparent cover (5) are inserted into the corresponding insertion slots (23).

5. The rapid weighing device for determination by liquid chromatography according to claim 4, characterized in that: The top of the first transparent cover (4) is provided with a cover plate (11), and the lower end face of the cover plate (11) is provided with a magnetic strip (24) corresponding to the top end face of the first transparent cover (4); the cover plate (11) is provided with a first sampling port (12) at equal intervals, and the lower end face of the cover plate (11) is provided with a guide tube (14) vertically, and the guide tube (14) corresponds to and is connected to the first sampling port (12).

6. The rapid weighing device for determination by liquid chromatography according to claim 5, characterized in that: Sample slots (10) are provided at equal intervals on the upper surface of the sample plate (9) of multiple batches. The position of the sample slots (10) corresponds to the lower end port of the guide tube (14).

7. The rapid weighing device for determination by liquid chromatography according to claim 4, characterized in that: The top of the second transparent cover (5) is provided with a second sampling port (19), which corresponds to the top port of the sampling bottle (22); a flip cover (20) is hinged at the second sampling port (19).

8. The rapid weighing device for determination by liquid chromatography according to claim 1, characterized in that: The auxiliary electronic balance (2) has a storage box (13) on the back, and a sampling dropper (16) is inserted in the storage box (13).

9. The rapid weighing device for determination by liquid chromatography according to claim 8, characterized in that: The upper end face of the storage box (13) is provided with a storage hole (15), and the outer wall of the sampling dropper (16) is provided with a protruding ring (17). The sampling dropper (16) is locked in the storage hole (15) by the protruding ring (17) to achieve the limit.

10. The rapid weighing device for determination by liquid chromatography according to claim 9, characterized in that: The sampling dropper (16) is made of transparent material and has scale strips (18) engraved on its wall.

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