METHODS FOR THE PREPARATION OF INJECTABLE STOCK COMPOSITIONS

Abstract

Injectable depot compositions, consisting of a biocompatible polymer, which is a polymer or a copolymer based on lactic acid and / or lactic acid together with glycolic acid with a ratio of lactic acid to glycolic acid monomers in a range of 48:52 to 100:0, a water-miscible solvent with a dipole moment of about 3.7-4.5 D and a dielectric constant between 30 and 50 and a drug, were deemed suitable for the in situ formation of biodegradable implants that can induce therapeutic levels of the drug in the plasma from the first day and for at least days.